DE60020100D1 - Dimerverbindungen und als inhibitoren der neuramidinase - Google Patents
Dimerverbindungen und als inhibitoren der neuramidinaseInfo
- Publication number
- DE60020100D1 DE60020100D1 DE60020100T DE60020100T DE60020100D1 DE 60020100 D1 DE60020100 D1 DE 60020100D1 DE 60020100 T DE60020100 T DE 60020100T DE 60020100 T DE60020100 T DE 60020100T DE 60020100 D1 DE60020100 D1 DE 60020100D1
- Authority
- DE
- Germany
- Prior art keywords
- dimerbindungen
- neuramidinase
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/595—Polyamides, e.g. nylon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPP9139A AUPP913999A0 (en) | 1999-03-12 | 1999-03-12 | Novel chemical compounds and their use |
AUPP913999 | 1999-03-12 | ||
PCT/AU2000/000165 WO2000055149A1 (en) | 1999-03-12 | 2000-03-09 | Dimeric compounds and as inhibitors of neuraminidase |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60020100D1 true DE60020100D1 (de) | 2005-06-16 |
DE60020100T2 DE60020100T2 (de) | 2006-01-19 |
Family
ID=3813338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60020100T Expired - Lifetime DE60020100T2 (de) | 1999-03-12 | 2000-03-09 | Dimerverbindungen und ihre Verwendung als Inhibitoren der Neuraminidase |
Country Status (26)
Country | Link |
---|---|
US (1) | US6548476B1 (de) |
EP (1) | EP1165541B1 (de) |
JP (1) | JP5160000B2 (de) |
KR (1) | KR100805906B1 (de) |
CN (1) | CN1343205A (de) |
AP (1) | AP2001002277A0 (de) |
AT (1) | ATE295361T1 (de) |
AU (2) | AUPP913999A0 (de) |
BR (1) | BR0008939A (de) |
CA (1) | CA2367755C (de) |
CZ (1) | CZ20013274A3 (de) |
DE (1) | DE60020100T2 (de) |
EA (1) | EA200100968A1 (de) |
ES (1) | ES2241581T3 (de) |
HK (1) | HK1041693B (de) |
HU (1) | HUP0200190A3 (de) |
ID (1) | ID29868A (de) |
IL (1) | IL145346A (de) |
MX (1) | MXPA01009203A (de) |
NO (1) | NO327812B1 (de) |
NZ (1) | NZ514041A (de) |
PL (1) | PL350228A1 (de) |
TR (1) | TR200102794T2 (de) |
TW (1) | TWI268279B (de) |
WO (1) | WO2000055149A1 (de) |
ZA (1) | ZA200107450B (de) |
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EP0951480A4 (de) * | 1996-11-14 | 2004-07-28 | Biota Scient Management | Verfahren und neue verbindungen, die in diesem verfahren einsetzbar sind. |
DE19930177B4 (de) | 1999-06-30 | 2007-02-08 | Nikolai Vladimirovich Bovin | Intermolekular assoziierende Verbindungen und deren Verwendung |
AUPQ288499A0 (en) | 1999-09-16 | 1999-10-07 | Biota Scientific Management Pty Ltd | Antiviral agents |
AUPR001000A0 (en) | 2000-09-08 | 2000-10-05 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
AUPR879401A0 (en) * | 2001-11-09 | 2001-12-06 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
AUPR879501A0 (en) * | 2001-11-09 | 2001-12-06 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
AUPR879701A0 (en) * | 2001-11-09 | 2001-12-06 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
AU2002340632B2 (en) * | 2001-11-09 | 2008-03-20 | Biota Scientific Management Pty Ltd | Dimeric compounds and their use as anti-viral agents |
AU2002336823B2 (en) * | 2001-11-09 | 2008-03-20 | Biota Scientific Management Pty Ltd | Dimeric compounds and their use as anti-viral agents |
AUPR879601A0 (en) * | 2001-11-09 | 2001-12-06 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
AU2002340635B2 (en) * | 2001-11-09 | 2008-03-13 | Biota Scientific Management Pty Ltd | Dimeric compounds and their use as anti-viral agents |
WO2003040135A1 (en) * | 2001-11-09 | 2003-05-15 | Biota Scientific Management Pty Ltd | Dimeric compounds and their use as anti-viral agents |
ES2666694T3 (es) | 2002-09-06 | 2018-05-07 | Cerulean Pharma Inc. | Polímeros a base de ciclodextrina para el suministro de los agentes terapéuticos enlazados covalentemente a ellos |
US7144450B2 (en) * | 2004-12-04 | 2006-12-05 | Xerox Corporation | Phase change inks containing trans-1,2-cyclohexane bis(urea-urethane) compounds |
US7153349B2 (en) | 2004-12-04 | 2006-12-26 | Xerox Corporation | Phase change inks containing curable trans-1,2-cyclohexane bis(urea-urethane) compounds |
US7317122B2 (en) | 2004-12-04 | 2008-01-08 | Xerox Corporation | Curable trans-1,2-cyclohexane bis(urea-urethane) compounds |
US7560587B2 (en) | 2004-12-04 | 2009-07-14 | Xerox Corporation | Bis[urea-urethane] compounds |
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JP5597130B2 (ja) | 2007-07-03 | 2014-10-01 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | ポリシアル酸脱n−アセチラーゼの阻害剤及びその使用方法 |
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WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
EP3041484B1 (de) | 2013-09-06 | 2021-03-03 | Academia Sinica | Humane inkt-zell-aktivierung mittels glykolipiden mit veränderten glycosylgruppen |
US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
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CN109963868B (zh) | 2016-08-22 | 2023-11-14 | 醣基生医股份有限公司 | 抗体、结合片段及使用方法 |
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AUPO104396A0 (en) | 1996-07-17 | 1996-08-08 | Biomolecular Research Institute Limited | Antiviral linear polymers |
DE69739750D1 (de) * | 1996-07-23 | 2010-03-18 | Seikagaku Kogyo Co Ltd | Neue laktosamin-oligosaccharide und verfahren zu ihrer herstellung |
EP0951480A4 (de) | 1996-11-14 | 2004-07-28 | Biota Scient Management | Verfahren und neue verbindungen, die in diesem verfahren einsetzbar sind. |
JPH10182686A (ja) * | 1996-12-26 | 1998-07-07 | Ngk Insulators Ltd | ガングリオシドGQ1b類縁物質 |
JP3304985B2 (ja) | 1997-04-17 | 2002-07-22 | ジョンソン・エンド・ジョンソン株式会社 | ケミカルインジケーターシートおよびそれを使用した滅菌用包装袋 |
EP1085846A2 (de) | 1998-06-08 | 2001-03-28 | Advanced Medicine, Inc. | Mehrfachbindende inhibitoren des microsomalen triglyceridtransferase-proteins |
-
1999
- 1999-03-12 AU AUPP9139A patent/AUPP913999A0/en not_active Abandoned
-
2000
- 2000-03-09 IL IL14534600A patent/IL145346A/xx not_active IP Right Cessation
- 2000-03-09 AT AT00907354T patent/ATE295361T1/de not_active IP Right Cessation
- 2000-03-09 CA CA002367755A patent/CA2367755C/en not_active Expired - Fee Related
- 2000-03-09 CZ CZ20013274A patent/CZ20013274A3/cs unknown
- 2000-03-09 EP EP00907354A patent/EP1165541B1/de not_active Expired - Lifetime
- 2000-03-09 AP APAP/P/2001/002277A patent/AP2001002277A0/en unknown
- 2000-03-09 CN CN00804901A patent/CN1343205A/zh active Pending
- 2000-03-09 BR BR0008939-7A patent/BR0008939A/pt not_active IP Right Cessation
- 2000-03-09 WO PCT/AU2000/000165 patent/WO2000055149A1/en active IP Right Grant
- 2000-03-09 KR KR1020017011546A patent/KR100805906B1/ko not_active IP Right Cessation
- 2000-03-09 HU HU0200190A patent/HUP0200190A3/hu unknown
- 2000-03-09 NZ NZ514041A patent/NZ514041A/xx not_active Application Discontinuation
- 2000-03-09 JP JP2000605578A patent/JP5160000B2/ja not_active Expired - Fee Related
- 2000-03-09 ES ES00907354T patent/ES2241581T3/es not_active Expired - Lifetime
- 2000-03-09 ID IDW00200101979A patent/ID29868A/id unknown
- 2000-03-09 MX MXPA01009203A patent/MXPA01009203A/es active IP Right Grant
- 2000-03-09 AU AU28966/00A patent/AU774222B2/en not_active Ceased
- 2000-03-09 DE DE60020100T patent/DE60020100T2/de not_active Expired - Lifetime
- 2000-03-09 EA EA200100968A patent/EA200100968A1/ru unknown
- 2000-03-09 TR TR2001/02794T patent/TR200102794T2/xx unknown
- 2000-03-09 PL PL00350228A patent/PL350228A1/xx unknown
- 2000-09-08 US US09/658,445 patent/US6548476B1/en not_active Expired - Lifetime
- 2000-09-08 TW TW089118492A patent/TWI268279B/zh not_active IP Right Cessation
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2001
- 2001-09-10 ZA ZA200107450A patent/ZA200107450B/xx unknown
- 2001-09-11 NO NO20014409A patent/NO327812B1/no not_active IP Right Cessation
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2002
- 2002-05-02 HK HK02103316.9A patent/HK1041693B/zh not_active IP Right Cessation
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