PT1185529E - Pirazolobenzodiazepinas como inibidores de cdk2 - Google Patents

Pirazolobenzodiazepinas como inibidores de cdk2

Info

Publication number: PT1185529E
Authority: PT; Portugal
Prior art keywords: pyrazolobenzodiazepinas; cdk2 inhibitors; cdk2; inhibitors
Prior art date: 1999-04-21

Application number

PT00929360T

Other languages

English (en)

Inventor

Vincent Stewart Madison

Giacomo Pizzolato

Peter Michael Wovkulich

Jin-Jun Liu

Ding Qingjie

Wei Chung-Chen

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-21

Filing date

2000-04-14

Publication date

2005-02-28

2000-04-14 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-02-28 Publication of PT1185529E publication Critical patent/PT1185529E/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/22—Sulfur atoms

PT00929360T 1999-04-21 2000-04-14 Pirazolobenzodiazepinas como inibidores de cdk2 PT1185529E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US13037099P	1999-04-21	1999-04-21

Publications (1)

Publication Number	Publication Date
PT1185529E true PT1185529E (pt)	2005-02-28

Family

ID=22444382

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT00929360T PT1185529E (pt)	1999-04-21	2000-04-14	Pirazolobenzodiazepinas como inibidores de cdk2

Country Status (33)

Country	Link
US (3)	US6440959B1 (pt)
EP (1)	EP1185529B1 (pt)
JP (1)	JP3746680B2 (pt)
KR (1)	KR100481757B1 (pt)
CN (2)	CN1196703C (pt)
AR (1)	AR023542A1 (pt)
AT (1)	ATE279413T1 (pt)
AU (1)	AU768667B2 (pt)
BR (1)	BR0009887A (pt)
CA (1)	CA2367704C (pt)
CO (1)	CO5170444A1 (pt)
CZ (1)	CZ20013738A3 (pt)
DE (1)	DE60014893T2 (pt)
DK (1)	DK1185529T3 (pt)
ES (1)	ES2228522T3 (pt)
HK (1)	HK1046278B (pt)
HR (1)	HRP20010742A2 (pt)
HU (1)	HUP0300318A3 (pt)
IL (1)	IL145764A0 (pt)
JO (1)	JO2248B1 (pt)
MA (1)	MA26782A1 (pt)
NO (1)	NO20015065D0 (pt)
NZ (1)	NZ514523A (pt)
PE (1)	PE20010054A1 (pt)
PL (1)	PL200933B1 (pt)
PT (1)	PT1185529E (pt)
RU (1)	RU2249593C2 (pt)
SI (1)	SI1185529T1 (pt)
TR (1)	TR200103016T2 (pt)
TW (1)	TW585866B (pt)
WO (1)	WO2000064900A1 (pt)
YU (1)	YU73101A (pt)
ZA (1)	ZA200108016B (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
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PL370176A1 (en) *	2001-11-13	2005-05-16	3-Dimensional Pharmaceuticals, Inc.	Substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
FR2847253B1 (fr) *	2002-11-19	2007-05-18	Aventis Pharma Sa	Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant
ES2545666T3 (es) *	2003-02-27	2015-09-14	Abbvie Inc.	5,10-Dihidro-11H-dibenzo[b,e][1,4]diazepin-11-ona como inhibidores de quinasa
PT1802625E (pt) *	2004-10-13	2008-08-06	Hoffmann La Roche	Pirazolobenzodiazepinas di-substituídas, úteis como inibidores de cdc2 e de angiogénese e para o tratamento de cancro da mama, do cólon, do pulmão e da próstata
JP2009511535A (ja) *	2005-10-14	2009-03-19	エフ．ホフマン−ラロシュアーゲー	５−（２−クロロフェニル）−１，２−ジヒドロ−７−フルオロ−８−メトキシ−３−メチル−ピラゾロ［３，４−ｂ］［１，４］ベンゾジアゼピン
CA2657347C (en)	2006-07-10	2014-11-18	Paion Uk Limited	Short-acting benzodiazepine salts and their polymorphic forms
KR20100073454A (ko) *	2008-12-23	2010-07-01	국립암센터	트란스글루타미나제 억제제로 사용되는 신규한 피라졸로디아제핀계 화합물, 이의 제조방법 및 이를 포함하는 조성물
EP2305647A1 (en)	2009-09-18	2011-04-06	PAION UK Limited	Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en)	2010-11-08	2012-05-09	PAION UK Ltd.	Dosing regimen for sedation with CNS 7056 (Remimazolam)
US9321737B2 (en) *	2012-02-02	2016-04-26	Senex Biotechnology Inc	CDK8-CDK19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer
CN102603743B (zh) *	2012-02-24	2014-05-28	南京天易生物科技有限公司	抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途
CN103288828A (zh) *	2012-02-24	2013-09-11	中国科学院大连化学物理研究所	一种合成手性二氢-6H-吲哚并[2,1-c][1,4]-苯并二氮杂卓的方法
CN103288830A (zh) *	2012-02-24	2013-09-11	中国科学院大连化学物理研究所	一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓的方法
AR094963A1 (es)	2013-03-04	2015-09-09	Ono Pharmaceutical Co	Reacción de oxidación excelente en el índice de conversión
CN106608877B (zh) *	2015-10-21	2018-11-13	新发药业有限公司	一种依鲁替尼中间体4-氨基-3-（4-苯氧基）苯基-1H-吡唑并[3,4-d]嘧啶的制备方法
JP7139323B2 (ja) *	2016-11-01	2022-09-20	エフ．ホフマン－ラロシュアーゲー	Ｃｎｓ関連疾患を処置するための１，３－ジヒドロ－１，４－ベンゾジアゼピン－２－チオン
CN108218868B (zh) *	2016-12-13	2019-02-19	南京药捷安康生物科技有限公司	多激酶抑制剂化合物、其晶型及用途
CN109020980B (zh) *	2017-06-09	2020-11-20	华东师范大学	一类抗肿瘤作用的吡唑并嘧啶二氮*衍生物
US11066404B2 (en)	2018-10-11	2021-07-20	Incyte Corporation	Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
US11384083B2 (en)	2019-02-15	2022-07-12	Incyte Corporation	Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
US11472791B2 (en)	2019-03-05	2022-10-18	Incyte Corporation	Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
US11919904B2 (en)	2019-03-29	2024-03-05	Incyte Corporation	Sulfonylamide compounds as CDK2 inhibitors
WO2020223469A1 (en)	2019-05-01	2020-11-05	Incyte Corporation	N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
US11447494B2 (en)	2019-05-01	2022-09-20	Incyte Corporation	Tricyclic amine compounds as CDK2 inhibitors
JP2023509260A (ja)	2019-08-14	2023-03-08	インサイト・コーポレイション	Ｃｄｋ２阻害剤としてのイミダゾリルピリミジニルアミン化合物
AR120184A1 (es)	2019-10-11	2022-02-02	Incyte Corp	Aminas bicíclicas como inhibidoras de la cdk2
WO2021223751A1 (zh) *	2020-05-08	2021-11-11	南京药捷安康生物科技有限公司	抗肿瘤化合物的合成方法及其中间体
WO2022113003A1 (en)	2020-11-27	2022-06-02	Rhizen Pharmaceuticals Ag	Cdk inhibitors
WO2022149057A1 (en)	2021-01-05	2022-07-14	Rhizen Pharmaceuticals Ag	Cdk inhibitors
TW202304427A (zh) *	2021-05-10	2023-02-01	大陸商藥捷安康(南京)科技股份有限公司	多激酶抑制劑的藥物組合物及其用途
US11976073B2 (en)	2021-12-10	2024-05-07	Incyte Corporation	Bicyclic amines as CDK2 inhibitors
WO2024030399A2 (en) *	2022-08-02	2024-02-08	Lab1636, Llc	Use of a gaba-a pam for reduction of tactile hypersensitivity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU720135B2 (en)	1996-10-02	2000-05-25	Novartis Ag	Pyrimidine derivatives and processes for the preparation thereof
US6350786B1 (en) *	1998-09-22	2002-02-26	Hoffmann-La Roche Inc.	Stable complexes of poorly soluble compounds in ionic polymers

2000
- 2000-04-12 US US09/548,091 patent/US6440959B1/en not_active Expired - Fee Related
- 2000-04-14 CA CA002367704A patent/CA2367704C/en not_active Expired - Fee Related
- 2000-04-14 IL IL14576400A patent/IL145764A0/xx unknown
- 2000-04-14 WO PCT/EP2000/003394 patent/WO2000064900A1/en active IP Right Grant
- 2000-04-14 ES ES00929360T patent/ES2228522T3/es not_active Expired - Lifetime
- 2000-04-14 JP JP2000614252A patent/JP3746680B2/ja not_active Expired - Fee Related
- 2000-04-14 AT AT00929360T patent/ATE279413T1/de active
- 2000-04-14 PT PT00929360T patent/PT1185529E/pt unknown
- 2000-04-14 HU HU0300318A patent/HUP0300318A3/hu unknown
- 2000-04-14 RU RU2001130446/04A patent/RU2249593C2/ru not_active IP Right Cessation
- 2000-04-14 TR TR2001/03016T patent/TR200103016T2/xx unknown
- 2000-04-14 EP EP00929360A patent/EP1185529B1/en not_active Expired - Lifetime
- 2000-04-14 BR BR0009887-6A patent/BR0009887A/pt not_active IP Right Cessation
- 2000-04-14 SI SI200030524T patent/SI1185529T1/xx unknown
- 2000-04-14 NZ NZ514523A patent/NZ514523A/en unknown
- 2000-04-14 CN CNB008065543A patent/CN1196703C/zh not_active Expired - Fee Related
- 2000-04-14 AU AU47480/00A patent/AU768667B2/en not_active Ceased
- 2000-04-14 YU YU73101A patent/YU73101A/sh unknown
- 2000-04-14 CN CNB2004100682242A patent/CN1279029C/zh not_active Expired - Fee Related
- 2000-04-14 DK DK00929360T patent/DK1185529T3/da active
- 2000-04-14 DE DE60014893T patent/DE60014893T2/de not_active Expired - Lifetime
- 2000-04-14 CZ CZ20013738A patent/CZ20013738A3/cs unknown
- 2000-04-14 PL PL354405A patent/PL200933B1/pl not_active IP Right Cessation
- 2000-04-14 KR KR10-2001-7013228A patent/KR100481757B1/ko not_active IP Right Cessation
- 2000-04-17 JO JO200054A patent/JO2248B1/en active
- 2000-04-18 AR ARP000101817A patent/AR023542A1/es not_active Application Discontinuation
- 2000-04-18 CO CO00028559A patent/CO5170444A1/es not_active Application Discontinuation
- 2000-04-19 TW TW089107370A patent/TW585866B/zh not_active IP Right Cessation
- 2000-04-19 PE PE2000000370A patent/PE20010054A1/es not_active Application Discontinuation
2001
- 2001-09-29 ZA ZA200108016A patent/ZA200108016B/xx unknown
- 2001-10-12 HR HR20010742A patent/HRP20010742A2/hr not_active Application Discontinuation
- 2001-10-18 NO NO20015065A patent/NO20015065D0/no not_active Application Discontinuation
- 2001-10-19 MA MA26368A patent/MA26782A1/fr unknown
2002
- 2002-04-15 US US10/122,559 patent/US6838558B2/en not_active Expired - Fee Related
- 2002-10-29 HK HK02107815.6A patent/HK1046278B/zh not_active IP Right Cessation
2004
- 2004-04-19 US US10/827,667 patent/US6916923B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CZ20013738A3 (cs)	2002-08-14
PL200933B1 (pl)	2009-02-27
YU73101A (sh)	2004-05-12
WO2000064900A1 (en)	2000-11-02
JO2248B1 (en)	2004-10-07
ZA200108016B (en)	2003-03-26
US6916923B2 (en)	2005-07-12
NZ514523A (en)	2003-11-28
HUP0300318A2 (hu)	2003-06-28
CN1196703C (zh)	2005-04-13
KR100481757B1 (ko)	2005-04-11
DE60014893D1 (de)	2004-11-18
KR20010112435A (ko)	2001-12-20
JP2002543081A (ja)	2002-12-17
AU4748000A (en)	2000-11-10
JP3746680B2 (ja)	2006-02-15
CN1603314A (zh)	2005-04-06
IL145764A0 (en)	2002-07-25
DE60014893T2 (de)	2005-10-13
MA26782A1 (fr)	2004-12-20
HRP20010742A2 (en)	2002-12-31
PL354405A1 (en)	2004-01-12
CO5170444A1 (es)	2002-06-27
RU2249593C2 (ru)	2005-04-10
AR023542A1 (es)	2002-09-04
AU768667B2 (en)	2003-12-18
PE20010054A1 (es)	2001-02-07
ATE279413T1 (de)	2004-10-15
SI1185529T1 (en)	2005-02-28
EP1185529B1 (en)	2004-10-13
HK1046278B (zh)	2005-08-12
EP1185529A1 (en)	2002-03-13
HUP0300318A3 (en)	2004-11-29
TR200103016T2 (tr)	2002-04-22
CN1279029C (zh)	2006-10-11
US20040198976A1 (en)	2004-10-07
US20020183514A1 (en)	2002-12-05
HK1046278A1 (en)	2003-01-03
US6838558B2 (en)	2005-01-04
TW585866B (en)	2004-05-01
ES2228522T3 (es)	2005-04-16
NO20015065L (no)	2001-10-18
CN1348455A (zh)	2002-05-08
US6440959B1 (en)	2002-08-27
DK1185529T3 (da)	2005-02-07
BR0009887A (pt)	2002-01-22
CA2367704A1 (en)	2000-11-02
CA2367704C (en)	2008-06-17
NO20015065D0 (no)	2001-10-18

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PT1185529E (pt)	2005-02-28	Pirazolobenzodiazepinas como inibidores de cdk2
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