PT1157019E - 4-alcenil (e alcinil) oxindolos como inibidores dequinases dependentes de ciclina em particular cdk2 - Google Patents

4-alcenil (e alcinil) oxindolos como inibidores dequinases dependentes de ciclina em particular cdk2

Info

Publication number
PT1157019E
PT1157019E PT99963422T PT99963422T PT1157019E PT 1157019 E PT1157019 E PT 1157019E PT 99963422 T PT99963422 T PT 99963422T PT 99963422 T PT99963422 T PT 99963422T PT 1157019 E PT1157019 E PT 1157019E
Authority
PT
Portugal
Prior art keywords
oxindoles
cyclin
alkynyl
alkenyl
inhibitors
Prior art date
Application number
PT99963422T
Other languages
English (en)
Inventor
Kin-Chun Luk
Steven Gregory Mischke
Yi Chen
Wendy Lea Corbett
Apostolos Dermatakis
Jin-Jun Liu
Paige E Mahaney
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT1157019E publication Critical patent/PT1157019E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
PT99963422T 1998-12-17 1999-12-08 4-alcenil (e alcinil) oxindolos como inibidores dequinases dependentes de ciclina em particular cdk2 PT1157019E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11259198P 1998-12-17 1998-12-17
US14907399P 1999-08-16 1999-08-16

Publications (1)

Publication Number Publication Date
PT1157019E true PT1157019E (pt) 2003-06-30

Family

ID=26810131

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99963422T PT1157019E (pt) 1998-12-17 1999-12-08 4-alcenil (e alcinil) oxindolos como inibidores dequinases dependentes de ciclina em particular cdk2

Country Status (20)

Country Link
US (3) US6130239A (pt)
EP (1) EP1157019B1 (pt)
JP (1) JP2002532492A (pt)
KR (1) KR100649925B1 (pt)
CN (1) CN1138773C (pt)
AR (1) AR024847A1 (pt)
AT (1) ATE234830T1 (pt)
AU (1) AU770375B2 (pt)
BR (1) BR9916327A (pt)
CA (1) CA2354873A1 (pt)
CO (1) CO5261600A1 (pt)
DE (1) DE69906152T2 (pt)
DK (1) DK1157019T3 (pt)
ES (1) ES2192877T3 (pt)
PE (1) PE20001537A1 (pt)
PT (1) PT1157019E (pt)
TR (1) TR200101860T2 (pt)
TW (1) TW550262B (pt)
UY (1) UY25857A1 (pt)
WO (1) WO2000035908A1 (pt)

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ES2367007T3 (es) * 1999-11-24 2011-10-27 Sugen, Inc. Derivados de indolinona ionizables y su uso como ligandos de ptk.
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
AU784266B2 (en) * 1999-12-22 2006-03-02 Sugen, Inc. Indolinone derivatives for modulation of c-kit tyrosine kinase
EP1255752B1 (en) * 2000-02-15 2007-08-08 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
EP1272483A2 (en) * 2000-03-24 2003-01-08 Millenium Pharmaceuticals, Inc. OXINDOLE INHIBITORS OF FACTOR Xa
MY128449A (en) 2000-05-24 2007-02-28 Sugen Inc Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US6706709B2 (en) 2000-06-02 2004-03-16 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
JP2004502686A (ja) 2000-06-30 2004-01-29 スージェン・インコーポレーテッド ４−ヘテロアリール−３−ヘテロアリーリデニル−２−インドリノンおよび蛋白質キナーゼ阻害剤としてのその使用
PE20020776A1 (es) * 2000-12-20 2002-08-22 Sugen Inc Indolinonas 4-aril sustituidas
US6504034B2 (en) * 2001-01-23 2003-01-07 Hoffmann-La Roche Inc. Naphthostyrils
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
FR2822155B1 (fr) 2001-03-13 2003-12-12 Aventis Pharma Sa Composes derives des oxindoles et leur application therapeutique en cancerologie
AU2002324684B2 (en) * 2001-08-15 2006-10-05 Pharmacia And Upjohn Company Llc Crystals including a malic acid salt of N-[2-(diethylamino) ethyl]-5-[(5-fluoro-2-oxo-3H-indole-3-ylidene) methyl]-2, 4-dimethyl-1H-pyrrole-3-carboxamide, processes for its preparation and compositions thereof
EP1434774A1 (en) 2001-10-10 2004-07-07 Sugen, Inc. 3-(4-substituted heterocyclyl)-pyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
CA2470480C (en) * 2001-12-27 2010-12-14 Theravance, Inc. Indolinone derivatives useful as protein kinase inhibitors
FR2948940B1 (fr) * 2009-08-04 2011-07-22 Servier Lab Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20140205537A1 (en) * 2011-06-24 2014-07-24 Zenobia Therapeutics, Inc. Lrrk2 inhibitors
CN106187904B (zh) * 2015-05-25 2021-07-06 中国医学科学院药物研究所 含丙炔酰胺基的2-苯基咪唑类衍生物及其制法和药物组合物与用途
AU2018333913B2 (en) 2017-09-14 2022-11-17 Daiichi Sankyo Company, Limited Compound having cyclic structure
WO2022113003A1 (en) 2020-11-27 2022-06-02 Rhizen Pharmaceuticals Ag Cdk inhibitors
WO2022149057A1 (en) 2021-01-05 2022-07-14 Rhizen Pharmaceuticals Ag Cdk inhibitors

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US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US5086186A (en) * 1989-05-25 1992-02-04 Pfizer Inc. N-trichloroacetyl-2-oxindole-1-carboxamides
US5206261A (en) * 1989-07-25 1993-04-27 Taiho Pharmaceutical Company, Limited Oxindole derivative
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WO1998024432A2 (en) * 1996-12-05 1998-06-11 Sugen, Inc. Use of indolinone compounds as modulators of protein kinases
ATE292623T1 (de) * 1997-05-07 2005-04-15 Sugen Inc 2-indolinonderivate als modulatoren der proteinkinase-ativität
GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
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AU3363599A (en) * 1998-03-26 1999-10-18 Max-Planck Institut Fur Biochemie Heterocyclic families of compounds for the modulation of tyrosine protein kinase
US6395734B1 (en) * 1998-05-29 2002-05-28 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors
JP2002522452A (ja) * 1998-08-04 2002-07-23 スージェン・インコーポレーテッド 蛋白質キナーゼの調節剤３−メチリデニル−２−インドリノン
CA2342222A1 (en) * 1998-08-31 2000-03-09 Sugen, Inc. Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity
CN1138773C (zh) * 1998-12-17 2004-02-18 霍夫曼-拉罗奇有限公司 4-链烯基(和炔基)氧吲哚作为细胞周期蛋白-依赖性激酶尤其是cdk2的抑制剂

Also Published As

Publication number Publication date
CN1138773C (zh) 2004-02-18
CO5261600A1 (es) 2003-03-31
AR024847A1 (es) 2002-10-30
ES2192877T3 (es) 2003-10-16
DK1157019T3 (da) 2003-07-14
DE69906152D1 (de) 2003-04-24
CA2354873A1 (en) 2000-06-22
BR9916327A (pt) 2001-09-18
CN1330647A (zh) 2002-01-09
AU770375B2 (en) 2004-02-19
JP2002532492A (ja) 2002-10-02
TR200101860T2 (tr) 2001-12-21
US6303793B1 (en) 2001-10-16
AU1972700A (en) 2000-07-03
EP1157019B1 (en) 2003-03-19
TW550262B (en) 2003-09-01
WO2000035908A1 (en) 2000-06-22
ATE234830T1 (de) 2003-04-15
UY25857A1 (es) 2001-07-31
DE69906152T2 (de) 2004-02-12
PE20001537A1 (es) 2001-01-09
US6252086B1 (en) 2001-06-26
US6130239A (en) 2000-10-10
KR20010101274A (ko) 2001-11-14
KR100649925B1 (ko) 2007-02-28
EP1157019A1 (en) 2001-11-28

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