AR083878A1 - Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento - Google Patents

Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento

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Publication number
AR083878A1
AR083878A1 ARP110104255A ARP110104255A AR083878A1 AR 083878 A1 AR083878 A1 AR 083878A1 AR P110104255 A ARP110104255 A AR P110104255A AR P110104255 A ARP110104255 A AR P110104255A AR 083878 A1 AR083878 A1 AR 083878A1
Authority
AR
Argentina
Prior art keywords
vasoprotectora
linagliptina
cardioprotectora
treatment method
stress
Prior art date
Application number
ARP110104255A
Other languages
English (en)
Inventor
Hans Woerle
Sanjaykumar Juergen-Patel
Odd Johansen
Thomas Eric-Klein
Michael Mark
Andreas Daiber
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46047951&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR083878(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR083878A1 publication Critical patent/AR083878A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
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    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
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Abstract

Inhibidores de DPP-4 para tratar y/o prevenir el estrés oxidativo, estrés vascular y/o disfunción endotelial así como al uso de dichos inhibidores de DPP-4 en el tratamiento y/o prevención de pacientes diabéticos o no diabéticos, incluyendo grupos de pacientes con riesgo de enfermedad cardiovascular y/o renal.Reivindicación 1: Linagliptina caracterizada porque es para uso en un método de tratamiento y/o prevención del estrés oxidativo, estrés vascular y/o disfunción endotelial en un paciente que lo necesita. Reivindicación 5: Linagliptina caracterizada porque es para uso en un método de la reivindicación 4, comprendiendo dicho método tratar la diabetes mellitus de tipo 2, particularmente en un paciente que tiene o con riesgo de tener estrés oxidativo, estrés vascular y/o disfunción endotelial.
ARP110104255A 2010-11-15 2011-11-14 Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento AR083878A1 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP10191261 2010-11-15
US41554510P 2010-11-19 2010-11-19
US42140010P 2010-12-09 2010-12-09
EP11168317 2011-05-31
US201161492391P 2011-06-02 2011-06-02
EP11170992 2011-06-22

Publications (1)

Publication Number Publication Date
AR083878A1 true AR083878A1 (es) 2013-03-27

Family

ID=46047951

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110104255A AR083878A1 (es) 2010-11-15 2011-11-14 Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento

Country Status (16)

Country Link
US (4) US9034883B2 (es)
EP (2) EP3692985A1 (es)
JP (4) JP5944401B2 (es)
KR (2) KR20130142131A (es)
CN (3) CN113288898A (es)
AR (1) AR083878A1 (es)
AU (1) AU2011331247C1 (es)
BR (1) BR112013011961B1 (es)
CA (3) CA3065586C (es)
CL (1) CL2013001247A1 (es)
EA (2) EA031012B1 (es)
IL (1) IL225639A0 (es)
MX (1) MX340515B (es)
NZ (2) NZ609223A (es)
UY (1) UY33734A (es)
WO (1) WO2012065993A1 (es)

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DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
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DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
MX2008014024A (es) 2006-05-04 2008-11-14 Boehringer Ingelheim Int Formas poliformas.
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
CL2008002427A1 (es) 2007-08-16 2009-09-11 Boehringer Ingelheim Int Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2.
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
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CN107011345A (zh) 2008-12-23 2017-08-04 勃林格殷格翰国际有限公司 有机化合物的盐形式
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
AU2010212867B2 (en) 2009-02-13 2013-05-16 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising a SGLT2 inhibitor, a DPP-IV inhibitor and optionally a further antidiabetic agent and uses thereof
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