AR068757A2 - Ligandos derivados de piperidina de alta afinidad para el receptor de nociceptina orl-1; composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos - Google Patents

Ligandos derivados de piperidina de alta afinidad para el receptor de nociceptina orl-1; composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos

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Publication number
AR068757A2
AR068757A2 ARP080104397A ARP080104397A AR068757A2 AR 068757 A2 AR068757 A2 AR 068757A2 AR P080104397 A ARP080104397 A AR P080104397A AR P080104397 A ARP080104397 A AR P080104397A AR 068757 A2 AR068757 A2 AR 068757A2
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
group
nr19r20
cycloalkyl
Prior art date
Application number
ARP080104397A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22405371&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR068757(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of AR068757A2 publication Critical patent/AR068757A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P11/08—Bronchodilators
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Abstract

Ligandos derivados de piperidina de alta afinidad para el receptor de nociceptina ORL-1, caracterizados porque comprenden un compuesto representado por la formula (1) o una sal o solvato del mismo farmacéuticamente aceptable donde: la línea de puntos representa un doble enlace opcional; X1 es R5-alquilo C1-12, R5-cicloalquilo C3-12, R7-arilo, R8-heteroarilo, R10-heterocicloalquilo C3-7; X2 es -CHO, -CN, -NHC(=NR26)NHR26, -CH(=NOR26), -NHOR26, R7-arilo, R7-arilalquilo C1-6, R7-arilalquenilo C1-6, R7-arilalquinilo C1-6, -(CH2)vOR13, -(CH2)vCOOR27, -(CH2)vCONR14R15, -(CH2)vNR21R22 o -(CH2)vNHC(O)R21, donde v es 0, 1, 2 o 3; o X1 es del grupo de formulas (2) y X2 es hidrogeno; o X1 y X2 conjuntamente forman un grupo espiro que tiene la formula del grupo de formulas (3); m es 1 o 2; n es 1, 2 o 3, con la condicion de que cuando n es 1, uno de R16 y R17 es -C(O)R28; p es 0 o 1, Q es -CH2-, -O-, -S-, -SO-, -SO2- o -NR17-; R1, R2, R3 y R4 son independientemente seleccionados del grupo que consiste en hidrogeno y alquilo C1-6, o (R1 y R4) o (R2 y R3) o (R1 y R3) o (R2 y R4) conjuntamente pueden formar un puente alquileno de 1 a 3 átomos de carbono; R5 representa de 1 a 3 substituyentes, independientemente seleccionados del grupo que consiste en H, R7-arilo, R6-cicloalquilo C3-12, R8-heteroarilo, R10-heterocicloalquilo C3-7, -NR19R20, -OR13 y S(O)0-2R13; R6 es de 1 a 3 substituyentes independientemente seleccionados del grupo que consiste en H, alquilo C1-6, R7-arilo, -NR19R20, -OR13, -SR13; R7 representa de 1 a 3 substituyentes seleccionados del grupo que consiste en hidrogeno, halo, alquilo C1-6, R25-arilo, cicloalquilo C3-12, -CN, -CF3, -OR19, -alquilo C1-6-OR19, -OCF3, -NR19R20, -alquilo C1-6-NR19R20, -NHSO2R19, -SO2N(R26)2, -SO2R19, -SOR19, -SR19, -NO2, -CONR19R20, -NR20COR19, -COR19, -COCF3, -OCOR19, -OCO2R19, -COOR19, -alquilo C1-6-NHCOOC(CH3)3, -alquilo C1-6-NHCOCF3, -alquilo C1-6-NHSO2-alquilo C1-6, -alquilo C1-6-NHCONH-alquilo C1-6- o un resto de formula (4), donde f es 0 a 6; o los substituyentes R7 en los átomos de carbono adyacentes del anillo pueden formar conjuntamente un anillo metilendioxi o etilendioxi; R8 representa de 1 a 3 substituyentes independientemente seleccionados del grupo que consiste en hidrogeno, halo, alquilo C1-6, R25-arilo cicloalquilo C3-12 CF3, -OR19, -alquilo C1-6-OR19, -OCF3, -NR19R20, -alquilo C1-6-NR19R20, -NHSO2R19, -SO2N(R26)2, -NO2, -CONR19R20, -NR20COR19, -COR19, -OCOR19, -OCO2R19, -COOR19, R9 es hidrogeno, alquilo C1-6, halo, -OR19, -NR19R20, -NHCN, -SR19 o -alquilo C1-6-NR19R20; R10 es H, alquilo C1-6, -OR19, -alquilo C1-6-OR19, -NR19R20, o alquilo C1-6-NR19R20; R11 está independientemente seleccionado del grupo que consiste en H, R5-alquilo C1-6, R6-cicloalquilo C3-12, -alquilo C1-6cicloalquilo C3-12, -alquilo C1-6-OR19, -alquilo C1-6-NR19R20 y un resto de formulas (5) donde q y a son tal como se han definido más arriba; R12 es H, alquilo C1-6, halo, -NO2, -CF3, -OCF3, -OR19, -alquilo C1-6-OR19, -NR19R20, o alquilo C1-6-NR19R20; R13 es H, alquilo C1-6, R7-arilo, -alquilo C1-6-OR19, -alquilo C1-6-NR19R20, -alquilo C1-6-SR19 o arilalquilo C1-6; R14 y R15 está independientemente seleccionados del grupo que consiste en H, R5-alquilo C1-6, R7-arilo y el resto de formula (6) donde q es 1 a 3 y a es 1 o 2; R16 y R17 son independientemente seleccionados del grupo que consiste en hidrogeno, R5-alquilo C1-6, R7-arilo, cicloalquilo C3-12, R8-heteroarilo, R8-heteroarilalquilo C1-6-C(O)R28, -alquil C1-6-heterocicloalquilo C3-7, -alquilo C1-6-OR19 y -alquilo C1-6-SR19; R19 y R20 son independientemente seleccionados del grupo que consiste en hidrogeno, alquilo C1-6, cicloalquilo C3-12, arilo, y arilalquilo C1-6; R21 y R22 hidrogeno, alquilo C1-6, cicloalquilo C3-12,cicloalquil C3-12 alquilo C1-6-heterocicloalquilo C3-7, -alquilo C1-6-heterocicloalquilo C3-7, R7-arilo, R7-aril-alquilo C1-6-, R8-heteroarilo-alquilo C1-6, alquilo C1-6-OR19, -alquilo C1-6, NR19R20, -alquilo C1-6-SR19, y alquilo C1-6-NR18-alquilo C1-6-NR18-alquilo C1-6; R18 es hidrogeno o alquilo C1-6; Z1 y Z2 son cada uno R7-arilo; Z3 es hidrogeno o alquilo C1-6; R25 representa 1 a 3 substituyentes independientemente seleccionados del grupo que consiste en H, alquilo C1-6, alcoxi C1-6 y halo; R26 está independientemente seleccionado del grupo que consiste en H, alquilo C1-6 y R25-C6H4-CH2-; R27es H, alquilo C1-6, R7-arilalquilo C1-6, o cicloalquilo C3-12; R28 es alquilo C1-6, alquil C1-6cicloalquilo C3-12, R7-arilo, R7-aril-alquilo C1-6-R8-heteroarilo alquil C1-6-NR19R20, -alquilo C1-6-OR19, o alquilo C1-6-SR19 con la condicion de que cuando X1 y X2 juntos son un compuesto del grupo de formulas (7) y Z1 y Z2 son cada uno R7-fenilo, R7 no es -OCH2-arilo y al menos un es orto-halo u orto-alquilo C1-6; arilo (incluyendo la porcion arilo de arilalquilo) representa un grupo carbocíclico que contiene de 6 a 15 átomos de carbono y que tiene por lo menos un anillo aromático donde dicho grupo arilo puede estar opcionalmente fusionado con anillos arilo, cicloalquilo C3-7, heteroarilo o heteroarilo-cicloalquilo C3-7;y donde R7-arilo significa que cualquiera de los átomos de carbono y nitrogeno sustituibles disponibles en dicho grupo arilo y/o anillos fusionados está opcionalmente e independientemente sustituido, y donde el anillo arilo está sustituido con 1-3 grupos R7; heteroarilo representa grupos cíclicos que tienen uno a tres heteroátomos seleccionados de O, S y N, interrumpiendo dicho(s) heteroátomo(s) una estructura de anillo carbocíclico y teniendo una cantidad suficiente de electrones pi deslocalizados para proporcionar carácter aromático, con grupos heterocíclicos aromáticos que contienen de 5 a 14 átomos de carbono, donde dicho grupo heteroarilo puede estar opcionalmente fusionado con uno o más anillos arilo, cicloalquilo, heteroarilo o heterocicloalquilo; y donde cualquiera de los átomos de nitrogeno o carbono disponibles en dicho grupo heteroarilo y/o dicho(s) anillo(s) fusionado(s) puede estar opcional e independientemente sustituido y donde el anillo heteroarilo puede estar sustituido con 1-3 grupos R8; y heterocicloalquilo representa un anillo saturado que contiene de 3 a 7 átomos de carbono, preferiblemente de 4 a 6 átomos de carbono, interrumpidos por 1 a 3 heteroátomos seleccionados de -O-, -S- y NR21, donde R21 es tal como se definio antes, y en donde opcionalmente, dicho anillo puede contener uno o dos enlaces insaturados que no imparten carácter aromático al anillo; y en donde cualquiera de los átomos de carbono sustituibles disponibles en el anillo puede estar sustituido y donde el anillo heterocicloalquilo puede estar sustituido con 1-3 grupos R10; los grupos heterocicloalquilo representativos incluyen 2- o 3-tetrahidrotienilo, 1-, 2-, 3- o 4-piperidinilo, 2- o 3-pirrolidinilo, 1-, 2-, o 3-piperazinilo, 2- o 4-dioxanilo, morfolinilo, o las estructuras del grupo de formulas (8), en donde R17 es como se ha definido antes y t es 0, 1 o 2. Composiciones farmacéuticas que incluyen los mismos y el uso de dichos compuestos como inhibidores, receptores de nociceptina para la manufactura de medicamentos utiles para el tratamiento, ansiedad, tos, asma, depresion y abuso de alcohol.
ARP080104397A 1998-07-27 2008-10-08 Ligandos derivados de piperidina de alta afinidad para el receptor de nociceptina orl-1; composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos AR068757A2 (es)

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