PE20071159A1 - Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina - Google Patents

Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina

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Publication number
PE20071159A1
PE20071159A1 PE2006001305A PE2006001305A PE20071159A1 PE 20071159 A1 PE20071159 A1 PE 20071159A1 PE 2006001305 A PE2006001305 A PE 2006001305A PE 2006001305 A PE2006001305 A PE 2006001305A PE 20071159 A1 PE20071159 A1 PE 20071159A1
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PE
Peru
Prior art keywords
arylalkyl
heteroaryl
aryl
tropane
derivatives
Prior art date
Application number
PE2006001305A
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English (en)
Inventor
Deen Tulshian
Ginny D Ho
Shu-Wei Yang
Original Assignee
Schering Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37670874&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20071159(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20071159A1 publication Critical patent/PE20071159A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A DERIVADOS DE TROPANO 3-MONOSUSTITUIDOS DE FORMULA (I), EN DONDE R1 ES R4-ARILO; R4-ARILALQUILO, R4-HETEROARILO, ENTRE OTROS; R2 ES R5-ARILO, R5-ARILALQUILO, R5-HETEROARILO, ENTRE OTROS; R3 ES R6-ALQUILO, R6-ARILO; R4-ARILALQUILO, R4-HETEROARILO, ENTRE OTROS; X ES UN ENLACE ALQUILENO(C1-C3), -(CH2)m-N(R7)-(CH2)n-, -C(O)N(R7)-, ENTRE OTROS; n Y m SON DE 0 A 6; CADA R4 Y R5 SON INDEPENDIENTEMENTE H, HALO, ALQUILO, ENTRE OTROS. SON SELECCIONADOS: 8-[BIS(2-CLOROFENIL)METIL]-3-FENIL-8-AZABICICLO-[3,2,1]OCTANO, 8-[BIS(2-CLOROFENIL)METIL]-3-PIRIDINIL-8-AZABICICLO-[3,2,1]OCTANO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICIONA FARMACEUTICA QUE ADEMAS PUEDE COMPRENDER AGENTES ADICIONALES. ESTOS COMPUESTOS SON AGONISTAS DEL RECEPTOR TIPO OPIOIDE NOP, POR LO QUE SON UTILES EN EL TRATAMIENTO DE DOLOR, ANSIEDAD, TOS, ASMA, ABUSO DE ALCOHOL, DEPRESION, INCONTINENCIA URINARIA O VEJIGA HIPERACTIVA
PE2006001305A 2005-10-31 2006-10-26 Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina PE20071159A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73170305P 2005-10-31 2005-10-31

Publications (1)

Publication Number Publication Date
PE20071159A1 true PE20071159A1 (es) 2007-11-30

Family

ID=37670874

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001305A PE20071159A1 (es) 2005-10-31 2006-10-26 Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina

Country Status (20)

Country Link
US (2) US7479494B2 (es)
EP (1) EP1951721B1 (es)
JP (1) JP2009513664A (es)
KR (1) KR20080064175A (es)
CN (1) CN101351465A (es)
AR (1) AR056588A1 (es)
AT (1) ATE490252T1 (es)
AU (1) AU2006309085A1 (es)
BR (1) BRPI0618137A2 (es)
CA (1) CA2627546A1 (es)
DE (1) DE602006018645D1 (es)
EC (1) ECSP088410A (es)
IL (1) IL191049A0 (es)
NO (1) NO20082443L (es)
PE (1) PE20071159A1 (es)
RU (1) RU2008121743A (es)
SG (1) SG166811A1 (es)
TW (1) TW200800189A (es)
WO (1) WO2007053435A1 (es)
ZA (1) ZA200803718B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY147661A (en) 2006-05-19 2012-12-31 Abbott Lab Fused bicycloheterocycle substituted azabicyclic alkane derivatives
EP2433935A1 (en) * 2007-08-31 2012-03-28 Purdue Pharma LP Substituted-quinoxaline-type-piperidine compounds and the uses thereof
US8822480B2 (en) 2008-07-16 2014-09-02 Merck Sharp & Dohme Corp. Bicyclic heterocycle derivatives and use thereof as GPR119 modulators
EP2537844A1 (en) 2008-07-21 2012-12-26 Purdue Pharma L.P. Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof
EP2676956A1 (en) * 2008-08-01 2013-12-25 Purdue Pharma L.P. Tetrahydropyridinyl and dihydropyrrolyl compounds and the use thereof
WO2012009263A1 (en) 2010-07-12 2012-01-19 Temple University-Of The Commonwealth System Of Higher Education Cocaine analogs and methods of preparation and uses thereof
JP6500201B2 (ja) * 2014-05-28 2019-04-17 トーアエイヨー株式会社 置換トロパン誘導体
US11131530B2 (en) 2018-01-29 2021-09-28 Lawrence Livermore National Security, Llc Opto-thermal laser detonator

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1265057B1 (it) * 1993-08-05 1996-10-28 Dompe Spa Tropil 7-azaindolil-3-carbossiamidi
DE19624668A1 (de) 1996-06-20 1998-02-19 Klinge Co Chem Pharm Fab Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden
US6451816B1 (en) * 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
CZ184199A3 (cs) 1996-11-26 1999-08-11 Zeneca Limited Deriváty 8-azabicyklo[3,2,1]oktanu, 8-azabicyklo[3,2,1]okt-6-enu, 9-azabicyklo[3,3,1]nonanu, 9-aza-3-oxabicyklo[3,3,1]nonanu a 9-aza-3-thiabicyklo[3,3,1]nonanu, způsob jejich přípravy a insekticidní, akaricidní nebo nematocidní prostředky, které je obsahují
US20040067950A1 (en) 1998-07-27 2004-04-08 Schering-Plough Corporation High affinity ligands for nociceptin receptor ORL-1
ID29137A (id) * 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
US7485650B2 (en) 1998-07-27 2009-02-03 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
TWI317360B (en) 2001-11-07 2009-11-21 Schering Corp Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1
AR037364A1 (es) 2001-11-16 2004-11-03 Schering Corp Azetidinil diaminas utiles como ligandos del receptor de nociceptina orl-1

Also Published As

Publication number Publication date
AR056588A1 (es) 2007-10-10
NO20082443L (no) 2008-07-30
KR20080064175A (ko) 2008-07-08
JP2009513664A (ja) 2009-04-02
BRPI0618137A2 (pt) 2011-08-16
EP1951721A1 (en) 2008-08-06
RU2008121743A (ru) 2009-12-10
SG166811A1 (en) 2010-12-29
IL191049A0 (en) 2008-12-29
AU2006309085A1 (en) 2007-05-10
ECSP088410A (es) 2008-05-30
US7910603B2 (en) 2011-03-22
ZA200803718B (en) 2009-03-25
US20070249604A1 (en) 2007-10-25
CN101351465A (zh) 2009-01-21
US20090105248A1 (en) 2009-04-23
CA2627546A1 (en) 2007-05-10
DE602006018645D1 (de) 2011-01-13
US7479494B2 (en) 2009-01-20
WO2007053435A1 (en) 2007-05-10
ATE490252T1 (de) 2010-12-15
EP1951721B1 (en) 2010-12-01
TW200800189A (en) 2008-01-01

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