AR045180A1 - Derivados 3-amino cromado y 2-amino tetralina y composiciones que contienen a dichos compuestos - Google Patents

Derivados 3-amino cromado y 2-amino tetralina y composiciones que contienen a dichos compuestos

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Publication number
AR045180A1
AR045180A1 ARP040102725A ARP040102725A AR045180A1 AR 045180 A1 AR045180 A1 AR 045180A1 AR P040102725 A ARP040102725 A AR P040102725A AR P040102725 A ARP040102725 A AR P040102725A AR 045180 A1 AR045180 A1 AR 045180A1
Authority
AR
Argentina
Prior art keywords
hydrogen
formula
integer
alkyl
amino
Prior art date
Application number
ARP040102725A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR045180A1 publication Critical patent/AR045180A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/48Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Se describen el uso de compuestos de 3-amino cromano y 2-amino tetralina y composiciones que contienen dichos compuestos para el tratamiento de desórdenes de serotonina, tales como depresión y ansiedad. Reivindicación 1: Un compuesto de fórmula (1), o un profármaco, un estereoisómero o una sal farmacéuticamente aceptable del mismo, donde: X es O o CH2; R1 es hidrógeno, alquilo, cicloalquilo, cicloalquilalquilo, aralquilo u oxetano; R2 es -(CH2)a-R5, M, o un resto de grupo de fórmula (2), donde a es un número entero de 2 a 4 y R5 es A, B, C, D, K, L o U; a es un número entero de 2 y R5 es E, G o J; a es un número entero de 3 o 4 y R5 es P; A es una fórmula (3); B es una fórmula (4); C es una fórmula (5); D es una fórmula (6); E es una fórmula (7); G es una fórmula (8); J es una fórmula (9); K es una fórmula (10); L es una fórmula (11); M es un grupo de fórmulas (12); Z es un grupo de fórmulas (13); P es una fórmula (14); U es una fórmula (15); R3 es -OCH3, -COR12, - SO2NR13R14, o un heterociclo; R4 es hidrógeno o halo; R6 es hidrógeno o alquilo; R7 es hidrógeno, flúor, cloro, ciano o alcoxi en cualquiera de las posiciones 4-, 5-, 6-, o 7; R8 es hidrógeno, halo, alcoxi C1-3 o alquilo C1-3; R9 es hidrógeno, halo, alcoxi C1-3 o alquilo C1-3; R10 es hidrógeno y R11 es metilo; o R10 y R11 son metilo; R12 es alquilo C1-4, alcoxi o NR13R14; R13 y R14 son independientemente hidrógeno, alquilo, cicloalquilo, metilciclopropilo, fenilo, o bencilo; R19 y R20 son independientemente hidrógeno, flúor, cloro, ciano, o alquilo C1-6 en cualquiera de las posiciones 5-, 6-, 7-, u 8-; R21 es hidrógeno o flúor en cualquiera de las posiciones 4-, 5-, 6-, o 7-; R22 es un anillo de 3- a 7- miembros; n es un número entero de 1 a 2; Y es O, S, o NH; donde, cuando Y es O, entonces R16 es hidrógeno; R17 es hidrógeno o OCH3; R18 es hidrógeno; y d es un número entero de 2 a 3; cuando Y es S, entonces R16 es hidrógeno o hidroxilo; R17 es hidrógeno; R18 es hidrógeno o flúor; y d es un número entero de 2; cuando Y es NH, entonces R16 es ceto o metilo; R17 es hidrógeno; R18 es flúor; y d es un número entero de 2.
ARP040102725A 2003-07-30 2004-07-30 Derivados 3-amino cromado y 2-amino tetralina y composiciones que contienen a dichos compuestos AR045180A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49113703P 2003-07-30 2003-07-30
US49179403P 2003-08-01 2003-08-01
US10/898,866 US20050032873A1 (en) 2003-07-30 2004-07-26 3-Amino chroman and 2-amino tetralin derivatives

Publications (1)

Publication Number Publication Date
AR045180A1 true AR045180A1 (es) 2005-10-19

Family

ID=34119805

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040102725A AR045180A1 (es) 2003-07-30 2004-07-30 Derivados 3-amino cromado y 2-amino tetralina y composiciones que contienen a dichos compuestos

Country Status (15)

Country Link
US (1) US20050032873A1 (es)
EP (1) EP1651637A1 (es)
JP (1) JP2007500718A (es)
KR (1) KR20060054376A (es)
AR (1) AR045180A1 (es)
AU (1) AU2004261649A1 (es)
BR (1) BRPI0413022A (es)
CA (1) CA2533363A1 (es)
CR (1) CR8191A (es)
EC (1) ECSP066336A (es)
IL (1) IL173193A0 (es)
MX (1) MXPA06001008A (es)
NO (1) NO20060402L (es)
TW (1) TW200503705A (es)
WO (1) WO2005012291A1 (es)

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Also Published As

Publication number Publication date
TW200503705A (en) 2005-02-01
CA2533363A1 (en) 2005-02-10
ECSP066336A (es) 2006-07-28
CR8191A (es) 2006-07-14
JP2007500718A (ja) 2007-01-18
BRPI0413022A (pt) 2006-10-03
AU2004261649A1 (en) 2005-02-10
EP1651637A1 (en) 2006-05-03
WO2005012291A1 (en) 2005-02-10
IL173193A0 (en) 2006-06-11
NO20060402L (no) 2006-04-06
MXPA06001008A (es) 2006-04-11
US20050032873A1 (en) 2005-02-10
KR20060054376A (ko) 2006-05-22

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