AR028474A1 - Un compuesto derivado heteroaromatico biciclico, su uso y una composicion farmaceutica que lo comprende - Google Patents
Un compuesto derivado heteroaromatico biciclico, su uso y una composicion farmaceutica que lo comprendeInfo
- Publication number
- AR028474A1 AR028474A1 ARP000101578A ARP000101578A AR028474A1 AR 028474 A1 AR028474 A1 AR 028474A1 AR P000101578 A ARP000101578 A AR P000101578A AR P000101578 A ARP000101578 A AR P000101578A AR 028474 A1 AR028474 A1 AR 028474A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- alkynyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Compuestos derivados heteroaromáticos bicíclicos de acuerdo a la formula general (1), o una sal farmacéuticamente aceptable de él, en donde R1 es NR5R6, OR5, SR5 o R7; R5 y R6 se seleccionan independientemente de H, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-8, heterocicloalquilo C2-7, alquil C1-8 carbonilo, arilcarbonilo C6-14, arilo C6-14, o heteroarilo C4-13,o R5 y R6 juntos se unen en un anillo de heterocicloalquilo C2-7; R7 es cicloalquilo C3-8, heterocicloalquilo C2-7, arilo C6-14 o heteroarilo C4-13; R2 es alquilo C1-8, alquenilo C2-8, alquinilo C2-8, o arilo C6-14 o heteroarilo C4-13, ambos opcionalmente sustituidos con uno o más sustitutos seleccionados de alquilo C1-8, alquiltio C1-8 (di)alquilamino C1-8, alcoxi C1-8, alquenilo C2-8 o alquinilo C2-8; R3 es alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-8, heterocicloalquilo C2-7, o arilo C6-14 o heteroarilo C4-13, ambos opcionalmente sustituidos con uno o más sustitutos seleccionados desde alquilo C1-8, (di) alquilamino C1-8, o alcoxi C1-8; X es S, O, o N(R4); R4 es H, alquilo C1-8, alquilcarbonilo C1-8, arilcarbonilo C6-14 o arilo C6-14 alquilo C1-8; Y es CH o N; Z es NH2 o OH; A es S, N(H), N(R9), O o un enlace; R9 puede seleccionarse de los mismos grupos como se describio para R2 y B es N(H), O o un enlace. Estos compuestos tienen actividad de activacion de receptores de LH y pueden usarse en terapias para la regulacion de la fertilidad.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99201152 | 1999-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR028474A1 true AR028474A1 (es) | 2003-05-14 |
Family
ID=8240094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000101578A AR028474A1 (es) | 1999-04-08 | 2000-04-06 | Un compuesto derivado heteroaromatico biciclico, su uso y una composicion farmaceutica que lo comprende |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US6569863B1 (es) |
| EP (1) | EP1171443B1 (es) |
| JP (1) | JP4854856B2 (es) |
| KR (1) | KR100691546B1 (es) |
| CN (1) | CN1177848C (es) |
| AR (1) | AR028474A1 (es) |
| AT (1) | ATE299507T1 (es) |
| AU (1) | AU772258B2 (es) |
| BR (1) | BRPI0009558B1 (es) |
| CA (1) | CA2368834C (es) |
| CO (1) | CO5160348A1 (es) |
| CZ (1) | CZ300832B6 (es) |
| DE (1) | DE60021262T2 (es) |
| DK (1) | DK1171443T3 (es) |
| ES (1) | ES2245304T3 (es) |
| HK (1) | HK1041266B (es) |
| HU (1) | HU229002B1 (es) |
| ID (1) | ID30502A (es) |
| IL (2) | IL145483A0 (es) |
| MX (1) | MXPA01010144A (es) |
| NO (1) | NO328826B1 (es) |
| NZ (1) | NZ514445A (es) |
| PE (1) | PE20010030A1 (es) |
| PL (1) | PL219316B1 (es) |
| PT (1) | PT1171443E (es) |
| RU (1) | RU2248979C2 (es) |
| TR (1) | TR200102839T2 (es) |
| TW (1) | TW564247B (es) |
| WO (1) | WO2000061586A1 (es) |
| ZA (1) | ZA200107917B (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0113987A (pt) * | 2000-09-22 | 2003-08-12 | Akzo Nobel Nv | Composto heteromático bicìclico, ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de derivados heteroaromáticos bicìclicos ou de um sal ou solvato farmaceuticamente aceitável dos mesmos |
| GB0100622D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds V111 |
| DE10108481A1 (de) * | 2001-02-22 | 2002-10-24 | Bayer Ag | Pyridylpyrimidine |
| TWI228508B (en) * | 2001-09-04 | 2005-03-01 | Akzo Nobel Nv | Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity |
| CN1261437C (zh) * | 2001-09-04 | 2006-06-28 | 阿克佐诺贝尔公司 | 具有LH与FSH联合激动活性的甘氨酸－取代的噻吩并[2,3－d]嘧啶 |
| US6974870B2 (en) | 2002-06-06 | 2005-12-13 | Boehringer Ingelheim Phamaceuticals, Inc. | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
| CN100386329C (zh) | 2002-06-06 | 2008-05-07 | 贝林格尔.英格海姆药物公司 | 取代的3-氨基-噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法和用途 |
| DE602004018637D1 (de) | 2003-04-09 | 2009-02-05 | Biogen Idec Inc | A2a-adenosinrezeptorantagonisten |
| EP1615930A2 (en) | 2003-04-09 | 2006-01-18 | Biogen Idec MA, Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists |
| US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| WO2005019225A1 (ja) * | 2003-08-21 | 2005-03-03 | Kyorin Pharmaceutical Co., Ltd. | Ｎｋ１受容体拮抗作用を有する化合物の製造方法及びその製造中間体 |
| US7550485B2 (en) * | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
| CA2541989C (en) * | 2003-10-24 | 2013-10-01 | Exelixis, Inc. | P70s6 kinase modulators and method of use |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| AU2005275182A1 (en) * | 2004-07-22 | 2006-02-23 | Ptc Therapeutics, Inc. | Thienopyridines for treating Hepatitis C |
| CA2630920A1 (en) * | 2005-11-22 | 2007-05-31 | University Of South Florida | Inhibition of cell proliferation |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| CA2652061A1 (en) * | 2006-05-17 | 2007-11-29 | Marvin C. Gershengorn | Pyrimidine low molecular weight ligands for modulating hormone receptors |
| WO2007146602A1 (en) | 2006-06-06 | 2007-12-21 | Boehringer Ingelheim International Gmbh | Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxamide compounds, their preparation and use |
| RU2444524C2 (ru) * | 2006-08-21 | 2012-03-10 | Дженентек, Инк. | Азабензотиофенильные соединения и способы применения |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| JP5433579B2 (ja) * | 2007-09-14 | 2014-03-05 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | １，３−二置換−４−フェニル−１ｈ−ピリジン−２−オン |
| PT2200985E (pt) | 2007-09-14 | 2011-07-21 | Ortho Mcneil Janssen Pharm | 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas |
| UA100126C2 (en) | 2007-09-14 | 2012-11-26 | Аддекс Фарма С.А. | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones |
| CA2702500A1 (en) * | 2007-10-18 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Preparation of dihydrothieno [3, 2-d] pyrimidines and intermediates used therein |
| CN101861316B (zh) | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| AU2009289784B2 (en) | 2008-09-02 | 2012-03-22 | Addex Pharma S.A. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| RU2517181C2 (ru) | 2008-10-16 | 2014-05-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов |
| BRPI0921333A2 (pt) | 2008-11-28 | 2015-12-29 | Addex Pharmaceuticals Sa | derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
| KR101753826B1 (ko) | 2009-05-12 | 2017-07-04 | 얀센 파마슈티칼즈, 인코포레이티드 | 1,２,４―트리아졸로［４,３―ａ］피리딘 유도체 및 신경정신 질환의 치료 또는 예방을 위한 이들의 용도 |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| EP2649069B1 (en) | 2010-11-08 | 2015-08-26 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| KR20140053991A (ko) | 2011-07-18 | 2014-05-08 | 아츠 바이올로직스 에이/에스 | 장기간 작용하는 황체 형성 호르몬 (ｌｈ) 화합물 |
| AU2012340869B2 (en) | 2011-11-23 | 2017-03-02 | Cancer Research Technology Limited | Thienopyrimidine inhibitors of atypical protein kinase C |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| MX2016009471A (es) | 2014-01-21 | 2016-10-13 | Janssen Pharmaceutica Nv | Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso. |
| HUE045610T2 (hu) | 2014-01-21 | 2020-01-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk |
| CN107602585A (zh) * | 2017-10-23 | 2018-01-19 | 遵义医学院 | 噻吩并吡啶双杂环化合物的制备工艺 |
| BR102019022529A2 (pt) * | 2019-10-25 | 2021-05-04 | Anhanguera Educacional Ltda. | Processo para obtenção de composições farmacêuticas antitumorais através de butadienos push-pull, compostos e seus usos |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3262593A (en) | 1992-01-11 | 1993-08-03 | Schering Agrochemicals Limited | Biheterocyclic fungicidal compounds |
| JP3854648B2 (ja) * | 1994-04-19 | 2006-12-06 | 武田薬品工業株式会社 | 縮合チオフェン誘導体、その製造法及び用途 |
| TW449600B (en) | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
| WO1996014319A1 (en) | 1994-11-08 | 1996-05-17 | Takeda Chemical Industries, Ltd. | Thienopyridine or thienopyrimidine derivatives and their use |
| JPH09169767A (ja) * | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | 複素環化合物、その製造法および用途 |
| JPH09169766A (ja) * | 1995-10-19 | 1997-06-30 | Takeda Chem Ind Ltd | チエノピリジン誘導体，その製造法および用途 |
| WO1997014697A1 (en) * | 1995-10-19 | 1997-04-24 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives as gonadotropin releasing hormone antagonists |
| AU2406597A (en) | 1996-04-26 | 1997-11-19 | Takeda Chemical Industries Ltd. | Thienopyridine derivatives, their production and use |
-
2000
- 2000-03-23 TW TW089105361A patent/TW564247B/zh not_active IP Right Cessation
- 2000-04-03 DK DK00917026T patent/DK1171443T3/da active
- 2000-04-03 CA CA002368834A patent/CA2368834C/en not_active Expired - Fee Related
- 2000-04-03 WO PCT/EP2000/002865 patent/WO2000061586A1/en active IP Right Grant
- 2000-04-03 MX MXPA01010144A patent/MXPA01010144A/es active IP Right Grant
- 2000-04-03 CZ CZ20013605A patent/CZ300832B6/cs not_active IP Right Cessation
- 2000-04-03 CN CNB008069077A patent/CN1177848C/zh not_active Expired - Fee Related
- 2000-04-03 KR KR1020017012792A patent/KR100691546B1/ko not_active IP Right Cessation
- 2000-04-03 BR BRPI0009558A patent/BRPI0009558B1/pt not_active IP Right Cessation
- 2000-04-03 AU AU38166/00A patent/AU772258B2/en not_active Ceased
- 2000-04-03 JP JP2000610857A patent/JP4854856B2/ja not_active Expired - Fee Related
- 2000-04-03 HU HU0200653A patent/HU229002B1/hu not_active IP Right Cessation
- 2000-04-03 NZ NZ514445A patent/NZ514445A/en not_active IP Right Cessation
- 2000-04-03 US US09/937,416 patent/US6569863B1/en not_active Expired - Lifetime
- 2000-04-03 DE DE60021262T patent/DE60021262T2/de not_active Expired - Lifetime
- 2000-04-03 ES ES00917026T patent/ES2245304T3/es not_active Expired - Lifetime
- 2000-04-03 AT AT00917026T patent/ATE299507T1/de active
- 2000-04-03 EP EP00917026A patent/EP1171443B1/en not_active Expired - Lifetime
- 2000-04-03 IL IL14548300A patent/IL145483A0/xx active IP Right Grant
- 2000-04-03 TR TR2001/02839T patent/TR200102839T2/xx unknown
- 2000-04-03 PT PT00917026T patent/PT1171443E/pt unknown
- 2000-04-03 ID IDW00200102449A patent/ID30502A/id unknown
- 2000-04-03 RU RU2001130051/04A patent/RU2248979C2/ru not_active IP Right Cessation
- 2000-04-03 PL PL350964A patent/PL219316B1/pl unknown
- 2000-04-06 AR ARP000101578A patent/AR028474A1/es not_active Application Discontinuation
- 2000-04-06 PE PE2000000312A patent/PE20010030A1/es not_active Application Discontinuation
- 2000-04-07 CO CO00025852A patent/CO5160348A1/es unknown
-
2001
- 2001-09-16 IL IL145483A patent/IL145483A/en not_active IP Right Cessation
- 2001-09-26 ZA ZA200107917A patent/ZA200107917B/xx unknown
- 2001-10-04 NO NO20014824A patent/NO328826B1/no not_active IP Right Cessation
-
2002
- 2002-04-23 HK HK02103025.1A patent/HK1041266B/zh not_active IP Right Cessation
-
2003
- 2003-04-11 US US10/411,960 patent/US6841553B2/en not_active Expired - Lifetime
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