CO5160348A1 - Derivados de tieno [2,3-d]pirimidina y composiciones farmaceuticas que los contienen - Google Patents

Derivados de tieno [2,3-d]pirimidina y composiciones farmaceuticas que los contienen

Info

Publication number
CO5160348A1
CO5160348A1 CO00025852A CO00025852A CO5160348A1 CO 5160348 A1 CO5160348 A1 CO 5160348A1 CO 00025852 A CO00025852 A CO 00025852A CO 00025852 A CO00025852 A CO 00025852A CO 5160348 A1 CO5160348 A1 CO 5160348A1
Authority
CO
Colombia
Prior art keywords
alkyl
aryl
heteroaryl
alkynyl
alkenyl
Prior art date
Application number
CO00025852A
Other languages
English (en)
Inventor
Gerritsma Gerrildina Geziena
Straten Van Nicole Corin Renee
Adang Anton Egbert Peter
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of CO5160348A1 publication Critical patent/CO5160348A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Un compuesto derivado heteroaromático bicíclico de acuerdo a la fórmula general I, o una sal farmacéuticamente aceptable de él,<EMI FILE="00025852_1" ID="1" IMF=JPEG >CARACTERIZADO porqueR1 es NR5R6, OR5, SR5 o R7;R5 y R6 se seleccionan independientemente de H, alquilo(1-8C), alquenilo (2-8C), alquinilo(2-8C), cicloalquilo(3-8C), heterocicloalquilo(2-7C), alquil(1-8C)carbonilo, arilcarbonilo(6-14C), arilo(6-14C) o heteroarilo(4-13C), o R5 y R6 juntos se unen en un anillo de heterocicloalquilo(2-7C);R7 es cicloalquilo(3-8C), heterocicloalquilo(2-7C) arilo(6-14C) o heteroarilo( 4-13C),R2 es alquilo (1-8C), alquenilo(2-8C), alquinilo(2-8C), o arilo(6-14C) o heteroarilo(4-13C), ambos opcionalmente sustituidos con uno o más substituyentes seleccionados de alquilo (1-8C), alquiltio(1-8C), (d)alquilamino(1-8C), alcoxi(1-8C), alquenilo(2-8C), o alquinilo(2-8C);R3 es alquilo (1-8C), alquenilo(2-8C), alquinilo(2-8C), cicloalquilo(3-8C), heterocicloalquilo(2-7C), o arilo(6-14C) o heteroarilo(4-13C), ambos opcionalmente con uno o más substituyentes seleccionados desde alquilo(C1-8C), (di)alquilamino(1-8C) o alcoxi(1-8C);X es S, O, o N(R4);R4 es H, alquilo (1-8C), alquilcarbonilo(1-8C), arilcarbonilo(6-14C) o arilo(6-14C)alquilo(1-8C);Y es CH o N;Z es NH2 o OH;A es S, N(H), N(R9), 0 o un enlace,R9 puede seleccionarse de los mismos grupos como se describió para R2;B es N(H), 0, o un enlace,para uso en terapia.
CO00025852A 1999-04-08 2000-04-07 Derivados de tieno [2,3-d]pirimidina y composiciones farmaceuticas que los contienen CO5160348A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99201152 1999-04-08

Publications (1)

Publication Number Publication Date
CO5160348A1 true CO5160348A1 (es) 2002-05-30

Family

ID=8240094

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00025852A CO5160348A1 (es) 1999-04-08 2000-04-07 Derivados de tieno [2,3-d]pirimidina y composiciones farmaceuticas que los contienen

Country Status (30)

Country Link
US (2) US6569863B1 (es)
EP (1) EP1171443B1 (es)
JP (1) JP4854856B2 (es)
KR (1) KR100691546B1 (es)
CN (1) CN1177848C (es)
AR (1) AR028474A1 (es)
AT (1) ATE299507T1 (es)
AU (1) AU772258B2 (es)
BR (1) BRPI0009558B1 (es)
CA (1) CA2368834C (es)
CO (1) CO5160348A1 (es)
CZ (1) CZ300832B6 (es)
DE (1) DE60021262T2 (es)
DK (1) DK1171443T3 (es)
ES (1) ES2245304T3 (es)
HK (1) HK1041266B (es)
HU (1) HU229002B1 (es)
ID (1) ID30502A (es)
IL (2) IL145483A0 (es)
MX (1) MXPA01010144A (es)
NO (1) NO328826B1 (es)
NZ (1) NZ514445A (es)
PE (1) PE20010030A1 (es)
PL (1) PL219316B1 (es)
PT (1) PT1171443E (es)
RU (1) RU2248979C2 (es)
TR (1) TR200102839T2 (es)
TW (1) TW564247B (es)
WO (1) WO2000061586A1 (es)
ZA (1) ZA200107917B (es)

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DE602004018637D1 (de) 2003-04-09 2009-02-05 Biogen Idec Inc A2a-adenosinrezeptorantagonisten
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Also Published As

Publication number Publication date
CA2368834A1 (en) 2000-10-19
TW564247B (en) 2003-12-01
ATE299507T1 (de) 2005-07-15
PL350964A1 (en) 2003-02-24
PE20010030A1 (es) 2001-01-27
HUP0200653A2 (en) 2002-06-29
ES2245304T3 (es) 2006-01-01
CN1349535A (zh) 2002-05-15
DK1171443T3 (da) 2005-11-07
HU229002B1 (en) 2013-07-29
PL219316B1 (pl) 2015-04-30
PT1171443E (pt) 2005-11-30
AR028474A1 (es) 2003-05-14
KR100691546B1 (ko) 2007-03-12
CZ20013605A3 (cs) 2002-03-13
JP2002541259A (ja) 2002-12-03
CA2368834C (en) 2009-11-03
RU2248979C2 (ru) 2005-03-27
ID30502A (id) 2001-12-13
BR0009558A (pt) 2002-02-19
KR20010103801A (ko) 2001-11-23
MXPA01010144A (es) 2002-04-24
EP1171443B1 (en) 2005-07-13
EP1171443A1 (en) 2002-01-16
CZ300832B6 (cs) 2009-08-19
US6569863B1 (en) 2003-05-27
IL145483A0 (en) 2002-06-30
NO328826B1 (no) 2010-05-25
US20030212081A1 (en) 2003-11-13
DE60021262D1 (de) 2005-08-18
ZA200107917B (en) 2003-09-23
AU772258B2 (en) 2004-04-22
DE60021262T2 (de) 2006-01-05
US6841553B2 (en) 2005-01-11
AU3816600A (en) 2000-11-14
CN1177848C (zh) 2004-12-01
WO2000061586A1 (en) 2000-10-19
NO20014824L (no) 2001-10-04
JP4854856B2 (ja) 2012-01-18
IL145483A (en) 2007-06-03
HK1041266B (zh) 2005-09-16
BRPI0009558B1 (pt) 2016-10-25
TR200102839T2 (tr) 2002-04-22
HUP0200653A3 (en) 2004-07-28
HK1041266A1 (en) 2002-07-05
NZ514445A (en) 2003-07-25
NO20014824D0 (no) 2001-10-04

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