DE602004018637D1 - A2a-adenosinrezeptorantagonisten - Google Patents

A2a-adenosinrezeptorantagonisten

Info

Publication number
DE602004018637D1
DE602004018637D1 DE602004018637T DE602004018637T DE602004018637D1 DE 602004018637 D1 DE602004018637 D1 DE 602004018637D1 DE 602004018637 T DE602004018637 T DE 602004018637T DE 602004018637 T DE602004018637 T DE 602004018637T DE 602004018637 D1 DE602004018637 D1 DE 602004018637D1
Authority
DE
Germany
Prior art keywords
adenosine receptor
receptor antagonistic
formula
antagonists
discovery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004018637T
Other languages
English (en)
Inventor
Hairuo Peng
Gang Yao
Chi Vu
Russell C Petter
Gnanasambandam Kumaravel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Biogen MA Inc
Original Assignee
Biogen Idec Inc
Biogen Idec MA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc, Biogen Idec MA Inc filed Critical Biogen Idec Inc
Publication of DE602004018637D1 publication Critical patent/DE602004018637D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
DE602004018637T 2003-04-09 2004-04-09 A2a-adenosinrezeptorantagonisten Expired - Lifetime DE602004018637D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46148403P 2003-04-09 2003-04-09
PCT/US2004/011009 WO2004092173A2 (en) 2003-04-09 2004-04-09 A2a adenosine receptor antagonists

Publications (1)

Publication Number Publication Date
DE602004018637D1 true DE602004018637D1 (de) 2009-02-05

Family

ID=33299825

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004018637T Expired - Lifetime DE602004018637D1 (de) 2003-04-09 2004-04-09 A2a-adenosinrezeptorantagonisten

Country Status (6)

Country Link
US (1) US7834014B2 (de)
EP (1) EP1633756B1 (de)
AT (1) ATE418555T1 (de)
DE (1) DE602004018637D1 (de)
HK (1) HK1083838A1 (de)
WO (1) WO2004092173A2 (de)

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US20060106040A1 (en) 2002-12-19 2006-05-18 Michael Grzelak Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
EP2258372B8 (de) 2005-06-07 2012-12-19 Kyowa Hakko Kirin Co., Ltd. A2A Antagonisten zur Behandlung von motorischen Störungen
US7728031B2 (en) 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
EP1939197A1 (de) 2006-12-22 2008-07-02 Schwarz Pharma Ag 8-Ethinylxanthinderivate als selektive Antagonisten des A2A-Rezeptors
RU2486187C2 (ru) 2007-09-11 2013-06-27 Эбботт Лэборетриз N-ОКСИДЫ ОКТАГИДРО-ПИРРОЛО[3,4-b]ПИРРОЛА
ES2658892T3 (es) * 2008-07-23 2018-03-12 Kyowa Hakko Kirin Co., Ltd. Agente terapéutico para la migraña
WO2011106688A1 (en) 2010-02-26 2011-09-01 Catabasis Pharmaceuticals, Inc. Bis-fatty acid conjugates and their uses
WO2011109681A1 (en) 2010-03-05 2011-09-09 Catabasis Pharmaceuticals, Inc. Fatty acid cox inhibitor derivatives and their uses
WO2011116312A1 (en) 2010-03-19 2011-09-22 Catabasis Pharmaceuticals, Inc. Fatty acid macrolide derivatives and their uses
JP6377068B2 (ja) 2012-11-16 2018-08-22 ユニバーシティ・ヘルス・ネットワーク ピラゾロピリミジン化合物
WO2014101120A1 (en) * 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
WO2018045071A1 (en) 2016-08-31 2018-03-08 Agios Pharmaceuticals, Inc. Inhibitors of cellular metabolic processes
AU2018237598B2 (en) 2017-03-24 2023-12-14 Piksci Inc. Fused triazolo-pyrimidine compounds having useful pharmaceutical application
PL3611174T3 (pl) * 2017-04-07 2022-08-08 Medshine Discovery Inc. Pochodne [1,2,4]triazolo[1,5-c]pirymidyny jako inhibitor receptora a2a
CN109535161B (zh) * 2017-09-22 2021-09-03 江苏恒瑞医药股份有限公司 ***并嘧啶类衍生物、其制备方法及其在医药上的应用
JP7474709B2 (ja) 2018-02-27 2024-04-25 インサイト・コーポレイション Ａ２ａ／ａ２ｂ阻害剤としてのイミダゾピリミジン及びトリアゾロピリミジン
GB201804922D0 (en) * 2018-03-27 2018-05-09 Ucl Business Plc Traatment
US11168089B2 (en) 2018-05-18 2021-11-09 Incyte Corporation Fused pyrimidine derivatives as A2A / A2B inhibitors
CN111164084B (zh) * 2018-06-26 2023-05-23 浙江春禾医药科技有限公司 可用作a2a受体拮抗剂的***并三嗪衍生物
GEP20237560B (en) 2018-07-05 2023-10-25 Incyte Corp Fused pyrazine derivatives as a2a / a2b inhibitors
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及***并吡啶
US20230048888A1 (en) * 2019-12-26 2023-02-16 Zhejiang Vimgreen Pharmaceuticals, Ltd. Use of triazolotriazine derivative in treatment of diseases
WO2023191400A1 (ko) * 2022-04-01 2023-10-05 에이치케이이노엔 주식회사 에틸 피페리딘 트리아졸로 트리아진 유도체, 이의 제조방법 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물

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Also Published As

Publication number Publication date
US20070173505A1 (en) 2007-07-26
WO2004092173A2 (en) 2004-10-28
ATE418555T1 (de) 2009-01-15
US7834014B2 (en) 2010-11-16
WO2004092173A3 (en) 2004-12-09
HK1083838A1 (en) 2006-07-14
EP1633756A2 (de) 2006-03-15
EP1633756B1 (de) 2008-12-24

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Legal Events

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