ZA200204244B - Novel benzoimidazole derivatives useful as antiproliferative agents. - Google Patents
Novel benzoimidazole derivatives useful as antiproliferative agents. Download PDFInfo
- Publication number
- ZA200204244B ZA200204244B ZA200204244A ZA200204244A ZA200204244B ZA 200204244 B ZA200204244 B ZA 200204244B ZA 200204244 A ZA200204244 A ZA 200204244A ZA 200204244 A ZA200204244 A ZA 200204244A ZA 200204244 B ZA200204244 B ZA 200204244B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzoimidazol
- quinolin
- methoxy
- piperidin
- ethoxy
- Prior art date
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- 230000001028 anti-proliverative effect Effects 0.000 title description 4
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 92
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- 125000000217 alkyl group Chemical group 0.000 claims description 58
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 38
- 229940002612 prodrug Drugs 0.000 claims description 34
- 239000000651 prodrug Substances 0.000 claims description 34
- 150000003839 salts Chemical class 0.000 claims description 34
- 125000003118 aryl group Chemical group 0.000 claims description 32
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 30
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- 238000000034 method Methods 0.000 claims description 23
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- 125000004093 cyano group Chemical group *C#N 0.000 claims description 17
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 16
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- 239000012453 solvate Substances 0.000 claims description 15
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- 125000005843 halogen group Chemical group 0.000 claims description 9
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- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
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