ZA200104948B - Method for preparing an effervescent granulate comprising iron bluconate, granulate thus obtained and tablets containing the same. - Google Patents
Method for preparing an effervescent granulate comprising iron bluconate, granulate thus obtained and tablets containing the same. Download PDFInfo
- Publication number
- ZA200104948B ZA200104948B ZA200104948A ZA200104948A ZA200104948B ZA 200104948 B ZA200104948 B ZA 200104948B ZA 200104948 A ZA200104948 A ZA 200104948A ZA 200104948 A ZA200104948 A ZA 200104948A ZA 200104948 B ZA200104948 B ZA 200104948B
- Authority
- ZA
- South Africa
- Prior art keywords
- granulate
- weight
- mixture
- effervescent
- citric acid
- Prior art date
Links
- 239000008187 granular material Substances 0.000 title claims description 53
- 238000000034 method Methods 0.000 title claims description 31
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title description 56
- 229910052742 iron Inorganic materials 0.000 title description 28
- 239000000203 mixture Substances 0.000 claims description 40
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 37
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 18
- 229960001645 ferrous gluconate Drugs 0.000 claims description 18
- 235000013924 ferrous gluconate Nutrition 0.000 claims description 18
- 239000004222 ferrous gluconate Substances 0.000 claims description 18
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 claims description 18
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 11
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 11
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 9
- 235000019454 L-leucine Nutrition 0.000 claims description 9
- 239000004395 L-leucine Substances 0.000 claims description 9
- 229960003136 leucine Drugs 0.000 claims description 9
- 239000000600 sorbitol Substances 0.000 claims description 9
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 3
- 239000002831 pharmacologic agent Substances 0.000 claims description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 150000004683 dihydrates Chemical class 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 238000005550 wet granulation Methods 0.000 claims description 2
- 238000009736 wetting Methods 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 description 15
- 238000002360 preparation method Methods 0.000 description 10
- 239000002245 particle Substances 0.000 description 7
- 229960004543 anhydrous citric acid Drugs 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 229960004106 citric acid Drugs 0.000 description 5
- 239000007938 effervescent tablet Substances 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- AYGJDUHQRFKLBG-UHFFFAOYSA-M sodium;1,1-dioxo-1,2-benzothiazol-3-olate;dihydrate Chemical compound O.O.[Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 AYGJDUHQRFKLBG-UHFFFAOYSA-M 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 244000248349 Citrus limon Species 0.000 description 4
- 235000005979 Citrus limon Nutrition 0.000 description 4
- 238000002161 passivation Methods 0.000 description 4
- 239000002798 polar solvent Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 238000007669 thermal treatment Methods 0.000 description 2
- OKGNXSFAYMSVNN-SYAJEJNSSA-L Ferrous gluconate Chemical compound O.O.[Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OKGNXSFAYMSVNN-SYAJEJNSSA-L 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- -1 for example Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229960001407 sodium bicarbonate Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glanulating (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1998MI002821A IT1304502B1 (it) | 1998-12-24 | 1998-12-24 | Metodo per preparare un granulato effervescente comprendente gluconatodi ferro, granulato cosi' ottenuto e compresse che lo contengono. |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200104948B true ZA200104948B (en) | 2002-09-16 |
Family
ID=11381344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200104948A ZA200104948B (en) | 1998-12-24 | 2001-06-15 | Method for preparing an effervescent granulate comprising iron bluconate, granulate thus obtained and tablets containing the same. |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP1140035B1 (hr) |
JP (1) | JP2002533382A (hr) |
KR (1) | KR20010090009A (hr) |
CN (1) | CN1331584A (hr) |
AR (1) | AR023924A1 (hr) |
AT (1) | ATE241342T1 (hr) |
AU (1) | AU1983400A (hr) |
BG (1) | BG105713A (hr) |
BR (1) | BR9916546A (hr) |
CA (1) | CA2355872A1 (hr) |
CO (1) | CO5160342A1 (hr) |
CZ (1) | CZ20012140A3 (hr) |
DE (1) | DE69908412D1 (hr) |
EA (1) | EA003335B1 (hr) |
EE (1) | EE200100343A (hr) |
HK (1) | HK1039575A1 (hr) |
HR (1) | HRP20010410A2 (hr) |
HU (1) | HUP0104847A2 (hr) |
ID (1) | ID29981A (hr) |
IL (1) | IL143626A0 (hr) |
IT (1) | IT1304502B1 (hr) |
MX (1) | MXPA01006461A (hr) |
NO (1) | NO20013165L (hr) |
PE (1) | PE20001426A1 (hr) |
PL (1) | PL349503A1 (hr) |
SK (1) | SK8722001A3 (hr) |
TR (1) | TR200101828T2 (hr) |
WO (1) | WO2000038657A1 (hr) |
ZA (1) | ZA200104948B (hr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6416981B1 (en) | 2000-05-23 | 2002-07-09 | Nec Partnership | Production of gluconate salts |
GR1004016B (el) * | 2000-07-17 | 2002-10-10 | Uni-Pharma Κλεων Τσετης, Φαρμακευτικα Εργαστηρια Αβεε | Αναβραζοντα δισκια, που περιεχουν ως δραστικο συστατικο συμπλοκες ενωσεις σιδηρου, για την θεραπεια των σιδηροπενικων αναιμιων |
RU2200583C1 (ru) * | 2002-03-26 | 2003-03-20 | Белозерская Галина Геннадьевна | Гемостатическая повязка |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1338071A (en) * | 1970-11-25 | 1973-11-21 | Laso Martinez V | Pharmaceutical iron preparations |
FR2537872B1 (fr) * | 1982-12-21 | 1988-07-01 | Bru Jean | Procede de fabrication de comprimes effervescents |
DE3632334A1 (de) * | 1986-09-24 | 1988-04-07 | Gergely Gerhard | Eisenpraeparat, dieses enthaltende brausetablette und verfahren zu deren herstellung |
EP0673644A1 (en) * | 1994-03-18 | 1995-09-27 | E-PHARMA TRENTO S.p.A. | Process and plant for preparation of effervescent granules |
-
1998
- 1998-12-24 IT IT1998MI002821A patent/IT1304502B1/it active
-
1999
- 1999-12-17 BR BR9916546-5A patent/BR9916546A/pt not_active IP Right Cessation
- 1999-12-17 EA EA200100712A patent/EA003335B1/ru not_active IP Right Cessation
- 1999-12-17 EP EP99963595A patent/EP1140035B1/en not_active Expired - Lifetime
- 1999-12-17 CA CA002355872A patent/CA2355872A1/en not_active Abandoned
- 1999-12-17 AU AU19834/00A patent/AU1983400A/en not_active Abandoned
- 1999-12-17 SK SK872-2001A patent/SK8722001A3/sk unknown
- 1999-12-17 DE DE69908412T patent/DE69908412D1/de not_active Expired - Lifetime
- 1999-12-17 PL PL99349503A patent/PL349503A1/xx unknown
- 1999-12-17 TR TR2001/01828T patent/TR200101828T2/xx unknown
- 1999-12-17 KR KR1020017008025A patent/KR20010090009A/ko not_active Application Discontinuation
- 1999-12-17 IL IL14362699A patent/IL143626A0/xx unknown
- 1999-12-17 AT AT99963595T patent/ATE241342T1/de not_active IP Right Cessation
- 1999-12-17 EE EEP200100343A patent/EE200100343A/xx unknown
- 1999-12-17 HU HU0104847A patent/HUP0104847A2/hu unknown
- 1999-12-17 ID IDW00200101620A patent/ID29981A/id unknown
- 1999-12-17 WO PCT/EP1999/010210 patent/WO2000038657A1/en not_active Application Discontinuation
- 1999-12-17 MX MXPA01006461A patent/MXPA01006461A/es not_active Application Discontinuation
- 1999-12-17 CN CN99814997A patent/CN1331584A/zh active Pending
- 1999-12-17 CZ CZ20012140A patent/CZ20012140A3/cs unknown
- 1999-12-17 JP JP2000590611A patent/JP2002533382A/ja active Pending
- 1999-12-22 CO CO99079992A patent/CO5160342A1/es unknown
- 1999-12-23 PE PE1999001319A patent/PE20001426A1/es not_active Application Discontinuation
- 1999-12-23 AR ARP990106714A patent/AR023924A1/es not_active Application Discontinuation
-
2001
- 2001-05-29 HR HR20010410A patent/HRP20010410A2/hr not_active Application Discontinuation
- 2001-06-15 ZA ZA200104948A patent/ZA200104948B/en unknown
- 2001-06-22 NO NO20013165A patent/NO20013165L/no not_active Application Discontinuation
- 2001-07-17 BG BG105713A patent/BG105713A/xx unknown
-
2002
- 2002-02-21 HK HK02101251.0A patent/HK1039575A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
NO20013165D0 (no) | 2001-06-22 |
JP2002533382A (ja) | 2002-10-08 |
SK8722001A3 (en) | 2001-12-03 |
PL349503A1 (en) | 2002-07-29 |
AU1983400A (en) | 2000-07-31 |
BR9916546A (pt) | 2001-09-04 |
DE69908412D1 (de) | 2003-07-03 |
ATE241342T1 (de) | 2003-06-15 |
PE20001426A1 (es) | 2000-12-28 |
EA200100712A1 (ru) | 2001-12-24 |
CZ20012140A3 (cs) | 2001-12-12 |
IL143626A0 (en) | 2002-04-21 |
IT1304502B1 (it) | 2001-03-19 |
WO2000038657A1 (en) | 2000-07-06 |
NO20013165L (no) | 2001-08-23 |
CO5160342A1 (es) | 2002-05-30 |
ITMI982821A1 (it) | 2000-06-24 |
TR200101828T2 (tr) | 2001-12-21 |
EA003335B1 (ru) | 2003-04-24 |
MXPA01006461A (es) | 2002-06-04 |
EE200100343A (et) | 2002-10-15 |
BG105713A (en) | 2002-03-29 |
EP1140035B1 (en) | 2003-05-28 |
HRP20010410A2 (en) | 2002-06-30 |
CA2355872A1 (en) | 2000-07-06 |
EP1140035A1 (en) | 2001-10-10 |
AR023924A1 (es) | 2002-09-04 |
ID29981A (id) | 2001-10-25 |
HUP0104847A2 (hu) | 2002-04-29 |
HK1039575A1 (zh) | 2002-05-03 |
CN1331584A (zh) | 2002-01-16 |
KR20010090009A (ko) | 2001-10-17 |
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