PE20001426A1 - Metodo para preparar un granulado efervescente que comprende gluconato de hierro, granulado asi obtenido y comprimidos que lo contienen - Google Patents
Metodo para preparar un granulado efervescente que comprende gluconato de hierro, granulado asi obtenido y comprimidos que lo contienenInfo
- Publication number
- PE20001426A1 PE20001426A1 PE1999001319A PE00131999A PE20001426A1 PE 20001426 A1 PE20001426 A1 PE 20001426A1 PE 1999001319 A PE1999001319 A PE 1999001319A PE 00131999 A PE00131999 A PE 00131999A PE 20001426 A1 PE20001426 A1 PE 20001426A1
- Authority
- PE
- Peru
- Prior art keywords
- granulate
- weight
- mixture
- effervescent
- moisture
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Glanulating (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UN METODO PARA PREPARAR UN GRANULO EFERVESCENTE QUE COMPRENDE UN AGENTE ACTIVO, DE 7% A 35% EN PESO DE GLUCONATO FERROSO DIHIDRATO, COMO SISTEMA EFERVESCENTE: DE 25% A 45% EN PESO DE ACIDO CITRICO, DE 15% A 25% DE BICARBONATO DE SODIO, 5% A 18% EN PESO DE SORBITOL, 2% DE L-LEUCINA, 5% A 11% EN PESO DE AROMAS; MEDIANTE GRANULACION EN HUMEDO EN UN GRANULADOR DE LECHO FLUIDO QUE COMPRENDE: I)INTRODUCIR UNA MEZCLA QUE COMPRENDE GLUCONATO FERROSO, ACIDO CITRICO, BICARBONATO DE SODIO, EN DICHO GRANULADOR MIENTRAS ESTE ES ALIMENTADO CON UN FLUJO DE AIRE CALENTADO A 70°C, CON UNA HUMEDAD MENOR 1,0 g/Kg, Y COMPRENDE ENTRE 3200 Y 3800 m3/HORA PARA CADA LOTE DE 265 Kg DE MEZCLA A GRANULAR; II)HUMEDECER DICHA MEZCLA MEDIANTE AGUA NEBULIZADA CUANDO LA MISMA HAYA ALCANZADO UNA TEMPERATURA DE 35°C COMPRENDIENDO UN FLUJO ENTRE 500 Y 2000 ml/MIN; CON UNA PRESION DE 3 ATMOSFERAS; III)EVAPORAR EL AGUA DE NEBULIZACION, MANTENIENDO LA TEMPERATURA DE DICHA MEZCLA SUSTANCIALMENTE CONSTANTE A 35°C; IV)REPETIR LAS FASES II Y III HASTA QUE SE HAYA FORMADO UN GRANULADO QUE TENGA LAS CARACATEISTICAS DESEADAS; V)SECAR DICHO GRANULADO CON AIRE CALENTADO A 80°C HASTA QUE SU CONTENIDO DE HUMEDAD ES MENOR O IGUAL 0,5% EN PESO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI002821A IT1304502B1 (it) | 1998-12-24 | 1998-12-24 | Metodo per preparare un granulato effervescente comprendente gluconatodi ferro, granulato cosi' ottenuto e compresse che lo contengono. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001426A1 true PE20001426A1 (es) | 2000-12-28 |
Family
ID=11381344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999001319A PE20001426A1 (es) | 1998-12-24 | 1999-12-23 | Metodo para preparar un granulado efervescente que comprende gluconato de hierro, granulado asi obtenido y comprimidos que lo contienen |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1140035B1 (es) |
| JP (1) | JP2002533382A (es) |
| KR (1) | KR20010090009A (es) |
| CN (1) | CN1331584A (es) |
| AR (1) | AR023924A1 (es) |
| AT (1) | ATE241342T1 (es) |
| AU (1) | AU1983400A (es) |
| BG (1) | BG105713A (es) |
| BR (1) | BR9916546A (es) |
| CA (1) | CA2355872A1 (es) |
| CO (1) | CO5160342A1 (es) |
| CZ (1) | CZ20012140A3 (es) |
| DE (1) | DE69908412D1 (es) |
| EA (1) | EA003335B1 (es) |
| EE (1) | EE200100343A (es) |
| HK (1) | HK1039575A1 (es) |
| HR (1) | HRP20010410A2 (es) |
| HU (1) | HUP0104847A2 (es) |
| ID (1) | ID29981A (es) |
| IL (1) | IL143626A0 (es) |
| IT (1) | IT1304502B1 (es) |
| MX (1) | MXPA01006461A (es) |
| NO (1) | NO20013165L (es) |
| PE (1) | PE20001426A1 (es) |
| PL (1) | PL349503A1 (es) |
| SK (1) | SK8722001A3 (es) |
| TR (1) | TR200101828T2 (es) |
| WO (1) | WO2000038657A1 (es) |
| ZA (1) | ZA200104948B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6416981B1 (en) | 2000-05-23 | 2002-07-09 | Nec Partnership | Production of gluconate salts |
| GR1004016B (el) * | 2000-07-17 | 2002-10-10 | Uni-Pharma Κλεων Τσετης, Φαρμακευτικα Εργαστηρια Αβεε | Αναβραζοντα δισκια, που περιεχουν ως δραστικο συστατικο συμπλοκες ενωσεις σιδηρου, για την θεραπεια των σιδηροπενικων αναιμιων |
| RU2200583C1 (ru) * | 2002-03-26 | 2003-03-20 | Белозерская Галина Геннадьевна | Гемостатическая повязка |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1338071A (en) * | 1970-11-25 | 1973-11-21 | Laso Martinez V | Pharmaceutical iron preparations |
| FR2537872B1 (fr) * | 1982-12-21 | 1988-07-01 | Bru Jean | Procede de fabrication de comprimes effervescents |
| DE3632334A1 (de) * | 1986-09-24 | 1988-04-07 | Gergely Gerhard | Eisenpraeparat, dieses enthaltende brausetablette und verfahren zu deren herstellung |
| EP0673644A1 (en) * | 1994-03-18 | 1995-09-27 | E-PHARMA TRENTO S.p.A. | Process and plant for preparation of effervescent granules |
-
1998
- 1998-12-24 IT IT1998MI002821A patent/IT1304502B1/it active
-
1999
- 1999-12-17 IL IL14362699A patent/IL143626A0/xx unknown
- 1999-12-17 TR TR2001/01828T patent/TR200101828T2/xx unknown
- 1999-12-17 CZ CZ20012140A patent/CZ20012140A3/cs unknown
- 1999-12-17 WO PCT/EP1999/010210 patent/WO2000038657A1/en not_active Application Discontinuation
- 1999-12-17 MX MXPA01006461A patent/MXPA01006461A/es not_active Application Discontinuation
- 1999-12-17 CN CN99814997A patent/CN1331584A/zh active Pending
- 1999-12-17 EP EP99963595A patent/EP1140035B1/en not_active Expired - Lifetime
- 1999-12-17 AU AU19834/00A patent/AU1983400A/en not_active Abandoned
- 1999-12-17 EA EA200100712A patent/EA003335B1/ru not_active IP Right Cessation
- 1999-12-17 SK SK872-2001A patent/SK8722001A3/sk unknown
- 1999-12-17 AT AT99963595T patent/ATE241342T1/de not_active IP Right Cessation
- 1999-12-17 EE EEP200100343A patent/EE200100343A/xx unknown
- 1999-12-17 JP JP2000590611A patent/JP2002533382A/ja active Pending
- 1999-12-17 CA CA002355872A patent/CA2355872A1/en not_active Abandoned
- 1999-12-17 PL PL99349503A patent/PL349503A1/xx unknown
- 1999-12-17 BR BR9916546-5A patent/BR9916546A/pt not_active IP Right Cessation
- 1999-12-17 KR KR1020017008025A patent/KR20010090009A/ko not_active Application Discontinuation
- 1999-12-17 HU HU0104847A patent/HUP0104847A2/hu unknown
- 1999-12-17 ID IDW00200101620A patent/ID29981A/id unknown
- 1999-12-17 DE DE69908412T patent/DE69908412D1/de not_active Expired - Lifetime
- 1999-12-22 CO CO99079992A patent/CO5160342A1/es unknown
- 1999-12-23 PE PE1999001319A patent/PE20001426A1/es not_active Application Discontinuation
- 1999-12-23 AR ARP990106714A patent/AR023924A1/es not_active Application Discontinuation
-
2001
- 2001-05-29 HR HR20010410A patent/HRP20010410A2/hr not_active Application Discontinuation
- 2001-06-15 ZA ZA200104948A patent/ZA200104948B/en unknown
- 2001-06-22 NO NO20013165A patent/NO20013165L/no not_active Application Discontinuation
- 2001-07-17 BG BG105713A patent/BG105713A/xx unknown
-
2002
- 2002-02-21 HK HK02101251.0A patent/HK1039575A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0104847A2 (hu) | 2002-04-29 |
| ATE241342T1 (de) | 2003-06-15 |
| NO20013165D0 (no) | 2001-06-22 |
| BR9916546A (pt) | 2001-09-04 |
| AR023924A1 (es) | 2002-09-04 |
| HRP20010410A2 (en) | 2002-06-30 |
| TR200101828T2 (tr) | 2001-12-21 |
| CZ20012140A3 (cs) | 2001-12-12 |
| JP2002533382A (ja) | 2002-10-08 |
| CO5160342A1 (es) | 2002-05-30 |
| NO20013165L (no) | 2001-08-23 |
| PL349503A1 (en) | 2002-07-29 |
| HK1039575A1 (zh) | 2002-05-03 |
| ID29981A (id) | 2001-10-25 |
| ITMI982821A1 (it) | 2000-06-24 |
| CN1331584A (zh) | 2002-01-16 |
| IT1304502B1 (it) | 2001-03-19 |
| AU1983400A (en) | 2000-07-31 |
| SK8722001A3 (en) | 2001-12-03 |
| CA2355872A1 (en) | 2000-07-06 |
| EE200100343A (et) | 2002-10-15 |
| WO2000038657A1 (en) | 2000-07-06 |
| EP1140035A1 (en) | 2001-10-10 |
| IL143626A0 (en) | 2002-04-21 |
| EA003335B1 (ru) | 2003-04-24 |
| MXPA01006461A (es) | 2002-06-04 |
| DE69908412D1 (de) | 2003-07-03 |
| EA200100712A1 (ru) | 2001-12-24 |
| KR20010090009A (ko) | 2001-10-17 |
| EP1140035B1 (en) | 2003-05-28 |
| BG105713A (en) | 2002-03-29 |
| ZA200104948B (en) | 2002-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |