YU47867B - Novi benzopiran-2-on-beta-d-tioksilozidi i postupak za njihovo dobijanje - Google Patents

Novi benzopiran-2-on-beta-d-tioksilozidi i postupak za njihovo dobijanje

Info

Publication number
YU47867B
YU47867B YU178790A YU178790A YU47867B YU 47867 B YU47867 B YU 47867B YU 178790 A YU178790 A YU 178790A YU 178790 A YU178790 A YU 178790A YU 47867 B YU47867 B YU 47867B
Authority
YU
Yugoslavia
Prior art keywords
group
atom
beta
benzopyranone
substituents
Prior art date
Application number
YU178790A
Other languages
English (en)
Other versions
YU178790A (sh
Inventor
S. Samreth
V. Barberousse
P. Renaut
F. Bellamy
J. Millet
Original Assignee
Fournier Industrie Et Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8912452A external-priority patent/FR2652353B1/fr
Priority claimed from FR9003401A external-priority patent/FR2659659B1/fr
Application filed by Fournier Industrie Et Sante filed Critical Fournier Industrie Et Sante
Priority to HRP-1787/90A priority Critical patent/HRP920811B1/xx
Publication of YU178790A publication Critical patent/YU178790A/sh
Publication of YU47867B publication Critical patent/YU47867B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones

Abstract

NOVI BENZOPIRAN-2-ON-BETA-D-TIOKSILOZIDI I POSTUPAK ZA NJIHOVO DOBIJANJE, ozidna jedinjenja okarakterisana time sto se biraju iz grupe koja obuhvata benzopiranon-beta-D-tioksilozidne formule: u kojoj: jedan od supstituenata R ili R' predstavlja atom kiseonika dvostruko vezan na ciklicni ugljenik, a drugi predstavlja grupu R1, Simbol = predstavlja dvostruku konjugovanu vezu prema dvostrukoj vezi na grupi CO formiranoj sa jednim od supstituenata R ili R'. X predstavlja atom sumpora ili kiseonika R1 i R2, identicni ili razliciti, predstavljaju svaki atom vodonika C1-4 alkil grupu, atom halogena, grupu trifluorometil ili fenil, R1 i R2 uzeti zajedno mogu da grade sa benzopiranon grupom za koju su vezani, grupu 7,8,9,10-tetrahidrodibenzo/b,d/-piran-6-on ili 1,2,3,4-tetrahidro-9H-ksanten-9-on, Y predstavlja atom vodonika ili alifaticnu acil grupu od C2-5. Postupak za dobijanje benzopiranon-beta-D-tioksilozida formule I prema zahtevu 1, naznacen time, sto (i) reaguje jedinjenje formule: gde X, R, R' i R2 su kao sto je definiasno napred, sa derivatom tioksiloze izabranim iz grupe koju cine: (i) acitioksilozil-halogenidi formule: (ii) peracilovana tioksiloza formule: (iii) aciltioksilozil trihloroacetamidati formule: u kojima Hal predstavlja atom halogena, takav kao Cl ili Br, atom broma je pozeljan kao atom halogena, i Y predstavlja alifaticnu acil grupu sa C2-5, u inertnom rastvaracu, u prporciji I mol II na oko 0.6-1.2 mola jedinjenja III, IV ili V u prisustvu akceptora kiseline i/ili Lewis-ove kiseline, i (ii) ako je potrebno, podvrgava se jedinjenje formule I tako dobijeno, gde je Y alitaticna acil grupa sa C2-5 reakciji dezacilacije na temperaturi izmedju 0°C i temperature refluksa reakcione sredine, u nizem alkoholu sa C1-4, pozeljno metanol, u prisustvu metalnog alkoholata, pozeljno magnezijum ili natrijum metilat, radi dobijanja jedinjenja formule I, gde Y je H. -Prijava sadrzi jos 11 zavisnih zahteva.
YU178790A 1989-09-22 1990-09-20 Novi benzopiran-2-on-beta-d-tioksilozidi i postupak za njihovo dobijanje YU47867B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HRP-1787/90A HRP920811B1 (en) 1989-09-22 1992-10-02 New benzophyranone-beta-d-thioxilozides, method for the preparation and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8912452A FR2652353B1 (fr) 1989-09-22 1989-09-22 Nouveaux benzopyran-2-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.
FR9003401A FR2659659B1 (fr) 1990-03-16 1990-03-16 Nouveaux benzopyran-4-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.

Publications (2)

Publication Number Publication Date
YU178790A YU178790A (sh) 1992-12-21
YU47867B true YU47867B (sh) 1996-02-19

Family

ID=26227568

Family Applications (1)

Application Number Title Priority Date Filing Date
YU178790A YU47867B (sh) 1989-09-22 1990-09-20 Novi benzopiran-2-on-beta-d-tioksilozidi i postupak za njihovo dobijanje

Country Status (24)

Country Link
US (1) US5169838A (sh)
EP (1) EP0421829B1 (sh)
JP (1) JPH07103147B2 (sh)
KR (1) KR0142670B1 (sh)
CN (1) CN1027268C (sh)
AT (1) ATE113956T1 (sh)
AU (2) AU631456B2 (sh)
CA (1) CA2024476C (sh)
DE (1) DE69014064T2 (sh)
DK (1) DK0421829T3 (sh)
ES (1) ES2066165T3 (sh)
FI (1) FI100183B (sh)
GR (1) GR3014966T3 (sh)
HR (1) HRP920811B1 (sh)
HU (1) HU207867B (sh)
IE (1) IE65092B1 (sh)
IL (1) IL95582A (sh)
NO (1) NO172987C (sh)
NZ (1) NZ245783A (sh)
PT (1) PT95369B (sh)
RU (1) RU1838323C (sh)
SK (1) SK280827B6 (sh)
UA (1) UA13476A (sh)
YU (1) YU47867B (sh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2801055B1 (fr) 1999-11-17 2002-02-08 Fournier Ind & Sante Derives de beta-d-5-thioxylose, procede de preparation et utilisation en therapeutique
FR2824559B1 (fr) 2001-05-11 2004-02-13 Fournier Lab Sa Nouveaux derives 5-thio-beta-xylopyronasides, procede de preparation, compositions pharmaceutiques les contenant et leur utilisation en therapeutique
FR2846966A1 (fr) * 2002-11-07 2004-05-14 Fournier Lab Sa Derive du 4-methyl-2-oxo-2h-1-benzopyran-7-yl 5-thio-beta-d- xylopyranoside, son procede de preparation et composition pharmaceutique le contenant
US7439260B2 (en) * 2003-06-11 2008-10-21 Merck Forsst Canada & Co. 7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors
FR2860234B1 (fr) 2003-09-25 2005-12-23 Fournier Lab Sa Nouveaux derives 666 du thioxylose
AR054226A1 (es) * 2005-02-18 2007-06-13 Smithkline Beecham Corp Composicion farmaceutica en forma de comprimido que comprende el compuesto 4-metil-2oxo-2h-1-benzopiran-7-il-tio-b-d-xilopiranosido, uso de sulfato de dermatan y de dicho compuesto para prepararla y metodo para su preparacion
FR2903698B1 (fr) 2006-07-13 2009-01-30 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose.
FR2906248B1 (fr) 2006-09-27 2008-12-26 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose
FR2906247B1 (fr) 2006-09-27 2008-12-26 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose
US20090075914A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched odiparcil
CN101397315B (zh) * 2007-09-24 2013-08-07 中国医学科学院药物研究所 香豆素苷类化合物、其制法和其药物组合物与用途
FR3011468B1 (fr) * 2013-10-04 2015-12-04 Inventiva Utilisation de l'odiparcil dans le traitement d'une mucopolysaccharidose
US10092540B2 (en) 2013-10-04 2018-10-09 Inventiva Method of treatment of a mucopolysaccharidosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2034306A1 (de) * 1970-07-10 1972-01-20 Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof 2 (3,4 Dimethyl-cumarin 7 yl) oxy alkylcarbonsaure Derivate und Verfahren zu ihrer Herstellung
FR2492830A1 (fr) * 1980-10-29 1982-04-30 Sori Soc Rech Ind Nouveaux composes appartenant a la famille des benzoyl- et a-hydroxybenzyl-phenyl-osides, leur procede de preparation et leur application en therapeutique
JPS6013788A (ja) * 1983-07-05 1985-01-24 Yamanouchi Pharmaceut Co Ltd 新規なクマリン誘導体
FR2549476B1 (fr) * 1983-07-20 1986-04-25 Rech Ind Benzyl-phenyl-osides, procede de preparation et utilisation en therapeutique
US4681954A (en) * 1985-10-07 1987-07-21 Pennwalt Corporation 7,8,9,10-tetrahydro-6-oxo-6H-dibenzo(b,d)pyranyloxy-propanes
FR2614893B1 (fr) * 1987-05-04 1989-12-22 Fournier Innovation Synergie Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
DK0421829T3 (da) 1995-01-16
YU178790A (sh) 1992-12-21
JPH07103147B2 (ja) 1995-11-08
NO172987C (no) 1993-10-06
NO904088D0 (no) 1990-09-19
AU6253190A (en) 1991-03-28
PT95369A (pt) 1991-05-22
HU906005D0 (en) 1991-03-28
DE69014064D1 (de) 1994-12-15
HU207867B (en) 1993-06-28
HUT55794A (en) 1991-06-28
DE69014064T2 (de) 1995-05-18
UA13476A (uk) 1997-04-25
HRP920811A2 (en) 1995-10-31
CN1050544A (zh) 1991-04-10
NO904088L (no) 1991-03-25
CN1027268C (zh) 1995-01-04
IE903414A1 (en) 1991-04-10
ES2066165T3 (es) 1995-03-01
IE65092B1 (en) 1995-10-04
FI904614A0 (fi) 1990-09-19
HRP920811B1 (en) 1998-12-31
SK463890A3 (en) 2000-08-14
FI100183B (fi) 1997-10-15
ATE113956T1 (de) 1994-11-15
NZ245783A (en) 1993-07-27
SK280827B6 (sk) 2000-08-14
RU1838323C (ru) 1993-08-30
EP0421829A1 (fr) 1991-04-10
CA2024476C (en) 1999-10-12
AU642829B2 (en) 1993-10-28
JPH03120292A (ja) 1991-05-22
EP0421829B1 (fr) 1994-11-09
GR3014966T3 (en) 1995-05-31
IL95582A (en) 2001-06-14
AU2539792A (en) 1992-11-26
IL95582A0 (en) 1991-06-30
KR0142670B1 (ko) 1998-07-01
US5169838A (en) 1992-12-08
NO172987B (no) 1993-06-28
AU631456B2 (en) 1992-11-26
CA2024476A1 (en) 1991-03-23
KR910006283A (ko) 1991-04-29
PT95369B (pt) 1997-06-30

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