DE69014064T2 - Benzopyranon-beta-D-thioxyloside, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung. - Google Patents

Benzopyranon-beta-D-thioxyloside, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung.

Info

Publication number
DE69014064T2
DE69014064T2 DE69014064T DE69014064T DE69014064T2 DE 69014064 T2 DE69014064 T2 DE 69014064T2 DE 69014064 T DE69014064 T DE 69014064T DE 69014064 T DE69014064 T DE 69014064T DE 69014064 T2 DE69014064 T2 DE 69014064T2
Authority
DE
Germany
Prior art keywords
group
benzopyranone
atom
beta
thioxyloside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69014064T
Other languages
English (en)
Other versions
DE69014064D1 (de
Inventor
Soth Samreth
Veronique Barberousse
Patrice Renaut
Francois Bellamy
Jean Millet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fournier Industrie et Sante SAS
Original Assignee
Fournier Industrie et Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8912452A external-priority patent/FR2652353B1/fr
Priority claimed from FR9003401A external-priority patent/FR2659659B1/fr
Application filed by Fournier Industrie et Sante SAS filed Critical Fournier Industrie et Sante SAS
Application granted granted Critical
Publication of DE69014064D1 publication Critical patent/DE69014064D1/de
Publication of DE69014064T2 publication Critical patent/DE69014064T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones
DE69014064T 1989-09-22 1990-08-31 Benzopyranon-beta-D-thioxyloside, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung. Expired - Fee Related DE69014064T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8912452A FR2652353B1 (fr) 1989-09-22 1989-09-22 Nouveaux benzopyran-2-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.
FR9003401A FR2659659B1 (fr) 1990-03-16 1990-03-16 Nouveaux benzopyran-4-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.

Publications (2)

Publication Number Publication Date
DE69014064D1 DE69014064D1 (de) 1994-12-15
DE69014064T2 true DE69014064T2 (de) 1995-05-18

Family

ID=26227568

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69014064T Expired - Fee Related DE69014064T2 (de) 1989-09-22 1990-08-31 Benzopyranon-beta-D-thioxyloside, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung.

Country Status (24)

Country Link
US (1) US5169838A (de)
EP (1) EP0421829B1 (de)
JP (1) JPH07103147B2 (de)
KR (1) KR0142670B1 (de)
CN (1) CN1027268C (de)
AT (1) ATE113956T1 (de)
AU (2) AU631456B2 (de)
CA (1) CA2024476C (de)
DE (1) DE69014064T2 (de)
DK (1) DK0421829T3 (de)
ES (1) ES2066165T3 (de)
FI (1) FI100183B (de)
GR (1) GR3014966T3 (de)
HR (1) HRP920811B1 (de)
HU (1) HU207867B (de)
IE (1) IE65092B1 (de)
IL (1) IL95582A (de)
NO (1) NO172987C (de)
NZ (1) NZ245783A (de)
PT (1) PT95369B (de)
RU (1) RU1838323C (de)
SK (1) SK463890A3 (de)
UA (1) UA13476A (de)
YU (1) YU47867B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2801055B1 (fr) * 1999-11-17 2002-02-08 Fournier Ind & Sante Derives de beta-d-5-thioxylose, procede de preparation et utilisation en therapeutique
FR2824559B1 (fr) * 2001-05-11 2004-02-13 Fournier Lab Sa Nouveaux derives 5-thio-beta-xylopyronasides, procede de preparation, compositions pharmaceutiques les contenant et leur utilisation en therapeutique
FR2846966A1 (fr) * 2002-11-07 2004-05-14 Fournier Lab Sa Derive du 4-methyl-2-oxo-2h-1-benzopyran-7-yl 5-thio-beta-d- xylopyranoside, son procede de preparation et composition pharmaceutique le contenant
JP2006527207A (ja) * 2003-06-11 2006-11-30 メルク フロスト カナダ リミテツド ７−（１，３−チアゾール−２−イル）チオ−クマリン誘導体およびそれのロイコトリエン生合成阻害薬としての使用
FR2860234B1 (fr) 2003-09-25 2005-12-23 Fournier Lab Sa Nouveaux derives 666 du thioxylose
TW200640449A (en) * 2005-02-18 2006-12-01 Smithkline Beecham Corp Pharmaceutical compositions and methods
FR2903698B1 (fr) 2006-07-13 2009-01-30 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose.
FR2906247B1 (fr) 2006-09-27 2008-12-26 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose
FR2906248B1 (fr) 2006-09-27 2008-12-26 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose
US20090075914A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched odiparcil
CN101397315B (zh) * 2007-09-24 2013-08-07 中国医学科学院药物研究所 香豆素苷类化合物、其制法和其药物组合物与用途
FR3011468B1 (fr) * 2013-10-04 2015-12-04 Inventiva Utilisation de l'odiparcil dans le traitement d'une mucopolysaccharidose
US10092540B2 (en) 2013-10-04 2018-10-09 Inventiva Method of treatment of a mucopolysaccharidosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2034306A1 (de) * 1970-07-10 1972-01-20 Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof 2 (3,4 Dimethyl-cumarin 7 yl) oxy alkylcarbonsaure Derivate und Verfahren zu ihrer Herstellung
FR2492830A1 (fr) * 1980-10-29 1982-04-30 Sori Soc Rech Ind Nouveaux composes appartenant a la famille des benzoyl- et a-hydroxybenzyl-phenyl-osides, leur procede de preparation et leur application en therapeutique
JPS6013788A (ja) * 1983-07-05 1985-01-24 Yamanouchi Pharmaceut Co Ltd 新規なクマリン誘導体
FR2549476B1 (fr) * 1983-07-20 1986-04-25 Rech Ind Benzyl-phenyl-osides, procede de preparation et utilisation en therapeutique
US4681954A (en) * 1985-10-07 1987-07-21 Pennwalt Corporation 7,8,9,10-tetrahydro-6-oxo-6H-dibenzo(b,d)pyranyloxy-propanes
FR2614893B1 (fr) * 1987-05-04 1989-12-22 Fournier Innovation Synergie Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
FI904614A0 (fi) 1990-09-19
IL95582A (en) 2001-06-14
IL95582A0 (en) 1991-06-30
PT95369A (pt) 1991-05-22
NO904088D0 (no) 1990-09-19
ES2066165T3 (es) 1995-03-01
SK280827B6 (sk) 2000-08-14
HRP920811B1 (en) 1998-12-31
RU1838323C (ru) 1993-08-30
NO172987B (no) 1993-06-28
HU906005D0 (en) 1991-03-28
AU6253190A (en) 1991-03-28
NZ245783A (en) 1993-07-27
EP0421829B1 (de) 1994-11-09
CA2024476A1 (en) 1991-03-23
DK0421829T3 (da) 1995-01-16
EP0421829A1 (de) 1991-04-10
HUT55794A (en) 1991-06-28
SK463890A3 (en) 2000-08-14
IE903414A1 (en) 1991-04-10
ATE113956T1 (de) 1994-11-15
IE65092B1 (en) 1995-10-04
KR0142670B1 (ko) 1998-07-01
PT95369B (pt) 1997-06-30
KR910006283A (ko) 1991-04-29
JPH07103147B2 (ja) 1995-11-08
YU47867B (sh) 1996-02-19
AU631456B2 (en) 1992-11-26
YU178790A (sh) 1992-12-21
NO904088L (no) 1991-03-25
DE69014064D1 (de) 1994-12-15
HRP920811A2 (en) 1995-10-31
FI100183B (fi) 1997-10-15
HU207867B (en) 1993-06-28
NO172987C (no) 1993-10-06
CN1027268C (zh) 1995-01-04
GR3014966T3 (en) 1995-05-31
UA13476A (uk) 1997-04-25
JPH03120292A (ja) 1991-05-22
US5169838A (en) 1992-12-08
AU642829B2 (en) 1993-10-28
AU2539792A (en) 1992-11-26
CN1050544A (zh) 1991-04-10
CA2024476C (en) 1999-10-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee