WO2009147951A1 - Composition épaississante et son procédé de production - Google Patents

Composition épaississante et son procédé de production Download PDF

Info

Publication number
WO2009147951A1
WO2009147951A1 PCT/JP2009/059316 JP2009059316W WO2009147951A1 WO 2009147951 A1 WO2009147951 A1 WO 2009147951A1 JP 2009059316 W JP2009059316 W JP 2009059316W WO 2009147951 A1 WO2009147951 A1 WO 2009147951A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid
crosslinked
thickening composition
composition
thickening
Prior art date
Application number
PCT/JP2009/059316
Other languages
English (en)
Japanese (ja)
Inventor
英樹 中田
哲夫 宮山
Original Assignee
出光テクノファイン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 出光テクノファイン株式会社 filed Critical 出光テクノファイン株式会社
Priority to JP2010515827A priority Critical patent/JP5840838B2/ja
Publication of WO2009147951A1 publication Critical patent/WO2009147951A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48—Thickener, Thickening system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00

Definitions

  • the present invention relates to a thickening composition that exhibits a thickening effect when dispersed in an aqueous medium, and a method for producing the same.
  • a thickener used in cosmetics and the like a composition to which an acrylic polymer (synthetic polymer compound) is added is known (see, for example, Patent Document 1).
  • a cosmetic comprising this composition is excellent in the improvement and moisturizing effects of skin creases and wrinkles, and is not sticky and spreads well on the skin.
  • a synthetic compound such as an acrylic polymer has low biodegradability and may be adversely affected by the human body. Therefore, a natural thickener is required instead of a synthetic thickener.
  • Xanthan gum and hyaluronic acid are known as natural thickening polysaccharides (see, for example, Patent Documents 2 and 3).
  • Xanthan gum and hyaluronic acid are widely used as cosmetic materials because they have excellent moisturizing effects and biodegradability upon disposal.
  • thickener compositions containing polysaccharides and polyamino acids see, for example, Patent Document 4
  • cosmetic compositions containing a cross-linked product composed of galactomannan or a derivative thereof as a moisturizing component are also known (for example, , See Patent Document 5).
  • the thickening effect is not always sufficient.
  • the present invention has a biodegradable, excellent thickening property, a non-sticky skin when used as a cosmetic, has excellent skin spreading properties, and also has a moisturizing effect and its production It aims to provide a method.
  • the present invention provides the following thickening composition.
  • a thickening composition comprising a crosslinked polyamino acid and a natural polymer.
  • the thickening composition of the present invention described above, wherein the natural polymer is blended in an amount of 0.01 parts by mass or more with respect to 100 parts by mass of the polyamino acid crosslinked product. object.
  • the thickening composition according to the invention wherein the polyamino acid cross-linked product is poly- ⁇ -glutamic acid or a salt thereof.
  • the thickening composition according to the invention wherein the polyamino acid crosslinked product is a radiation crosslinked product of a polyamino acid having a molecular weight of 10 to 3000 kDa.
  • the thickening composition according to the present invention wherein the crosslinked polyamino acids have an average particle size of 0.1 to 300 ⁇ m.
  • the present invention also provides a method for producing a thickening composition, wherein a polyamino acid is crosslinked to produce a crosslinked polyamino acid, and then a natural polymer is blended.
  • the combined use of a polyamino acid crosslinked product and a natural polymer, particularly a natural polysaccharide can dramatically increase the viscosity when dispersed in an aqueous medium. it can. Therefore, an appropriate viscosity can be imparted to a natural polymer that does not normally exhibit high viscosity, for example, a natural polysaccharide having various functions, and the range of use can be expanded.
  • the thickening composition of the present invention is a natural formulation, it has high safety to the human body and excellent biodegradability.
  • the thickening composition of the present invention can be widely applied to cosmetics, daily necessities, toiletries, hygiene products, medical supplies, agriculture / horticultural fields, food fields and environmental fields.
  • hyaluronic acid is used as a natural polysaccharide
  • a significant increase in viscosity can be expected, and a moisturizing effect by hyaluronic acid can be obtained in addition to a moisturizing effect by a crosslinked polyamino acid.
  • xanthan gum as a natural polysaccharide is well known as a thickener having characteristics such as excellent salt resistance, acid resistance and heat resistance. The feeling of use was not so good that the spread was inferior, and the range of use was limited.
  • an excellent feeling of use can be obtained by using xanthan gum in combination with a crosslinked polyamino acid.
  • the method for producing a thickening composition according to the present invention after a polyamino acid is cross-linked to produce a polyamino acid cross-linked product, the viscosity when dispersed in an aqueous medium is obtained by blending a natural polymer. Can be dramatically improved.
  • the thickening composition of the present invention (hereinafter also referred to as “the present composition”) is characterized by blending a crosslinked polyamino acid and a natural polymer.
  • the polyamino acid cross-linked product, the natural polymer, and the composition composed of these will be described in detail.
  • polyamino acid cross-linked product polyamino acids are not limited to free acids, but may be alkali metal salts such as sodium, potassium, lithium, ammonium salts, ethanolamine salts, diethanolamine salts, triethanolamine salts, etc.
  • the basic amine salt may be used.
  • the crosslinked polyamino acids include not only crosslinked polyamino acids but also crosslinked polyamino acid salts.
  • the salt is preferably a sodium salt or a potassium salt from the viewpoint of odor.
  • the free acid and its salt are not distinguished from each other and expressed as “polyamino acids” or “crosslinked polyamino acids”.
  • polyamino acids cross-linked product of the present invention can be applied using polyamino acids composed of the following various amino acids as raw materials.
  • amino acids having non-polar or hydrophobic atomic groups include alanine, valine, leucine, isoleucine, methionine, tryptophan, phenylalanine, and proline.
  • polar but uncharged amino acids include glycine, serine, threonine, cysteine, tyrosine, asparagine, and glutamine.
  • amino acids having a positively charged atomic group include lysine, histidine, and arginine.
  • amino acids having a negatively charged atomic group include aspartic acid and glutamic acid.
  • amino acids include L-ornithine, a series of ⁇ -amino acids, ⁇ -alanine, ⁇ -aminobutyric acid, neutral amino acids, acidic amino acids, ⁇ -esters of acidic amino acids, basic amino acids, N of basic amino acids -Substituents, amino acids and amino acid derivatives such as aspartic acid-L-phenylalanine dimer (aspartame), aminosulfonic acids such as L-cysteic acid, and the like.
  • the ⁇ -amino acid may be an optically active substance (L form, D form) or a racemate.
  • the polyamino acid may be a copolymer containing other monomer components.
  • the polyamino acid crosslinked product used in the present invention may be a homopolymer or a copolymer.
  • the copolymerization format is not particularly limited, and may take any format such as a block copolymer, a random copolymer, a graft copolymer, and the like.
  • Specific examples of copolymer components (monomer components other than amino acids) when the polyamino acid cross-linked product is a copolymer include, for example, aminocarboxylic acid, aminosulfonic acid, aminophosphonic acid, hydroxycarboxylic acid, mercaptocarboxylic acid, mercaptosulfonic acid And mercaptophosphonic acid.
  • a homopolymer is preferably used.
  • a crosslinked product having a basic skeleton of polyaspartic acid, poly- ⁇ -glutamic acid (hereinafter also referred to as “ ⁇ -PGA”), or a polylysine homopolymer is preferable.
  • a polyaspartic acid crosslinked body and a ⁇ -PGA crosslinked body are preferable from the viewpoint of water absorption.
  • the crosslinked polyamino acids by radiation crosslinking.
  • radiation cross-linking makes it easier to specify the gelation rate of the crosslinked polyamino acids compared to peroxide cross-linking.
  • a radiation For example, a gamma ray, an electron beam, etc. are mentioned.
  • an electron beam with good operability is preferable.
  • ⁇ -rays have higher transmission power than electron beams, the irradiation dose is small, and the transmission power of electron beams is smaller than ⁇ -rays, but the irradiation dose can be set larger.
  • the sample thickness corresponding to the acceleration voltage can be irradiated in a shorter time than ⁇ rays.
  • the irradiation dose is preferably in the range of 10 to 300 kGy, more preferably 20 to 200 kGy.
  • the irradiation time is preferably 1 second or longer. If the irradiation time is less than 1 second in total, the formation of a crosslinked product may be insufficient.
  • the form of the crosslinked polyamino acids compounded for preparing the thickening composition used in the present invention is not particularly limited.
  • the average particle size is preferably in the range of 0.1 to 300 ⁇ m, more preferably the average particle size is in the range of 1 to 50 ⁇ m, and even more preferably the average particle size
  • the particle size range is 5-30 ⁇ m.
  • an average particle diameter is 0.1 micrometer or more. When the particle size is outside this range, a grainy feeling remains when the composition is used as a cosmetic, and a preferable feeling of use and an appropriate viscosity cannot be obtained.
  • the average particle diameter can be measured by a laser particle size distribution analyzer (LMS-30 manufactured by Seishin Enterprise Co., Ltd.) applying Fraunhofer's diffraction principle.
  • the molecular weight of the polyamino acid used for radiation crosslinking in the present invention is preferably in the range of 10 to 3000 kDa as measured by gel filtration chromatography, and more preferably 50 to 1000 kDa from the viewpoint of moisture absorption and retention.
  • the molecular weight can be measured by dissolving a sample in pure water and performing gel filtration analysis as it is.
  • a standard pullulan manufactured by Showa Denko
  • a calibration curve based on the elution time in gel filtration and the molecular weight of the standard solution, the same applies to the sample.
  • the molecular weight of the sample is determined from the peak position (elution time) in the gel filtration curve.
  • Natural polymer examples of the natural polymer used in the thickening composition of the present invention include natural polysaccharides, proteins and lipids. It is particularly preferable to use natural polysaccharides from the viewpoint of the thickening effect.
  • natural polysaccharides as plant polymers, for example, gum arabic, gum tragacanth, galactan, guar gum, carob gum, caraya gum, carrageenan, pectin, agar, quince seed (malmello), alge colloid (gypsum extract), starch (rice, rice, Corn, potato, wheat) and glycyrrhizic acid.
  • microbial polymer examples include xanthan gum, dextran, succinoglucan, and bullulan.
  • animal polymer examples include hyaluronic acid and mucoitin sulfate. , Caronic acid, collagen, casein, albumin, gelatin and the like.
  • hyaluronic acid is preferably used as the natural polysaccharide from the viewpoint of thickening effect.
  • hyaluronic acid used as the natural polysaccharide is not particularly limited, but hyaluronic acid having a molecular weight of 10,000 or more is preferably used from the viewpoint of a thickening effect, and hyaluronic acid having a molecular weight of 500,000 or more is more preferably used.
  • hyaluronic acid having a molecular weight of 1 million or more is more preferably used.
  • the thickening composition of the present invention it is preferable to blend a natural polysaccharide or the like in a proportion of 0.01 parts by mass or more when the polyamino acid crosslinked product is 100 parts by mass.
  • the blending ratio of the natural polymer is preferably 0.01 parts by mass or more.
  • the blending ratio of the natural polymer is preferably 1 part by mass or more and 100 parts by mass or less in consideration of the thickening effect.
  • the viscosity of the crosslinked polyamino acid (single) in a B-type viscometer is 0.1 to 100 Pa.
  • Condition A is set in advance so as to be in the range of s
  • condition B is set in advance so that the viscosity of the natural polymer (single) such as natural polysaccharide is in the range of 0.01 to 100 Pa ⁇ s. It is good to decide.
  • the high viscosity liquid whose viscosity is 1 Pa * s or more can be preferably manufactured by mix
  • FIG. When the viscosity of the crosslinked polyamino acids and natural polymer (natural polysaccharides, etc.) is in a range not satisfying either of the above conditions A or B, it is preferable when both components are blended (as a cosmetic) There is a risk that it will not be possible to obtain.
  • the viscosity of the obtained mixed liquid can be dramatically increased.
  • hydrocarbons such as liquid paraffin, squalane and petrolatum; fats and oils such as macadamia nut oil, olive oil and lanolin; waxes such as jojoba oil, carnauba wax and candelilla wax; silicones such as dimethylpolysiloxane and methylphenylsiloxane; Higher alcohols such as capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cholesterol, phytosterol; higher fatty acids such as capric acid, myristic acid, palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid, linolenic acid; polyethylene Glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, mucopolysaccharide, hyaluronic acid, chondroitin sulfate, chit
  • amino acids such as glycine, alanine, valine, leucine, threonine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamine, taurine, arginine, histidine and their alkali metal salts and hydrochlorides; acyl sarcosine acid (for example, lauroyl sarcosine sodium) Glutathione; organic acids such as citric acid, malic acid, tartaric acid, lactic acid; vitamin A and its derivatives; vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and its derivatives, vitamin B12, vitamin B15 and Vitamin B such as derivatives thereof; Vitamin C such as ascorbic acid, ascorbic acid sulfate (salt), ascorbic acid phosphate (salt), ascorbic acid dipalmitate; ⁇ - Vitamin E such as coferol, ⁇ -tocopherol, ⁇ ,
  • the surfactant that can be added for the purpose of improving the stability or can be added for other purposes is not particularly limited.
  • sorbitan monolaurate, sorbitan monopalmitate, Sorbitan oleate, sorbitan trioleate polyoxyethylene sorbitan monolaurate, polyoxyethylene glycol monooleate, polyoxyethylene alkyl ether, polyethylene glycol difatty acid ester, lauroyl diethanolamide, fatty acid dipropanolamide, maltitol hydroxy aliphatic ether
  • Nonionic surfactants such as alkylated polysaccharides, alkyl glucosides, sugar esters, polyether-modified silicones; stearyltrimethylammonium chloride, benzalkonium chloride, Cationic surfactants such as rilamine oxide; anionic surfactants such as sodium palmitate, sodium laurate, sodium lauryl sulfate, potassium lauryl sulfate, triethanol
  • this composition When this composition is used as a cosmetic, it is suitable as, for example, a skin cosmetic, a makeup cosmetic, and a hair cosmetic.
  • the dosage form of this composition is not particularly limited, and can be any dosage form.
  • this composition is used for skin cosmetics, for example, surfactants, oils, moisturizers, film forming agents, oil gelling agents, metal oxides, organic ultraviolet rays generally used as skin cosmetic ingredients.
  • Absorbents, inorganic metal salts, organic metal salts, alcohols, chelating agents, pH adjusters, preservatives, other thickeners, medicinal ingredients, pigments, fragrances and other additive components may be combined in any combination. .
  • aqueous solutions solubilization systems, emulsion systems, powder dispersion systems, water-oil two-layer systems, water-oil-powder three-layer systems, oil / water (O / W) type emulsified cosmetics, water / oil ( Various forms such as (W / O) type emulsified cosmetics can also be taken.
  • Specific applications include creams, cosmetic emulsions, lotions, oily lotions, lipsticks, foundations, skin cleansing agents, and the like.
  • Example 1 A ⁇ -PGA crosslinked product (manufactured by Idemitsu Techno Fine Co., Ltd., trade name: Gel Protein A-8002, average particle size 26.5 ⁇ m) is blended in pure water, and 1.0% by mass and 2.0% by mass, respectively.
  • ⁇ -PGA cross-linked dispersion liquids were prepared.
  • hyaluronic acid (trade name: hyaluronic acid FCH120, manufactured by Kibun Food Chemifa Co., Ltd.) are mixed with the above-mentioned two types of ⁇ -PGA crosslinked dispersion and pure water.
  • 12 types of sample solutions shown in Table 1 were prepared.
  • the viscosity of each sample liquid was measured using the B-type viscosity meter (rotor No. 4, 6 rpm, 25 degreeC). The results are shown in Table 1.
  • the parentheses to the right of each viscosity value indicate each part by mass of hyaluronic acid (HA) with respect to 100 parts by mass of the ⁇ -PGA crosslinked body.
  • the crosslinked ⁇ -PGA used in the present embodiment was obtained by subjecting poly- ⁇ -glutamic acid having a molecular weight of 70 kDa to an electron beam irradiation treatment of 140 kGy.
  • Example 2 The same ⁇ -PGA cross-linked product used in Example 1 was mixed with pure water, and three kinds of ⁇ -- were added so as to be 0.5% by mass, 1.0% by mass, and 2.0% by mass, respectively.
  • a PGA crosslinked dispersion was prepared.
  • xanthan gum (XG) manufactured by Nisshin Eulio, trade name: Nomcoat ZZ
  • XG xanthan gum
  • Nomcoat ZZ Nomcoat ZZ
  • Example 3 The same ⁇ -PGA crosslinked product used in Example 1 was mixed with pure water to prepare one kind of ⁇ -PGA crosslinked product dispersion to 2.0% by mass. Next, the protein (product name: Atelocollagen, manufactured by Koken Co., Ltd.) was mixed with the above-mentioned ⁇ -PGA crosslinked dispersion and pure water to prepare four types of sample solutions shown in Table 3. And the viscosity of each sample liquid was measured like Example 1. FIG. The results are shown in Table 3. In the parentheses on the right side of each viscosity value, each part by mass of the protein with respect to 100 parts by mass of the ⁇ -PGA crosslinked body is shown.
  • the protein product name: Atelocollagen, manufactured by Koken Co., Ltd.
  • Example 4 The same ⁇ -PGA crosslinked product used in Example 1 was mixed with pure water to prepare one kind of ⁇ -PGA crosslinked product dispersion to 2.0% by mass. Next, lipids (manufactured by NOF Corporation, trade name: Lipidure) were mixed with the above-mentioned ⁇ -PGA crosslinked body dispersion and pure water to prepare four types of sample solutions shown in Table 4. And the viscosity of each sample liquid was measured like Example 1. FIG. The results are shown in Table 4. In the parentheses on the right of each viscosity value, each part by mass of lipid with respect to 100 parts by mass of the ⁇ -PGA crosslinked body is shown.
  • lipids manufactured by NOF Corporation, trade name: Lipidure
  • the thickening composition of the present invention has a very high thickening effect and can be suitably used in the fields of cosmetics and hygiene products.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

L'invention concerne une composition épaississante caractérisée en ce qu'elle comprend 100 parties en masse d'un acide polyaminé réticulé et 0,01 partie en masse ou plus d'un polysaccharide naturel.  La composition peut améliorer considérablement la viscosité d'un milieu aqueux lorsqu'elle est ajoutée au milieu aqueux.  Lorsqu'elle est utilisée comme produit cosmétique, la composition n'est pas grasse au toucher et s'étale très facilement sur la peau, en plus d'exercer un effet humectant élevé.  En outre, la composition présente une sécurité élevée pour le corps humain et une excellente biodégradabilité en raison de sa formulation à base d'ingrédients naturels.
PCT/JP2009/059316 2008-06-02 2009-05-21 Composition épaississante et son procédé de production WO2009147951A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2010515827A JP5840838B2 (ja) 2008-06-02 2009-05-21 増粘性組成物およびその製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008-144749 2008-06-02
JP2008144749 2008-06-02

Publications (1)

Publication Number Publication Date
WO2009147951A1 true WO2009147951A1 (fr) 2009-12-10

Family

ID=41398027

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2009/059316 WO2009147951A1 (fr) 2008-06-02 2009-05-21 Composition épaississante et son procédé de production

Country Status (3)

Country Link
JP (1) JP5840838B2 (fr)
TW (1) TW201012482A (fr)
WO (1) WO2009147951A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018222545A1 (fr) * 2017-05-27 2018-12-06 Ecovia Renewables Inc. Compositions de modificateur de rhéologie de poly(acide aminé) et procédés d'utilisation
JP2019099509A (ja) * 2017-12-04 2019-06-24 花王株式会社 油中水型乳化化粧料
CN112063221A (zh) * 2020-09-18 2020-12-11 山东华熙海御生物医药有限公司 含透明质酸的着色助剂、制法及其应用
CN114129471A (zh) * 2021-12-06 2022-03-04 华熙生物科技股份有限公司 一种悬浮增稠组合物及其应用
FR3118578A1 (fr) * 2021-01-07 2022-07-08 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Composition pharmaceutique comprenant comme agent épaississant une composition qui présente des propriétés épaississantes de milieux polaires

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003146830A (ja) * 2001-11-08 2003-05-21 Sakata Kyoko 化粧料
JP2005179534A (ja) * 2003-12-19 2005-07-07 Tung Hai Biotechnology Corp 三次元架橋した、安定した生分解性の高吸水性γポリグルタミン酸ヒドロゲル、及びその調製方法
JP3126848U (ja) * 2006-08-30 2006-11-09 株式会社 ユ−モインク フェイシャルマスク
JP2006342164A (ja) * 2005-06-07 2006-12-21 Goldschmidt Gmbh 皮膚の水分含有量を調節および改善するための局所化粧料配合物
WO2007135801A1 (fr) * 2006-05-23 2007-11-29 Toyo Boseki Kabushiki Kaisha MICROORGANISME CAPABLE DE PRODUIRE DE L'ACIDE POLY-γ-L-GLUTAMIQUE (γ-L-PGA), PROCÉDÉ DE PRODUCTION DE γ-L-PGA À L'AIDE DE CE MICROORGANISME, PRODUIT RÉTICULÉ ET AGENT POUR APPLICATION EXTERNE SUR LA PEAU
JP2007320889A (ja) * 2006-05-31 2007-12-13 Umo Inc Co Ltd 美顔用薬剤を調剤する方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003146830A (ja) * 2001-11-08 2003-05-21 Sakata Kyoko 化粧料
JP2005179534A (ja) * 2003-12-19 2005-07-07 Tung Hai Biotechnology Corp 三次元架橋した、安定した生分解性の高吸水性γポリグルタミン酸ヒドロゲル、及びその調製方法
JP2006342164A (ja) * 2005-06-07 2006-12-21 Goldschmidt Gmbh 皮膚の水分含有量を調節および改善するための局所化粧料配合物
WO2007135801A1 (fr) * 2006-05-23 2007-11-29 Toyo Boseki Kabushiki Kaisha MICROORGANISME CAPABLE DE PRODUIRE DE L'ACIDE POLY-γ-L-GLUTAMIQUE (γ-L-PGA), PROCÉDÉ DE PRODUCTION DE γ-L-PGA À L'AIDE DE CE MICROORGANISME, PRODUIT RÉTICULÉ ET AGENT POUR APPLICATION EXTERNE SUR LA PEAU
JP2007320889A (ja) * 2006-05-31 2007-12-13 Umo Inc Co Ltd 美顔用薬剤を調剤する方法
JP3126848U (ja) * 2006-08-30 2006-11-09 株式会社 ユ−モインク フェイシャルマスク

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018222545A1 (fr) * 2017-05-27 2018-12-06 Ecovia Renewables Inc. Compositions de modificateur de rhéologie de poly(acide aminé) et procédés d'utilisation
US11708464B2 (en) 2017-05-27 2023-07-25 Ecovia Renewables Inc. Poly (amino acid) rheology modifier compositions and methods of use
JP2019099509A (ja) * 2017-12-04 2019-06-24 花王株式会社 油中水型乳化化粧料
CN112063221A (zh) * 2020-09-18 2020-12-11 山东华熙海御生物医药有限公司 含透明质酸的着色助剂、制法及其应用
FR3118578A1 (fr) * 2021-01-07 2022-07-08 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Composition pharmaceutique comprenant comme agent épaississant une composition qui présente des propriétés épaississantes de milieux polaires
WO2022148660A1 (fr) * 2021-01-07 2022-07-14 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Composition pharmaceutique comprenant comme agent épaississant une composition qui présente des propriétés épaississantes de milieux polaires
CN114129471A (zh) * 2021-12-06 2022-03-04 华熙生物科技股份有限公司 一种悬浮增稠组合物及其应用
CN114129471B (zh) * 2021-12-06 2023-07-18 华熙生物科技股份有限公司 一种悬浮增稠组合物及其应用

Also Published As

Publication number Publication date
JPWO2009147951A1 (ja) 2011-10-27
JP5840838B2 (ja) 2016-01-06
TW201012482A (en) 2010-04-01

Similar Documents

Publication Publication Date Title
JP5433128B2 (ja) 皮膚外用剤
JP6274440B2 (ja) 分散液及びヒドロゲル形成方法
US11564395B2 (en) Formulations with colloidal silver
KR20200116478A (ko) 기능성 다당 입자
JP2010070492A (ja) 化粧料
WO2014077174A1 (fr) Composition de type émulsion huile dans eau
JP5840838B2 (ja) 増粘性組成物およびその製造方法
JP5550863B2 (ja) 化粧料
JP2008222970A (ja) 水性ゲル、皮膚外用剤および化粧料
JPH10259114A (ja) 水中油型乳化組成物
JP6367003B2 (ja) 水中油型乳化化粧料
KR20000022959A (ko) 외용 조성물
JP2008230994A (ja) 化粧料
JP3559688B2 (ja) 化粧料
CN107530260B (zh) 皮肤外用制剂
JP2007314427A (ja) リポ酸含有複合体
JP4370595B2 (ja) ゲル状組成物、芳香剤、皮膚外用剤及び化粧料
JP2016121187A (ja) 増粘性組成物および皮膚外用剤
JP2008230995A (ja) 化粧料
JP2001131016A (ja) 外用組成物
US20200171083A1 (en) Compositions of silver and cannabinoids
TW201427711A (zh) 皮膚外用組成物
JP2013103910A (ja) 増粘性組成物および皮膚外用剤
JP2000143436A (ja) 外用組成物
JP2019077675A (ja) ジェル状皮膚外用剤又は皮膚化粧料

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09758218

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2010515827

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09758218

Country of ref document: EP

Kind code of ref document: A1