WO2003009831A1 - Compositions containing sustained-release fine grains for tablets quickly disintegrable in the oral cavity and process for producing the same - Google Patents

Compositions containing sustained-release fine grains for tablets quickly disintegrable in the oral cavity and process for producing the same Download PDF

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Publication number
WO2003009831A1
WO2003009831A1 PCT/JP2002/007550 JP0207550W WO03009831A1 WO 2003009831 A1 WO2003009831 A1 WO 2003009831A1 JP 0207550 W JP0207550 W JP 0207550W WO 03009831 A1 WO03009831 A1 WO 03009831A1
Authority
WO
WIPO (PCT)
Prior art keywords
oral cavity
fine grains
release fine
producing
compositions containing
Prior art date
Application number
PCT/JP2002/007550
Other languages
English (en)
French (fr)
Inventor
Tatsuki Shinoda
Atsushi Maeda
Naoki Itou
Takao Mizumoto
Shigeru Yamazaki
Yuuki Takaishi
Original Assignee
Yamanouchi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co., Ltd. filed Critical Yamanouchi Pharmaceutical Co., Ltd.
Priority to CN028028864A priority Critical patent/CN1473035B/zh
Priority to BR0205509-0A priority patent/BR0205509A/pt
Priority to AU2002355222A priority patent/AU2002355222B2/en
Priority to CA002419089A priority patent/CA2419089A1/en
Priority to MXPA03000985A priority patent/MXPA03000985A/es
Priority to DE60237826T priority patent/DE60237826D1/de
Priority to JP2003515224A priority patent/JP4019374B2/ja
Priority to KR10-2003-7001324A priority patent/KR100530546B1/ko
Priority to HU0302351A priority patent/HUP0302351A3/hu
Priority to AT02751684T priority patent/ATE482692T1/de
Priority to EP02751684A priority patent/EP1413294B1/en
Priority to TW092100259A priority patent/TWI281868B/zh
Publication of WO2003009831A1 publication Critical patent/WO2003009831A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
PCT/JP2002/007550 2001-07-27 2002-07-25 Compositions containing sustained-release fine grains for tablets quickly disintegrable in the oral cavity and process for producing the same WO2003009831A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN028028864A CN1473035B (zh) 2001-07-27 2002-07-25 含有口腔内迅速崩解片剂用缓释微粒的组合物及其制造方法
BR0205509-0A BR0205509A (pt) 2001-07-27 2002-07-25 Composição compreendendo partìculas finas de liberação prolongada para comprimidos de rápida desintegração na cavidade bucal e método de fabricação da mesma
AU2002355222A AU2002355222B2 (en) 2001-07-27 2002-07-25 Compositions containing sustained-release fine grains for tablets quickly disintegrable in the oral cavity and process for producing the same
CA002419089A CA2419089A1 (en) 2001-07-27 2002-07-25 Composition comprises sustained-release fine particles for quick-disintegrating tablets in the buccal cavity and manufacturing method thereof
MXPA03000985A MXPA03000985A (es) 2001-07-27 2002-07-25 Composicion que comprende particulas finas de liberacion sostenida para tabletas de desintegracion rapida en la cavidad bucal y metodo de fabricacion de la misma.
DE60237826T DE60237826D1 (de) 2001-07-27 2002-07-25 Zusammensetzung enthaltend feine Körner mit verzögerter Freisetzung für in der Mundhöhle schnell zerfallende Tabletten
JP2003515224A JP4019374B2 (ja) 2001-07-27 2002-07-25 口腔内速崩壊錠用徐放性微粒子含有組成物およびその製造法
KR10-2003-7001324A KR100530546B1 (ko) 2001-07-27 2002-07-25 구강내에서 신속하게 붕괴되는 정제용 서방성 미립자가함유된 조성물 및 그의 제조 방법
HU0302351A HUP0302351A3 (en) 2001-07-27 2002-07-25 Compoaitions containing sustained-release fine grains for tablets quickly disintegrable in the oral cavity and process for producing the same
AT02751684T ATE482692T1 (de) 2001-07-27 2002-07-25 Zusammensetzung enthaltend feine körner mit verzögerter freisetzung für in der mundhöhle schnell zerfallende tabletten
EP02751684A EP1413294B1 (en) 2001-07-27 2002-07-25 Composition comprising sustained-release fine particles for quick-disintegrating tablets in the buccal cavity
TW092100259A TWI281868B (en) 2002-07-25 2003-01-07 Composition comprises sustained-release fine particles for quick-disintegrating tablets in the buccal cavity and manufacturing method thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30830301P 2001-07-27 2001-07-27
US60/308,303 2001-07-27

Publications (1)

Publication Number Publication Date
WO2003009831A1 true WO2003009831A1 (en) 2003-02-06

Family

ID=23193419

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/007550 WO2003009831A1 (en) 2001-07-27 2002-07-25 Compositions containing sustained-release fine grains for tablets quickly disintegrable in the oral cavity and process for producing the same

Country Status (18)

Country Link
US (2) US7255876B2 (ja)
EP (1) EP1413294B1 (ja)
JP (3) JP4019374B2 (ja)
KR (1) KR100530546B1 (ja)
CN (1) CN1473035B (ja)
AT (1) ATE482692T1 (ja)
AU (1) AU2002355222B2 (ja)
BR (1) BR0205509A (ja)
CA (1) CA2419089A1 (ja)
CZ (1) CZ14921U1 (ja)
DE (2) DE60237826D1 (ja)
ES (1) ES2351249T3 (ja)
HU (1) HUP0302351A3 (ja)
MX (1) MXPA03000985A (ja)
PL (1) PL361452A1 (ja)
RU (1) RU2245136C2 (ja)
WO (1) WO2003009831A1 (ja)
ZA (1) ZA200300647B (ja)

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JP2003261439A (ja) * 2002-03-08 2003-09-16 Asahi Kasei Corp 口腔内崩壊製剤
JP2004175796A (ja) * 2002-11-13 2004-06-24 Asahi Kasei Pharma Kk 排尿障害治療用口腔内崩壊製剤
WO2005037254A1 (ja) * 2003-10-15 2005-04-28 Fuji Chemical Industry Co., Ltd. 口腔内速崩壊性錠剤
DE10350322A1 (de) * 2003-10-23 2005-06-09 Coty B.V. Klimabeständiger kosmetischer Komplex
EP1600157A1 (en) * 2003-01-27 2005-11-30 Astellas Pharma Inc. Enteric sustained-release fine particles for tamsulosin or its salt and process for producing the same
JP2006503855A (ja) * 2002-09-25 2006-02-02 カプサルーション ナノサイエンス アクチェン ゲゼルシャフト 難溶性活性成分を含む速放性の投与形態
WO2006115285A1 (ja) * 2005-04-21 2006-11-02 Takeda Pharmaceutical Company Limited 医薬組成物
JP2006524663A (ja) * 2003-04-30 2006-11-02 フェリング ベスローテン フェンノートシャップ 固体剤形としての医薬組成物およびその製造方法
WO2007026755A1 (ja) * 2005-08-31 2007-03-08 Ezaki Glico Co., Ltd. 舌苔除去用タブレット
JP2007516282A (ja) * 2003-12-23 2007-06-21 レツク・フアーマシユーテイカルズ・デー・デー 放出制御医薬製剤
JP2007522258A (ja) * 2004-02-17 2007-08-09 ハンミ ファーム． シーオー．， エルティーディー． 塩酸タムスロシンの経口投与用組成物及びその徐放性顆粒製剤
WO2008032726A1 (fr) 2006-09-15 2008-03-20 Astellas Pharma Inc. Composition pharmaceutique solide pour administration orale comprenant du ramosétron optiquement stable
JP2009235066A (ja) * 2008-03-07 2009-10-15 Sawai Pharmaceutical Co Ltd 被覆微粒子含有口腔内崩壊錠
WO2010001574A1 (ja) * 2008-07-01 2010-01-07 沢井製薬株式会社 タムスロシン塩酸塩を含有する球形微粒子の製造方法
CN101639340B (zh) * 2008-08-01 2011-01-12 广东省计量科学研究院 读数显微镜检定装置
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CN1856298B (zh) * 2003-10-15 2013-04-10 富士化学工业株式会社 在口腔内快速崩解的片剂
JP2015003915A (ja) * 2012-10-12 2015-01-08 味の素株式会社 カルシウム拮抗薬／アンジオテンシンｉｉ受容体拮抗薬含有医薬製剤の製造方法
JP2016193894A (ja) * 2015-04-01 2016-11-17 京都薬品工業株式会社 生菌含有製剤
JPWO2019151405A1 (ja) * 2018-02-02 2021-01-14 ニプロ株式会社 錠剤及びその製造方法

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JP2003261439A (ja) * 2002-03-08 2003-09-16 Asahi Kasei Corp 口腔内崩壊製剤
JP2006503855A (ja) * 2002-09-25 2006-02-02 カプサルーション ナノサイエンス アクチェン ゲゼルシャフト 難溶性活性成分を含む速放性の投与形態
JP2004175796A (ja) * 2002-11-13 2004-06-24 Asahi Kasei Pharma Kk 排尿障害治療用口腔内崩壊製剤
JP4523265B2 (ja) * 2002-11-13 2010-08-11 旭化成ファーマ株式会社 排尿障害治療用口腔内崩壊製剤
EP1600157A4 (en) * 2003-01-27 2006-02-08 Astellas Pharma Inc FINE DARK ARTICLES WITH DELAYED RELEASE FOR TAMSULOSINE OR ITS SALTS AND METHOD OF PREPARATION THEREOF
EP1600157A1 (en) * 2003-01-27 2005-11-30 Astellas Pharma Inc. Enteric sustained-release fine particles for tamsulosin or its salt and process for producing the same
JP2006524663A (ja) * 2003-04-30 2006-11-02 フェリング ベスローテン フェンノートシャップ 固体剤形としての医薬組成物およびその製造方法
EP1656126B1 (en) * 2003-08-12 2011-08-10 Kyungdong Pharm. Co., Ltd. Preparing method for controlled released type tablet comprising tamsulosin hcl and the tablet produced thereof
CN1856298B (zh) * 2003-10-15 2013-04-10 富士化学工业株式会社 在口腔内快速崩解的片剂
WO2005037254A1 (ja) * 2003-10-15 2005-04-28 Fuji Chemical Industry Co., Ltd. 口腔内速崩壊性錠剤
US8647668B2 (en) 2003-10-15 2014-02-11 Fuji Chemical Industry Co., Ltd. Tablet quickly disintegrating in oral cavity
DE10350322A1 (de) * 2003-10-23 2005-06-09 Coty B.V. Klimabeständiger kosmetischer Komplex
JP2007516282A (ja) * 2003-12-23 2007-06-21 レツク・フアーマシユーテイカルズ・デー・デー 放出制御医薬製剤
JP2007522258A (ja) * 2004-02-17 2007-08-09 ハンミ ファーム． シーオー．， エルティーディー． 塩酸タムスロシンの経口投与用組成物及びその徐放性顆粒製剤
JP4827915B2 (ja) * 2005-03-07 2011-11-30 アルファ ワッセルマン ソシエタ ペル アチオニ リファキシミンを含む胃抵抗性薬剤組成物
WO2006115285A1 (ja) * 2005-04-21 2006-11-02 Takeda Pharmaceutical Company Limited 医薬組成物
WO2007026755A1 (ja) * 2005-08-31 2007-03-08 Ezaki Glico Co., Ltd. 舌苔除去用タブレット
WO2008032726A1 (fr) 2006-09-15 2008-03-20 Astellas Pharma Inc. Composition pharmaceutique solide pour administration orale comprenant du ramosétron optiquement stable
JP2009235066A (ja) * 2008-03-07 2009-10-15 Sawai Pharmaceutical Co Ltd 被覆微粒子含有口腔内崩壊錠
WO2010001574A1 (ja) * 2008-07-01 2010-01-07 沢井製薬株式会社 タムスロシン塩酸塩を含有する球形微粒子の製造方法
JPWO2010001574A1 (ja) * 2008-07-01 2011-12-15 沢井製薬株式会社 タムスロシン塩酸塩を含有する球形微粒子の製造方法
US8529953B2 (en) 2008-07-01 2013-09-10 Sawai Pharmaceutical Co., Ltd. Process for production of spherical microparticles comprising tamsulosin hydrochloride
JP5511663B2 (ja) * 2008-07-01 2014-06-04 沢井製薬株式会社 タムスロシン塩酸塩を含有する球形微粒子の製造方法
CN101639340B (zh) * 2008-08-01 2011-01-12 广东省计量科学研究院 读数显微镜检定装置
JP2015003915A (ja) * 2012-10-12 2015-01-08 味の素株式会社 カルシウム拮抗薬／アンジオテンシンｉｉ受容体拮抗薬含有医薬製剤の製造方法
JP2016193894A (ja) * 2015-04-01 2016-11-17 京都薬品工業株式会社 生菌含有製剤
JPWO2019151405A1 (ja) * 2018-02-02 2021-01-14 ニプロ株式会社 錠剤及びその製造方法
JP7336388B2 (ja) 2018-02-02 2023-08-31 ニプロ株式会社 錠剤及びその製造方法

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KR100530546B1 (ko) 2005-11-23
US20030147948A1 (en) 2003-08-07
BR0205509A (pt) 2003-06-24
CN1473035A (zh) 2004-02-04
EP1413294B1 (en) 2010-09-29
EP1413294A4 (en) 2006-06-07
JPWO2003009831A1 (ja) 2004-11-11
CN1473035B (zh) 2012-07-18
US7255876B2 (en) 2007-08-14
ATE482692T1 (de) 2010-10-15
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US20070202168A1 (en) 2007-08-30
EP1413294A1 (en) 2004-04-28
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CZ14921U1 (cs) 2004-11-23
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MXPA03000985A (es) 2004-04-02
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