TW360712B - Nucleic acid sequence amplification method, composition and kit - Google Patents

Nucleic acid sequence amplification method, composition and kit

Info

Publication number
TW360712B
TW360712B TW082104439A TW82104439A TW360712B TW 360712 B TW360712 B TW 360712B TW 082104439 A TW082104439 A TW 082104439A TW 82104439 A TW82104439 A TW 82104439A TW 360712 B TW360712 B TW 360712B
Authority
TW
Taiwan
Prior art keywords
nucleic acid
kit
composition
primer
target sequence
Prior art date
Application number
TW082104439A
Other languages
English (en)
Inventor
Daniel Louis Kacian
Diane Lisa Mcallister
Sherrol Hoffa Mcdonough
Nanibhushan Dattagupta
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of TW360712B publication Critical patent/TW360712B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW082104439A 1992-05-06 1993-06-03 Nucleic acid sequence amplification method, composition and kit TW360712B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87968692A 1992-05-06 1992-05-06

Publications (1)

Publication Number Publication Date
TW360712B true TW360712B (en) 1999-06-11

Family

ID=25374679

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082104439A TW360712B (en) 1992-05-06 1993-06-03 Nucleic acid sequence amplification method, composition and kit

Country Status (12)

Country Link
US (2) US5554516A (zh)
EP (1) EP0587266B1 (zh)
JP (1) JP4137996B2 (zh)
KR (1) KR100249110B1 (zh)
AT (1) ATE307898T1 (zh)
AU (1) AU681082B2 (zh)
CA (1) CA2135073C (zh)
DE (1) DE69333891T2 (zh)
DK (1) DK0587266T3 (zh)
ES (1) ES2250960T3 (zh)
TW (1) TW360712B (zh)
WO (1) WO1993022461A1 (zh)

Families Citing this family (299)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766849A (en) * 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
US7009041B1 (en) 1989-07-11 2006-03-07 Gen-Probe Incorporated Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis
US6093538A (en) * 1992-05-06 2000-07-25 Gen-Probe Incorporated Nucleic acid probes to ureaplasma
WO1994003472A1 (en) * 1992-08-04 1994-02-17 Gen-Probe Incorporated Nucleic acid sequence amplification
US20050123926A1 (en) * 1994-01-13 2005-06-09 Enzo Diagnostics, Inc., In vitro process for producing multiple nucleic acid copies
US20110097791A1 (en) * 1999-04-16 2011-04-28 Engelhardt Dean L Novel process, construct and conjugate for producing multiple nucleic acid copies
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
US5622827A (en) * 1995-02-07 1997-04-22 Gen-Probe Incorporated Amplification primers and nucleic acid probes targeted to coccidioides immitis nucleic acid
US5652126A (en) * 1995-06-07 1997-07-29 Gen-Probe Incorporated Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
US5916777A (en) * 1995-06-07 1999-06-29 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
US5710029A (en) * 1995-06-07 1998-01-20 Gen-Probe Incorporated Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5705365A (en) * 1995-06-07 1998-01-06 Gen-Probe Incorporated Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5739311A (en) * 1995-06-07 1998-04-14 Gen-Probe Incorporated Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases
CA2223241C (en) * 1995-06-07 2009-11-17 Gen-Probe Incorporated Methods and kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5932450A (en) * 1995-06-07 1999-08-03 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using digestible templates
US5882867A (en) * 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
JP4241929B2 (ja) 1996-05-22 2009-03-18 ジェン―プローブ・インコーポレーテッド Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｋａｎｓａｓｉｉを検出するための組成物および方法
US5919638A (en) * 1996-10-08 1999-07-06 Abbott Laboratories Reagents and methods useful for detecting prostate tumors
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US5837466A (en) * 1996-12-16 1998-11-17 Vysis, Inc. Devices and methods for detecting nucleic acid analytes in samples
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
JP3968810B2 (ja) * 1997-01-24 2007-08-29 東ソー株式会社 核酸配列分析方法
CA2286304C (en) * 1997-04-10 2007-08-07 Diagnocure Inc. Pca3, pca3 genes, and methods of use
US5989499A (en) * 1997-05-02 1999-11-23 Biomerieux, Inc. Dual chamber disposable reaction vessel for amplification reactions
US6410275B1 (en) 1997-05-02 2002-06-25 Biomerieux, Inc. Disposable test devices for performing nucleic acid amplification reactions
US6558901B1 (en) 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
US6429007B1 (en) * 1997-05-02 2002-08-06 BIOMéRIEUX, INC. Nucleic acid amplification reaction station for disposable test devices
US5786182A (en) * 1997-05-02 1998-07-28 Biomerieux Vitek, Inc. Dual chamber disposable reaction vessel for amplification reactions, reaction processing station therefor, and methods of use
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
IL124275A (en) * 1997-05-02 2002-03-10 Bio Merieux Vitek Inc A method to produce sequences of nucleic acids
EP0975807B1 (en) * 1997-05-02 2006-09-27 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
DE1002138T1 (de) 1997-08-08 2001-06-07 Akzo Nobel Nv Nukleinsäuresequenzen als primer und sonden zur amplifizierung und erkennung von allen hiv-1 subtypen
WO1999037806A2 (en) * 1998-01-27 1999-07-29 Cytocell Limited Modified nucleic acid probes and uses thereof
US20040002079A1 (en) * 1998-02-11 2004-01-01 Gunn Robert B. Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness
US6365346B1 (en) * 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
KR100440044B1 (ko) * 1998-02-27 2004-07-14 팸진 비.브이. 핵산의 비특이적 증폭방법
DK1614475T3 (da) 1998-05-01 2007-09-17 Gen Probe Inc Indretning til omröring af væskeindholdet i en beholder
US8337753B2 (en) 1998-05-01 2012-12-25 Gen-Probe Incorporated Temperature-controlled incubator having a receptacle mixing mechanism
EP2360271A1 (en) 1998-06-24 2011-08-24 Illumina, Inc. Decoding of array sensors with microspheres
JP4438110B2 (ja) * 1998-07-01 2010-03-24 東ソー株式会社 標的核酸の定量方法
JP2002521070A (ja) * 1998-07-31 2002-07-16 ジェン−プローブ・インコーポレーテッド 可逆的阻害プローブ
CA2360073C (en) 1999-01-28 2011-01-18 Gen-Probe Incorporated Probes and primers for detecting prostate specific antigen (psa) in a biological sample
US6846460B1 (en) 1999-01-29 2005-01-25 Illumina, Inc. Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses
AU779411B2 (en) 1999-02-12 2005-01-20 Serono Genetics Institute S.A. Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism
US6582906B1 (en) 1999-04-05 2003-06-24 Affymetrix, Inc. Proportional amplification of nucleic acids
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) * 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6132997A (en) * 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
JP4824236B2 (ja) * 1999-07-09 2011-11-30 ジェン−プローブ・インコーポレーテッド 核酸増幅によるｈｉｖ−１の検出
DK1238100T3 (da) 1999-07-23 2006-01-23 Gen Probe Inc Polynucleotid-amplifikationsfremgangsmåde
GB9917816D0 (en) * 1999-07-29 1999-09-29 Cytocell Ltd Chemically modified probes used to regulate nucleic acid amplification assays
US6864050B2 (en) 1999-07-30 2005-03-08 Affymetrix, Inc. Single-phase amplification of nucleic acids
US6232104B1 (en) 1999-08-17 2001-05-15 Dade Behring Inc. Detection of differences in nucleic acids by inhibition of spontaneous DNA branch migration
DK1431303T3 (en) 1999-09-13 2014-02-17 Nugen Technologies Inc A composition for isothermal linear amplification of polynucleotide sequences
US6692918B2 (en) * 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
JP2003510075A (ja) * 1999-09-29 2003-03-18 ディグノキュアー・インコーポレーテッド 良性および悪性の前立腺組織におけるｐｃａ３メッセンジャーｒｎａ種
US6747141B2 (en) 1999-12-15 2004-06-08 Gen-Probe Incorporated Methods and compositions for detection of mycobacterium avium complex species
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
DE69943134D1 (de) 1999-12-17 2011-02-24 Gen Probe Inc Nukleinsäureamplifizierung und detektion von mykobacterium-spezies
US6664081B2 (en) * 1999-12-17 2003-12-16 Gen-Probe Incorporated Nucleic acid amplification and detection of mycobacterium species
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
EP1259643B1 (en) * 2000-02-07 2008-10-15 Illumina, Inc. Nucleic acid detection methods using universal priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US6812005B2 (en) 2000-02-07 2004-11-02 The Regents Of The University Of California Nucleic acid detection methods using universal priming
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
ATE455186T1 (de) * 2000-06-26 2010-01-15 Nugen Technologies Inc Methoden und zusammensetzungen zur auf transkription basierenden vervielfältigung von nukleinsäuren
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
US6743592B1 (en) * 2000-07-25 2004-06-01 The Trustees Of The University Of Pennsylvania Methods, systems and kits for immuno-detection of epitopes expressed on molecules
US7524628B2 (en) * 2000-07-25 2009-04-28 The Trustees Of The University Of Pennsylvania Method for detecting molecules expressing a selected epitope via fluorescent dyes
US6582920B2 (en) * 2000-09-01 2003-06-24 Gen-Probe Incorporated Amplification of HIV-1 RT sequences for detection of sequences associated with drug-resistance mutations
ATE414794T1 (de) 2000-09-01 2008-12-15 Gen Probe Inc Amplifizierung von hiv-1 sequenzen zur detektion von sequenzen, die mit wirkstoff-resistenz mutationen einhergehen
AU2002213096B2 (en) 2000-10-06 2007-03-29 Nugen Technologies, Inc. Methods and probes for detection and/or quantification of nucleic acid sequences
DE60132924T2 (de) 2000-10-23 2009-03-05 Gen-Probe Inc., San Diego Zusammensetzungen und methoden zur detektion von humanem immundefizienz virus 2 (hiv-2)
US20040018491A1 (en) * 2000-10-26 2004-01-29 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
AU2002236524A1 (en) * 2000-11-28 2002-06-11 Rosetta Inpharmatics, Inc. In vitro transcription method for rna amplification
CA2430329A1 (en) 2000-12-13 2002-06-20 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
EP1390537B1 (en) 2001-03-09 2013-11-13 Nugen Technologies, Inc. Methods and compositions for amplification of rna sequences
JP4542312B2 (ja) 2001-03-09 2010-09-15 ニューゲン テクノロジーズ， インコーポレイテッド Ｒｎａ配列の増幅のための方法および組成物
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US7341831B2 (en) * 2001-07-18 2008-03-11 The Trustees Of The University Of Pennsylvania Method for immuno-detection of epitopes
US7285631B2 (en) 2001-08-10 2007-10-23 Serono Genetics Institute S.A. Human cDNAs and proteins and uses thereof
US7045319B2 (en) * 2001-10-30 2006-05-16 Ribomed Biotechnologies, Inc. Molecular detection systems utilizing reiterative oligonucleotide synthesis
US20040054162A1 (en) * 2001-10-30 2004-03-18 Hanna Michelle M. Molecular detection systems utilizing reiterative oligonucleotide synthesis
EP2163652B2 (en) 2002-01-28 2023-05-31 Life Technologies Corporation Preparing crude biological extracts using protease, suitable for preparing cDNA
ATE405676T1 (de) * 2002-03-11 2008-09-15 Nugen Technologies Inc Verfahren zur erzeugung doppelsträngiger dna mit einem 3'-einzelstranganteil und verwendungen dieser komplexe zur rekombination
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
AU2003220249A1 (en) * 2002-03-15 2003-09-29 Arcturus Bioscience, Inc. Improved nucleic acid amplification
DE10215238C1 (de) * 2002-04-06 2003-08-14 Cytonet Gmbh & Co Kg Nachweis von Mykobakterien in klinischem Material
US7405062B2 (en) * 2002-05-14 2008-07-29 San Diego Antibody Method for cloning variable domain sequences of immunological gene repertoire
BRPI0310060B8 (pt) 2002-05-17 2021-07-27 Becton Dickinson Co sistema automatizado para isolar, amplificar e detectar uma seqüência de ácido nucléico alvo ou uma proteína
JP4551216B2 (ja) * 2002-05-17 2010-09-22 ニューゲン テクノロジーズ， インコーポレイテッド 核酸の断片化、標識および固定化の方法
US20040029111A1 (en) 2002-06-14 2004-02-12 Linnen Jeffrey M. Compositions and methods for detecting hepatitis B virus
EP2366803B8 (en) 2002-10-16 2015-08-19 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
US7074561B2 (en) * 2002-10-22 2006-07-11 Biomerieux, Inc. Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA
US20040101844A1 (en) * 2002-11-21 2004-05-27 Amorese Douglas A. Methods and compositions for producing linearly amplified amounts of (+) strand RNA
US7887752B2 (en) 2003-01-21 2011-02-15 Illumina, Inc. Chemical reaction monitor
WO2004083806A2 (en) 2003-01-22 2004-09-30 University Of South Florida Autonomous genosensor apparatus and methods for use
WO2004070056A2 (en) 2003-02-07 2004-08-19 Diagnocure Inc. Method to detect prostate cancer in a sample
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
US8206913B1 (en) 2003-03-07 2012-06-26 Rubicon Genomics, Inc. Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process
EP2374900B1 (en) * 2003-03-07 2016-07-13 Rubicon Genomics, Inc. Polynucleotides for the amplification and analysis of whole genome and whole transcriptome libraries generated by a dna polymerization process
US7402386B2 (en) * 2003-04-14 2008-07-22 Nugen Technologies, Inc. Global amplification using random priming by a composite primer
EP1633893B1 (en) 2003-05-19 2012-01-25 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample
US20040248102A1 (en) 2003-06-03 2004-12-09 Diane Ilsley-Tyree Methods and compositions for performing template dependent nucleic acid primer extension reactions that produce a reduced complexity product
KR20070012779A (ko) * 2003-10-29 2007-01-29 리보메드 바이오테그놀로지스 인코포레이티드 반복적 올리고뉴클레오티드 합성을 위한 조성물, 방법 및검출 기법
US20050153333A1 (en) * 2003-12-02 2005-07-14 Sooknanan Roy R. Selective terminal tagging of nucleic acids
AU2004303886B2 (en) 2003-12-19 2009-09-03 Gen-Probe Incorporated Compositions, methods and kits for detecting the nucleic acids of HIV-1 and HIV-2
US20050147975A1 (en) * 2003-12-24 2005-07-07 Schembri Carol T. Methods and compositions for amplification of genomic DNA
WO2005065321A2 (en) 2003-12-29 2005-07-21 Nugen Technologies, Inc. Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
US7670771B2 (en) 2004-01-21 2010-03-02 University Of Utah Research Foundation Mutant sodium channel Nav1.7 nucleic acid methods
DE602005025424D1 (de) 2004-01-23 2011-01-27 Bio Merieux Inc Neuartiges Nukleotidgemisch für eine verbesserte Nukleinsäurenamplifikationsleistung
US20050277121A1 (en) * 2004-06-11 2005-12-15 Ambion, Inc. Crude biological derivatives competent for nucleic acid detection
AU2005262317B2 (en) 2004-07-13 2009-07-16 Gen-Probe Incorporated Compositions and methods for detection of hepatitis A virus nucleic acid
US7713697B2 (en) * 2004-08-27 2010-05-11 Gen-Probe Incorporated Methods and kits for amplifying DNA
EP2071031B1 (en) * 2004-08-27 2013-10-09 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
EP1794328B1 (en) 2004-09-30 2015-05-27 Gen-Probe Incorporated Assay for detecting and quantifying hiv-1
AU2005333163B2 (en) * 2004-11-09 2011-06-16 Gen-Probe Incorporated Compositions and methods for detecting Group A streptococci
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
CA2592179C (en) 2005-02-07 2012-04-03 Gen-Probe Incorporated Compositions and methods for detecting group b streptococci
DE602006019203D1 (de) 2005-02-18 2011-02-10 Gen Probe Inc Probenherstellungsverfahren mit einem alkali-stoss
AU2006244394B2 (en) 2005-05-06 2010-10-21 Gen-Probe Incorporated Methods of nucleic acid target capture
US8124335B2 (en) 2005-05-06 2012-02-28 Gen-Probe Incorporated Compositions and assays to detect influenza virus A and B nucleic acids
US7550264B2 (en) 2005-06-10 2009-06-23 Datascope Investment Corporation Methods and kits for sense RNA synthesis
US20070048741A1 (en) * 2005-08-24 2007-03-01 Getts Robert C Methods and kits for sense RNA synthesis
EP1929046B1 (en) 2005-09-07 2012-07-11 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
AU2006304721B2 (en) 2005-10-17 2012-01-19 Gen-Probe Incorporated Compositions and methods to detect Legionella pneumophila nucleic acid
EP1941058A4 (en) * 2005-10-27 2010-01-20 Rosetta Inpharmatics Llc AMPLIFICATION OF NUCLEIC ACIDS USING NON-RANDOM PRIMERS
US7831417B2 (en) 2005-11-14 2010-11-09 Gen-Probe Incorporated Parametric calibration method
ATE488587T1 (de) 2005-12-06 2010-12-15 Ambion Inc Rückübertragungs-primer und verfahren zu deren entwurf
AU2007282135C1 (en) 2006-01-18 2012-05-24 Coimmune, Inc. Systems and methods for processing samples in a closed container, and related devices
RU2394915C2 (ru) * 2006-03-24 2010-07-20 Александр Борисович Четверин Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления
CA2651946A1 (en) * 2006-05-12 2007-11-22 Gen-Probe Incorporated Compositions and methods to detect enterococci nucleic acid
EP2038429B1 (en) * 2006-06-30 2013-08-21 Nugen Technologies, Inc. Methods for fragmentation and labeling of nucleic acids
EP3159417B1 (en) 2006-08-01 2021-10-06 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
US20080261216A1 (en) * 2006-09-08 2008-10-23 The Regents Of The University Of Michigan HERV Group II Viruses In Lymphoma And Cancer
US7709203B2 (en) * 2006-10-20 2010-05-04 E.I. Du Pont De Nemours And Company Sequences diagnostic for shrimp pathogens
JP5340167B2 (ja) 2006-12-21 2013-11-13 ジェン−プロウブ インコーポレイテッド 核酸増幅のための方法および組成物
US8183359B2 (en) * 2007-03-01 2012-05-22 Gen-Probe Incorporated Kits for amplifying DNA
AU2007348215A1 (en) * 2007-03-01 2008-09-12 Gen-Probe Incorporated Methods and kits for amplifying DNA
US7964350B1 (en) 2007-05-18 2011-06-21 Applied Biosystems, Llc Sample preparation for in situ nucleic acid analysis
WO2009002931A2 (en) 2007-06-22 2008-12-31 Children's Medical Center Corporation Methods and uses thereof of prosaposin
CA2693973A1 (en) * 2007-07-18 2009-01-22 Gen-Probe Incorporated Compositions and methods to detect tmprss2/erg transcript variants in prostate cancer
US8716190B2 (en) 2007-09-14 2014-05-06 Affymetrix, Inc. Amplification and analysis of selected targets on solid supports
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
JP5498954B2 (ja) * 2007-12-21 2014-05-21 ジェン−プロウブ インコーポレイテッド 抗生剤耐性微生物の検出
AU2008343380B2 (en) * 2007-12-26 2012-07-12 Gen-Probe Incorporated Compositions and methods to detect Candida albicans nucleic acid
US8034568B2 (en) 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
GB2470672B (en) 2008-03-21 2012-09-12 Nugen Technologies Inc Methods of RNA amplification in the presence of DNA
EP3392351A1 (en) 2008-04-21 2018-10-24 Gen-Probe Incorporated Method for detecting chikungunya virus
JP5539325B2 (ja) 2008-04-30 2014-07-02 インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド 修飾されたｒｎａ単量体を用いるｒｎアーゼｈを基礎とするアッセイ
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
US8242243B2 (en) 2008-05-15 2012-08-14 Ribomed Biotechnologies, Inc. Methods and reagents for detecting CpG methylation with a methyl CpG binding protein (MBP)
US8211644B2 (en) * 2008-07-13 2012-07-03 Ribomed Biotechnologies, Inc. Molecular beacon-based methods for detection of targets using abscription
WO2010071833A1 (en) 2008-12-19 2010-06-24 Life Technologies Corporation Proteinase k inhibitors, methods and compositions therefor
AU2010217928B2 (en) 2009-02-26 2013-06-06 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
AU2010225937B2 (en) 2009-03-15 2014-09-18 Ribomed Biotechnologies, Inc. Abscription based molecular detection
EP3450573B1 (en) 2009-06-23 2022-01-26 Gen-Probe Incorporated Compositions and methods for detecting nucleic acid from mollicutes
US8512955B2 (en) 2009-07-01 2013-08-20 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
WO2011060014A1 (en) 2009-11-13 2011-05-19 Integrated Dna Technologies, Inc. Small rna detection assays
EP2905332B1 (en) 2009-11-19 2018-09-12 Solis BioDyne OÜ Compositions for increasing polypeptide stability and activity, and related methods
US9121054B2 (en) * 2009-12-08 2015-09-01 Biohelix Corporation Detection of nucleic acid amplification products in the presence of an internal control sequence on an immunochromatographic strip
AU2010339794B2 (en) 2009-12-17 2016-09-22 Children's Medical Center Corporation Saposin-A derived peptides and uses thereof
CA2896129C (en) 2010-01-22 2015-12-29 Gen-Probe Incorporated Probes for detecting the presence of trichomonas vaginalis in a sample
WO2011091393A1 (en) 2010-01-25 2011-07-28 Rd Biosciences, Inc. Self-folding amplification of target nucleic acid
EP2536849B1 (en) 2010-02-17 2016-05-11 Gen-Probe Incorporated Compositions and methods to detect atopobium vaginae nucleic acid
US9206484B2 (en) 2010-04-21 2015-12-08 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acids
WO2012009373A2 (en) 2010-07-12 2012-01-19 Gen-Probe Incorporated Compositions and assays to detect swine h1n1 influenza a virus, seasonal h1 influenza a virus and seasonal h3 influenza a virus nucleic acids
EP2752245A3 (en) 2010-07-23 2016-08-24 Beckman Coulter, Inc. System Or Method Of Including Analytical Units
WO2012030856A2 (en) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
CA2812194C (en) 2010-09-17 2022-12-13 President And Fellows Of Harvard College Functional genomics assay for characterizing pluripotent stem cell utility and safety
EP3438289A1 (en) 2010-10-04 2019-02-06 Gen-Probe Prodesse, Inc. Compositions, methods and kits to detect adenovirus nucleic acids
EP2683833B1 (en) 2011-03-10 2018-09-26 Gen-Probe Incorporated Methods for the selection and optimization of oligonucleotide tag sequences
WO2012135053A2 (en) 2011-03-25 2012-10-04 Integrated Dna Technologies, Inc. Rnase h-based assays utilizing modified rna monomers
AU2012249751B2 (en) 2011-04-25 2016-11-03 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
WO2013003112A1 (en) 2011-06-27 2013-01-03 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
CA3113828A1 (en) 2011-07-15 2013-01-24 Gen-Probe Incorporated Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis a virus nucleic acids in single-plex or multiplex assays
SG2014010276A (en) * 2011-08-18 2014-03-28 Nestec Sa Compositions and methods for detecting allelic variants
WO2013036928A1 (en) 2011-09-08 2013-03-14 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
US10378060B2 (en) 2011-10-14 2019-08-13 Dana-Farber Cancer Institute, Inc. ZNF365/ZFP365 biomarker predictive of anti-cancer response
EP2769007B1 (en) 2011-10-19 2016-12-07 Nugen Technologies, Inc. Compositions and methods for directional nucleic acid amplification and sequencing
JP6190380B2 (ja) 2011-11-07 2017-08-30 ベックマン コールター， インコーポレイテッド 等分機システムおよびワークフロー
WO2013070754A1 (en) 2011-11-07 2013-05-16 Beckman Coulter, Inc. Robotic arm
EP2776843B1 (en) 2011-11-07 2019-03-27 Beckman Coulter, Inc. Centrifuge system and workflow
BR112014010955A2 (pt) 2011-11-07 2017-06-06 Beckman Coulter Inc sistema e método para processar amostras
BR112014011044A2 (pt) 2011-11-07 2017-04-25 Beckman Coulter Inc amortecimento magnético para sistema de transporte de espécime
BR112014011043A2 (pt) 2011-11-07 2017-06-13 Beckman Coulter Inc detecção de recipiente de espécime
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
ES2867924T3 (es) 2011-12-09 2021-10-21 Adaptive Biotechnologies Corp Diagnóstico de tumores malignos linfoides y detección de enfermedad residual mínima
ES2645418T3 (es) * 2011-12-22 2017-12-05 Ibis Biosciences, Inc. Amplificación de una secuencia de un ácido ribonucleico
EP3560509B1 (en) 2011-12-22 2024-01-31 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
GB2533882B (en) 2012-01-26 2016-10-12 Nugen Tech Inc Method of enriching and sequencing nucleic acids of interest using massively parallel sequencing
EP2817416B1 (en) 2012-02-24 2018-10-31 Gen-Probe Prodesse Inc. Detection of shiga toxin genes in bacteria
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
RU2631797C2 (ru) 2012-05-08 2017-09-26 Эдэптив Байотекнолоджиз Корпорейшн Композиции и способы измерения и калибровки систематической ошибки амплификации в мультиплексных пцр-реакциях
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
CA2876209A1 (en) 2012-06-15 2013-12-19 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
WO2013191775A2 (en) 2012-06-18 2013-12-27 Nugen Technologies, Inc. Compositions and methods for negative selection of non-desired nucleic acid sequences
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
AU2013205087B2 (en) 2012-07-13 2016-03-03 Gen-Probe Incorporated Method for detecting a minority genotype
EP2877952B1 (en) 2012-07-27 2023-04-12 Gen-Probe Incorporated Dual reference calibration method and system for quantifying polynucleotides
AU2013202808B2 (en) 2012-07-31 2014-11-13 Gen-Probe Incorporated System and method for performing multiplex thermal melt analysis
AU2013308647B2 (en) 2012-08-30 2018-10-18 Gen-Probe Incorporated Multiphase nucleic acid amplification
EP3640343A1 (en) 2012-10-01 2020-04-22 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
WO2014055746A1 (en) 2012-10-04 2014-04-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and reagents for detection, quantitation, and serotyping of dengue viruses
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
CA2897474A1 (en) 2013-01-24 2014-07-31 California Institute Of Technology Chromophore-based characterization and detection methods
US10077475B2 (en) 2013-01-24 2018-09-18 California Institute Of Technology FRET-based analytes detection and related methods and systems
WO2014153260A1 (en) 2013-03-14 2014-09-25 Arnold Lyle J Methods for amplification of nucleic acids on solid support
US20140274738A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
SG11201506991VA (en) 2013-03-15 2015-10-29 Adaptive Biotechnologies Corp Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
JP6463332B2 (ja) 2013-03-15 2019-01-30 ジェン−プローブ・インコーポレーテッド 較正の方法、装置およびコンピュータプログラム製品
CN105392892A (zh) 2013-03-27 2016-03-09 六品科技公司 重组噬菌体和细菌检测方法
WO2014200905A2 (en) 2013-06-10 2014-12-18 President And Fellows Of Harvard College Early developmental genomic assay for characterizing pluripotent stem cell utility and safety
CA2915820A1 (en) 2013-06-19 2014-12-24 Michael Sandor Koeris Phage-based bacterial detection assay
EP3159695A3 (en) 2013-06-20 2017-07-05 The Trustees of The University of Pennsylvania Methods for diagnosing pancreatic cancer
US10047406B2 (en) 2013-08-14 2018-08-14 Gen-Probe Incorporated Compositions and methods for detecting HEV nucleic acid
EP3068883B1 (en) 2013-11-13 2020-04-29 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
US9243289B2 (en) * 2013-12-23 2016-01-26 Roche Molecular Systems, Inc. Method for screening reagents used in PCR assays
GB2528344B (en) 2014-02-28 2018-10-31 Gen Probe Inc Method of isolating nucleic acid from specimens in liquid-based cytology preservatives containing formaldehyde
JP6322292B2 (ja) 2014-02-28 2018-05-09 ジェン−プローブ・インコーポレーテッド ホルムアルデヒドを含有する液体系細胞診用保存剤中検体から核酸を単離する方法
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
CA2944903A1 (en) 2014-04-24 2015-10-29 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
US20170227541A1 (en) 2014-07-17 2017-08-10 The Trustees Of The University Of Pennsylvania Methods for using exosomes to monitor transplanted organ status
WO2016057367A1 (en) 2014-10-06 2016-04-14 Dana-Farber Cancer Institute, Inc. Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
CN113230384A (zh) 2014-10-09 2021-08-10 丹娜法伯癌症研究院 用于治疗免疫失调的多次-可变il-2剂量方案
GB2536745B (en) 2014-10-20 2019-06-26 Gen Probe Inc Red Blood cell lysis solution
AU2016205179B2 (en) 2015-01-09 2021-06-17 Gen-Probe Incorporated Methods and compositions for diagnosing bacterial vaginosis
US10948492B2 (en) 2015-03-06 2021-03-16 Dana-Farber Cancer Institute, Inc. PD-L2 biomarkers predictive of PD-1 pathway inhibitor responses in esophagogastric cancers
CN107429297A (zh) 2015-03-16 2017-12-01 简·探针公司 用于检测细菌核酸和诊断细菌性***病的方法和组合物
WO2017120216A2 (en) 2016-01-04 2017-07-13 Gen-Probe Incorporated Methods and compositions for detecting candida species
DE202017007130U1 (de) 2016-04-27 2019-08-29 Gen-Probe Inc. Lysereagenz für Blutzellen
US10508312B2 (en) 2016-06-10 2019-12-17 Gen-Probe Incorporated Compositions and methods for detecting Zika virus nucleic acid
US11136409B2 (en) 2016-09-20 2021-10-05 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators
AU2017346854B2 (en) 2016-10-19 2024-05-23 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis C virus
WO2018094171A1 (en) 2016-11-21 2018-05-24 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis b virus
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
GB201703383D0 (en) 2017-03-02 2017-04-19 Gargle Tech Ltd Testing for particulates
CA3176536C (en) 2017-03-24 2024-03-05 Gen-Probe Incorporated Compositions and methods for detection of viral pathogens in samples
WO2018175883A1 (en) 2017-03-24 2018-09-27 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
EP3634496A4 (en) 2017-06-06 2021-09-08 Dana-Farber Cancer Institute, Inc. METHOD FOR RISING AWARENESS IN CANCER CELLS AGAINST T-CELL-MEDIATED KILLING BY MODULATING MOLECULAR SIGNAL PATHS
CA3064603A1 (en) 2017-06-07 2018-12-13 Gen-Probe Incorporated Detecting babesia species nucleic acid in a sample
EP4286055A3 (en) 2017-07-10 2024-02-28 Gen-Probe Incorporated Analytical systems and methods for nucleic acid amplification using sample assigning parameters
WO2019032809A1 (en) 2017-08-11 2019-02-14 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCUS AUREUS
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
EP3710595A1 (en) 2017-11-17 2020-09-23 Gen-Probe Incorporated Compositions and methods for detecting c1orf43 nucleic acid
JP2021506274A (ja) 2017-12-15 2021-02-22 ジェン−プローブ・インコーポレーテッド 毒素産生Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅを検出するための組成物および方法
US20210071242A1 (en) 2018-01-29 2021-03-11 Gen-Probe Incorporated Analytical systems and methods
GB2597566B (en) 2018-06-13 2023-02-01 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
WO2020014400A1 (en) 2018-07-10 2020-01-16 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
CA3106975A1 (en) 2018-08-01 2020-02-06 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
CA3108105A1 (en) 2018-08-08 2020-02-13 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
EP3841224A1 (en) 2018-08-21 2021-06-30 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
KR20210063347A (ko) 2018-08-24 2021-06-01 젠-프로브 인코포레이티드 세균성 핵산을 검출하고 세균성 질염을 진단하기 위한 조성물 및 방법
EP3846939B1 (en) 2018-09-05 2023-05-03 Hero Scientific Ltd Testing for particulates
AU2019350777A1 (en) 2018-09-27 2021-05-20 Gen-Probe Incorporated Compositions and methods for detecting Bordetella pertussis and Bordetellaparapertussis nucleic acid
JP2022508954A (ja) 2018-10-22 2022-01-19 ジェン－プローブ・インコーポレーテッド ヒトポリオーマウイルスｂｋウイルスを増幅、検出または定量化するための組成物および方法
CA3120713A1 (en) * 2018-11-21 2020-05-28 Avida Biomed, Inc. Methods for targeted nucleic acid library formation
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
US20220080425A1 (en) 2018-12-31 2022-03-17 Gen-Probe Incorporated Tray for transfering solid reagents to a multi-well cartridge
EP4389916A2 (en) 2019-03-22 2024-06-26 Gen-Probe Incorporated Compositions and methods for detecting group a streptococcus
WO2020223121A1 (en) 2019-04-30 2020-11-05 Dana-Farber Cancer Institute, Inc. Methods for treating cancer using combinations of anti-cx3cr1 and immune checkpoint blockade agents
CA3176696C (en) 2019-05-03 2024-06-11 Gen-Probe Incorporated Receptacle transport system for an analytical system
AU2020299621A1 (en) 2019-07-03 2022-02-24 Gen-Probe Incorporated Oligonucleotides for use in determining the presence of Trichomonas vaginalis in a sample.
AU2020335996A1 (en) 2019-08-23 2022-03-31 Gen-Probe Incorporated Compositions, methods and kits for detecting Treponema pallidum
AU2020343334A1 (en) 2019-09-05 2022-04-07 Gen-Probe Incorporated Detection of Chlamydia trachomatis nucleic acid variants
JP2023503946A (ja) 2019-12-09 2023-02-01 ジェン－プローブ・インコーポレーテッド 乾燥試料からのポリヌクレオチド分析物の定量化
JP2023510395A (ja) 2020-01-16 2023-03-13 ディーエヌエイイー ダイアグノスティックス リミテッド 標的ポリヌクレオチドを単離するための組成物、キットおよび方法
AU2021230341A1 (en) 2020-03-04 2022-10-27 Gen-Probe Incorporated Compositions and methods for detecting SARS-CoV-2 nucleic acid
EP4146821A1 (en) 2020-05-07 2023-03-15 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
CA3188657A1 (en) 2020-07-17 2022-01-20 Gen-Probe Incorporated Detection of macrolide-resistant mycoplasma genitalium
JP2023545400A (ja) 2020-10-02 2023-10-30 レクソジェン・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 転写核酸の生成方法及び手段
EP3978626A1 (en) * 2020-10-02 2022-04-06 Lexogen GmbH Method and means for generating transcribed nucleic acids
WO2022087257A2 (en) 2020-10-21 2022-04-28 Gen-Probe Incorporated Fluid container management system
CN116648253A (zh) 2020-10-29 2023-08-25 伊夫罗生物科学公司 包含螺旋藻组分的组合物
EP4165385B1 (en) 2021-01-06 2024-04-17 Hero Scientific Ltd Filtration sampling devices
US20240083995A1 (en) 2021-03-02 2024-03-14 Laurie H. Glimcher Methods of treating red blood cell disorders
CA3218222A1 (en) 2021-05-14 2022-11-17 Gen-Probe Incorporated Compositions and methods for detecting human adenovirus nucleic acid
WO2022251166A2 (en) 2021-05-25 2022-12-01 Evelo Biosciences, Inc. Bacterial compositions comprising soy hemoglobin
WO2022261183A2 (en) 2021-06-08 2022-12-15 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating and/or identifying an agent for treating intestinal cancers
AU2022304654A1 (en) 2021-07-01 2023-12-14 Gen-Probe Incorporated Enzyme formulations and reaction mixtures for nucleic acid amplification
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
EP4373965A1 (en) 2021-07-21 2024-05-29 DNAe Diagnostics Limited Method and system comprising a cartridge for sequencing target polynucleotides
CA3226812A1 (en) 2021-07-27 2023-02-02 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2023097119A2 (en) 2021-11-29 2023-06-01 Dana-Farber Cancer Institute, Inc. Methods and compositions to modulate riok2
EP4282980A1 (en) 2022-05-23 2023-11-29 Mobidiag Oy Methods for amplifying a nucleic acid
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
WO2024081776A1 (en) 2022-10-13 2024-04-18 Gen-Probe Incorporated Cellularity control for nucleic acid assays
EP4389911A1 (en) 2022-12-21 2024-06-26 Mobidiag Oy Methods and systems for isolating an analyte
EP4389887A1 (en) 2022-12-21 2024-06-26 Mobidiag Oy Isolating and lysing cells

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA559709A (en) * 1958-07-01 International Standard Electric Corporation Travelling wave tubes
US4876197A (en) * 1983-02-22 1989-10-24 Chiron Corporation Eukaryotic regulatable transcription
US4786600A (en) * 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DK171161B1 (da) * 1985-03-28 1996-07-08 Hoffmann La Roche Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
AU606043B2 (en) * 1985-03-28 1991-01-31 F. Hoffmann-La Roche Ag Detection of viruses by amplification and hybridization
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4876187A (en) * 1985-12-05 1989-10-24 Meiogenics, Inc. Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences
US4800159A (en) * 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
AU616646B2 (en) * 1986-11-24 1991-11-07 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
IE72468B1 (en) * 1987-07-31 1997-04-09 Univ Leland Stanford Junior Selective amplification of target polynucleotide sequences
EP0638807B1 (en) * 1987-09-21 2002-07-17 Gen-Probe Incorporated Protection assay
PT88550A (pt) * 1987-09-21 1989-07-31 Ml Tecnology Ventures Lp Processo para a preparacao de reagentes de ligacao nao nucleotidicos para sondas nucleotidicas
US5030557A (en) * 1987-11-24 1991-07-09 Ml Technology Venture Means and method for enhancing nucleic acid hybridization
AU622426B2 (en) * 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
EP0359789B1 (en) * 1988-01-21 1993-08-04 Genentech, Inc. Amplification and detection of nucleic acid sequences
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5130238A (en) * 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
HU216105B (hu) * 1988-12-16 1999-04-28 Akzo Nobel N.V. Amplifikációs eljárás önfenntartó szekvenciareplikációs rendszerrel
IE66597B1 (en) * 1989-05-10 1996-01-24 Akzo Nv Method for the synthesis of ribonucleic acid (RNA)
CA2016553A1 (en) * 1989-05-16 1990-11-16 Dyann F. Wirth Dna hybridization probes for identification of mycobacteria
US5112734A (en) * 1989-05-26 1992-05-12 Gene-Trak Systems Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
EP0731175A3 (en) * 1989-07-11 2004-05-26 Gen-Probe Incorporated Oligonucleotide probes for HIV nucleic acid
FR2659086B1 (fr) * 1990-03-02 1992-06-12 Pasteur Institut Fragments nucleotidiques caracteristiques de fragments d'adn de mycobacteries. leur utilisation comme amorce pour la detection d'une infection due a des mycobacteries.
FR2651505B1 (fr) * 1989-09-06 1994-07-22 Pasteur Institut Fragments d'acides nucleiques derives d'un genome de mycobacterie appropriee, leurs applications dans le diagnostic des infections a mycobacteries et plasmides contenant lesdits fragments.
WO1991004340A1 (en) * 1989-09-20 1991-04-04 Cambridge Biotech Corporation In vitro, isothermal nucleic acid amplification
US5215899A (en) * 1989-11-09 1993-06-01 Miles Inc. Nucleic acid amplification employing ligatable hairpin probe and transcription
IE910081A1 (en) * 1990-01-10 1991-07-17 Chiron Corp The use of DNA-dependent RNA polymerase transcripts as¹reporter molecules for signal amplification in nucleic acid¹hybridization assays
CA2033718A1 (en) * 1990-01-19 1991-07-20 Ronald M. Atlas Process for detection of water-borne microbial pathogens and indicators of human fecal contamination in water samples and kits therefor
WO1991015601A1 (en) * 1990-04-05 1991-10-17 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Modified rna template-specific polymerase chain reaction
FR2663033B1 (fr) * 1990-06-08 1992-09-04 Pasteur Institut Detection specifique du mycobacterium tuberculosis.
CH681075A5 (zh) * 1990-06-08 1993-01-15 Sigg Aluminium & Metallwaren

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CA2135073C (en) 2002-11-19
ATE307898T1 (de) 2005-11-15
KR950701393A (ko) 1995-03-23
AU681082B2 (en) 1997-08-21
WO1993022461A1 (en) 1993-11-11
JPH07506255A (ja) 1995-07-13
AU4222493A (en) 1993-11-29
US5888729A (en) 1999-03-30
EP0587266A1 (en) 1994-03-16
DE69333891D1 (de) 2005-12-01
CA2135073A1 (en) 1993-11-11
JP4137996B2 (ja) 2008-08-20
KR100249110B1 (ko) 2000-04-01
ES2250960T3 (es) 2006-04-16
US5554516A (en) 1996-09-10
DE69333891T2 (de) 2006-07-27
EP0587266B1 (en) 2005-10-26
DK0587266T3 (da) 2005-12-05

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