SK283693B6 - Spôsob prípravy kamptotecínu alebo jeho farmaceuticky prijateľnej soli - Google Patents

Spôsob prípravy kamptotecínu alebo jeho farmaceuticky prijateľnej soli Download PDF

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Publication number
SK283693B6
SK283693B6 SK259-93A SK25993A SK283693B6 SK 283693 B6 SK283693 B6 SK 283693B6 SK 25993 A SK25993 A SK 25993A SK 283693 B6 SK283693 B6 SK 283693B6
Authority
SK
Slovakia
Prior art keywords
camptothecin
formula
compound
alkoxy
hydrogen
Prior art date
Application number
SK259-93A
Other languages
English (en)
Slovak (sk)
Other versions
SK25993A3 (en
Inventor
Joseph Marian Fortunak
Antonietta Rose Mastrocola
Mark Mellinger
Jeffery Lee Wood
Patrick Lee Burk
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of SK25993A3 publication Critical patent/SK25993A3/sk
Publication of SK283693B6 publication Critical patent/SK283693B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
SK259-93A 1990-09-28 1991-09-23 Spôsob prípravy kamptotecínu alebo jeho farmaceuticky prijateľnej soli SK283693B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58964390A 1990-09-28 1990-09-28
PCT/US1991/006888 WO1992005785A1 (en) 1990-09-28 1991-09-23 Water soluble camptothecin analogues, processes and methods

Publications (2)

Publication Number Publication Date
SK25993A3 SK25993A3 (en) 1993-07-07
SK283693B6 true SK283693B6 (sk) 2003-12-02

Family

ID=24358879

Family Applications (1)

Application Number Title Priority Date Filing Date
SK259-93A SK283693B6 (sk) 1990-09-28 1991-09-23 Spôsob prípravy kamptotecínu alebo jeho farmaceuticky prijateľnej soli

Country Status (25)

Country Link
US (1) US5734056A (de)
EP (1) EP0547165B1 (de)
JP (1) JP2848958B2 (de)
CN (1) CN1033509C (de)
AT (1) ATE186461T1 (de)
AU (1) AU664830B2 (de)
CA (1) CA2090967C (de)
CZ (1) CZ51593A3 (de)
DE (1) DE69131775T2 (de)
DK (1) DK0547165T3 (de)
ES (1) ES2137932T3 (de)
FI (1) FI931384A (de)
GR (1) GR3031823T3 (de)
HK (1) HK1012283A1 (de)
HU (1) HUT70024A (de)
IE (1) IE913402A1 (de)
IL (1) IL99571A (de)
NO (1) NO931153D0 (de)
NZ (1) NZ239947A (de)
PT (1) PT99109B (de)
SI (1) SI9111599A (de)
SK (1) SK283693B6 (de)
WO (1) WO1992005785A1 (de)
YU (1) YU159991A (de)
ZA (1) ZA917748B (de)

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US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
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US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
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US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
WO2004055020A1 (en) * 2002-12-16 2004-07-01 Council Of Scientific And Industrial Research Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of campthothecins or mappicene ketones
AU2003223109A1 (en) * 2003-03-31 2004-10-25 Council Of Scientific And Industrial Research Process for preparing topotecan from 10-hydroxy-4-(s) camptothecin
CN100344633C (zh) * 2003-05-12 2007-10-24 台湾神隆股份有限公司 用于制备7－烷基－10－羟基－20(s)－喜树碱的方法
CZ298934B6 (cs) * 2003-08-26 2008-03-12 Pliva- Lachema A.S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
TWI333492B (en) * 2003-11-12 2010-11-21 Smithkline Beecham Cork Ltd Crystalline topotecan hydrochloride product and preparation thereof
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
US20080182990A1 (en) * 2004-08-09 2008-07-31 Shilpa Medicare Limited Process for the Preparation of Irinotecan Hydrochloride Trihydrate
NZ554677A (en) * 2004-11-05 2010-08-27 Samyang Corp Pharmaceutical formulation for increasing solubility of 10-hydroxycamptothecin compounds in non-aqueous polar solvents
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
JP5177429B2 (ja) * 2005-07-18 2013-04-03 バイパー サイエンシズ，インコーポレイティド 癌の治療
EP1943253A1 (de) * 2005-10-10 2008-07-16 Cipla Limited Neue kristalline formen
US7547785B2 (en) 2005-12-26 2009-06-16 Dr. Reddy's Laboratories Limited Process for preparing topotecan
WO2007127839A2 (en) * 2006-04-26 2007-11-08 The Regents Of The University Of California Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics
PE20080695A1 (es) 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
JP2010504079A (ja) * 2006-06-12 2010-02-12 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤を用いる疾病の治療方法
US20080039485A1 (en) * 2006-08-08 2008-02-14 Targetgen Biotechnology Co., Ltd. Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
US7994222B2 (en) * 2006-09-05 2011-08-09 Bipar Sciences, Inc. Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds
CN101522609A (zh) * 2006-09-05 2009-09-02 彼帕科学公司 癌症的治疗
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US7977483B2 (en) 2007-04-11 2011-07-12 Scinopharm Taiwan, Ltd. Process for making topotecan
EP2211854A4 (de) * 2007-10-19 2011-01-12 Bipar Sciences Inc Verfahren und zusammensetzungen zur behandlung von krebs mit parp-inhibitoren vom benzopyrontyp
JPWO2009054332A1 (ja) 2007-10-23 2011-03-03 萬有製薬株式会社 ピリドン置換ジヒドロピラゾロピリミジノン誘導体
US7732491B2 (en) * 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
CA2705417A1 (en) * 2007-11-12 2009-05-22 Bipar Sciences, Inc. Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents
ITMI20072268A1 (it) 2007-12-04 2009-06-05 Antibioticos Spa Polimorfi cristallini di topotecan cloridrato con elevato grado di purezza e metodi per la loro preparazione
CN101450949B (zh) * 2007-12-07 2011-10-05 上海龙翔生物医药开发有限公司 一种10-羟基喜树碱的化学半合成工艺
CN101888777A (zh) * 2007-12-07 2010-11-17 彼帕科学公司 用拓扑异构酶抑制剂和parp抑制剂的组合治疗癌症
AU2009252303B2 (en) 2008-05-29 2013-04-04 Microbiopharm Japan Co., Ltd. Production method for camptothecin derivative
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US8481503B2 (en) 2009-03-06 2013-07-09 Merck Sharp & Dohme Corp. Combination cancer therapy with an AKT inhibitor and other anticancer agents
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CN103145720B (zh) * 2013-02-20 2015-09-30 上海北卡医药技术有限公司 一种10-羟基喜树碱的一水合物的制备方法
EP2881396A1 (de) * 2013-12-03 2015-06-10 Synbias Pharma AG Verfahren zur Synthese von Irinotecan
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JPS595188A (ja) * 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
JPS5946284A (ja) * 1982-09-10 1984-03-15 Yakult Honsha Co Ltd １１−ニトロカンプトテシン誘導体およびその製造法
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
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Also Published As

Publication number Publication date
PT99109A (pt) 1992-08-31
DE69131775T2 (de) 2000-04-20
ATE186461T1 (de) 1999-11-15
ZA917748B (en) 1992-09-30
HK1012283A1 (en) 1999-07-30
AU8739991A (en) 1992-04-28
DE69131775D1 (de) 1999-12-16
JP2848958B2 (ja) 1999-01-20
NO931153L (no) 1993-03-26
FI931384A0 (fi) 1993-03-26
CA2090967A1 (en) 1992-03-29
IL99571A0 (en) 1992-08-18
US5734056A (en) 1998-03-31
HUT70024A (en) 1995-09-28
DK0547165T3 (da) 2000-03-27
EP0547165B1 (de) 1999-11-10
WO1992005785A1 (en) 1992-04-16
AU664830B2 (en) 1995-12-07
SK25993A3 (en) 1993-07-07
ES2137932T3 (es) 2000-01-01
EP0547165A1 (de) 1993-06-23
GR3031823T3 (en) 2000-02-29
PT99109B (pt) 1999-02-26
IE913402A1 (en) 1992-04-08
IL99571A (en) 2000-08-31
JPH06501476A (ja) 1994-02-17
CZ51593A3 (en) 1994-01-19
HU9300878D0 (en) 1993-06-28
YU159991A (sh) 1994-06-10
NZ239947A (en) 1994-07-26
CN1033509C (zh) 1996-12-11
CA2090967C (en) 2007-02-06
EP0547165A4 (de) 1994-03-30
NO931153D0 (no) 1993-03-26
FI931384A (fi) 1993-03-26
SI9111599A (sl) 1998-02-28
CN1062731A (zh) 1992-07-15

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MK4A Patent expired

Expiry date: 20110923