DK0547165T3 - Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc - Google Patents

Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc

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Publication number
DK0547165T3
DK0547165T3 DK91918278T DK91918278T DK0547165T3 DK 0547165 T3 DK0547165 T3 DK 0547165T3 DK 91918278 T DK91918278 T DK 91918278T DK 91918278 T DK91918278 T DK 91918278T DK 0547165 T3 DK0547165 T3 DK 0547165T3
Authority
DK
Denmark
Prior art keywords
preparation
compounds
alkoxyc
hydroxy
water
Prior art date
Application number
DK91918278T
Other languages
Danish (da)
English (en)
Inventor
Joseph Marian Fortunak
Jeffery Lee Wood
Antonietta Rose Mastrocola
Mark Mellinger
Patrick Lee Burk
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of DK0547165T3 publication Critical patent/DK0547165T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Steroid Compounds (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK91918278T 1990-09-28 1991-09-23 Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc DK0547165T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58964390A 1990-09-28 1990-09-28
PCT/US1991/006888 WO1992005785A1 (en) 1990-09-28 1991-09-23 Water soluble camptothecin analogues, processes and methods

Publications (1)

Publication Number Publication Date
DK0547165T3 true DK0547165T3 (da) 2000-03-27

Family

ID=24358879

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91918278T DK0547165T3 (da) 1990-09-28 1991-09-23 Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc

Country Status (25)

Country Link
US (1) US5734056A (de)
EP (1) EP0547165B1 (de)
JP (1) JP2848958B2 (de)
CN (1) CN1033509C (de)
AT (1) ATE186461T1 (de)
AU (1) AU664830B2 (de)
CA (1) CA2090967C (de)
CZ (1) CZ51593A3 (de)
DE (1) DE69131775T2 (de)
DK (1) DK0547165T3 (de)
ES (1) ES2137932T3 (de)
FI (1) FI931384A (de)
GR (1) GR3031823T3 (de)
HK (1) HK1012283A1 (de)
HU (1) HUT70024A (de)
IE (1) IE913402A1 (de)
IL (1) IL99571A (de)
NO (1) NO931153L (de)
NZ (1) NZ239947A (de)
PT (1) PT99109B (de)
SI (1) SI9111599A (de)
SK (1) SK283693B6 (de)
WO (1) WO1992005785A1 (de)
YU (1) YU159991A (de)
ZA (1) ZA917748B (de)

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US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
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KR100848919B1 (ko) * 2004-11-05 2008-07-29 주식회사 삼양사 10-히드록시캄토테신 화합물의 극성 비수성 용매에 대한용해도를 증가시키기 위한 약제학적 제형
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
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US7547785B2 (en) 2005-12-26 2009-06-16 Dr. Reddy's Laboratories Limited Process for preparing topotecan
US20070259031A1 (en) * 2006-04-26 2007-11-08 The Regents Of The University Of California Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics
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US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20080039485A1 (en) * 2006-08-08 2008-02-14 Targetgen Biotechnology Co., Ltd. Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
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JP2014504638A (ja) 2011-02-01 2014-02-24 グラクソスミスクライン インテレクチュアル プロパティ リミテッド 組合せ
CN103145720B (zh) * 2013-02-20 2015-09-30 上海北卡医药技术有限公司 一种10-羟基喜树碱的一水合物的制备方法
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JPS595188A (ja) * 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
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Also Published As

Publication number Publication date
IE913402A1 (en) 1992-04-08
NO931153D0 (no) 1993-03-26
FI931384A0 (fi) 1993-03-26
EP0547165A4 (de) 1994-03-30
CN1033509C (zh) 1996-12-11
DE69131775D1 (de) 1999-12-16
NO931153L (no) 1993-03-26
IL99571A0 (en) 1992-08-18
WO1992005785A1 (en) 1992-04-16
NZ239947A (en) 1994-07-26
CA2090967C (en) 2007-02-06
SK283693B6 (sk) 2003-12-02
ZA917748B (en) 1992-09-30
EP0547165B1 (de) 1999-11-10
AU8739991A (en) 1992-04-28
US5734056A (en) 1998-03-31
IL99571A (en) 2000-08-31
CA2090967A1 (en) 1992-03-29
PT99109A (pt) 1992-08-31
ES2137932T3 (es) 2000-01-01
AU664830B2 (en) 1995-12-07
PT99109B (pt) 1999-02-26
SK25993A3 (en) 1993-07-07
CN1062731A (zh) 1992-07-15
ATE186461T1 (de) 1999-11-15
FI931384A (fi) 1993-03-26
JPH06501476A (ja) 1994-02-17
CZ51593A3 (en) 1994-01-19
GR3031823T3 (en) 2000-02-29
JP2848958B2 (ja) 1999-01-20
DE69131775T2 (de) 2000-04-20
YU159991A (sh) 1994-06-10
EP0547165A1 (de) 1993-06-23
SI9111599A (sl) 1998-02-28
HU9300878D0 (en) 1993-06-28
HK1012283A1 (en) 1999-07-30
HUT70024A (en) 1995-09-28

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