DE69131775T2 - Verfahren zur Herstellung wasserlöslicher Camptothecinanaloge, sowie die Verbindungen 10-Hydroxy-11-C(1-6)-alkoxycamptothecin - Google Patents

Verfahren zur Herstellung wasserlöslicher Camptothecinanaloge, sowie die Verbindungen 10-Hydroxy-11-C(1-6)-alkoxycamptothecin

Info

Publication number
DE69131775T2
DE69131775T2 DE69131775T DE69131775T DE69131775T2 DE 69131775 T2 DE69131775 T2 DE 69131775T2 DE 69131775 T DE69131775 T DE 69131775T DE 69131775 T DE69131775 T DE 69131775T DE 69131775 T2 DE69131775 T2 DE 69131775T2
Authority
DE
Germany
Prior art keywords
preparation
compounds
alkoxycamptothecin
hydroxy
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69131775T
Other languages
English (en)
Other versions
DE69131775D1 (de
Inventor
Joseph Marian Fortunak
Jeffery Lee Smithkline Be Wood
Antonietta Rose Smi Mastrocola
Mark Mellinger
Patrick Lee Smithkline Be Burk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of DE69131775D1 publication Critical patent/DE69131775D1/de
Application granted granted Critical
Publication of DE69131775T2 publication Critical patent/DE69131775T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DE69131775T 1990-09-28 1991-09-23 Verfahren zur Herstellung wasserlöslicher Camptothecinanaloge, sowie die Verbindungen 10-Hydroxy-11-C(1-6)-alkoxycamptothecin Expired - Lifetime DE69131775T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58964390A 1990-09-28 1990-09-28
PCT/US1991/006888 WO1992005785A1 (en) 1990-09-28 1991-09-23 Water soluble camptothecin analogues, processes and methods

Publications (2)

Publication Number Publication Date
DE69131775D1 DE69131775D1 (de) 1999-12-16
DE69131775T2 true DE69131775T2 (de) 2000-04-20

Family

ID=24358879

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131775T Expired - Lifetime DE69131775T2 (de) 1990-09-28 1991-09-23 Verfahren zur Herstellung wasserlöslicher Camptothecinanaloge, sowie die Verbindungen 10-Hydroxy-11-C(1-6)-alkoxycamptothecin

Country Status (25)

Country Link
US (1) US5734056A (de)
EP (1) EP0547165B1 (de)
JP (1) JP2848958B2 (de)
CN (1) CN1033509C (de)
AT (1) ATE186461T1 (de)
AU (1) AU664830B2 (de)
CA (1) CA2090967C (de)
CZ (1) CZ51593A3 (de)
DE (1) DE69131775T2 (de)
DK (1) DK0547165T3 (de)
ES (1) ES2137932T3 (de)
FI (1) FI931384A0 (de)
GR (1) GR3031823T3 (de)
HK (1) HK1012283A1 (de)
HU (1) HUT70024A (de)
IE (1) IE913402A1 (de)
IL (1) IL99571A (de)
NO (1) NO931153D0 (de)
NZ (1) NZ239947A (de)
PT (1) PT99109B (de)
SI (1) SI9111599A (de)
SK (1) SK283693B6 (de)
WO (1) WO1992005785A1 (de)
YU (1) YU159991A (de)
ZA (1) ZA917748B (de)

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KR960029336A (ko) 1995-01-09 1996-08-17 김충환 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
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AU7732996A (en) * 1995-11-22 1997-06-11 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
GB9601779D0 (en) * 1996-01-30 1996-04-03 Pharmacia Spa 9, 10 Disubstituted camptothecin derivatives
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2004055020A1 (en) * 2002-12-16 2004-07-01 Council Of Scientific And Industrial Research Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of campthothecins or mappicene ketones
AU2003223109A1 (en) * 2003-03-31 2004-10-25 Council Of Scientific And Industrial Research Process for preparing topotecan from 10-hydroxy-4-(s) camptothecin
AU2004238358B2 (en) 2003-05-12 2010-05-13 Scinopharm Taiwan, Ltd. Process for the preparation of 7-alkyl-10-hydroxy-20(S)-camptothecin
CZ298934B6 (cs) * 2003-08-26 2008-03-12 Pliva- Lachema A.S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
AR046579A1 (es) * 2003-11-12 2005-12-14 Smithkline Beecham Corp Compuesto cristalino de topotecan, composicion farmaceutica que lo comprende, procedimiento para prepararlo y su uso para preparar dicha composicion farmaceutica
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
US20080182990A1 (en) * 2004-08-09 2008-07-31 Shilpa Medicare Limited Process for the Preparation of Irinotecan Hydrochloride Trihydrate
US20070254905A1 (en) * 2004-11-05 2007-11-01 Samyang Corporation Pharmaceutical Formulation for Increasing Solubility of 10-Hydroxycamptothecin Compounds in Non-Aqueous Polar Solvents
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
EP1906948A4 (de) * 2005-07-18 2010-03-17 Bipar Sciences Inc Krebsbehandlung
EP1943253A1 (de) * 2005-10-10 2008-07-16 Cipla Limited Neue kristalline formen
US7547785B2 (en) 2005-12-26 2009-06-16 Dr. Reddy's Laboratories Limited Process for preparing topotecan
US20070259031A1 (en) * 2006-04-26 2007-11-08 The Regents Of The University Of California Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics
AR060635A1 (es) 2006-04-27 2008-07-02 Banyu Pharma Co Ltd Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
EP2038654A4 (de) * 2006-06-12 2010-08-11 Bipar Sciences Inc Verfahren zur behandlung von krankheiten mit parp-hemmern
US20080039485A1 (en) * 2006-08-08 2008-02-14 Targetgen Biotechnology Co., Ltd. Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
US8143447B2 (en) * 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
JP2010502731A (ja) * 2006-09-05 2010-01-28 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤による脂肪酸合成の阻害、及びその治療方法
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US7977483B2 (en) 2007-04-11 2011-07-12 Scinopharm Taiwan, Ltd. Process for making topotecan
US20090149417A1 (en) * 2007-10-19 2009-06-11 Valeria Ossovskaya Methods and compositions for the treatment of cancer using benzopyrone-type PARP inhibitors
AU2008315048A1 (en) 2007-10-23 2009-04-30 Msd K.K. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
MX2010005222A (es) * 2007-11-12 2010-09-28 Bipar Sciences Inc Tratamiento de cancer de mama con un inhibidor de parp solo o en combinacion con agentes anti-tumorales.
EP2217244A4 (de) * 2007-11-12 2011-08-31 Bipar Sciences Inc Behandlung von gebärmutterkrebs und eierstockkrebs mit einem parp-inhibitor allein oder in kombination mit antitumoralen mitteln
ITMI20072268A1 (it) 2007-12-04 2009-06-05 Antibioticos Spa Polimorfi cristallini di topotecan cloridrato con elevato grado di purezza e metodi per la loro preparazione
KR20100102637A (ko) * 2007-12-07 2010-09-24 바이파 사이언스 인코포레이티드 토포이소머라제 억제제 및 ｐａｒｐ 억제제의 병용물에 의한 암의 치료
CN101450949B (zh) * 2007-12-07 2011-10-05 上海龙翔生物医药开发有限公司 一种10-羟基喜树碱的化学半合成工艺
AU2009252303B2 (en) 2008-05-29 2013-04-04 Microbiopharm Japan Co., Ltd. Production method for camptothecin derivative
US8288396B2 (en) 2009-02-25 2012-10-16 Msdkk Pyrimidopyrimidoindazole derivative
EP2403339B1 (de) 2009-03-06 2017-01-18 Merck Sharp & Dohme Corp. Tumorkombinationstherapie mit einem akt-hemmer und anderen antumormitteln
WO2012082337A2 (en) 2010-12-17 2012-06-21 Glaxo Wellcome Manufacturing Pte Ltd Combination
EP2672969A4 (de) 2011-02-01 2014-07-16 Glaxosmithkline Intellectual Property Ltd Kombination
CN103145720B (zh) * 2013-02-20 2015-09-30 上海北卡医药技术有限公司 一种10-羟基喜树碱的一水合物的制备方法
EP2881396A1 (de) * 2013-12-03 2015-06-10 Synbias Pharma AG Verfahren zur Synthese von Irinotecan
WO2023220641A2 (en) 2022-05-11 2023-11-16 Juno Therapeutics, Inc. Methods and uses related to t cell therapy and production of same

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US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS595188A (ja) * 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
JPS5946284A (ja) * 1982-09-10 1984-03-15 Yakult Honsha Co Ltd １１−ニトロカンプトテシン誘導体およびその製造法
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds

Also Published As

Publication number Publication date
FI931384A (fi) 1993-03-26
PT99109A (pt) 1992-08-31
AU8739991A (en) 1992-04-28
JPH06501476A (ja) 1994-02-17
NZ239947A (en) 1994-07-26
SK25993A3 (en) 1993-07-07
ZA917748B (en) 1992-09-30
CA2090967A1 (en) 1992-03-29
EP0547165A4 (de) 1994-03-30
HK1012283A1 (en) 1999-07-30
ATE186461T1 (de) 1999-11-15
AU664830B2 (en) 1995-12-07
CA2090967C (en) 2007-02-06
NO931153L (no) 1993-03-26
IL99571A (en) 2000-08-31
US5734056A (en) 1998-03-31
DE69131775D1 (de) 1999-12-16
GR3031823T3 (en) 2000-02-29
PT99109B (pt) 1999-02-26
DK0547165T3 (da) 2000-03-27
SI9111599A (sl) 1998-02-28
NO931153D0 (no) 1993-03-26
FI931384A0 (fi) 1993-03-26
CN1033509C (zh) 1996-12-11
IL99571A0 (en) 1992-08-18
CZ51593A3 (en) 1994-01-19
CN1062731A (zh) 1992-07-15
WO1992005785A1 (en) 1992-04-16
IE913402A1 (en) 1992-04-08
YU159991A (sh) 1994-06-10
HUT70024A (en) 1995-09-28
EP0547165A1 (de) 1993-06-23
HU9300878D0 (en) 1993-06-28
ES2137932T3 (es) 2000-01-01
JP2848958B2 (ja) 1999-01-20
SK283693B6 (sk) 2003-12-02
EP0547165B1 (de) 1999-11-10

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