PT99109A - Processo para preparacao de intermediarios de 9-metil(substituido)-10-hidroxi ou alcoxi-11-hidro ou alcoxi 1-6camptotecina soluveis em agua, para preparacao destas comptotecinas, sua purificacao e isolamento, e preparacao de composicoes farmaceuticas - Google Patents
Processo para preparacao de intermediarios de 9-metil(substituido)-10-hidroxi ou alcoxi-11-hidro ou alcoxi 1-6camptotecina soluveis em agua, para preparacao destas comptotecinas, sua purificacao e isolamento, e preparacao de composicoes farmaceuticasInfo
- Publication number
- PT99109A PT99109A PT99109A PT9910991A PT99109A PT 99109 A PT99109 A PT 99109A PT 99109 A PT99109 A PT 99109A PT 9910991 A PT9910991 A PT 9910991A PT 99109 A PT99109 A PT 99109A
- Authority
- PT
- Portugal
- Prior art keywords
- preparation
- alcoxy
- comptotecins
- intermediaries
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58964390A | 1990-09-28 | 1990-09-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT99109A true PT99109A (pt) | 1992-08-31 |
PT99109B PT99109B (pt) | 1999-02-26 |
Family
ID=24358879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99109A PT99109B (pt) | 1990-09-28 | 1991-09-27 | Processo para preparacao de intermediarios de 9-metil(substituido)-10-hidroxi ou alcoxi-11-hidro ou alcoxi 1-6camptotecina soluveis em agua, para preparacao destas comptotecinas, sua purificacao e isolamento, e preparacao de composicoes farmaceuticas |
Country Status (25)
Country | Link |
---|---|
US (1) | US5734056A (pt) |
EP (1) | EP0547165B1 (pt) |
JP (1) | JP2848958B2 (pt) |
CN (1) | CN1033509C (pt) |
AT (1) | ATE186461T1 (pt) |
AU (1) | AU664830B2 (pt) |
CA (1) | CA2090967C (pt) |
CZ (1) | CZ51593A3 (pt) |
DE (1) | DE69131775T2 (pt) |
DK (1) | DK0547165T3 (pt) |
ES (1) | ES2137932T3 (pt) |
FI (1) | FI931384A (pt) |
GR (1) | GR3031823T3 (pt) |
HK (1) | HK1012283A1 (pt) |
HU (1) | HUT70024A (pt) |
IE (1) | IE913402A1 (pt) |
IL (1) | IL99571A (pt) |
NO (1) | NO931153D0 (pt) |
NZ (1) | NZ239947A (pt) |
PT (1) | PT99109B (pt) |
SI (1) | SI9111599A (pt) |
SK (1) | SK283693B6 (pt) |
WO (1) | WO1992005785A1 (pt) |
YU (1) | YU159991A (pt) |
ZA (1) | ZA917748B (pt) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
US5527913A (en) * | 1993-02-25 | 1996-06-18 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
GB9402934D0 (en) * | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
KR960029336A (ko) | 1995-01-09 | 1996-08-17 | 김충환 | 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제 |
US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
JPH08333370A (ja) * | 1995-06-08 | 1996-12-17 | Kyorin Pharmaceut Co Ltd | 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法 |
WO1997019085A1 (en) * | 1995-11-22 | 1997-05-29 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties |
US5731316A (en) | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
US6407118B1 (en) | 1996-01-30 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
GB9601779D0 (en) * | 1996-01-30 | 1996-04-03 | Pharmacia Spa | 9, 10 Disubstituted camptothecin derivatives |
US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
US6043367A (en) * | 1998-09-30 | 2000-03-28 | Roffler; Steve | Proactive antitumor compounds |
US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
EP2266607A3 (en) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Immunoconjugates for treating cancer |
WO2004055020A1 (en) * | 2002-12-16 | 2004-07-01 | Council Of Scientific And Industrial Research | Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of campthothecins or mappicene ketones |
AU2003223109A1 (en) * | 2003-03-31 | 2004-10-25 | Council Of Scientific And Industrial Research | Process for preparing topotecan from 10-hydroxy-4-(s) camptothecin |
CN100344633C (zh) * | 2003-05-12 | 2007-10-24 | 台湾神隆股份有限公司 | 用于制备7-烷基-10-羟基-20(s)-喜树碱的方法 |
CZ298934B6 (cs) * | 2003-08-26 | 2008-03-12 | Pliva- Lachema A.S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
CZ299329B6 (cs) * | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
TWI333492B (en) * | 2003-11-12 | 2010-11-21 | Smithkline Beecham Cork Ltd | Crystalline topotecan hydrochloride product and preparation thereof |
CZ299593B6 (cs) * | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
US20050267141A1 (en) | 2004-05-28 | 2005-12-01 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives |
US20050272757A1 (en) * | 2004-06-04 | 2005-12-08 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives and novel intermediate and compounds thereof |
US20080182990A1 (en) * | 2004-08-09 | 2008-07-31 | Shilpa Medicare Limited | Process for the Preparation of Irinotecan Hydrochloride Trihydrate |
NZ554677A (en) * | 2004-11-05 | 2010-08-27 | Samyang Corp | Pharmaceutical formulation for increasing solubility of 10-hydroxycamptothecin compounds in non-aqueous polar solvents |
US20060135546A1 (en) * | 2004-12-16 | 2006-06-22 | Jagadevappa Basavaraja | Methods for the purification of 20(S)- camptothecin |
JP5177429B2 (ja) * | 2005-07-18 | 2013-04-03 | バイパー サイエンシズ,インコーポレイティド | 癌の治療 |
EP1943253A1 (en) * | 2005-10-10 | 2008-07-16 | Cipla Limited | Novel crystalline forms |
US7547785B2 (en) | 2005-12-26 | 2009-06-16 | Dr. Reddy's Laboratories Limited | Process for preparing topotecan |
WO2007127839A2 (en) * | 2006-04-26 | 2007-11-08 | The Regents Of The University Of California | Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics |
PE20080695A1 (es) | 2006-04-27 | 2008-06-28 | Banyu Pharma Co Ltd | Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel |
US20100279327A1 (en) * | 2006-06-12 | 2010-11-04 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
JP2010504079A (ja) * | 2006-06-12 | 2010-02-12 | バイパー サイエンシズ,インコーポレイティド | Parp阻害剤を用いる疾病の治療方法 |
US20080039485A1 (en) * | 2006-08-08 | 2008-02-14 | Targetgen Biotechnology Co., Ltd. | Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers |
JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
US7994222B2 (en) * | 2006-09-05 | 2011-08-09 | Bipar Sciences, Inc. | Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds |
CN101522609A (zh) * | 2006-09-05 | 2009-09-02 | 彼帕科学公司 | 癌症的治疗 |
US7977336B2 (en) | 2006-12-28 | 2011-07-12 | Banyu Pharmaceutical Co. Ltd | Aminopyrimidine derivatives as PLK1 inhibitors |
US7977483B2 (en) | 2007-04-11 | 2011-07-12 | Scinopharm Taiwan, Ltd. | Process for making topotecan |
EP2211854A4 (en) * | 2007-10-19 | 2011-01-12 | Bipar Sciences Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER USING BENZOPYRONE-TYPE PARP INHIBITORS |
JPWO2009054332A1 (ja) | 2007-10-23 | 2011-03-03 | 萬有製薬株式会社 | ピリドン置換ジヒドロピラゾロピリミジノン誘導体 |
US7732491B2 (en) * | 2007-11-12 | 2010-06-08 | Bipar Sciences, Inc. | Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents |
CA2705417A1 (en) * | 2007-11-12 | 2009-05-22 | Bipar Sciences, Inc. | Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents |
ITMI20072268A1 (it) | 2007-12-04 | 2009-06-05 | Antibioticos Spa | Polimorfi cristallini di topotecan cloridrato con elevato grado di purezza e metodi per la loro preparazione |
CN101450949B (zh) * | 2007-12-07 | 2011-10-05 | 上海龙翔生物医药开发有限公司 | 一种10-羟基喜树碱的化学半合成工艺 |
CN101888777A (zh) * | 2007-12-07 | 2010-11-17 | 彼帕科学公司 | 用拓扑异构酶抑制剂和parp抑制剂的组合治疗癌症 |
AU2009252303B2 (en) | 2008-05-29 | 2013-04-04 | Microbiopharm Japan Co., Ltd. | Production method for camptothecin derivative |
AU2010218781A1 (en) | 2009-02-25 | 2011-07-28 | Msd K.K. | Pyrimidopyrimidoindazole derivative |
US8481503B2 (en) | 2009-03-06 | 2013-07-09 | Merck Sharp & Dohme Corp. | Combination cancer therapy with an AKT inhibitor and other anticancer agents |
JP6013359B2 (ja) | 2010-12-17 | 2016-10-25 | ノバルティス アーゲー | 組合せ |
US20130303560A1 (en) | 2011-02-01 | 2013-11-14 | Sunnybrook Research Institute | Combination |
CN103145720B (zh) * | 2013-02-20 | 2015-09-30 | 上海北卡医药技术有限公司 | 一种10-羟基喜树碱的一水合物的制备方法 |
EP2881396A1 (en) * | 2013-12-03 | 2015-06-10 | Synbias Pharma AG | Method for the synthesis of irinotecan |
WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
JPS595188A (ja) * | 1982-06-30 | 1984-01-12 | Yakult Honsha Co Ltd | 10−ヒドロキシカンプトテシンの製造法 |
JPS5946284A (ja) * | 1982-09-10 | 1984-03-15 | Yakult Honsha Co Ltd | 11−ニトロカンプトテシン誘導体およびその製造法 |
US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
GB9008605D0 (en) * | 1990-04-17 | 1990-06-13 | Smith Kline French Lab | Process |
HU213136B (en) * | 1990-08-14 | 1997-02-28 | Kyorin Seiyaku Kk | Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them |
US5352789A (en) * | 1993-02-25 | 1994-10-04 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
-
1991
- 1991-09-23 SK SK259-93A patent/SK283693B6/sk not_active IP Right Cessation
- 1991-09-23 ES ES91918278T patent/ES2137932T3/es not_active Expired - Lifetime
- 1991-09-23 WO PCT/US1991/006888 patent/WO1992005785A1/en active IP Right Grant
- 1991-09-23 DK DK91918278T patent/DK0547165T3/da active
- 1991-09-23 CZ CS93515A patent/CZ51593A3/cs unknown
- 1991-09-23 AU AU87399/91A patent/AU664830B2/en not_active Expired
- 1991-09-23 JP JP3516992A patent/JP2848958B2/ja not_active Expired - Lifetime
- 1991-09-23 EP EP91918278A patent/EP0547165B1/en not_active Expired - Lifetime
- 1991-09-23 HU HU9300878A patent/HUT70024A/hu unknown
- 1991-09-23 CA CA002090967A patent/CA2090967C/en not_active Expired - Lifetime
- 1991-09-23 AT AT91918278T patent/ATE186461T1/de not_active IP Right Cessation
- 1991-09-23 DE DE69131775T patent/DE69131775T2/de not_active Expired - Lifetime
- 1991-09-26 IL IL9957191A patent/IL99571A/xx not_active IP Right Cessation
- 1991-09-26 NZ NZ23994791A patent/NZ239947A/en not_active IP Right Cessation
- 1991-09-27 ZA ZA917748A patent/ZA917748B/xx unknown
- 1991-09-27 PT PT99109A patent/PT99109B/pt not_active IP Right Cessation
- 1991-09-27 IE IE340291A patent/IE913402A1/en not_active IP Right Cessation
- 1991-09-28 CN CN91110656A patent/CN1033509C/zh not_active Expired - Lifetime
- 1991-09-30 SI SI9111599A patent/SI9111599A/sl unknown
- 1991-09-30 YU YU159991A patent/YU159991A/sh unknown
-
1993
- 1993-03-26 NO NO931153A patent/NO931153D0/no unknown
- 1993-03-26 FI FI931384A patent/FI931384A/fi not_active Application Discontinuation
-
1995
- 1995-05-25 US US08/451,079 patent/US5734056A/en not_active Expired - Lifetime
-
1998
- 1998-12-16 HK HK98113607A patent/HK1012283A1/xx not_active IP Right Cessation
-
1999
- 1999-11-11 GR GR990402820T patent/GR3031823T3/el unknown
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