SE0002102D0 - Chemical compound - Google Patents

Chemical compound

Info

Publication number
SE0002102D0
SE0002102D0 SE0002102A SE0002102A SE0002102D0 SE 0002102 D0 SE0002102 D0 SE 0002102D0 SE 0002102 A SE0002102 A SE 0002102A SE 0002102 A SE0002102 A SE 0002102A SE 0002102 D0 SE0002102 D0 SE 0002102D0
Authority
SE
Sweden
Prior art keywords
chemical compound
pyrimidine compound
pharmaceuticals
preparing
useful
Prior art date
Application number
SE0002102A
Other languages
English (en)
Swedish (sv)
Inventor
Ulf Larsson
Mattias Magnusson
Tibor Musil
Andreas Palmgren
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26244413&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE0002102(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to GBGB0013488.2A priority Critical patent/GB0013488D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0002102A priority patent/SE0002102D0/xx
Publication of SE0002102D0 publication Critical patent/SE0002102D0/xx
Priority to ARP010102431A priority patent/AR028605A1/es
Priority to TW090112235A priority patent/TWI285203B/zh
Priority to HU0302345A priority patent/HU229281B1/hu
Priority to IL15277601A priority patent/IL152776A0/xx
Priority to CNB018105645A priority patent/CN1200940C/zh
Priority to AU6287601A priority patent/AU6287601A/xx
Priority to UA20021210810A priority patent/UA73182C2/uk
Priority to MYPI20012586A priority patent/MY131942A/en
Priority to EEP200200669A priority patent/EE05223B1/xx
Priority to SK1683-2002A priority patent/SK286845B6/sk
Priority to JP2002500876A priority patent/JP4947870B2/ja
Priority to CZ20100462A priority patent/CZ303162B6/cs
Priority to PL392726A priority patent/PL212128B1/pl
Priority to NZ522637A priority patent/NZ522637A/en
Priority to DK01937111T priority patent/DK1299390T3/da
Priority to BR0111319-4A priority patent/BR0111319A/pt
Priority to PL359183A priority patent/PL210375B1/pl
Priority to DE60132776T priority patent/DE60132776T2/de
Priority to RU2002135596/04A priority patent/RU2295526C2/ru
Priority to MXPA02011793A priority patent/MXPA02011793A/es
Priority to CNA2007101528077A priority patent/CN101143864A/zh
Priority to ES01937111T priority patent/ES2299487T3/es
Priority to KR1020077028366A priority patent/KR100814229B1/ko
Priority to US10/275,560 priority patent/US7067663B2/en
Priority to CA002408914A priority patent/CA2408914C/en
Priority to KR1020027016378A priority patent/KR100802884B1/ko
Priority to PL392725A priority patent/PL211318B1/pl
Priority to CZ20100616A priority patent/CZ302644B6/cs
Priority to SI200130817T priority patent/SI1299390T1/sl
Priority to AT01937111T priority patent/ATE386039T1/de
Priority to CNB2005100594528A priority patent/CN100354268C/zh
Priority to CZ20023919A priority patent/CZ302645B6/cs
Priority to AU2001262876A priority patent/AU2001262876B2/en
Priority to PCT/SE2001/001241 priority patent/WO2001092263A1/en
Priority to EP01937111A priority patent/EP1299390B1/en
Priority to PT01937111T priority patent/PT1299390E/pt
Priority to ZA200209068A priority patent/ZA200209068B/en
Priority to IL152776A priority patent/IL152776A/en
Priority to IS6614A priority patent/IS2600B/is
Priority to MX2013006281A priority patent/MX336939B/es
Priority to NO20025719A priority patent/NO324266B1/no
Priority to BG107333A priority patent/BG65866B1/bg
Priority to HK03105490A priority patent/HK1053122A1/xx
Priority to US11/255,838 priority patent/US20060041132A1/en
Priority to US11/591,464 priority patent/US7381828B2/en
Priority to AU2007200776A priority patent/AU2007200776B2/en
Priority to CY20081100388T priority patent/CY1108101T1/el
Priority to US12/149,145 priority patent/US20080234481A1/en
Priority to US12/585,285 priority patent/US20100004444A1/en
Priority to AU2010200461A priority patent/AU2010200461B2/en
Priority to US13/064,443 priority patent/US8273879B2/en
Priority to IL225893A priority patent/IL225893A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SE0002102A 2000-06-02 2000-06-06 Chemical compound SE0002102D0 (sv)

Priority Applications (54)

Application Number Priority Date Filing Date Title
GBGB0013488.2A GB0013488D0 (en) 2000-06-02 2000-06-02 Chemical compound
SE0002102A SE0002102D0 (sv) 2000-06-02 2000-06-06 Chemical compound
ARP010102431A AR028605A1 (es) 2000-06-02 2001-05-22 Compuesto quimico
TW090112235A TWI285203B (en) 2000-06-02 2001-05-22 Pyrimidine compounds, process for their preparation, and intermediates used therein
HU0302345A HU229281B1 (en) 2000-06-02 2001-05-31 Novel triazolo pyrimidine compounds
IL15277601A IL152776A0 (en) 2000-06-02 2001-05-31 Novel triazolo pyrimidine compounds
CNB018105645A CN1200940C (zh) 2000-06-02 2001-05-31 新的***并嘧啶化合物
AU6287601A AU6287601A (en) 2000-06-02 2001-05-31 Novel triazolo pyrimidine compounds
UA20021210810A UA73182C2 (en) 2000-06-02 2001-05-31 Triazolpirimidin compounds, method for obtaining thereof (variants) and intermediate compounds (variants)
MYPI20012586A MY131942A (en) 2000-06-02 2001-05-31 Novel triazolo pyrimidine compounds
EEP200200669A EE05223B1 (et) 2000-06-02 2001-05-31 Triasoloprimidiini hendid, meetod nende valmistamiseks ning nende kasutamine
SK1683-2002A SK286845B6 (sk) 2000-06-02 2001-05-31 Pyrimidínové zlúčeniny, spôsob ich prípravy, ich použitie a medziprodukty na ich prípravu
JP2002500876A JP4947870B2 (ja) 2000-06-02 2001-05-31 新規トリアゾロピリミジン化合物
CZ20100462A CZ303162B6 (cs) 2000-06-02 2001-05-31 Zpusob prípravy pyrimidinové slouceniny
PL392726A PL212128B1 (pl) 2000-06-02 2001-05-31 Nowe związki pośrednie do syntezy związków triazolopirymidyny oraz sposób ich wytwarzania
NZ522637A NZ522637A (en) 2000-06-02 2001-05-31 Novel triazolo pyrimidine compounds
DK01937111T DK1299390T3 (da) 2000-06-02 2001-05-31 Pyrimidinforbindelser og deres anvendelse ved fremstilling af et triazolopyrimidincarbanukleosid
BR0111319-4A BR0111319A (pt) 2000-06-02 2001-05-31 Composto, processo para preparar um composto, uso de um composto, processo para preparar um sal de um composto, e, composto intermediário
PL359183A PL210375B1 (pl) 2000-06-02 2001-05-31 Nowe związki triazolopirymidyny, sposób wytwarzania tych związków, sposób wytwarzania farmaceutycznego związku pirymidyny i związek pośredni stosowany w tym sposobie
DE60132776T DE60132776T2 (de) 2000-06-02 2001-05-31 Pyrimidine derivate und deren verwendung zur herstellung eines triazolo-pyrimidin carba nucleosids
RU2002135596/04A RU2295526C2 (ru) 2000-06-02 2001-05-31 Пиримидиновые соединения, способ их получения (варианты), промежуточные продукты (варианты) и способы их получения (варианты), способ получения триазолопиримидиновых соединений
MXPA02011793A MXPA02011793A (es) 2000-06-02 2001-05-31 Novedosos compuestos de triazolo pirimidina..
CNA2007101528077A CN101143864A (zh) 2000-06-02 2001-05-31 ***并嘧啶化合物
ES01937111T ES2299487T3 (es) 2000-06-02 2001-05-31 Compuestos de pirimidina y su uso en la preparacion de un carbanucleosido de triazolo-pirimidina.
KR1020077028366A KR100814229B1 (ko) 2000-06-02 2001-05-31 신규 트리아졸로 피리미딘 화합물
US10/275,560 US7067663B2 (en) 2000-06-02 2001-05-31 Triazolo pyrimidine compounds
CA002408914A CA2408914C (en) 2000-06-02 2001-05-31 Novel triazolo pyrimidine compounds
KR1020027016378A KR100802884B1 (ko) 2000-06-02 2001-05-31 신규 트리아졸로 피리미딘 화합물
PL392725A PL211318B1 (pl) 2000-06-02 2001-05-31 Nowe związki pośrednie do syntezy związków triazolopirymidyny oraz sposób ich wytwarzania
CZ20100616A CZ302644B6 (cs) 2000-06-02 2001-05-31 Triazolopyrimidinová sloucenina
SI200130817T SI1299390T1 (sl) 2000-06-02 2001-05-31 Pirimidinske spojine in njihova uporaba v pripravi triazolo-pirimidin karba nukleozida
AT01937111T ATE386039T1 (de) 2000-06-02 2001-05-31 Pyrimidine derivate und deren verwendung zur herstellung eines triazolo-pyrimidin carba nucleosids
CNB2005100594528A CN100354268C (zh) 2000-06-02 2001-05-31 ***并嘧啶化合物
CZ20023919A CZ302645B6 (cs) 2000-06-02 2001-05-31 Triazolopyrimidinové slouceniny
AU2001262876A AU2001262876B2 (en) 2000-06-02 2001-05-31 Novel triazolo pyrimidine compounds
PCT/SE2001/001241 WO2001092263A1 (en) 2000-06-02 2001-05-31 Novel triazolo pyrimidine compounds
EP01937111A EP1299390B1 (en) 2000-06-02 2001-05-31 Pyrimidine compounds and their use in the preparation of a triazolo -pyrimidine carba nucleoside
PT01937111T PT1299390E (pt) 2000-06-02 2001-05-31 Compostos de pirimidina e sua utilização na preparação de um triazolo-pirimidina-carbanucleósido
ZA200209068A ZA200209068B (en) 2000-06-02 2002-11-07 Novel triazolo pyrimidine compounds.
IL152776A IL152776A (en) 2000-06-02 2002-11-11 Compounds of triazolo pyrimidine and process for their preparation
IS6614A IS2600B (is) 2000-06-02 2002-11-14 Ný tríasólpýrimídínefnasambönd
MX2013006281A MX336939B (es) 2000-06-02 2002-11-28 Novedosos compuestos de triazolo pirimidina.
NO20025719A NO324266B1 (no) 2000-06-02 2002-11-28 Nye triazolpyrimidinforbindelser samt fremgangsmater for deres fremstilling
BG107333A BG65866B1 (bg) 2000-06-02 2002-11-28 Триазолпиримидинови съединения
HK03105490A HK1053122A1 (en) 2000-06-02 2003-07-30 Pyrimidine compounds and their use in the preparation of a triazolo-pyrimidine carba nucleoside
US11/255,838 US20060041132A1 (en) 2000-06-02 2005-10-24 Novel triazolo pyrimidine compounds
US11/591,464 US7381828B2 (en) 2000-06-02 2006-11-02 Triazolo pyrimidine compounds
AU2007200776A AU2007200776B2 (en) 2000-06-02 2007-02-16 Novel triazolo pyrimidine compounds
CY20081100388T CY1108101T1 (el) 2000-06-02 2008-04-09 Ενωσεις πυριμιδινης και η χρηση τους στην παρασκευη ενος τριαζολο-πυριμιδιν καρβα νουκλεοζιτη
US12/149,145 US20080234481A1 (en) 2000-06-02 2008-04-28 Novel triazolo pyrimidine compounds
US12/585,285 US20100004444A1 (en) 2000-06-02 2009-09-10 Novel Triazolo pyrimidine compounds
AU2010200461A AU2010200461B2 (en) 2000-06-02 2010-02-09 Novel triazolo pyrimidine compounds
US13/064,443 US8273879B2 (en) 2000-06-02 2011-03-24 Triazolo pyrimidine compounds
IL225893A IL225893A (en) 2000-06-02 2013-04-22 2 - ({3ar, 4s, 6r, 6as) –6– [7– Chloro – 5– (Prosulfonyl – 3 h– [1,2,3] Triazolo [d – 4,5] Pyrimidine – 3 – Yl] –2 , 2-Dimethyltetrahydro-3 ah- Cyclopenta- [C] [1,3] Dioxol-4-Yl} Oxy) -1-Ethanol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0013488.2A GB0013488D0 (en) 2000-06-02 2000-06-02 Chemical compound
SE0002102A SE0002102D0 (sv) 2000-06-02 2000-06-06 Chemical compound

Publications (1)

Publication Number Publication Date
SE0002102D0 true SE0002102D0 (sv) 2000-06-06

Family

ID=26244413

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0002102A SE0002102D0 (sv) 2000-06-02 2000-06-06 Chemical compound

Country Status (36)

Country Link
US (6) US7067663B2 (pt)
EP (1) EP1299390B1 (pt)
JP (1) JP4947870B2 (pt)
KR (2) KR100802884B1 (pt)
CN (3) CN100354268C (pt)
AR (1) AR028605A1 (pt)
AT (1) ATE386039T1 (pt)
AU (4) AU2001262876B2 (pt)
BG (1) BG65866B1 (pt)
BR (1) BR0111319A (pt)
CA (1) CA2408914C (pt)
CY (1) CY1108101T1 (pt)
CZ (3) CZ302645B6 (pt)
DE (1) DE60132776T2 (pt)
DK (1) DK1299390T3 (pt)
EE (1) EE05223B1 (pt)
ES (1) ES2299487T3 (pt)
GB (1) GB0013488D0 (pt)
HK (1) HK1053122A1 (pt)
HU (1) HU229281B1 (pt)
IL (3) IL152776A0 (pt)
IS (1) IS2600B (pt)
MX (2) MXPA02011793A (pt)
MY (1) MY131942A (pt)
NO (1) NO324266B1 (pt)
NZ (1) NZ522637A (pt)
PL (3) PL211318B1 (pt)
PT (1) PT1299390E (pt)
RU (1) RU2295526C2 (pt)
SE (1) SE0002102D0 (pt)
SI (1) SI1299390T1 (pt)
SK (1) SK286845B6 (pt)
TW (1) TWI285203B (pt)
UA (1) UA73182C2 (pt)
WO (1) WO2001092263A1 (pt)
ZA (1) ZA200209068B (pt)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
SE0400873D0 (sv) * 2004-03-31 2004-03-31 Astrazeneca Ab Chemical process
SE0401001D0 (sv) * 2004-03-31 2004-03-31 Astrazeneca Ab Chemical process
GB0615620D0 (en) 2006-08-05 2006-09-13 Astrazeneca Ab A process for the preparation of optically active intermediates
GB0615619D0 (en) 2006-08-05 2006-09-13 Astrazeneca Ab Chemical process for preparation of intermediates
EP2081433A2 (en) 2006-10-31 2009-07-29 Janssen Pharmaceutica N.V. Triazolopyrimidine derivatives as adp p2y12 receptor antagonists
TWI496776B (zh) * 2007-11-15 2015-08-21 Astrazeneca Ab 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法
JP5656837B2 (ja) * 2008-09-09 2015-01-21 アストラゼネカ アクチボラグ ［１Ｓ−［１α，２α，３β（１Ｓ＊，２Ｒ＊），５β］］−３−［７−［２−（３，４−ジフルオロフェニル）−シクロプロピルアミノ］−５−（プロピルチオ）−３Ｈ−１，２，３−トリアゾロ［４，５−ｄ］ピリミジン−３−イル］−５−（２−ヒドロキシエトキシ）シクロペンタン−１，２−ジオールおよびその中間体の製造方法
USRE49686E1 (en) 2008-09-19 2023-10-10 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound and use of same
CN101977842A (zh) * 2009-03-02 2011-02-16 卡勒拉公司 气流多污染物控制***和方法
EP3135675A1 (en) 2009-07-27 2017-03-01 Auspex Pharmaceuticals, Inc. Deuterated derivatives of ticagrelor for medical use
EP2305376A1 (en) 2009-09-23 2011-04-06 Lonza Ltd. Process and catalyst for the catalytic hydrogenation of aromatic and heteroaromatic nitro compounds
US8859769B2 (en) 2010-02-16 2014-10-14 Actavis Group Ptc Ehf Processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine
US20130150577A1 (en) 2010-04-20 2013-06-13 Actavis Group Ptc Ehf Novel process for preparing phenylcyclopropylamine derivatives using novel intermediates
CN103003231A (zh) * 2010-06-30 2013-03-27 阿特维斯集团公司 制备苯基环丙基胺衍生物的新方法及其用于制备替卡格雷的用途
WO2012063126A2 (en) 2010-11-09 2012-05-18 Actavis Group Ptc Ehf Improved processes for preparing pure (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol and its key starting material
MX2013007115A (es) 2010-12-20 2014-02-10 Actavis Group Ptc Ehf Procesos novedosos para preparar derivados de triazolo[4, 5 - d] pirimidina e intermediarios de los mismos.
US9056838B2 (en) 2011-04-06 2015-06-16 Teva Pharmaceutical Industries Ltd. Intermediates and processes for preparing Ticagrelor
CN102731467B (zh) * 2011-04-15 2015-12-16 博瑞生物医药（苏州）股份有限公司 替卡格雷的中间体及制备替卡格雷的方法
MY163203A (en) * 2011-05-13 2017-08-15 Astrazeneca Ab A process for the preparation of benzyl [(3as,4r,6s,6ar)-6-hydroxy-2,2- dimethyltetrahydro-3ah-cyclopenta[d][1,3]dioxol]-4-yl]carbamate and intermediates in the process
EP2721018A1 (en) 2011-06-15 2014-04-23 Actavis Group Ptc Ehf Improved process for preparing cyclopentylamine derivatives and intermediates thereof
HUE031673T2 (en) 2011-09-14 2017-07-28 Lek Pharmaceuticals Synthesis of triazolopyrimidine compounds
EP2570405A1 (en) 2011-09-14 2013-03-20 LEK Pharmaceuticals d.d. Synthesis of Triazolopyrimidine Compounds
IN2014KN01062A (pt) * 2011-10-27 2015-10-09 Lek Pharmaceuticals
EP2586773A1 (en) 2011-10-27 2013-05-01 LEK Pharmaceuticals d.d. Synthesis of Triazolopyrimidine Compounds
WO2013079589A1 (en) 2011-11-30 2013-06-06 Actavis Group Ptc Ehf Novel crystalline form of ticagrelor and process for the preparation thereof
CA2859580A1 (en) 2011-12-23 2013-06-27 Lek Pharmaceuticals D.D. Synthesis of triazolopyrimidine compounds
EP2628721A1 (en) 2012-02-20 2013-08-21 LEK Pharmaceuticals d.d. Synthesis of 2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
EP2644590A1 (en) 2012-03-30 2013-10-02 LEK Pharmaceuticals d.d. Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts
CN104603098B (zh) * 2012-03-30 2016-06-29 桑多斯股份公司 2-(3,4-二氟苯基)环丙胺衍生物和盐的合成
EP2834247A4 (en) * 2012-04-05 2016-03-30 Reddys Lab Ltd Dr PREPARATION OF TICAGRELOR
WO2013163892A1 (en) * 2012-05-02 2013-11-07 Sunshine Lake Pharma Co., Ltd. Novel triazolo pyrimidine compounds and a process of preparation thereof
CN102659815B (zh) * 2012-05-04 2013-07-17 开原亨泰制药股份有限公司 一种制备选择性抗凝血药替卡格雷及其中间体的方法
CN102675321B (zh) * 2012-05-11 2014-12-10 上海皓元化学科技有限公司 一种替卡格雷的制备方法
EP2666771A1 (en) 2012-05-24 2013-11-27 LEK Pharmaceuticals d.d. Synthesis of Aminocyclopentanetriol Derivatives
CN104520278A (zh) * 2012-08-06 2015-04-15 埃南蒂亚有限公司 ***并嘧啶碳核苷的中间体的制备方法
CN103588674B (zh) * 2012-08-14 2015-02-11 上海医药工业研究院 一种具有光学活性的环丙烷酰阱化合物、其制备和应用
CN103626743B (zh) * 2012-08-23 2018-06-08 广东东阳光药业有限公司 替卡格雷的新型中间体及其制备方法
CN102875537A (zh) * 2012-09-10 2013-01-16 常州制药厂有限公司 一种新的抗血栓药物的制备方法
WO2014083139A1 (en) 2012-11-29 2014-06-05 Actavis Group Ptc Ehf Novel amorphous form of ticagrelor
US20150322071A1 (en) * 2012-12-06 2015-11-12 Brightgene Bio-Medical Technology (Suzhou) Co., Ltd Process for preparing triazole pyrimidine compounds and intermediates thereof
CN103848834B (zh) * 2012-12-06 2017-09-22 博瑞生物医药（苏州）股份有限公司 一种制备替卡格雷的方法及其中间体
CN104341402B (zh) * 2013-07-23 2018-04-27 博瑞生物医药（苏州）股份有限公司 一种制备替卡格雷中间体的方法
WO2014102830A1 (en) 2012-12-31 2014-07-03 Megafine Pharma (P) Ltd. A process for preparation of ticagrelor and intermediates thereof
CN103936767B (zh) * 2013-01-23 2016-08-03 上海医药工业研究院 一种制备化合物(1r,2s,6s,7s)-4,4-二甲基-9-苯甲基-3,5,8-三氧杂-9-氮杂三环[5.2.1.02.6]葵烷的方法
CZ307217B6 (cs) 2013-03-14 2018-04-04 Zentiva, K.S. Zlepšený způsob výroby a nové intermediáty syntézy ticagreloru
ITMI20130487A1 (it) 2013-03-29 2014-09-30 Chemo Res S L Alchilazione selettiva di ciclopentilalcoli
CN107573333B (zh) 2013-04-10 2019-10-18 江苏恒瑞医药股份有限公司 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法
CN103275056B (zh) * 2013-05-24 2015-06-17 浙江普洛医药科技有限公司 一种替卡格雷中间体的制备方法
WO2014195861A2 (en) * 2013-06-04 2014-12-11 Dr. Reddy’S Laboratories Limited Preparation of ticagrelor
CN104230818B (zh) * 2013-06-06 2018-01-12 郝聪梅 替卡格雷中间体的改进制备方法
WO2014206187A1 (zh) * 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
CN103275087A (zh) * 2013-06-28 2013-09-04 南京工业大学 一种三氮唑并嘧啶类衍生物及其制备方法
CN104059069B (zh) * 2013-08-22 2016-08-10 北京康立生医药技术开发有限公司 一种替卡格雷的制备方法
CN104592237A (zh) * 2013-10-31 2015-05-06 徐州万邦金桥制药有限公司 一种抗凝血药替格瑞洛的合成方法
CN103588750B (zh) * 2013-11-07 2014-11-26 苏州明锐医药科技有限公司 替卡格雷中间体的制备方法
CZ2013866A3 (cs) 2013-11-08 2015-05-20 Zentiva, K.S. Způsob výroby a nová krystalická forma intermediátu syntézy ticagreloru
CN103588712B (zh) * 2013-11-08 2016-06-08 南京欧信医药技术有限公司 一种嘧啶类化合物及其制备方法、和应用
CN104710425B (zh) * 2013-12-16 2019-06-14 石药集团中奇制药技术（石家庄）有限公司 一种替格瑞洛新结晶及其制备方法
CN104744424B (zh) * 2013-12-27 2018-12-25 博瑞生物医药（苏州）股份有限公司 一种替卡格雷中间体的制备方法
CN103923020A (zh) * 2014-04-02 2014-07-16 黄河三角洲京博化工研究院有限公司 一种2-丙硫基-4,6-二氯-5-氨基嘧啶的制备方法
CN103992323B (zh) * 2014-04-18 2017-03-29 南通常佑药业科技有限公司 一种替格瑞洛的制备方法
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
US10011605B2 (en) 2014-06-18 2018-07-03 Flamma Spa Process for the preparation of triazolo[4,5-D] pyrimidine cyclopentane compounds
WO2016001851A1 (en) * 2014-07-02 2016-01-07 Dr. Reddy's Laboratories Limited Preparation of ticagrelor
CN104193748A (zh) * 2014-08-14 2014-12-10 严白双 一种替卡格雷的合成方法
WO2016030704A1 (en) * 2014-08-30 2016-03-03 Cipla Limited Solid form of intermediate of ticagrelor
CN105801583A (zh) * 2014-12-31 2016-07-27 徐州万邦金桥制药有限公司 一种替格瑞洛的纯化方法
WO2016116942A1 (en) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin
WO2016117852A2 (ko) * 2015-01-22 2016-07-28 동아에스티 주식회사 티카그렐러 제조방법 및 이를 위한 신규한 중간체
CN105968113B (zh) * 2015-03-12 2019-06-07 四川海思科制药有限公司 一种***并嘧啶衍生物及其应用
CN105153167B (zh) * 2015-09-06 2017-09-19 惠州信立泰药业有限公司 一种替格瑞洛结晶及含有该结晶的药物组合物
CN105198864B (zh) * 2015-10-21 2018-11-06 华仁药业股份有限公司 一种环戊基嘧啶化合物的无溶剂制备方法
WO2017072790A1 (en) * 2015-10-26 2017-05-04 Avra Laboratories Pvt. Ltd. An improved process for synthesis of ticagrelor
CN105669681A (zh) * 2016-04-11 2016-06-15 成都华宇制药有限公司 一种替格瑞洛的合成方法
CN106543191B (zh) * 2016-10-28 2019-03-01 天津红日药业股份有限公司 一种替格瑞洛制备工艺
CN107337675A (zh) * 2017-06-03 2017-11-10 湖南天济草堂制药股份有限公司 一种制备替格瑞洛的改进方法
CN107382953A (zh) * 2017-07-25 2017-11-24 安徽诺全药业有限公司 一种制备多取代环戊烷衍生物的方法
CN108689984B (zh) * 2018-05-02 2019-09-20 淮阴工学院 一种替格瑞洛中间体的生物合成方法及其中间体
CN110894184B (zh) * 2019-11-25 2022-02-18 安徽一帆香料有限公司 一种基于绿色环保的替格瑞洛中间体的制备方法
EP3919497A1 (en) 2020-06-04 2021-12-08 Zaklady Farmaceutyczne Polpharma S.A. Process for the preparation of ticagrelor
CN112457316B (zh) * 2020-11-05 2022-04-12 南通常佑药业科技有限公司 一种应用连续流反应技术制备替卡格雷高级中间体的方法
CN112724119B (zh) * 2020-12-30 2022-05-03 江苏恒沛药物科技有限公司 一种替卡格雷关键中间体的合成方法
CN115160320B (zh) * 2022-06-27 2024-05-07 南通常佑药业科技有限公司 一种手性嘧啶并***类替格瑞洛的制备方法
CN115785058B (zh) * 2022-12-09 2024-05-03 广州康瑞泰药业有限公司 一种合成替格瑞洛五元环中间体的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3040406A1 (de) * 1980-10-27 1982-05-27 Degussa Ag, 6000 Frankfurt Verfahren zur gewinnung von n-tert-alkylaminen und ameisensaeureestern
GB8916477D0 (en) 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
IL95165A0 (en) * 1989-07-24 1991-06-10 Glaxo Group Ltd Cyclopentane derivatives
HUT64967A (en) * 1991-04-06 1994-03-28 Fisons Plc Atp analogues and pharmaceutical compositions containing them
US5654285A (en) * 1991-04-06 1997-08-05 Astra Pharmaceuticals Limited ADP and ATP analogues, process for making and administration to inhibit ADP-induced platelet aggregation
US5817672A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
BR9609467A (pt) 1995-07-11 1999-03-02 Astra Pharma Prod Composto uso de um composto composição farmacéutica e processos para preparação de um composto e tratamento de distúrbios de agregação planquetária
ATE213245T1 (de) * 1996-12-20 2002-02-15 Triazolo(4,5-d)pyrimidinyl-derivate und ihre verwendung als medikamente
AR017014A1 (es) * 1997-07-22 2001-08-22 Astrazeneca Ab Compuestos de triazolo [4,5-d]pirimidina, composiciones farmaceuticas, uso de los mismos para preparar medicamentos y procesos para la preparacionde dichos compuestos
SE9702773D0 (sv) * 1997-07-22 1997-07-22 Astra Pharma Prod Novel compounds
TR200002380T2 (tr) * 1998-02-17 2001-03-21 Astrazeneca Uk Limited Yeni triazolo (4,5-d) pirimidin bileşikleri
TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
CZ20002947A3 (cs) * 1999-02-05 2000-11-15 Astrazeneca Uk Limited Nové triazolo(4,5-d)pyrimidiny, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
SE9904129D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound

Also Published As

Publication number Publication date
CN100354268C (zh) 2007-12-12
HU229281B1 (en) 2013-10-28
US20030148888A1 (en) 2003-08-07
IS6614A (is) 2002-11-14
SK286845B6 (sk) 2009-06-05
EP1299390A1 (en) 2003-04-09
US7067663B2 (en) 2006-06-27
CY1108101T1 (el) 2014-02-12
NO20025719L (no) 2003-02-03
BR0111319A (pt) 2003-06-03
AU2001262876B2 (en) 2007-03-01
PL212128B1 (pl) 2012-08-31
CN1432017A (zh) 2003-07-23
PT1299390E (pt) 2008-04-17
IL225893A (en) 2015-08-31
SK16832002A3 (sk) 2003-06-03
AU2010200461A1 (en) 2010-02-25
IL225893A0 (en) 2013-06-27
SI1299390T1 (sl) 2008-06-30
KR100814229B1 (ko) 2008-03-17
PL359183A1 (en) 2004-08-23
US20080234481A1 (en) 2008-09-25
US20110218330A1 (en) 2011-09-08
JP4947870B2 (ja) 2012-06-06
IL152776A0 (en) 2003-06-24
HUP0302345A2 (hu) 2003-11-28
EE05223B1 (et) 2009-10-15
TWI285203B (en) 2007-08-11
US20060041132A1 (en) 2006-02-23
NO20025719D0 (no) 2002-11-28
AU2007200776A1 (en) 2007-03-15
IL152776A (en) 2013-06-27
EP1299390B1 (en) 2008-02-13
IS2600B (is) 2010-04-15
WO2001092263A1 (en) 2001-12-06
KR20080003458A (ko) 2008-01-07
AR028605A1 (es) 2003-05-14
NZ522637A (en) 2004-09-24
US7381828B2 (en) 2008-06-03
PL211318B1 (pl) 2012-05-31
CZ302645B6 (cs) 2011-08-10
DE60132776D1 (de) 2008-03-27
BG65866B1 (bg) 2010-03-31
US8273879B2 (en) 2012-09-25
CZ20023919A3 (cs) 2003-05-14
ES2299487T3 (es) 2008-06-01
KR20030007828A (ko) 2003-01-23
EE200200669A (et) 2004-06-15
JP2003535093A (ja) 2003-11-25
MX336939B (es) 2016-02-08
UA73182C2 (en) 2005-06-15
MXPA02011793A (es) 2003-04-10
CN1200940C (zh) 2005-05-11
CA2408914A1 (en) 2001-12-06
PL392726A1 (pl) 2010-12-06
PL392725A1 (pl) 2010-12-06
CN1680340A (zh) 2005-10-12
AU2007200776B2 (en) 2009-11-19
ZA200209068B (en) 2003-12-02
MY131942A (en) 2007-09-28
HK1053122A1 (en) 2003-10-10
AU2010200461B2 (en) 2011-08-18
DE60132776T2 (de) 2009-02-12
HUP0302345A3 (en) 2007-10-29
RU2295526C2 (ru) 2007-03-20
GB0013488D0 (en) 2000-07-26
PL210375B1 (pl) 2012-01-31
CZ302644B6 (cs) 2011-08-10
NO324266B1 (no) 2007-09-17
ATE386039T1 (de) 2008-03-15
US20070049755A1 (en) 2007-03-01
AU6287601A (en) 2001-12-11
KR100802884B1 (ko) 2008-02-13
BG107333A (bg) 2003-07-31
US20100004444A1 (en) 2010-01-07
CA2408914C (en) 2009-12-29
CZ303162B6 (cs) 2012-05-09
DK1299390T3 (da) 2008-05-26
CN101143864A (zh) 2008-03-19

Similar Documents

Publication Publication Date Title
SE0002102D0 (sv) Chemical compound
DK1599478T3 (da) Dihydropteridinoner, fremgangsmåde til fremstilling af disse og anvendelse af disse som lægemiddel
MXPA03008754A (es) Derivados de piridina fundidos para utilizarse como agonistas receptores vaniloide para tratar dolor.
MY134892A (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and their use
MY144659A (en) 2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
GB0003154D0 (en) Novel compounds
SE9904505D0 (sv) Novel compounds
DOP2002000433A (es) 2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituidas y su uso
SE0102438D0 (sv) New compounds
YU7804A (sh) Stabilni polimorf flibanserina,postupak za njegovo dobijanje u industrijskim razmerama i njegova primena za pripremanje lekova
MY133969A (en) Indoloquinazolinones
NO20043016L (no) 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav
BR0114903A (pt) 7-azaindóis, sua aplicação como inibidores da fosfodiesterase 4 e processos para a sua preparação
IL160171A0 (en) Depsipeptide derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
SE9804212D0 (sv) Compounds
MY134026A (en) ?-carboline derivatives and its pharmaceutical use against depression and anxiety
BR0316724A (pt) Compostos, uso de um ou mais compostos, e, processo para a fabricação de composições farmacêuticas
ATE333901T1 (de) Pharmazeutische zusammensetzung eines biguanin (metformin) und arginin
BR0114380A (pt) Derivados-1-aminobutan-3-ol-substituìdos
NO20016151L (no) Fremstilling av substituerte piperidin-4-oner
IT1317049B1 (it) Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.
NO20024679D0 (no) Krystallinsk farmasöytikum
MXPA03003466A (es) Derivados de piranosido.
DE50212538D1 (de) Substituierte 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzoäcüfluoren-6-carbonsäurederivate als nmda-antagonisten
MXPA04002400A (es) Sales de acidos salicilicos, metodos para su preparacion y su uso como medicamentos.