RU2015139758A - Хиназолины в качестве ингибиторов киназы - Google Patents
Хиназолины в качестве ингибиторов киназы Download PDFInfo
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- RU2015139758A RU2015139758A RU2015139758A RU2015139758A RU2015139758A RU 2015139758 A RU2015139758 A RU 2015139758A RU 2015139758 A RU2015139758 A RU 2015139758A RU 2015139758 A RU2015139758 A RU 2015139758A RU 2015139758 A RU2015139758 A RU 2015139758A
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Claims (14)
1. Соединение, имеющее формулу:
или его соль.
2. Соединение, которое представляет собой 6-(трет-бутилсульфонил)-N-(4,5-диметил-1H-пиразол-3-ил)-7-этоксихиназолин-4-амин.
3. Соединение, которое представляет собой 6-(трет-бутилсульфонил)-N-(4,5-диметил-1H-пиразол-3-ил)-7-этоксихиназолин-4-амин или его фармацевтически приемлемую соль.
4. Соединение или его фармацевтически приемлемая соль по п. 3 для применения в терапии.
5. Соединение или его фармацевтически приемлемая соль по п. 3 для применения в лечении опосредованного киназой RIP2 заболевания или нарушения, где заболевание или нарушение выбрано из увеита, лихорадочного синдрома, связанного с интерлейкин-1-превращающим ферментом, дерматита, острого повреждения легких, сахарного диабета типа 2, артрита, ревматоидного артрита, язвенного колита, болезни Крона, раннего воспалительного заболевания кишечника, имеющего внекишечные проявления воспалительного заболевания кишечника, предотвращения ишемического реперфузионного повреждения трансплантата паренхиматозного органа, неалкогольного стеатогепатита, алкогольного стеатогепатита, аутоиммунного гепатита, астмы, реакции “трансплантат против хозяина”, системной красной волчанки, множественного склероза, саркоидоза, синдрома Блау, раннего саркоидоза, гранулематоза Вегенера и интерстициального заболевания легких.
6. Соединение или его фармацевтически приемлемая соль по п. 5, где заболевание или нарушение выбрано из увеита, лихорадочного синдрома, связанного с интерлейкин-1-превращающим ферментом, синдрома Блау, раннего саркоидоза, язвенного колита, болезни Крона, гранулематоза Вегенера и саркоидоза.
7. Фармацевтическая композиция, содержащая 6-(трет-бутилсульфонил)-N-(4,5-диметил-1H-пиразол-3-ил)-7-этоксихиназолин-4-амин или его фармацевтически приемлемую соль и одно или более фармацевтически приемлемых вспомогательных веществ.
8. Фармацевтическая композиция, содержащая 6-(трет-бутилсульфонил)-N-(4,5-диметил-1H-пиразол-3-ил)-7-этоксихиназолин-4-амин и одно или более фармацевтически приемлемых вспомогательных веществ.
9. Способ лечения опосредованного киназой RIP2 заболевания или нарушения, который включает в себя введение терапевтически эффективного количества соединения или его фармацевтически приемлемой соли по п. 3 человеку, нуждающемуся в нем, где заболевание или нарушение выбрано из увеита, лихорадочного синдрома, связанного с интерлейкин-1-превращающим ферментом, дерматита, острого повреждения легких, сахарного диабета типа 2, артрита, ревматоидного артрита, язвенного колита, болезни Крона, раннего воспалительного заболевания кишечника, имеющего внекишечные проявления воспалительного заболевания кишечника, предотвращения ишемического реперфузионного повреждения трансплантата паренхиматозного органа, неалкогольного стеатогепатита, алкогольного стеатогепатита, аутоиммунного гепатита, астмы, реакции “трансплантат против хозяина”, системной красной волчанки, множественного склероза, саркоидоза, синдрома Блау, раннего саркоидоза, гранулематоза Вегенера и интерстициального заболевания легких.
10. Способ по п. 9, в котором заболевание или нарушение выбрано из увеита, лихорадочного синдрома, связанного с интерлейкин-1-превращающим ферментом, синдрома Блау, раннего саркоидоза, язвенного колита, болезни Крона, гранулематоза Вегенера и саркоидоза.
11. Применение соединения или его фармацевтически приемлемой соли по п. 3 в производстве медикамента для лечения опосредованного киназой RIP2 заболевания или нарушения, где заболевание или нарушение выбрано из увеита, лихорадочного синдрома, связанного с интерлейкин-1-превращающим ферментом, дерматита, острого повреждения легких, сахарного диабета типа 2, артрита, ревматоидного артрита, язвенного колита, болезни Крона, раннего воспалительного заболевания кишечника, имеющего внекишечные проявления воспалительного заболевания кишечника, предотвращения ишемического реперфузионного повреждения трансплантата паренхиматозного органа, неалкогольного стеатогепатита, алкогольного стеатогепатита, аутоиммунного гепатита, астмы, реакции “трансплантат против хозяина”, системной красной волчанки, множественного склероза, саркоидоза, синдрома Блау, раннего саркоидоза, гранулематоза Вегенера и интерстициального заболевания легких.
12. Применение по п. 11, в котором заболевание или нарушение выбрано из увеита, лихорадочного синдрома, связанного с интерлейкин-1-превращающим ферментом, синдрома Блау, раннего саркоидоза, язвенного колита, болезни Крона, гранулематоза Вегенера и саркоидоза.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201361767423P | 2013-02-21 | 2013-02-21 | |
US61/767,423 | 2013-02-21 | ||
PCT/IB2014/059094 WO2014128622A1 (en) | 2013-02-21 | 2014-02-19 | Quinazolines as kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
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RU2015139758A true RU2015139758A (ru) | 2017-03-24 |
RU2662810C2 RU2662810C2 (ru) | 2018-07-31 |
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Application Number | Title | Priority Date | Filing Date |
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RU2015139758A RU2662810C2 (ru) | 2013-02-21 | 2014-02-19 | Хиназолины в качестве ингибиторов киназы |
Country Status (13)
Country | Link |
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US (1) | US9650364B2 (ru) |
EP (1) | EP2958911B1 (ru) |
JP (1) | JP6301374B2 (ru) |
KR (1) | KR20150118152A (ru) |
CN (1) | CN105143208B (ru) |
AR (1) | AR094707A1 (ru) |
AU (1) | AU2014220300B2 (ru) |
BR (1) | BR112015019624A2 (ru) |
CA (1) | CA2902132C (ru) |
ES (1) | ES2654100T3 (ru) |
RU (1) | RU2662810C2 (ru) |
TW (1) | TWI630203B (ru) |
WO (1) | WO2014128622A1 (ru) |
Families Citing this family (9)
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KR101940340B1 (ko) | 2011-03-04 | 2019-01-18 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 키나제 억제제로서의 아미노-퀴놀린 |
TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基-喹啉類 |
AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
KR20150118152A (ko) | 2013-02-21 | 2015-10-21 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 키나제 억제제로서의 퀴나졸린 |
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- 2014-02-19 CN CN201480009917.6A patent/CN105143208B/zh not_active Expired - Fee Related
- 2014-02-19 AR ARP140100520A patent/AR094707A1/es unknown
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- 2014-02-19 WO PCT/IB2014/059094 patent/WO2014128622A1/en active Application Filing
- 2014-02-19 BR BR112015019624A patent/BR112015019624A2/pt not_active Application Discontinuation
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AU2014220300A1 (en) | 2015-08-06 |
AU2014220300B2 (en) | 2016-10-13 |
ES2654100T3 (es) | 2018-02-12 |
AR094707A1 (es) | 2015-08-19 |
WO2014128622A1 (en) | 2014-08-28 |
CN105143208B (zh) | 2017-09-26 |
CA2902132A1 (en) | 2014-08-28 |
RU2662810C2 (ru) | 2018-07-31 |
TWI630203B (zh) | 2018-07-21 |
CA2902132C (en) | 2020-09-22 |
EP2958911A1 (en) | 2015-12-30 |
BR112015019624A2 (pt) | 2017-07-18 |
CN105143208A (zh) | 2015-12-09 |
US20150361069A1 (en) | 2015-12-17 |
EP2958911B1 (en) | 2017-10-18 |
KR20150118152A (ko) | 2015-10-21 |
US9650364B2 (en) | 2017-05-16 |
TW201444824A (zh) | 2014-12-01 |
JP2016509051A (ja) | 2016-03-24 |
JP6301374B2 (ja) | 2018-03-28 |
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