RS64182B1 - Inhibitori kras g12c - Google Patents
Inhibitori kras g12cInfo
- Publication number
- RS64182B1 RS64182B1 RS20230345A RSP20230345A RS64182B1 RS 64182 B1 RS64182 B1 RS 64182B1 RS 20230345 A RS20230345 A RS 20230345A RS P20230345 A RSP20230345 A RS P20230345A RS 64182 B1 RS64182 B1 RS 64182B1
- Authority
- RS
- Serbia
- Prior art keywords
- kras
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762586775P | 2017-11-15 | 2017-11-15 | |
| PCT/US2018/061060 WO2019099524A1 (en) | 2017-11-15 | 2018-11-14 | Kras g12c inhibitors |
| EP18879484.6A EP3710439B1 (en) | 2017-11-15 | 2018-11-14 | Kras g12c inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS64182B1 true RS64182B1 (sr) | 2023-05-31 |
Family
ID=66431793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20230345A RS64182B1 (sr) | 2017-11-15 | 2018-11-14 | Inhibitori kras g12c |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US10689377B2 (sr) |
| EP (2) | EP3710439B1 (sr) |
| JP (2) | JP7322019B2 (sr) |
| KR (1) | KR20200100632A (sr) |
| CN (1) | CN111989321A (sr) |
| AU (1) | AU2018369759B2 (sr) |
| BR (1) | BR112020009818A2 (sr) |
| CA (1) | CA3082579A1 (sr) |
| CL (1) | CL2020001271A1 (sr) |
| CO (1) | CO2020007244A2 (sr) |
| DK (1) | DK3710439T3 (sr) |
| EA (1) | EA202091186A1 (sr) |
| ES (1) | ES2944547T3 (sr) |
| FI (1) | FI3710439T3 (sr) |
| HR (1) | HRP20230377T1 (sr) |
| HU (1) | HUE061599T2 (sr) |
| IL (1) | IL274601B2 (sr) |
| LT (1) | LT3710439T (sr) |
| MX (1) | MX2020005063A (sr) |
| PH (1) | PH12020550622A1 (sr) |
| PL (1) | PL3710439T3 (sr) |
| PT (1) | PT3710439T (sr) |
| RS (1) | RS64182B1 (sr) |
| SG (1) | SG11202004427TA (sr) |
| SI (1) | SI3710439T1 (sr) |
| TW (1) | TWI809005B (sr) |
| UA (1) | UA125802C2 (sr) |
| WO (2) | WO2019099524A1 (sr) |
| ZA (1) | ZA202002105B (sr) |
Families Citing this family (130)
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| TW202012415A (zh) | 2018-05-08 | 2020-04-01 | 瑞典商阿斯特捷利康公司 | 化學化合物 |
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| JP2022500388A (ja) | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス， インコーポレイテッド | 組み合わせ療法 |
| JP2022500379A (ja) * | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス， インコーポレイテッド | 組み合わせ療法 |
| WO2020055755A1 (en) * | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| EP3849536A4 (en) * | 2018-09-10 | 2022-06-29 | Mirati Therapeutics, Inc. | Combination therapies |
| MA51530A (fr) | 2018-11-09 | 2021-04-21 | Hoffmann La Roche | Composés cycliques fondus |
| US20220079947A1 (en) | 2018-12-05 | 2022-03-17 | Mirati Therapeutics, Inc. | Combination therapies |
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| EP4249000A3 (en) | 2019-02-12 | 2023-12-27 | Novartis AG | Pharmaceutical combination comprising tno155 and a krasg12c inhibitor |
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| CN112390788A (zh) * | 2019-08-13 | 2021-02-23 | 苏州闻天医药科技有限公司 | 一种用于抑制krasg12c突变蛋白的化合物及其制备方法和用途 |
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