MX2020005063A - Inhibidores de kras g12c. - Google Patents

Inhibidores de kras g12c.

Info

Publication number
MX2020005063A
MX2020005063A MX2020005063A MX2020005063A MX2020005063A MX 2020005063 A MX2020005063 A MX 2020005063A MX 2020005063 A MX2020005063 A MX 2020005063A MX 2020005063 A MX2020005063 A MX 2020005063A MX 2020005063 A MX2020005063 A MX 2020005063A
Authority
MX
Mexico
Prior art keywords
kras
inhibitors
compounds
relates
present
Prior art date
Application number
MX2020005063A
Other languages
English (en)
Inventor
James F Blake
Mark Joseph Chicarelli
Laurence E Burgess
John P Fischer
Matthew Arnold Marx
James Gail Christensen
Jay Bradford Fell
Macedonio J Mejia
Guy P A Vigers
Pavel Savechenkov
Adam Cook
Christopher Ronald Smith
Martha E Rodriguez
Original Assignee
Mirati Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirati Therapeutics Inc filed Critical Mirati Therapeutics Inc
Publication of MX2020005063A publication Critical patent/MX2020005063A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Abstract

La presente invención se refiere a compuestos que inhiben KRas G12C, en particular, la presente invención se refiere a compuestos que inhiben irreversiblemente la actividad de KRas G12C, composiciones farmacéuticas que comprenden los compuestos 5 y métodos de uso de los mismos.
MX2020005063A 2017-11-15 2018-11-14 Inhibidores de kras g12c. MX2020005063A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762586775P 2017-11-15 2017-11-15
PCT/US2018/061060 WO2019099524A1 (en) 2017-11-15 2018-11-14 Kras g12c inhibitors

Publications (1)

Publication Number Publication Date
MX2020005063A true MX2020005063A (es) 2021-01-08

Family

ID=66431793

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020005063A MX2020005063A (es) 2017-11-15 2018-11-14 Inhibidores de kras g12c.

Country Status (28)

Country Link
US (4) US10689377B2 (es)
EP (2) EP3710439B1 (es)
JP (2) JP7322019B2 (es)
KR (1) KR20200100632A (es)
AU (1) AU2018369759B2 (es)
BR (1) BR112020009818A2 (es)
CA (1) CA3082579A1 (es)
CL (1) CL2020001271A1 (es)
CO (1) CO2020007244A2 (es)
DK (1) DK3710439T3 (es)
EA (1) EA202091186A1 (es)
ES (1) ES2944547T3 (es)
FI (1) FI3710439T3 (es)
HR (1) HRP20230377T1 (es)
HU (1) HUE061599T2 (es)
IL (1) IL274601B2 (es)
LT (1) LT3710439T (es)
MX (1) MX2020005063A (es)
PH (1) PH12020550622A1 (es)
PL (1) PL3710439T3 (es)
PT (1) PT3710439T (es)
RS (1) RS64182B1 (es)
SG (1) SG11202004427TA (es)
SI (1) SI3710439T1 (es)
TW (1) TWI809005B (es)
UA (1) UA125802C2 (es)
WO (2) WO2019099524A1 (es)
ZA (1) ZA202002105B (es)

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