RS59512B1 - Derivati heksahidropirolo[3,4−c]pirola i srodna jedinjenja kao inhibitori autotaksina (atx) i kao inhibitori proizvodnje lizofosfatidne kiseline (lpa) za lečenje npr. bubrežnih bolesti - Google Patents
Derivati heksahidropirolo[3,4−c]pirola i srodna jedinjenja kao inhibitori autotaksina (atx) i kao inhibitori proizvodnje lizofosfatidne kiseline (lpa) za lečenje npr. bubrežnih bolestiInfo
- Publication number
- RS59512B1 RS59512B1 RS20191402A RSP20191402A RS59512B1 RS 59512 B1 RS59512 B1 RS 59512B1 RS 20191402 A RS20191402 A RS 20191402A RS P20191402 A RSP20191402 A RS P20191402A RS 59512 B1 RS59512 B1 RS 59512B1
- Authority
- RS
- Serbia
- Prior art keywords
- inhibitors
- autotaxin
- hexahydropyrrolo
- atx
- lpa
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12185941 | 2012-09-25 | ||
EP13766056.9A EP2900669B1 (en) | 2012-09-25 | 2013-09-23 | Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases |
PCT/EP2013/069679 WO2014048865A1 (en) | 2012-09-25 | 2013-09-23 | New bicyclic derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
RS59512B1 true RS59512B1 (sr) | 2019-12-31 |
Family
ID=47073290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20191402A RS59512B1 (sr) | 2012-09-25 | 2013-09-23 | Derivati heksahidropirolo[3,4−c]pirola i srodna jedinjenja kao inhibitori autotaksina (atx) i kao inhibitori proizvodnje lizofosfatidne kiseline (lpa) za lečenje npr. bubrežnih bolesti |
Country Status (33)
Country | Link |
---|---|
US (4) | US20150353559A1 (sr) |
EP (2) | EP3590940B1 (sr) |
JP (1) | JP6285444B2 (sr) |
KR (1) | KR102179599B1 (sr) |
CN (1) | CN104684915B (sr) |
AR (1) | AR092645A1 (sr) |
AU (1) | AU2013322838B2 (sr) |
BR (1) | BR112015004111A2 (sr) |
CA (1) | CA2878442A1 (sr) |
CL (1) | CL2015000706A1 (sr) |
CR (1) | CR20150120A (sr) |
DK (1) | DK2900669T3 (sr) |
EA (1) | EA036630B1 (sr) |
ES (1) | ES2753163T3 (sr) |
HK (1) | HK1206722A1 (sr) |
HR (1) | HRP20191937T1 (sr) |
HU (1) | HUE045797T2 (sr) |
IL (1) | IL237126A (sr) |
IN (1) | IN2015DN00960A (sr) |
LT (1) | LT2900669T (sr) |
MA (1) | MA37940B1 (sr) |
MX (1) | MX368615B (sr) |
PE (1) | PE20150758A1 (sr) |
PH (1) | PH12015500263B1 (sr) |
PL (1) | PL2900669T3 (sr) |
PT (1) | PT2900669T (sr) |
RS (1) | RS59512B1 (sr) |
SG (1) | SG11201500572YA (sr) |
SI (1) | SI2900669T1 (sr) |
TW (1) | TWI609018B (sr) |
UA (1) | UA116547C2 (sr) |
WO (1) | WO2014048865A1 (sr) |
ZA (1) | ZA201500345B (sr) |
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PT2900669T (pt) | 2012-09-25 | 2019-10-29 | Hoffmann La Roche | Derivados de hexahidropirrolo[3,4−c]pirrol e compostos relacionados enquanto inibidores da autotaxina (atx) e enquanto inibidores da produção de ácido lisofosfatídico (lpa) para o tratamento de, por exemplo, doenças renais |
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JP6647592B2 (ja) | 2013-07-03 | 2020-02-14 | ルンドベック ラ ホーヤ リサーチ センター,インク. | ピロロピロールカルバメート、および関連する有機化合物、医薬組成物、ならびにその医学的使用 |
JP6546596B2 (ja) | 2013-09-26 | 2019-07-17 | カデント セラピューティクス,インコーポレーテッド | Nr2bの選択的オクタヒドロ−シクロペンタ[c]ピロール負調節因子 |
SI3071561T1 (sl) | 2013-11-22 | 2021-11-30 | Sabre Therapeutics Llc | Spojine, ki inhibirajo avtotaksin |
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CN106029667B (zh) | 2014-03-26 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物 |
SI3122750T1 (sl) * | 2014-03-26 | 2019-12-31 | F. Hoffmann-La Roche Ag | Biciklične spojine kot zaviralci proizvodnje avtotaksina (ATX) in lizofosfatidne kisline (LPA) |
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JO3579B1 (ar) * | 2014-09-26 | 2020-07-05 | Luc Therapeutics Inc | مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول |
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