RO81114A - Procedeu de preparare a unor 4-desacetilvincalencoblastin-c3-carboxihidracide - Google Patents

Procedeu de preparare a unor 4-desacetilvincalencoblastin-c3-carboxihidracide

Info

Publication number
RO81114A
RO81114A RO79102376A RO10237679A RO81114A RO 81114 A RO81114 A RO 81114A RO 79102376 A RO79102376 A RO 79102376A RO 10237679 A RO10237679 A RO 10237679A RO 81114 A RO81114 A RO 81114A
Authority
RO
Romania
Prior art keywords
desacylvincalencoblastin
carboxyhydracide
preparation
Prior art date
Application number
RO79102376A
Other languages
English (en)
French (fr)
Other versions
RO81114B (ro
Inventor
George J Cullinan
Koert Cerzen
Original Assignee
Eli Lilly And Co,Us
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co,Us filed Critical Eli Lilly And Co,Us
Publication of RO81114B publication Critical patent/RO81114B/ro
Publication of RO81114A publication Critical patent/RO81114A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
RO79102376A 1978-04-20 1979-04-18 Procedeu de preparare a unor 4-desacetilvincalencoblastin-c3-carboxihidracide RO81114A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/899,032 US4166810A (en) 1978-04-20 1978-04-20 Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (2)

Publication Number Publication Date
RO81114B RO81114B (ro) 1983-01-30
RO81114A true RO81114A (ro) 1983-02-01

Family

ID=25410402

Family Applications (3)

Application Number Title Priority Date Filing Date
RO79102377A RO81037A (ro) 1978-04-20 1979-04-18 Procedeu de preparare a unor 4-dezacelil-vincaleucoblastin-c3-carboxuhydrazide
RO79102376A RO81114A (ro) 1978-04-20 1979-04-18 Procedeu de preparare a unor 4-desacetilvincalencoblastin-c3-carboxihidracide
RO7997290A RO80084A (ro) 1978-04-20 1979-04-18 Procedeu de preparare a unor derivati ai 4-desacetil vincalencoblastinei c-o carboxi hidrazinei

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO79102377A RO81037A (ro) 1978-04-20 1979-04-18 Procedeu de preparare a unor 4-dezacelil-vincaleucoblastin-c3-carboxuhydrazide

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO7997290A RO80084A (ro) 1978-04-20 1979-04-18 Procedeu de preparare a unor derivati ai 4-desacetil vincalencoblastinei c-o carboxi hidrazinei

Country Status (32)

Country Link
US (1) US4166810A (ro)
EP (1) EP0005051B1 (ro)
JP (1) JPS54141798A (ro)
AR (1) AR228940A1 (ro)
AT (1) AT369010B (ro)
AU (1) AU527109B2 (ro)
BE (1) BE875652A (ro)
BG (3) BG33294A3 (ro)
CA (1) CA1097629A (ro)
CH (1) CH643269A5 (ro)
CS (3) CS218584B2 (ro)
DD (1) DD143075A5 (ro)
DE (1) DE2964130D1 (ro)
DK (1) DK147484C (ro)
EG (1) EG14867A (ro)
ES (2) ES479754A1 (ro)
FI (1) FI791286A (ro)
FR (1) FR2423495A1 (ro)
GB (1) GB2019396B (ro)
GR (1) GR69987B (ro)
HU (1) HU181431B (ro)
IE (1) IE48213B1 (ro)
IL (1) IL57168A (ro)
LU (1) LU81166A1 (ro)
NZ (1) NZ190213A (ro)
PH (1) PH14163A (ro)
PL (3) PL125470B1 (ro)
PT (1) PT69496A (ro)
RO (3) RO81037A (ro)
SU (3) SU893135A3 (ro)
YU (1) YU93179A (ro)
ZA (1) ZA791856B (ro)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322351A (en) * 1980-08-25 1982-03-30 Eli Lilly And Company Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
DK167984A (da) * 1983-03-30 1984-10-01 Lilly Industries Ltd Alkaloidderivater
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
US5043336A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5043340A (en) * 1990-04-03 1991-08-27 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
DE60231868D1 (de) 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
EP1504010B1 (en) * 2002-05-15 2009-03-25 Endocyte, Inc. Vitamin-mitomycin conjugates
AU2004210136C1 (en) 2003-01-27 2010-10-07 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
EP1789391B1 (en) 2004-07-23 2017-06-28 Endocyte, Inc. Bivalent linkers and conjugates thereof
US8044200B2 (en) * 2005-03-16 2011-10-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
JP5475992B2 (ja) 2005-08-19 2014-04-16 エンドサイト，インコーポレイテッド 多剤リガンド結合体
US20080280937A1 (en) * 2005-08-19 2008-11-13 Christopher Paul Leamon Ligand Conjugates of Vinca Alkaloids, Analogs, and Derivatives
US20100087370A1 (en) * 2007-02-14 2010-04-08 The General Hospital Corporation Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en) * 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
US9555139B2 (en) * 2007-03-14 2017-01-31 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
EP3569251A1 (en) 2007-06-25 2019-11-20 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
JP2011500835A (ja) * 2007-10-25 2011-01-06 エンドサイト，インコーポレイテッド チューブリシン類および調製プロセス
ES2574032T3 (es) * 2009-09-07 2016-06-14 Nipro Patch Co., Ltd. Preparación absorbible por vía transdérmica
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
MX2015004757A (es) 2012-10-16 2015-07-17 Endocyte Inc Conjugados de suministro de farmacos que contienen aminoacidos no naturales y metodo para usarlos.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3205220A (en) * 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
US3392173A (en) * 1964-03-09 1968-07-09 Lilly Co Eli Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) * 1964-04-27 1968-02-20 Lilly Co Eli Leurosine
US3387001A (en) * 1964-10-19 1968-06-04 Lilly Co Eli Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) * 1974-05-06 1975-06-03 Lilly Co Eli Vincadioline
US3890325A (en) * 1974-05-15 1975-06-17 Lilly Co Eli Leurocolombine
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

Also Published As

Publication number Publication date
CS218585B2 (en) 1983-02-25
FR2423495B1 (ro) 1983-02-11
SU1225490A3 (ru) 1986-04-15
PH14163A (en) 1981-03-19
AU527109B2 (en) 1983-02-17
BG33294A3 (en) 1983-01-14
PL125470B1 (en) 1983-05-31
RO81037A (ro) 1983-02-01
CS218584B2 (en) 1983-02-25
IE790795L (en) 1979-10-20
DE2964130D1 (en) 1983-01-05
YU93179A (en) 1983-01-21
JPS54141798A (en) 1979-11-05
SU1061698A3 (ru) 1983-12-15
GB2019396A (en) 1979-10-31
CH643269A5 (fr) 1984-05-30
ZA791856B (en) 1980-11-26
DK160679A (da) 1979-10-21
ES479754A1 (es) 1980-08-16
AR228940A1 (es) 1983-05-13
EP0005051A1 (en) 1979-10-31
EP0005051B1 (en) 1982-12-01
GR69987B (ro) 1982-07-22
NZ190213A (en) 1982-12-21
CA1097629A (en) 1981-03-17
BG33296A3 (en) 1983-01-14
GB2019396B (en) 1982-09-15
RO80084A (ro) 1983-02-01
RO81037B (ro) 1983-01-30
SU893135A3 (ru) 1981-12-23
DK147484C (da) 1985-03-25
RO80084B (ro) 1983-01-30
BE875652A (fr) 1979-10-18
LU81166A1 (fr) 1979-09-07
US4166810A (en) 1979-09-04
PT69496A (en) 1979-05-01
PL119416B1 (en) 1981-12-31
AT369010B (de) 1982-11-25
ES479753A1 (es) 1980-08-16
IL57168A0 (en) 1979-07-25
BG33297A3 (en) 1983-01-14
RO81114B (ro) 1983-01-30
DD143075A5 (de) 1980-07-30
ATA291279A (de) 1982-04-15
FR2423495A1 (fr) 1979-11-16
IL57168A (en) 1983-10-31
FI791286A (fi) 1979-10-21
IE48213B1 (en) 1984-10-31
AU4609779A (en) 1979-10-25
CS218583B2 (en) 1983-02-25
DK147484B (da) 1984-08-27
HU181431B (en) 1983-07-28
PL215911A1 (ro) 1980-03-24
JPS6245873B2 (ro) 1987-09-29
EG14867A (en) 1986-09-30

Similar Documents

Publication Publication Date Title
RO79320A (ro) Procedeu de preparare a unor 4-piperidinamine
RO81857A (ro) Procedeu de preparare a unor 6-n-propil-8-metoximetilergoline sau 6-n-propil-8-metilmercaptometilergoline
RO81114A (ro) Procedeu de preparare a unor 4-desacetilvincalencoblastin-c3-carboxihidracide
RO77008A (ro) Procedeu de microincapsulare a unor agenti pesticizi solizi
RO86824A (ro) Procedeu pentru prepararea unor cefalosporine
RO75070A (ro) Procedeu de preparare a unor oxadetiacefalosporine
RO76886A (ro) Procedeu pentru prepararea unor 9-iminodibenzopirani
RO79871A (ro) Procedeu de preparare a unor fenonoxime aromatice substituite
RO79700A (ro) Procedeu de obtinere a vinilpolibutadienei
RO76811A (ro) Procedeu pentru prepararea unor oximinotriozolitani
RO76554A (ro) Procedeu de preparare a unor pirolidinilbenzamide
RO77327A (ro) Procedeu pentru prepararea unor &-azolil-beta-hidroxicetone
RO78358A (ro) Procedeu de preparare a unor 3-tiometilcefalosporine
RO79822A (ro) Procedeu pentru prepararea unor 9-aminoalchilfluoreni
RO81504A (ro) Procedeu pentru prepararea unor 1-fenil-iminoidazolidine substituite
RO72582A (ro) Procedeu pentru prepararea unor benzoil-uree
RO78952A (ro) Procedeu pentru prepararea unor gama-pirone
RO78954A (ro) Procedeu pentru prepararea unor gama-pirone
RO81532A (ro) Procedeu de preparare a unor fenoxiamine heterociclice
RO76593A (ro) Procedeu pentru prepararea unor n-azolilalchil-halogen-acetanilide
RO71258A (ro) Procedeu de preparare a unor hidroxibenzofenone substituite
RO75804A (ro) Procedeu de preparare a unor cefalosporine
RO80087A (ro) Procedeu de preparare a unor tiazoliliden-oxo-propionitrili
FR2424286B1 (fr) Procede de preparation de 6-halo-pregnanes
RO77295A (ro) Procedeu pentru prepararea unor ozicarbamati-n-sulfenilati