DE2964130D1 - 4-desacetyl vlb c-3 carboxhydrazides, their preparation and formulations containing them - Google Patents

4-desacetyl vlb c-3 carboxhydrazides, their preparation and formulations containing them

Info

Publication number: DE2964130D1
Authority: DE; Germany
Prior art keywords: carboxhydrazides; preparation; formulations containing; desacetyl vlb; desacetyl
Prior art date: 1978-04-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

DE7979300638T

Other languages

English (en)

Inventor

George Joseph Cullinan

Koert Gerzon

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-18

Publication date

1983-01-05

1979-04-18 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1983-01-05 Application granted granted Critical

1983-01-05 Publication of DE2964130D1 publication Critical patent/DE2964130D1/de

Status Expired legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DE7979300638T 1978-04-20 1979-04-18 4-desacetyl vlb c-3 carboxhydrazides, their preparation and formulations containing them Expired DE2964130D1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number	Publication Date
DE2964130D1 true DE2964130D1 (en)	1983-01-05

Family

ID=25410402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE7979300638T Expired DE2964130D1 (en)	1978-04-20	1979-04-18	4-desacetyl vlb c-3 carboxhydrazides, their preparation and formulations containing them

Country Status (32)

Country	Link
US (1)	US4166810A (de)
EP (1)	EP0005051B1 (de)
JP (1)	JPS54141798A (de)
AR (1)	AR228940A1 (de)
AT (1)	AT369010B (de)
AU (1)	AU527109B2 (de)
BE (1)	BE875652A (de)
BG (3)	BG33294A3 (de)
CA (1)	CA1097629A (de)
CH (1)	CH643269A5 (de)
CS (3)	CS218585B2 (de)
DD (1)	DD143075A5 (de)
DE (1)	DE2964130D1 (de)
DK (1)	DK147484C (de)
EG (1)	EG14867A (de)
ES (2)	ES479753A1 (de)
FI (1)	FI791286A (de)
FR (1)	FR2423495A1 (de)
GB (1)	GB2019396B (de)
GR (1)	GR69987B (de)
HU (1)	HU181431B (de)
IE (1)	IE48213B1 (de)
IL (1)	IL57168A (de)
LU (1)	LU81166A1 (de)
NZ (1)	NZ190213A (de)
PH (1)	PH14163A (de)
PL (3)	PL119416B1 (de)
PT (1)	PT69496A (de)
RO (3)	RO81114A (de)
SU (3)	SU1225490A3 (de)
YU (1)	YU93179A (de)
ZA (1)	ZA791856B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
GR79898B (de) *	1983-03-30	1984-10-31	Lilly Industries Ltd
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
DE60231868D1 (de)	2001-04-24	2009-05-20	Purdue Research Foundation	Folat-mimetika und deren folatrezeptorbindende konjugate
AU2003243226A1 (en) *	2002-05-15	2003-12-02	Endocyte, Inc.	Vitamin-mitomycin conjugates
EP2529758A3 (de)	2003-01-27	2013-01-02	Endocyte, Inc.	Vitaminrezeptorbindende Wirkstofffreisetzungskonjugate
WO2006012527A1 (en)	2004-07-23	2006-02-02	Endocyte, Inc.	Bivalent linkers and conjugates thereof
US8044200B2 (en) *	2005-03-16	2011-10-25	Endocyte, Inc.	Synthesis and purification of pteroic acid and conjugates thereof
EP2382995A3 (de)	2005-08-19	2013-09-25	Endocyte, Inc.	Ligandenkonjugate von Vincaalkaloiden, Analoga und Derivaten
CN103893779A (zh)	2005-08-19	2014-07-02	恩多塞特公司	多药物配体缀合物
WO2008100591A2 (en) *	2007-02-14	2008-08-21	The General Hospital Corporation	Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en)	2007-02-16	2008-08-21	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
CA2680535C (en) *	2007-03-14	2016-09-20	Endocyte, Inc.	Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
WO2009002993A1 (en)	2007-06-25	2008-12-31	Endocyte, Inc.	Conjugates containing hydrophilic spacer linkers
AU2008316835B2 (en) *	2007-10-25	2015-07-16	Endocyte, Inc.	Tubulysins and processes for preparing
ES2574032T3 (es) *	2009-09-07	2016-06-14	Nipro Patch Co., Ltd.	Preparación absorbible por vía transdérmica
WO2013126797A1 (en)	2012-02-24	2013-08-29	Purdue Research Foundation	Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
WO2014062697A2 (en)	2012-10-16	2014-04-24	Endocyte, Inc.	Drug delivery conjugates containing unnatural amino acids and methods for using

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-18 EP EP79300638A patent/EP0005051B1/de not_active Expired
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 FI FI791286A patent/FI791286A/fi not_active Application Discontinuation
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-20 BG BG7943323A patent/BG33294A3/xx unknown
- 1979-04-20 BG BG8256470A patent/BG33297A3/xx unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 BG BG8256469A patent/BG33296A3/xx unknown
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
YU93179A (en)	1983-01-21
RO81037A (ro)	1983-02-01
GR69987B (de)	1982-07-22
RO81114B (ro)	1983-01-30
RO81114A (ro)	1983-02-01
CA1097629A (en)	1981-03-17
ATA291279A (de)	1982-04-15
HU181431B (en)	1983-07-28
CS218583B2 (en)	1983-02-25
IL57168A0 (en)	1979-07-25
AU4609779A (en)	1979-10-25
AU527109B2 (en)	1983-02-17
CS218585B2 (en)	1983-02-25
GB2019396B (en)	1982-09-15
IL57168A (en)	1983-10-31
GB2019396A (en)	1979-10-31
RO80084A (ro)	1983-02-01
BG33294A3 (en)	1983-01-14
PL119416B1 (en)	1981-12-31
FR2423495B1 (de)	1983-02-11
RO80084B (ro)	1983-01-30
PH14163A (en)	1981-03-19
RO81037B (ro)	1983-01-30
JPS6245873B2 (de)	1987-09-29
FR2423495A1 (fr)	1979-11-16
DK147484C (da)	1985-03-25
FI791286A (fi)	1979-10-21
IE48213B1 (en)	1984-10-31
BE875652A (fr)	1979-10-18
CS218584B2 (en)	1983-02-25
DK160679A (da)	1979-10-21
ES479754A1 (es)	1980-08-16
AT369010B (de)	1982-11-25
PL125470B1 (en)	1983-05-31
DK147484B (da)	1984-08-27
EP0005051B1 (de)	1982-12-01
EG14867A (en)	1986-09-30
DD143075A5 (de)	1980-07-30
PT69496A (en)	1979-05-01
AR228940A1 (es)	1983-05-13
BG33297A3 (en)	1983-01-14
ZA791856B (en)	1980-11-26
BG33296A3 (en)	1983-01-14
CH643269A5 (fr)	1984-05-30
SU1061698A3 (ru)	1983-12-15
NZ190213A (en)	1982-12-21
LU81166A1 (fr)	1979-09-07
PL215911A1 (de)	1980-03-24
JPS54141798A (en)	1979-11-05
SU1225490A3 (ru)	1986-04-15
US4166810A (en)	1979-09-04
ES479753A1 (es)	1980-08-16
SU893135A3 (ru)	1981-12-23
EP0005051A1 (de)	1979-10-31
IE790795L (en)	1979-10-20

Legal Events

Date	Code	Title	Description
1991-01-31	8328	Change in the person/name/address of the agent	Free format text: SPOTT, G., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN
1992-05-07	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE2964130D1 (en)	1983-01-05	4-desacetyl vlb c-3 carboxhydrazides, their preparation and formulations containing them
IL56578A0 (en)	1979-05-31	Quinazoline derivatives,their preparation and phapmaceuticcal compositions containing them
IL56774A0 (en)	1979-05-31	Arylsulfamates,their preparation and their use as hermicid
IL56992A (en)	1983-03-31	N-heterocyclyl-4-piperidinamines,their preparation and pharmaceutical compositions containing them
IL60138A0 (en)	1980-07-31	Novel 3-thiovinyl-cephalosporins,their preparation and compositions containing them
IL57801A0 (en)	1979-11-30	Fluorovitamin d compounds and their preparation
MY8500596A (en)	1985-12-31	Phenethandlamines, their formulations, preparation and use
PT70045A (en)	1979-09-01	Aerosol preparation
DE2965287D1 (en)	1983-06-01	Bis-imidazoles, their preparation and pharmaceutical compositions containing them
IL58415A (en)	1982-11-30	Substituted octahydro-7-phenylquinolizines,their manufacture and pharmaceutical compositions containing them
ZA803886B (en)	1981-06-24	Tripeptides, their preparation and compositions containing them
IL57891A (en)	1983-09-30	Alkylthiophenoxyalkylamines,their preparation and pharmaceutical compositions containing them
IL56686A0 (en)	1979-05-31	Acylaminoalkyl-syanoguanidines,their preparation and pharmaceutical compositions containing them
DE2967095D1 (en)	1984-08-09	Phenyliminomethyl-3-pyridine derivatives, their preparation and use
ZA794295B (en)	1980-08-27	Beta-lamtam compounds,their preparation and use
IL57754A0 (en)	1979-11-30	Benzopyranotriazoles,their preparation and pharmaceutical compositions containing them
JPS5455763A (en)	1979-05-04	Drink composition
IL56728A (en)	1981-11-30	Androstadienes,their preparation and pharmaceutical compositions containing them
IL56512A0 (en)	1979-03-12	Anilide derivatives, their preparation and plant-microbicidal compositions containing them
IL56615A (en)	1982-01-31	N-azolylalkyl-anilines and their preparation
HK12384A (en)	1984-02-24	Novel veratramides,their preparation and pharmaceutical compositions containing them
PH15477A (en)	1983-01-27	R-n-(2-phenyl-2-hydroxymethylo)-3-phenylpropylamines and formulations
GB2024818B (en)	1982-12-01	Phenathrenederivatives, their preparation and pharmaceutical compositions containing them
IL57300A (en)	1983-06-15	Arylalkyl-and aryloxyalkylphosphonates,their preparation and antiviral compositions containing them
IL56962A (en)	1983-03-31	Substituted n-iminomethyl-piperidines,their preparation and pharmaceutical compositions containing them