DK160679A - Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid - Google Patents

Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid

Info

Publication number: DK160679A
Authority: DK; Denmark
Prior art keywords: desacethyl; vincaleucoblastin; preparing; carboxhydrazide; derivatives
Prior art date: 1978-04-20

Application number

DK160679A

Other languages

English (en)

Other versions

DK147484C (da

DK147484B (da

Inventor

G J Cullinan

K Gerzon

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-19

Publication date

1979-10-21

1979-04-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1979-10-21 Publication of DK160679A publication Critical patent/DK160679A/da

1983-01-14 Priority to DK13983A priority Critical patent/DK148655C/da

1983-01-14 Priority to DK14083A priority patent/DK148510C/da

1984-08-27 Publication of DK147484B publication Critical patent/DK147484B/da

1985-03-25 Application granted granted Critical

1985-03-25 Publication of DK147484C publication Critical patent/DK147484C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK160679A 1978-04-20 1979-04-19 Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid DK147484C (da)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
DK13983A DK148655C (da)	1978-04-20	1983-01-14	Analogifremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid
DK14083A DK148510C (da)	1978-04-20	1983-01-14	Analogifremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US89903278		1978-04-20
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (3)

Publication Number	Publication Date
DK160679A true DK160679A (da)	1979-10-21
DK147484B DK147484B (da)	1984-08-27
DK147484C DK147484C (da)	1985-03-25

Family

ID=25410402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK160679A DK147484C (da)	1978-04-20	1979-04-19	Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid

Country Status (32)

Country	Link
US (1)	US4166810A (da)
EP (1)	EP0005051B1 (da)
JP (1)	JPS54141798A (da)
AR (1)	AR228940A1 (da)
AT (1)	AT369010B (da)
AU (1)	AU527109B2 (da)
BE (1)	BE875652A (da)
BG (3)	BG33296A3 (da)
CA (1)	CA1097629A (da)
CH (1)	CH643269A5 (da)
CS (3)	CS218583B2 (da)
DD (1)	DD143075A5 (da)
DE (1)	DE2964130D1 (da)
DK (1)	DK147484C (da)
EG (1)	EG14867A (da)
ES (2)	ES479754A1 (da)
FI (1)	FI791286A (da)
FR (1)	FR2423495A1 (da)
GB (1)	GB2019396B (da)
GR (1)	GR69987B (da)
HU (1)	HU181431B (da)
IE (1)	IE48213B1 (da)
IL (1)	IL57168A (da)
LU (1)	LU81166A1 (da)
NZ (1)	NZ190213A (da)
PH (1)	PH14163A (da)
PL (3)	PL125470B1 (da)
PT (1)	PT69496A (da)
RO (3)	RO80084A (da)
SU (3)	SU1225490A3 (da)
YU (1)	YU93179A (da)
ZA (1)	ZA791856B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
EP0123441B1 (en) *	1983-03-30	1990-10-03	Lilly Industries Limited	Vincaleukoblastine derivatives
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
DE60231868D1 (de) *	2001-04-24	2009-05-20	Purdue Research Foundation	Folat-mimetika und deren folatrezeptorbindende konjugate
DE60326833D1 (de) *	2002-05-15	2009-05-07	Endocyte Inc	Vitamin-mitomycin-konjugate
EP2529758A3 (en)	2003-01-27	2013-01-02	Endocyte, Inc.	Vitamin receptor binding drug delivery conjugates
US8288557B2 (en)	2004-07-23	2012-10-16	Endocyte, Inc.	Bivalent linkers and conjugates thereof
US8044200B2 (en) *	2005-03-16	2011-10-25	Endocyte, Inc.	Synthesis and purification of pteroic acid and conjugates thereof
KR101364912B1 (ko) *	2005-08-19	2014-02-21	엔도사이트, 인코포레이티드	복수-약제 리간드 공액체
WO2007022493A2 (en)	2005-08-19	2007-02-22	Endocyte, Inc.	Ligand conjugates of vinca alkaloids, analogs, and derivatives
WO2008100591A2 (en) *	2007-02-14	2008-08-21	The General Hospital Corporation	Modulation of nitric oxide signaling to normalize tumor vasculature
US20100104626A1 (en) *	2007-02-16	2010-04-29	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
NZ580132A (en) *	2007-03-14	2012-11-30	Endocyte Inc	Binding ligand linked drug delivery conjugates of tubulysins to vitamins
AU2008268432B2 (en) *	2007-06-25	2015-01-15	Endocyte, Inc.	Conjugates containing hydrophilic spacer linkers
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
EP2209374B1 (en) *	2007-10-25	2014-12-03	Endocyte, Inc.	Tubulysins and processes for preparing
RU2543639C2 (ru) *	2009-09-07	2015-03-10	Нипро Пэтч Ко., Лтд.	Чрескожно всасывающийся препарат
WO2013126797A1 (en)	2012-02-24	2013-08-29	Purdue Research Foundation	Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
CA2887727A1 (en)	2012-10-16	2014-04-24	Endocyte, Inc.	Drug delivery conjugates containing unnatural amino acids and methods for using

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en)	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 EP EP79300638A patent/EP0005051B1/en not_active Expired
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 FI FI791286A patent/FI791286A/fi not_active Application Discontinuation
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-20 BG BG8256469A patent/BG33296A3/xx unknown
- 1979-04-20 BG BG7943323A patent/BG33294A3/xx unknown
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-20 BG BG8256470A patent/BG33297A3/xx unknown
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
IE790795L (en)	1979-10-20
PL215911A1 (da)	1980-03-24
CS218584B2 (en)	1983-02-25
FR2423495B1 (da)	1983-02-11
BG33294A3 (en)	1983-01-14
RO80084B (ro)	1983-01-30
YU93179A (en)	1983-01-21
IL57168A (en)	1983-10-31
LU81166A1 (fr)	1979-09-07
HU181431B (en)	1983-07-28
IE48213B1 (en)	1984-10-31
PL125470B1 (en)	1983-05-31
NZ190213A (en)	1982-12-21
SU893135A3 (ru)	1981-12-23
ES479754A1 (es)	1980-08-16
BE875652A (fr)	1979-10-18
PL119416B1 (en)	1981-12-31
US4166810A (en)	1979-09-04
ES479753A1 (es)	1980-08-16
FI791286A (fi)	1979-10-21
EP0005051B1 (en)	1982-12-01
EP0005051A1 (en)	1979-10-31
SU1225490A3 (ru)	1986-04-15
PT69496A (en)	1979-05-01
ZA791856B (en)	1980-11-26
AT369010B (de)	1982-11-25
CS218583B2 (en)	1983-02-25
RO80084A (ro)	1983-02-01
RO81037A (ro)	1983-02-01
JPS6245873B2 (da)	1987-09-29
SU1061698A3 (ru)	1983-12-15
DK147484C (da)	1985-03-25
RO81037B (ro)	1983-01-30
RO81114B (ro)	1983-01-30
AU527109B2 (en)	1983-02-17
BG33296A3 (en)	1983-01-14
BG33297A3 (en)	1983-01-14
ATA291279A (de)	1982-04-15
FR2423495A1 (fr)	1979-11-16
DD143075A5 (de)	1980-07-30
IL57168A0 (en)	1979-07-25
CA1097629A (en)	1981-03-17
GR69987B (da)	1982-07-22
EG14867A (en)	1986-09-30
CS218585B2 (en)	1983-02-25
AR228940A1 (es)	1983-05-13
GB2019396A (en)	1979-10-31
CH643269A5 (fr)	1984-05-30
JPS54141798A (en)	1979-11-05
AU4609779A (en)	1979-10-25
DE2964130D1 (en)	1983-01-05
RO81114A (ro)	1983-02-01
PH14163A (en)	1981-03-19
DK147484B (da)	1984-08-27
GB2019396B (en)	1982-09-15

Legal Events

Date	Code	Title	Description
1995-11-27	PBP	Patent lapsed

Publication	Publication Date	Title
DK377079A (da)	1980-03-12	Fremgangsmaade til fremstilling af 4-anilinoquinazolinderivater
DK160679A (da)	1979-10-21	Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid
DK251079A (da)	1979-12-21	Fremgangsmaade til fremstilling af phenylpiperazinderivater
DK140480A (da)	1980-10-03	Fremgangsmaade til fremstilling af mercaptoacyldipeptider
DK229980A (da)	1980-11-30	Fremgangsmaade til fremstilling af n-heterocyclyl-thienamyciner
DK520679A (da)	1980-06-09	Fremgangsmaade til fremstilling af 3-quinolincarboxulsyrederivater
DK156253C (da)	1989-12-11	Fremgangsmaade til fremstilling af pyruvatoxidase
DK70979A (da)	1979-08-22	Fremgangsmaade til fremstilling af phthalocyaninpigmeneter
DK366379A (da)	1980-03-02	Fremgangsmaade til fremstilling af alkyl-eller arylthiomethylphenoler
DK232080A (da)	1980-12-01	Fremgangsmaade til fremstilling af hydroxyaminoeburnanderivater
DK152752C (da)	1988-09-26	Fremgangsmaade til fremstilling af l-sulpirid
DK300781A (da)	1981-07-07	Fremgangsmaade til fremstilling af halogenfenylpyridyllylamin-derivater
DK87079A (da)	1979-09-03	Fremgangsmaade til fremstilling af dialkylphospohorchloridothioter
DK226579A (da)	1979-12-09	Fremgangsmaade til fremstilling af metaboliter
DK36379A (da)	1979-07-31	Fremgangsmaade til fremstilling af n-ethylethylendiamin
DK172779A (da)	1979-10-29	Fremgangsmaade til fremstilling af cyklopropanderivater
DK183880A (da)	1980-10-31	Fremgangsmaade til fremstilling af hydroxyderivater af isopropyrimidin
DK143107C (da)	1981-11-09	Fremgangsmaade til fremstilling af 2-isopropylaminopyrimidin
DK147420C (da)	1985-02-18	Fremgangsmaade til fremstilling af acylcyanider
DK341980A (da)	1981-02-10	Fremgangsmaade til fremstilling af 2-isopropylaminopyrimidin
DK144280A (da)	1980-10-07	Fremgangsmaade til fremstilling af 2-aminopyraziner
DK195979A (da)	1979-11-13	Fremgangsmaade til fremstilling af d-homosteroider
DK160294C (da)	1991-08-05	Fremgangsmaade til fremstilling af 3-oxycyclopentener
DK335479A (da)	1980-02-12	Fremgangsmaade til fremstilling af oligomere af pyridocarbazoler
DK150822C (da)	1988-01-25	Framgangsmaade til fremstilling af cis-2-phenyl-bicyclooctylaminer