YU93179A - Process for obtaining 4-deacetyl-vinca-leublastin c-3-carboxhydrazide - Google Patents

Process for obtaining 4-deacetyl-vinca-leublastin c-3-carboxhydrazide

Info

Publication number: YU93179A
Authority: YU; Yugoslavia
Prior art keywords: leublastin; carboxhydrazide; deacetyl; vinca; obtaining
Prior art date: 1978-04-20

Application number

YU00931/79A

Other languages

English (en)

Inventor

J G Cullinan

K Gerzon

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-18

Publication date

1983-01-21

1979-04-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1983-01-21 Publication of YU93179A publication Critical patent/YU93179A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

YU00931/79A 1978-04-20 1979-04-18 Process for obtaining 4-deacetyl-vinca-leublastin c-3-carboxhydrazide YU93179A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number	Publication Date
YU93179A true YU93179A (en)	1983-01-21

Family

ID=25410402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU00931/79A YU93179A (en)	1978-04-20	1979-04-18	Process for obtaining 4-deacetyl-vinca-leublastin c-3-carboxhydrazide

Country Status (32)

Country	Link
US (1)	US4166810A (xx)
EP (1)	EP0005051B1 (xx)
JP (1)	JPS54141798A (xx)
AR (1)	AR228940A1 (xx)
AT (1)	AT369010B (xx)
AU (1)	AU527109B2 (xx)
BE (1)	BE875652A (xx)
BG (3)	BG33294A3 (xx)
CA (1)	CA1097629A (xx)
CH (1)	CH643269A5 (xx)
CS (3)	CS218585B2 (xx)
DD (1)	DD143075A5 (xx)
DE (1)	DE2964130D1 (xx)
DK (1)	DK147484C (xx)
EG (1)	EG14867A (xx)
ES (2)	ES479753A1 (xx)
FI (1)	FI791286A (xx)
FR (1)	FR2423495A1 (xx)
GB (1)	GB2019396B (xx)
GR (1)	GR69987B (xx)
HU (1)	HU181431B (xx)
IE (1)	IE48213B1 (xx)
IL (1)	IL57168A (xx)
LU (1)	LU81166A1 (xx)
NZ (1)	NZ190213A (xx)
PH (1)	PH14163A (xx)
PL (3)	PL119416B1 (xx)
PT (1)	PT69496A (xx)
RO (3)	RO81114A (xx)
SU (3)	SU1225490A3 (xx)
YU (1)	YU93179A (xx)
ZA (1)	ZA791856B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
GR79898B (xx) *	1983-03-30	1984-10-31	Lilly Industries Ltd
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
DE60231868D1 (de)	2001-04-24	2009-05-20	Purdue Research Foundation	Folat-mimetika und deren folatrezeptorbindende konjugate
AU2003243226A1 (en) *	2002-05-15	2003-12-02	Endocyte, Inc.	Vitamin-mitomycin conjugates
EP2529758A3 (en)	2003-01-27	2013-01-02	Endocyte, Inc.	Vitamin receptor binding drug delivery conjugates
WO2006012527A1 (en)	2004-07-23	2006-02-02	Endocyte, Inc.	Bivalent linkers and conjugates thereof
US8044200B2 (en) *	2005-03-16	2011-10-25	Endocyte, Inc.	Synthesis and purification of pteroic acid and conjugates thereof
EP2382995A3 (en)	2005-08-19	2013-09-25	Endocyte, Inc.	Ligand conjugates of Vinca alkaloids, analogs and derivatives
CN103893779A (zh)	2005-08-19	2014-07-02	恩多塞特公司	多药物配体缀合物
WO2008100591A2 (en) *	2007-02-14	2008-08-21	The General Hospital Corporation	Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en)	2007-02-16	2008-08-21	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
CA2680535C (en) *	2007-03-14	2016-09-20	Endocyte, Inc.	Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
WO2009002993A1 (en)	2007-06-25	2008-12-31	Endocyte, Inc.	Conjugates containing hydrophilic spacer linkers
AU2008316835B2 (en) *	2007-10-25	2015-07-16	Endocyte, Inc.	Tubulysins and processes for preparing
ES2574032T3 (es) *	2009-09-07	2016-06-14	Nipro Patch Co., Ltd.	Preparación absorbible por vía transdérmica
WO2013126797A1 (en)	2012-02-24	2013-08-29	Purdue Research Foundation	Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
WO2014062697A2 (en)	2012-10-16	2014-04-24	Endocyte, Inc.	Drug delivery conjugates containing unnatural amino acids and methods for using

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-18 EP EP79300638A patent/EP0005051B1/en not_active Expired
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 FI FI791286A patent/FI791286A/fi not_active Application Discontinuation
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-20 BG BG7943323A patent/BG33294A3/xx unknown
- 1979-04-20 BG BG8256470A patent/BG33297A3/xx unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 BG BG8256469A patent/BG33296A3/xx unknown
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
RO81037A (ro)	1983-02-01
GR69987B (xx)	1982-07-22
RO81114B (ro)	1983-01-30
RO81114A (ro)	1983-02-01
CA1097629A (en)	1981-03-17
DE2964130D1 (en)	1983-01-05
ATA291279A (de)	1982-04-15
HU181431B (en)	1983-07-28
CS218583B2 (en)	1983-02-25
IL57168A0 (en)	1979-07-25
AU4609779A (en)	1979-10-25
AU527109B2 (en)	1983-02-17
CS218585B2 (en)	1983-02-25
GB2019396B (en)	1982-09-15
IL57168A (en)	1983-10-31
GB2019396A (en)	1979-10-31
RO80084A (ro)	1983-02-01
BG33294A3 (en)	1983-01-14
PL119416B1 (en)	1981-12-31
FR2423495B1 (xx)	1983-02-11
RO80084B (ro)	1983-01-30
PH14163A (en)	1981-03-19
RO81037B (ro)	1983-01-30
JPS6245873B2 (xx)	1987-09-29
FR2423495A1 (fr)	1979-11-16
DK147484C (da)	1985-03-25
FI791286A (fi)	1979-10-21
IE48213B1 (en)	1984-10-31
BE875652A (fr)	1979-10-18
CS218584B2 (en)	1983-02-25
DK160679A (da)	1979-10-21
ES479754A1 (es)	1980-08-16
AT369010B (de)	1982-11-25
PL125470B1 (en)	1983-05-31
DK147484B (da)	1984-08-27
EP0005051B1 (en)	1982-12-01
EG14867A (en)	1986-09-30
DD143075A5 (de)	1980-07-30
PT69496A (en)	1979-05-01
AR228940A1 (es)	1983-05-13
BG33297A3 (en)	1983-01-14
ZA791856B (en)	1980-11-26
BG33296A3 (en)	1983-01-14
CH643269A5 (fr)	1984-05-30
SU1061698A3 (ru)	1983-12-15
NZ190213A (en)	1982-12-21
LU81166A1 (fr)	1979-09-07
PL215911A1 (xx)	1980-03-24
JPS54141798A (en)	1979-11-05
SU1225490A3 (ru)	1986-04-15
US4166810A (en)	1979-09-04
ES479753A1 (es)	1980-08-16
SU893135A3 (ru)	1981-12-23
EP0005051A1 (en)	1979-10-31
IE790795L (en)	1979-10-20

Publication	Publication Date	Title
YU42191B (en)	1988-06-30	Process for preparing 2-chloro-6-nitroanilines
YU93179A (en)	1983-01-21	Process for obtaining 4-deacetyl-vinca-leublastin c-3-carboxhydrazide
GB2018816B (en)	1982-11-03	Process for preparing hexamethyltetrahydronaphthalenes
YU271582A (en)	1983-02-28	Process for obtaining new flavanes
PH19618A (en)	1986-05-30	Process for preparing -2-pyrrolidone
YU241279A (en)	1983-10-31	Process for obtaining 2-chlorosulfinyl-azetidine-4-one
YU227679A (en)	1983-06-30	Process for obtaining n-benzylhaloacetamide deriatives
YU198879A (en)	1982-08-31	New process for obtaining benzothiazyl-disulfide
GB2019835B (en)	1982-08-04	Process for preparing n-carbamoyl-d-thienylglycines
YU112279A (en)	1983-01-21	Process for obtaining substituted dibenzylethers
YU86879A (en)	1983-10-31	Process for obtaining 17-beta-carboxy-5-androstane-3-one
DE2960047D1 (en)	1981-02-05	Process for preparing 2-oximinophenylacetonitrile
DE2961058D1 (en)	1981-12-24	Process for preparing alpha-chloro-n-monoalkyl-acetoacetamides
YU86978A (en)	1982-08-31	Process for preparing 6-deoxy-5-hydroxy-tetracycline
YU219379A (en)	1983-02-28	Process for obtaining new 1-benzoyl-3-thiosemicarbazide
YU304478A (en)	1983-02-28	Process for obtaining chloro-acetanilides
YU258179A (en)	1983-01-21	New process for obtaining benzothiazole-sulfenamide
YU105179A (en)	1982-10-31	Process for obtaining new deoxyanthracyclins
YU40533B (en)	1986-02-28	Process for preparing 2-bromoergosinine
YU134179A (en)	1983-01-21	Process for obtaining n-phenethylimidazole deivatives
DE2964629D1 (en)	1983-03-03	Process for preparing 3-amino-5-t-butylisoxazole
YU169879A (en)	1983-04-30	Process for obtaining cis-bicyclooctyl-amine
YU41345B (en)	1987-02-28	Process for obtaining chloroambucial
DE2963897D1 (en)	1982-11-25	Process for preparing sodium-m-nitrobenzenesulfonate
PT69287A (en)	1979-03-01	Process for preparing benzocycloheptapyrans