CS218584B2 - Process for production of c3- carboxyhydrazides c4-diacetylvinkaleukoblastime - Google Patents

Process for production of c3- carboxyhydrazides c4-diacetylvinkaleukoblastime Download PDF

Info

Publication number: CS218584B2
Authority: CS; Czechoslovakia
Prior art keywords: vlb; reacted; group; carboxazide; compounds
Prior art date: 1978-04-20

Application number

CS807545A

Other languages

Czech (cs)

English (en)

Inventor

George J Culliman

Koert Gerzon

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-19

Publication date

1983-02-25

1979-04-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1983-02-25 Publication of CS218584B2 publication Critical patent/CS218584B2/cs

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

CS807545A 1978-04-20 1979-04-19 Process for production of c3- carboxyhydrazides c4-diacetylvinkaleukoblastime CS218584B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number	Publication Date
CS218584B2 true CS218584B2 (en)	1983-02-25

Family

ID=25410402

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
CS792678A CS218583B2 (en)	1978-04-20	1979-04-19	Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine
CS807546A CS218585B2 (en)	1978-04-20	1979-04-19	Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine
CS807545A CS218584B2 (en)	1978-04-20	1979-04-19	Process for production of c3- carboxyhydrazides c4-diacetylvinkaleukoblastime

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
CS792678A CS218583B2 (en)	1978-04-20	1979-04-19	Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine
CS807546A CS218585B2 (en)	1978-04-20	1979-04-19	Method of making the c3-carboxhydrazides 4-deacetylvinkaleukoblastine

Country Status (32)

Country	Link
US (1)	US4166810A (ro)
EP (1)	EP0005051B1 (ro)
JP (1)	JPS54141798A (ro)
AR (1)	AR228940A1 (ro)
AT (1)	AT369010B (ro)
AU (1)	AU527109B2 (ro)
BE (1)	BE875652A (ro)
BG (3)	BG33294A3 (ro)
CA (1)	CA1097629A (ro)
CH (1)	CH643269A5 (ro)
CS (3)	CS218583B2 (ro)
DD (1)	DD143075A5 (ro)
DE (1)	DE2964130D1 (ro)
DK (1)	DK147484C (ro)
EG (1)	EG14867A (ro)
ES (2)	ES479754A1 (ro)
FI (1)	FI791286A (ro)
FR (1)	FR2423495A1 (ro)
GB (1)	GB2019396B (ro)
GR (1)	GR69987B (ro)
HU (1)	HU181431B (ro)
IE (1)	IE48213B1 (ro)
IL (1)	IL57168A (ro)
LU (1)	LU81166A1 (ro)
NZ (1)	NZ190213A (ro)
PH (1)	PH14163A (ro)
PL (3)	PL119416B1 (ro)
PT (1)	PT69496A (ro)
RO (3)	RO80084A (ro)
SU (3)	SU893135A3 (ro)
YU (1)	YU93179A (ro)
ZA (1)	ZA791856B (ro)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
EP0123441B1 (en) *	1983-03-30	1990-10-03	Lilly Industries Limited	Vincaleukoblastine derivatives
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
EP1389209B1 (en) *	2001-04-24	2009-04-08	Purdue Research Foundation	Folate mimetics and folate-receptor binding conjugates thereof
JP4814520B2 (ja) *	2002-05-15	2011-11-16	エンドサイト，インコーポレイテッド	ビタミン−マイトマイシン結合体
NZ541846A (en)	2003-01-27	2008-12-24	Endocyte Inc	Vitamin receptor binding drug delivery conjugates
US8288557B2 (en) *	2004-07-23	2012-10-16	Endocyte, Inc.	Bivalent linkers and conjugates thereof
US8044200B2 (en) *	2005-03-16	2011-10-25	Endocyte, Inc.	Synthesis and purification of pteroic acid and conjugates thereof
CN103893778A (zh)	2005-08-19	2014-07-02	恩多塞特公司	多药物配体缀合物
WO2007022493A2 (en)	2005-08-19	2007-02-22	Endocyte, Inc.	Ligand conjugates of vinca alkaloids, analogs, and derivatives
WO2008100591A2 (en) *	2007-02-14	2008-08-21	The General Hospital Corporation	Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en)	2007-02-16	2008-08-21	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
EP2489372A3 (en) *	2007-03-14	2013-01-02	Endocyte, Inc.	Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
CN104383553A (zh) *	2007-06-25	2015-03-04	恩多塞特公司	含有亲水性间隔区接头的共轭物
WO2009055562A1 (en) *	2007-10-25	2009-04-30	Endocyte, Inc.	Tubulysins and processes for preparing
EP2476414B1 (en) *	2009-09-07	2015-03-04	NIPRO Patch Co., Ltd.	Transdermally absorbable preparation
WO2013126797A1 (en)	2012-02-24	2013-08-29	Purdue Research Foundation	Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
JP2015536323A (ja)	2012-10-16	2015-12-21	エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ，Ｉｎｃ．	非天然アミノ酸を含む薬物送達結合体および使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-18 EP EP79300638A patent/EP0005051B1/en not_active Expired
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 FI FI791286A patent/FI791286A/fi not_active Application Discontinuation
- 1979-04-20 BG BG7943323A patent/BG33294A3/xx unknown
- 1979-04-20 BG BG8256470A patent/BG33297A3/xx unknown
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-20 BG BG8256469A patent/BG33296A3/xx unknown
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
YU93179A (en)	1983-01-21
CA1097629A (en)	1981-03-17
FR2423495A1 (fr)	1979-11-16
DK147484C (da)	1985-03-25
IL57168A0 (en)	1979-07-25
BG33294A3 (en)	1983-01-14
PL125470B1 (en)	1983-05-31
CH643269A5 (fr)	1984-05-30
GB2019396B (en)	1982-09-15
CS218583B2 (en)	1983-02-25
IE48213B1 (en)	1984-10-31
PH14163A (en)	1981-03-19
PL215911A1 (ro)	1980-03-24
RO81114B (ro)	1983-01-30
JPS6245873B2 (ro)	1987-09-29
FI791286A (fi)	1979-10-21
LU81166A1 (fr)	1979-09-07
SU1225490A3 (ru)	1986-04-15
BE875652A (fr)	1979-10-18
AU527109B2 (en)	1983-02-17
US4166810A (en)	1979-09-04
AU4609779A (en)	1979-10-25
CS218585B2 (en)	1983-02-25
EG14867A (en)	1986-09-30
HU181431B (en)	1983-07-28
ES479753A1 (es)	1980-08-16
RO81037B (ro)	1983-01-30
PL119416B1 (en)	1981-12-31
GB2019396A (en)	1979-10-31
DD143075A5 (de)	1980-07-30
PT69496A (en)	1979-05-01
AT369010B (de)	1982-11-25
RO81037A (ro)	1983-02-01
GR69987B (ro)	1982-07-22
SU893135A3 (ru)	1981-12-23
RO80084A (ro)	1983-02-01
IL57168A (en)	1983-10-31
ATA291279A (de)	1982-04-15
DE2964130D1 (en)	1983-01-05
EP0005051A1 (en)	1979-10-31
RO80084B (ro)	1983-01-30
NZ190213A (en)	1982-12-21
BG33297A3 (en)	1983-01-14
FR2423495B1 (ro)	1983-02-11
AR228940A1 (es)	1983-05-13
EP0005051B1 (en)	1982-12-01
DK160679A (da)	1979-10-21
ES479754A1 (es)	1980-08-16
DK147484B (da)	1984-08-27
SU1061698A3 (ru)	1983-12-15
BG33296A3 (en)	1983-01-14
ZA791856B (en)	1980-11-26
JPS54141798A (en)	1979-11-05
RO81114A (ro)	1983-02-01
IE790795L (en)	1979-10-20

Publication	Publication Date	Title
CS218584B2 (en)	1983-02-25	Process for production of c3- carboxyhydrazides c4-diacetylvinkaleukoblastime
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Li et al.	2013	A functional scaffold in marine alkaloid: An anticancer moiety for human
CA1082179A (en)	1980-07-22	Amide derivatives of vlb, leurosidine, leurocristine and related dimeric alkaloids
US4096148A (en)	1978-06-20	Oxazolidinedione derivatives of Vinca alkaloids
GB2196006A (en)	1988-04-20	Preparation of mitomycin derivatives
KR820001240B1 (ko)	1982-07-07	4-데스 아세틸 vlb c-3카복스하이드라지드의 항종양 유도체 제조방법
USRE30560E (en)	1981-03-31	Oxazolidinedione derivatives of Vinca alkaloids
KR810000494B1 (ko)	1981-05-20	빈카 알카로이드의 옥사졸리딘 디온 유도체의 제조방법
Mohi El-Deen et al.	2023	Synthesis and Biological Evaluation of Some New Thieno [2, 3-b] pyridine-based Compounds As Antimicrobial and Anticancer Agents
CS214792B2 (en)	1982-05-28	Method of making the dimeric compounds of indol-dihydroindole derivatives genus vinca connected by the bridge
EP0205168B1 (en)	1990-12-12	Furfuryl derivatives of vinblastine-type bis-indoles, a process for preparing same and pharmaceutical compositions containing them
KR820001241B1 (ko)	1982-07-07	4-데스아세틸 vlb c-3카복스하이드라지드의 항종양유도체 제조방법
KR810001453B1 (ko)	1981-10-22	인돌-디하이드로인돌 카복스 아마이드 이량체의 제조방법
DK148510B (da)	1985-07-22	Analogifremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid
KR790000810B1 (ko)	1979-07-12	빈브라스틴 유도체의 제조방법
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Rizk et al.	0	NSC 2382
CS214794B2 (cs)	1982-05-28	Způsob výroby poloamidů dimerních indol-dihydroindolových derivátů z rodu Vinca, spojených můstkem
JPS6153360B2 (ro)	1986-11-17
PL90467B1 (ro)	1977-01-31