AR228940A1 - Procedimiento para preparar derivados de 4-desacetil vlb c-3 carboxi-hidrazida - Google Patents

Procedimiento para preparar derivados de 4-desacetil vlb c-3 carboxi-hidrazida

Info

Publication number: AR228940A1
Authority: AR; Argentina
Prior art keywords: desacetile; carboxi; vlb; hydrazide; procedure
Prior art date: 1978-04-20

Application number

AR276248A

Other languages

English (en)

Spanish (es)

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-20

Publication date

1983-05-13

1979-04-20 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1983-05-13 Application granted granted Critical

1983-05-13 Publication of AR228940A1 publication Critical patent/AR228940A1/es

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AR276248A 1978-04-20 1979-04-20 Procedimiento para preparar derivados de 4-desacetil vlb c-3 carboxi-hidrazida AR228940A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Publications (1)

Publication Number	Publication Date
AR228940A1 true AR228940A1 (es)	1983-05-13

Family

ID=25410402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AR276248A AR228940A1 (es)	1978-04-20	1979-04-20	Procedimiento para preparar derivados de 4-desacetil vlb c-3 carboxi-hidrazida

Country Status (32)

Country	Link
US (1)	US4166810A (ro)
EP (1)	EP0005051B1 (ro)
JP (1)	JPS54141798A (ro)
AR (1)	AR228940A1 (ro)
AT (1)	AT369010B (ro)
AU (1)	AU527109B2 (ro)
BE (1)	BE875652A (ro)
BG (3)	BG33294A3 (ro)
CA (1)	CA1097629A (ro)
CH (1)	CH643269A5 (ro)
CS (3)	CS218583B2 (ro)
DD (1)	DD143075A5 (ro)
DE (1)	DE2964130D1 (ro)
DK (1)	DK147484C (ro)
EG (1)	EG14867A (ro)
ES (2)	ES479754A1 (ro)
FI (1)	FI791286A (ro)
FR (1)	FR2423495A1 (ro)
GB (1)	GB2019396B (ro)
GR (1)	GR69987B (ro)
HU (1)	HU181431B (ro)
IE (1)	IE48213B1 (ro)
IL (1)	IL57168A (ro)
LU (1)	LU81166A1 (ro)
NZ (1)	NZ190213A (ro)
PH (1)	PH14163A (ro)
PL (3)	PL119416B1 (ro)
PT (1)	PT69496A (ro)
RO (3)	RO80084A (ro)
SU (3)	SU893135A3 (ro)
YU (1)	YU93179A (ro)
ZA (1)	ZA791856B (ro)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
EP0123441B1 (en) *	1983-03-30	1990-10-03	Lilly Industries Limited	Vincaleukoblastine derivatives
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
EP1389209B1 (en) *	2001-04-24	2009-04-08	Purdue Research Foundation	Folate mimetics and folate-receptor binding conjugates thereof
JP4814520B2 (ja) *	2002-05-15	2011-11-16	エンドサイト，インコーポレイテッド	ビタミン−マイトマイシン結合体
NZ541846A (en)	2003-01-27	2008-12-24	Endocyte Inc	Vitamin receptor binding drug delivery conjugates
US8288557B2 (en) *	2004-07-23	2012-10-16	Endocyte, Inc.	Bivalent linkers and conjugates thereof
US8044200B2 (en) *	2005-03-16	2011-10-25	Endocyte, Inc.	Synthesis and purification of pteroic acid and conjugates thereof
CN103893778A (zh)	2005-08-19	2014-07-02	恩多塞特公司	多药物配体缀合物
WO2007022493A2 (en)	2005-08-19	2007-02-22	Endocyte, Inc.	Ligand conjugates of vinca alkaloids, analogs, and derivatives
WO2008100591A2 (en) *	2007-02-14	2008-08-21	The General Hospital Corporation	Modulation of nitric oxide signaling to normalize tumor vasculature
WO2008101231A2 (en)	2007-02-16	2008-08-21	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
EP2489372A3 (en) *	2007-03-14	2013-01-02	Endocyte, Inc.	Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
CN104383553A (zh) *	2007-06-25	2015-03-04	恩多塞特公司	含有亲水性间隔区接头的共轭物
WO2009055562A1 (en) *	2007-10-25	2009-04-30	Endocyte, Inc.	Tubulysins and processes for preparing
EP2476414B1 (en) *	2009-09-07	2015-03-04	NIPRO Patch Co., Ltd.	Transdermally absorbable preparation
WO2013126797A1 (en)	2012-02-24	2013-08-29	Purdue Research Foundation	Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
JP2015536323A (ja)	2012-10-16	2015-12-21	エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ，Ｉｎｃ．	非天然アミノ酸を含む薬物送達結合体および使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-18 EP EP79300638A patent/EP0005051B1/en not_active Expired
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-18 RO RO7997290A patent/RO80084A/ro unknown
- 1979-04-18 RO RO79102377A patent/RO81037A/ro unknown
- 1979-04-18 BE BE1/9358A patent/BE875652A/xx unknown
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 LU LU81166A patent/LU81166A1/xx unknown
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 RO RO79102376A patent/RO81114A/ro unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 CA CA325,844A patent/CA1097629A/en not_active Expired
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 FI FI791286A patent/FI791286A/fi not_active Application Discontinuation
- 1979-04-20 BG BG7943323A patent/BG33294A3/xx unknown
- 1979-04-20 BG BG8256470A patent/BG33297A3/xx unknown
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-20 BG BG8256469A patent/BG33296A3/xx unknown
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
YU93179A (en)	1983-01-21
CA1097629A (en)	1981-03-17
FR2423495A1 (fr)	1979-11-16
DK147484C (da)	1985-03-25
IL57168A0 (en)	1979-07-25
BG33294A3 (en)	1983-01-14
PL125470B1 (en)	1983-05-31
CH643269A5 (fr)	1984-05-30
GB2019396B (en)	1982-09-15
CS218583B2 (en)	1983-02-25
IE48213B1 (en)	1984-10-31
PH14163A (en)	1981-03-19
PL215911A1 (ro)	1980-03-24
RO81114B (ro)	1983-01-30
JPS6245873B2 (ro)	1987-09-29
FI791286A (fi)	1979-10-21
LU81166A1 (fr)	1979-09-07
SU1225490A3 (ru)	1986-04-15
BE875652A (fr)	1979-10-18
AU527109B2 (en)	1983-02-17
US4166810A (en)	1979-09-04
AU4609779A (en)	1979-10-25
CS218585B2 (en)	1983-02-25
EG14867A (en)	1986-09-30
HU181431B (en)	1983-07-28
ES479753A1 (es)	1980-08-16
RO81037B (ro)	1983-01-30
PL119416B1 (en)	1981-12-31
GB2019396A (en)	1979-10-31
DD143075A5 (de)	1980-07-30
PT69496A (en)	1979-05-01
AT369010B (de)	1982-11-25
RO81037A (ro)	1983-02-01
CS218584B2 (en)	1983-02-25
GR69987B (ro)	1982-07-22
SU893135A3 (ru)	1981-12-23
RO80084A (ro)	1983-02-01
IL57168A (en)	1983-10-31
ATA291279A (de)	1982-04-15
DE2964130D1 (en)	1983-01-05
EP0005051A1 (en)	1979-10-31
RO80084B (ro)	1983-01-30
NZ190213A (en)	1982-12-21
BG33297A3 (en)	1983-01-14
FR2423495B1 (ro)	1983-02-11
EP0005051B1 (en)	1982-12-01
DK160679A (da)	1979-10-21
ES479754A1 (es)	1980-08-16
DK147484B (da)	1984-08-27
SU1061698A3 (ru)	1983-12-15
BG33296A3 (en)	1983-01-14
ZA791856B (en)	1980-11-26
JPS54141798A (en)	1979-11-05
RO81114A (ro)	1983-02-01
IE790795L (en)	1979-10-20

Publication	Publication Date	Title
AR228940A1 (es)	1983-05-13	Procedimiento para preparar derivados de 4-desacetil vlb c-3 carboxi-hidrazida
AR226847A1 (es)	1982-08-31	Procedimiento para preparar derivados de 1-benzimidazol
AR219150A1 (es)	1980-07-31	Procedimiento para preparar nuevos derivados de aminoazucares
ES494635A0 (es)	1981-08-16	Procedimiento de preparacion de derivados de tiadiazol
AR230270A1 (es)	1984-03-01	Procedimiento para preparar nuevos derivados de 2-alquiltio-3(-alcanoil alcoxicarbonil)-5-halogeno-6-fenoxi-bencimidazol substituidos
AR225143A1 (es)	1982-02-26	Procedimiento para preparar derivados de fenil-metil-hidantoina
ES487584A0 (es)	1981-02-16	Procedimiento para preparar nuevos derivados de pleuromuti- lin
ES497927A0 (es)	1982-05-01	Procedimiento para preparar derivados de dihidropiridina
AR222691A1 (es)	1981-06-15	Procedimiento de preparacion de derivados hidroxi-de 2-isopropilamino-pirimidina
MX6291E (es)	1985-03-18	Procedimiento para preparar derivados de n-bencilhalogenoacetamida
AR226446A1 (es)	1982-07-15	Procedimiento para preparar derivados de acidos fenilalcanoicos
AR226119A1 (es)	1982-05-31	Procedimiento para preparar derivados de 4-sulfamoilfenil-3-sustituido-2-fenil-imino-4-tiazolina
ES490061A0 (es)	1980-12-01	Procedimiento para preparar nuevos derivados de (piridil-2)-2-tetrahidrotiofeno
MX5826E (es)	1984-07-30	Procedimiento para la obtencion de derivados de fenilimino metil-piridina
AR224499A1 (es)	1981-12-15	Procedimiento para preparar esteres de derivados de aril-1 amino-2-alcoholes
ES494480A0 (es)	1981-09-01	Procedimiento para preparar nuevos derivados de cefalospori-na
ES486028A0 (es)	1980-11-01	Un procedimiento para preparar derivados de indol policiclicos
AR228020A1 (es)	1983-01-14	Procedimiento para preparar derivados de 2-benciliden-benzofuran-3-ona
ES499421A0 (es)	1982-12-16	Procedimiento para preparar derivados de indano
AR223177A1 (es)	1981-07-31	Procedimiento para preparar derivados de indolo-isoquinolina
AR227341A1 (es)	1982-10-15	Procedimiento para preparar derivados de bis-aminometil-antraquinona
ES488216A0 (es)	1981-01-16	Procedimiento para la preparacion estereoselectiva de deri- vados de imidazoliloximas
MX6563E (es)	1985-07-15	Procedimiento para preparar derivados de 10-halo e-homoeburnanos
MX6564E (es)	1985-07-15	Procedimiento para preparar derivados de 15-hidroxi-e-homoeburnano helogenados
MX6565E (es)	1985-07-15	Procedimiento para preparar derivados de 15-hidroxiimino-e-homoeburnano