RO79320A - Procedeu de preparare a unor 4-piperidinamine - Google Patents

Procedeu de preparare a unor 4-piperidinamine

Info

Publication number
RO79320A
RO79320A RO7997082A RO9708279A RO79320A RO 79320 A RO79320 A RO 79320A RO 7997082 A RO7997082 A RO 7997082A RO 9708279 A RO9708279 A RO 9708279A RO 79320 A RO79320 A RO 79320A
Authority
RO
Romania
Prior art keywords
piperidinamins
preparing
Prior art date
Application number
RO7997082A
Other languages
English (en)
French (fr)
Inventor
Frans Janssens
Raymond Stokbrook
Joseph Torremans
Original Assignee
Janssen Pharmaceutica Nv,Be
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26670178&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO79320(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/002,276 external-priority patent/US4219559A/en
Application filed by Janssen Pharmaceutica Nv,Be filed Critical Janssen Pharmaceutica Nv,Be
Publication of RO79320A publication Critical patent/RO79320A/ro

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
RO7997082A 1978-04-03 1979-03-30 Procedeu de preparare a unor 4-piperidinamine RO79320A (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89253478A 1978-04-03 1978-04-03
US06/002,276 US4219559A (en) 1979-01-10 1979-01-10 N-Heterocyclyl-4-piperidinamines

Publications (1)

Publication Number Publication Date
RO79320A true RO79320A (ro) 1982-08-17

Family

ID=26670178

Family Applications (1)

Application Number Title Priority Date Filing Date
RO7997082A RO79320A (ro) 1978-04-03 1979-03-30 Procedeu de preparare a unor 4-piperidinamine

Country Status (29)

Country Link
EP (1) EP0005318B1 (ro)
JP (2) JPS54151982A (ro)
AT (1) AT373887B (ro)
AU (1) AU523352B2 (ro)
BG (1) BG38164A3 (ro)
CA (1) CA1140119A (ro)
CS (1) CS256358B2 (ro)
CY (1) CY1250A (ro)
DE (1) DE2961740D1 (ro)
DK (1) DK169325B1 (ro)
EG (1) EG13913A (ro)
ES (1) ES479206A1 (ro)
FI (1) FI64801C (ro)
GR (1) GR64907B (ro)
HK (1) HK3184A (ro)
HU (1) HU182965B (ro)
IE (1) IE47818B1 (ro)
IL (1) IL56992A (ro)
MY (1) MY8500046A (ro)
NO (2) NO154058C (ro)
NZ (1) NZ189978A (ro)
PH (1) PH15877A (ro)
PL (1) PL123380B1 (ro)
PT (1) PT69429A (ro)
RO (1) RO79320A (ro)
SG (1) SG29883G (ro)
SU (1) SU1056902A3 (ro)
YU (2) YU42484B (ro)
ZA (1) ZA791557B (ro)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA19091A1 (fr) * 1980-03-10 1981-10-01 Janssen Pharmaceutica Nv Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine .
IN156065B (ro) * 1982-07-12 1985-05-04 Janssen Pharmaceutica Nv
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
EP0144101B1 (en) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
JPS60174778A (ja) * 1984-01-09 1985-09-09 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ N−ヘテロシクリル−4−ピペリジンアミン
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
CA1327579C (en) * 1986-02-03 1994-03-08 Frans Eduard Janssens Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
FR2618435B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
US5210091A (en) * 1991-06-24 1993-05-11 Neurosearch A/S Imidazole compounds and their use
KR960702445A (ko) * 1993-05-20 1996-04-27 간자와 무츠오 1-(2-벤조이미다졸일)-1, 5- 디아자시클로옥탄 유도체(1-(2-benzimidazo-lyl)-1,5-diazacyclooctane compounds)
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
PL343435A1 (en) * 1998-03-06 2001-08-13 Janssen Pharmaceutica Nv Glycine transport inhibitors
DE60033859T2 (de) 1999-06-28 2007-11-08 Janssen Pharmaceutica N.V. Hemmer des Respiratorischen Syncytial Virus
ES2215683T3 (es) * 1999-06-28 2004-10-16 Janssen Pharmaceutica N.V. Inhibidores de la replicacion del virus sincitial respiratorio.
WO2001000611A1 (en) * 1999-06-28 2001-01-04 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
CA2397981C (en) 2000-03-06 2010-12-21 Acadia Pharmaceuticals, Inc. Azacyclic compounds for use in the treatment of serotonin related diseases
WO2002062786A1 (en) 2001-02-02 2002-08-15 Teva Pharmaceutical Industries Ltd. Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1h-benzimidazoles
CN101050215A (zh) 2001-12-28 2007-10-10 阿卡蒂亚药品公司 作为单胺受体调节剂的螺氮杂环化合物
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
AU2003247615B2 (en) 2002-06-24 2007-08-09 Acadia Pharmaceuticals Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
RU2332401C2 (ru) 2003-01-16 2008-08-27 Акадиа Фармасьютикалз Инк. Селективные обратные агонисты серотонин 2а/2с рецептора, применяемые в качестве лекарственных средств при нейродегенеративных заболеваниях
WO2005058869A1 (en) 2003-12-18 2005-06-30 Tibotec Pharmaceuticals Ltd. Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
EP1697347B1 (en) 2003-12-18 2011-02-23 Tibotec Pharmaceuticals 5- or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
RU2381224C2 (ru) * 2003-12-18 2010-02-10 Тиботек Фармасьютикалз Лтд. Пиперидинаминобензимидазольные производные как ингибиторы репликации респираторного синцитиального вируса
US20050261278A1 (en) 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
BRPI0516063A (pt) 2004-09-27 2008-08-19 Acadia Pharm Inc sìntese de n-(4-fluorbenzil)-n-(1-metilpiperidin-4-il)-n'-(4-(2-metilp ropi-loxi)fenilmetil)carbamida e seu sal tartarato e formas cristalinas
US7790899B2 (en) 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
EP2134330B1 (en) 2007-03-19 2013-05-08 Acadia Pharmaceuticals Inc. Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics
DK3325444T3 (da) 2015-07-20 2021-10-04 Acadia Pharm Inc Fremgangsmåder til fremstilling af n-(4-fluorbenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamid og dets tartratsalt og polymorf form c
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
WO2018118626A1 (en) 2016-12-20 2018-06-28 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
US11135211B2 (en) 2017-04-28 2021-10-05 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
US20210077479A1 (en) 2017-08-30 2021-03-18 Acadia Pharmaceuticals Inc. Formulations of pimavanserin

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US2857391A (en) * 1955-04-15 1958-10-21 Merck & Co Inc Aminomethylbenzimidazoles
US2971005A (en) * 1958-10-17 1961-02-07 Merck & Co Inc Nu-substituted derivatives of 2-benzylaminobenzimidazoles
BE788065A (fr) * 1971-08-26 1973-02-26 Degussa Nouvelles aza-benzimidazoles et procede pour leur preparation

Also Published As

Publication number Publication date
BG38164A3 (en) 1985-10-15
CS222779A2 (en) 1987-03-12
DK169325B1 (da) 1994-10-10
AU523352B2 (en) 1982-07-22
NZ189978A (en) 1984-05-31
NO154058B (no) 1986-04-01
IE47818B1 (en) 1984-06-27
NO154090B (no) 1986-04-07
FI791084A (fi) 1979-10-04
IL56992A (en) 1983-03-31
SG29883G (en) 1984-04-19
JPS641477B2 (ro) 1989-01-11
CS256358B2 (en) 1988-04-15
AU4529679A (en) 1979-10-18
AT373887B (de) 1984-02-27
HU182965B (en) 1984-03-28
FI64801C (fi) 1984-01-10
YU78479A (en) 1983-10-31
MY8500046A (en) 1985-12-31
NO791097L (no) 1979-10-04
PT69429A (pt) 1979-05-01
SU1056902A3 (ru) 1983-11-23
YU50283A (en) 1983-12-31
PH15877A (en) 1983-04-13
DK129879A (da) 1979-10-04
CY1250A (en) 1984-08-31
HK3184A (en) 1984-01-20
EP0005318B1 (en) 1982-01-06
PL123380B1 (en) 1982-10-30
NO154090C (no) 1986-07-16
YU43158B (en) 1989-04-30
DE2961740D1 (en) 1982-02-25
EP0005318A1 (en) 1979-11-14
JPH01117880A (ja) 1989-05-10
FI64801B (fi) 1983-09-30
NO154058C (no) 1986-07-09
NO842563L (no) 1979-10-04
IL56992A0 (en) 1979-07-25
JPS54151982A (en) 1979-11-29
ES479206A1 (es) 1979-12-16
YU42484B (en) 1988-10-31
GR64907B (en) 1980-06-07
IE790676L (en) 1979-10-03
ATA242579A (de) 1983-07-15
PL214648A1 (ro) 1980-03-24
ZA791557B (en) 1980-11-26
EG13913A (en) 1982-09-30
JPH0240666B2 (ro) 1990-09-12
CA1140119A (en) 1983-01-25

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