PT1658302E - Análogos do nucleósido purina para o tratamento de doenças provocadas por flaviviridae incluindo hepatite c - Google Patents
Análogos do nucleósido purina para o tratamento de doenças provocadas por flaviviridae incluindo hepatite c Download PDFInfo
- Publication number
- PT1658302E PT1658302E PT04744307T PT04744307T PT1658302E PT 1658302 E PT1658302 E PT 1658302E PT 04744307 T PT04744307 T PT 04744307T PT 04744307 T PT04744307 T PT 04744307T PT 1658302 E PT1658302 E PT 1658302E
- Authority
- PT
- Portugal
- Prior art keywords
- alkyl
- alkenyl
- alkynyl
- acyl
- compound
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49021603P | 2003-07-25 | 2003-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1658302E true PT1658302E (pt) | 2010-10-25 |
Family
ID=34102969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04744307T PT1658302E (pt) | 2003-07-25 | 2004-07-26 | Análogos do nucleósido purina para o tratamento de doenças provocadas por flaviviridae incluindo hepatite c |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US20050075309A1 (fr) |
| EP (1) | EP1658302B1 (fr) |
| JP (1) | JP2007501185A (fr) |
| KR (1) | KR20060084845A (fr) |
| CN (1) | CN1852915A (fr) |
| AT (1) | ATE478886T1 (fr) |
| AU (1) | AU2004258750A1 (fr) |
| BR (1) | BRPI0412849A (fr) |
| CA (1) | CA2533367C (fr) |
| DE (1) | DE602004028841D1 (fr) |
| DK (1) | DK1658302T3 (fr) |
| ES (1) | ES2351603T3 (fr) |
| NO (1) | NO20060914L (fr) |
| PL (1) | PL1658302T3 (fr) |
| PT (1) | PT1658302E (fr) |
| RU (1) | RU2006105640A (fr) |
| WO (1) | WO2005009418A2 (fr) |
Families Citing this family (74)
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| EP2345657A1 (fr) * | 2003-05-30 | 2011-07-20 | Pharmasset, Inc. | Analogues de nucléosides fluores modifiés |
| EP1658302B1 (fr) * | 2003-07-25 | 2010-08-25 | IDENIX Pharmaceuticals, Inc. | Analogues des nucleosides puriques pour traiter flaviviridae et notamment l'hepatite c |
| US7534767B2 (en) | 2004-06-15 | 2009-05-19 | Merck & Co., Inc. | C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase |
| CN101023094B (zh) * | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| PL3109244T3 (pl) * | 2004-09-14 | 2019-09-30 | Gilead Pharmasset Llc | Wytwarzanie 2'fluoro-2'-alkilo-podstawionych lub innych ewentualnie podstawionych rybofuranozylopirymidyn i puryn oraz ich pochodnych |
| WO2007144686A1 (fr) * | 2005-03-09 | 2007-12-21 | Idenix (Cayman) Limited | Nucleosides a bases non naturelles en tant qu'agents anti-viraux |
| WO2007041775A1 (fr) * | 2005-10-10 | 2007-04-19 | The University Of Queensland | Inhibiteurs de cystéine protéase incorporant des groupements azide |
| MY150667A (en) | 2005-12-09 | 2014-02-28 | Gilead Pharmasset Llc | Antiviral nucleosides |
| WO2007113159A1 (fr) | 2006-04-04 | 2007-10-11 | F. Hoffmann-La Roche Ag | Nucléosides 3',5'-di-o-acylés destinés au traitement du vhc |
| AU2007286754A1 (en) * | 2006-08-25 | 2008-02-28 | Viropharma Incorporated | Identification and characterization of HCV replicon variants with reduced susceptibility to HCV-796, and methods related thereto |
| JP5252459B2 (ja) | 2006-10-10 | 2013-07-31 | ギリアド ファーマセット エルエルシー | リボフラノシルピリミジンヌクレオシドの調製 |
| MX2009004900A (es) | 2006-11-09 | 2009-05-19 | Hoffmann La Roche | Arilamidas sustituidas por tiazol u oxazol. |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| CL2008003511A1 (es) * | 2007-11-29 | 2010-02-19 | Metabasis Therapeutics Inc | Compuestos derivados nucleotidicos, inhibidores de polimerasa ns5b del virus de la hepatitis c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la hepatitis c. |
| CN101903355B (zh) | 2007-12-17 | 2014-05-14 | 霍夫曼-拉罗奇有限公司 | 咪唑取代的芳基酰胺 |
| BR122019016794B8 (pt) | 2007-12-17 | 2021-07-27 | Hoffmann La Roche | derivados de arilamida substituídos por tetrazol, composição farmacêutica que os compreende e seu uso no tratamento de uma condição inflamatória e/ou autoimune |
| CN101903359B (zh) | 2007-12-17 | 2013-05-22 | 霍夫曼-拉罗奇有限公司 | ***取代的芳基酰胺衍生物和它们作为p2x3和/或p2x2/3嘌呤能受体拮抗物的用途 |
| JP5301561B2 (ja) | 2007-12-17 | 2013-09-25 | エフ．ホフマン−ラ ロシュ アーゲー | 新規なピラゾール置換アリールアミド |
| HUE038946T2 (hu) * | 2008-04-23 | 2018-12-28 | Gilead Sciences Inc | 1'-szubsztituált carba-nukleozid analógok antivirális kezelésre |
| US8173621B2 (en) * | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| CN102753563A (zh) | 2008-12-23 | 2012-10-24 | 吉利德制药有限责任公司 | 核苷类似物 |
| PA8855601A1 (es) | 2008-12-23 | 2010-07-27 | Forformidatos de nucleósidos | |
| WO2010075554A1 (fr) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Synthèse de nucléosides de type purine |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| CA2761921A1 (fr) | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Arylamides indoles, indazoles et benzimidazoles |
| EP2445868B1 (fr) | 2009-06-22 | 2013-12-18 | F.Hoffmann-La Roche Ag | Amides biphényles utiles en tant que modulateurs des récepteurs p2x3 et/ou p2x2/3 |
| WO2010149541A1 (fr) | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Nouveaux arylamides substitués par oxazolone et pyrrolidinone |
| MX2012003126A (es) | 2009-09-21 | 2012-06-19 | Gilead Sciences Inc | Procesos e intermedios para la preparacion de analogos de 1'-carbonucleosidos sustituidos. |
| MX2012005528A (es) | 2009-11-14 | 2012-06-12 | Hoffmann La Roche | Biomarcadores para pronosticar rapida respuesta a tratamiento hcv. |
| BR112012011393A2 (pt) | 2009-12-02 | 2017-06-20 | Hoffmann La Roche | biomarcadores para a previsão da resposta sustentada ao tratamento de hcv |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| JP6058528B2 (ja) | 2010-03-31 | 2017-01-11 | ギリアド ファーマセット エルエルシー | ヌクレオシドホスホルアミデート |
| CA2804375C (fr) | 2010-07-19 | 2018-08-21 | Gilead Sciences, Inc. | Procedes de preparation de promedicaments au phosphoramidate pur au plan diastereomere |
| PL2595980T3 (pl) | 2010-07-22 | 2015-03-31 | Gilead Sciences Inc | Sposoby i związki do leczenia infekcji wirusowych Paramyxoviridae |
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| CN102850355B (zh) * | 2011-06-29 | 2015-02-11 | 四川大学 | 9-磺酰基-9h-嘌呤衍生物及其制备方法和用途 |
| MX354958B (es) | 2011-09-16 | 2018-03-27 | Gilead Pharmasset Llc | Metodos para el tratamiento de vhc. |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| CA2871547C (fr) | 2012-05-25 | 2021-05-25 | Janssen R&D Ireland | Nucleosides d'uracyl spirooxetane |
| KR102327888B1 (ko) | 2012-12-21 | 2021-11-17 | 얀센 바이오파마, 인코퍼레이트. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체 |
| EP2950786B1 (fr) | 2013-01-31 | 2019-11-27 | Gilead Pharmasset LLC | Formulation de combinaison de deux composés antiviraux |
| RU2534613C2 (ru) | 2013-03-22 | 2014-11-27 | Александр Васильевич Иващенко | Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения |
| PL3038601T3 (pl) | 2013-08-27 | 2020-08-24 | Gilead Pharmasset Llc | Formulacja złożona dwóch związków przeciwwirusowych |
| US9862743B2 (en) | 2013-10-11 | 2018-01-09 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
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| JP6491486B2 (ja) * | 2015-01-29 | 2019-03-27 | 学校法人日本大学 | ８−アザ−３，７−ジデアザアデニンヌクレオシド誘導体、８−アザ−３，７−ジデアザアデニンヌクレオチド誘導体及びポリヌクレオチド誘導体ならびにプローブ |
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| ES2938859T3 (es) | 2017-05-01 | 2023-04-17 | Gilead Sciences Inc | Una forma cristalina de (S)-2-etilbutilo 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopirrolo[2,1-f][1,2,4]triazin-7-il)-5-ciano-3,4-dihidroxitetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato |
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-
2004
- 2004-07-26 EP EP04744307A patent/EP1658302B1/fr not_active Expired - Lifetime
- 2004-07-26 CN CNA2004800270217A patent/CN1852915A/zh active Pending
- 2004-07-26 RU RU2006105640/04A patent/RU2006105640A/ru not_active Application Discontinuation
- 2004-07-26 PT PT04744307T patent/PT1658302E/pt unknown
- 2004-07-26 WO PCT/IB2004/002703 patent/WO2005009418A2/fr active Application Filing
- 2004-07-26 DK DK04744307.2T patent/DK1658302T3/da active
- 2004-07-26 BR BRPI0412849-4A patent/BRPI0412849A/pt not_active IP Right Cessation
- 2004-07-26 US US10/900,008 patent/US20050075309A1/en not_active Abandoned
- 2004-07-26 DE DE602004028841T patent/DE602004028841D1/de not_active Expired - Lifetime
- 2004-07-26 AT AT04744307T patent/ATE478886T1/de active
- 2004-07-26 KR KR1020067001534A patent/KR20060084845A/ko not_active Application Discontinuation
- 2004-07-26 CA CA2533367A patent/CA2533367C/fr not_active Expired - Fee Related
- 2004-07-26 ES ES04744307T patent/ES2351603T3/es not_active Expired - Lifetime
- 2004-07-26 AU AU2004258750A patent/AU2004258750A1/en not_active Abandoned
- 2004-07-26 JP JP2006520940A patent/JP2007501185A/ja active Pending
- 2004-07-26 PL PL04744307T patent/PL1658302T3/pl unknown
-
2006
- 2006-02-24 NO NO20060914A patent/NO20060914L/no not_active Application Discontinuation
-
2008
- 2008-11-13 US US12/270,795 patent/US8742101B2/en active Active
-
2014
- 2014-05-02 US US14/269,003 patent/US9186369B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE478886T1 (de) | 2010-09-15 |
| US20090169507A1 (en) | 2009-07-02 |
| RU2006105640A (ru) | 2007-09-10 |
| PL1658302T3 (pl) | 2011-03-31 |
| KR20060084845A (ko) | 2006-07-25 |
| US20140234251A1 (en) | 2014-08-21 |
| CA2533367A1 (fr) | 2005-02-03 |
| NO20060914L (no) | 2006-04-25 |
| DE602004028841D1 (de) | 2010-10-07 |
| CN1852915A (zh) | 2006-10-25 |
| WO2005009418A3 (fr) | 2005-04-07 |
| ES2351603T3 (es) | 2011-02-08 |
| US20050075309A1 (en) | 2005-04-07 |
| AU2004258750A1 (en) | 2005-02-03 |
| WO2005009418A2 (fr) | 2005-02-03 |
| US9186369B2 (en) | 2015-11-17 |
| JP2007501185A (ja) | 2007-01-25 |
| US8742101B2 (en) | 2014-06-03 |
| CA2533367C (fr) | 2013-10-01 |
| BRPI0412849A (pt) | 2006-09-26 |
| DK1658302T3 (da) | 2010-11-22 |
| EP1658302A2 (fr) | 2006-05-24 |
| EP1658302B1 (fr) | 2010-08-25 |
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