PE20181044A1 - Anticuerpos anti-pd-1 y composiciones - Google Patents
Anticuerpos anti-pd-1 y composicionesInfo
- Publication number
- PE20181044A1 PE20181044A1 PE2018000485A PE2018000485A PE20181044A1 PE 20181044 A1 PE20181044 A1 PE 20181044A1 PE 2018000485 A PE2018000485 A PE 2018000485A PE 2018000485 A PE2018000485 A PE 2018000485A PE 20181044 A1 PE20181044 A1 PE 20181044A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- nos
- antibody
- antigen
- vector
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 abstract 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Se refiere a un anticuerpo anti-PD-1 o una porcion de union a antigeno del mismo, en donde el anticuerpo compite por la union a Proteina de Muerte Celular Programada 1 (PD-1) humana, o se une al mismo epitopo, cuyos dominios variables de cadena pesada y ligera comprenden las secuencias de aminoacidos de: a) SEQ ID Nos: 2 y 3, respectivamente; b) SEQ ID Nos: 4 y 5, respectivamente; c) SEQ ID Nos: 4 y 66, respectivamente; d) SEQ ID Nos: 6 y 7, respectivamente; e) SEQ ID Nos: 8 y 9, respectivamente; f) SEQ ID Nos: 10 y 11, respectivamente; g) SEQ ID Nos: 12 y 13, respectivamente; h) SEQ ID Nos: 14 y 15, respectivamente; i) SEQ ID Nos: 16 y 17, respectivamente. Ademas, se refiere a una molecula de acido nucleico aislada que comprende una secuencia de nucleotidos que codifica la cadena pesada o una porcion de union a antigeno, un vector que comprende la molecula de acido nucleico y una celula anfitriona que comprende el vector; y un metodo para producir dicho anticuerpo o una porcion de ella. Se usa en el tratamiento de enfermedades y afecciones relacionadas con la actividad de PD-1, como el cancer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562236341P | 2015-10-02 | 2015-10-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20181044A1 true PE20181044A1 (es) | 2018-07-03 |
Family
ID=57042898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2018000485A PE20181044A1 (es) | 2015-10-02 | 2016-09-30 | Anticuerpos anti-pd-1 y composiciones |
Country Status (28)
Country | Link |
---|---|
US (1) | US11034765B2 (es) |
EP (2) | EP3368572B9 (es) |
JP (1) | JP6875385B2 (es) |
KR (1) | KR20180053752A (es) |
CN (1) | CN108290953B (es) |
AU (1) | AU2016333517B2 (es) |
BR (1) | BR112018006257A2 (es) |
CA (1) | CA3000564A1 (es) |
CO (1) | CO2018003500A2 (es) |
DK (1) | DK3368572T3 (es) |
ES (1) | ES2924402T3 (es) |
HR (1) | HRP20221041T1 (es) |
HU (1) | HUE059788T2 (es) |
IL (1) | IL258214B2 (es) |
LT (1) | LT3368572T (es) |
MX (1) | MX2018003936A (es) |
MY (1) | MY190324A (es) |
PE (1) | PE20181044A1 (es) |
PL (1) | PL3368572T3 (es) |
PT (1) | PT3368572T (es) |
RS (1) | RS63490B1 (es) |
RU (1) | RU2750675C1 (es) |
SA (1) | SA518391262B1 (es) |
SG (1) | SG10201912943RA (es) |
SI (1) | SI3368572T1 (es) |
TW (1) | TWI751981B (es) |
WO (1) | WO2017055547A1 (es) |
ZA (1) | ZA201801852B (es) |
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CN107969128A (zh) | 2015-04-17 | 2018-04-27 | 高山免疫科学股份有限公司 | 具有可调的亲和力的免疫调节蛋白 |
KR20180040138A (ko) | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | 항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법 |
CA2993276A1 (en) | 2015-08-11 | 2017-02-16 | Yong Zheng | Novel anti-pd-1 antibodies |
EA201890630A1 (ru) | 2015-09-01 | 2018-10-31 | Эйдженус Инк. | Антитела против pd-1 и способы их применения |
EA201890790A1 (ru) | 2015-09-29 | 2018-10-31 | Селджин Корпорейшн | Связывающие pd-1 белки и способы их применения |
BR112018008904A2 (pt) | 2015-11-03 | 2018-11-27 | Janssen Biotech Inc | anticorpos que se ligam especificamente a tim-3 e seus usos |
KR20190006495A (ko) | 2016-04-15 | 2019-01-18 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Cd80 변이체 면역조절 단백질 및 그의 용도 |
KR20230051602A (ko) | 2016-04-15 | 2023-04-18 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
TWI784957B (zh) | 2016-06-20 | 2022-12-01 | 英商克馬伯有限公司 | 免疫細胞介素 |
WO2018053405A1 (en) | 2016-09-19 | 2018-03-22 | Celgene Corporation | Methods of treating immune disorders using pd-1 binding proteins |
US10766958B2 (en) | 2016-09-19 | 2020-09-08 | Celgene Corporation | Methods of treating vitiligo using PD-1 binding antibodies |
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US11359018B2 (en) | 2016-11-18 | 2022-06-14 | Symphogen A/S | Anti-PD-1 antibodies and compositions |
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EA202090974A1 (ru) | 2017-10-18 | 2020-08-05 | Элпайн Иммьюн Сайенсиз, Инк. | Вариантные иммуномодулирующие белки лиганда icos и сопутствующие композиции и способы |
AR114127A1 (es) | 2018-03-02 | 2020-07-22 | Lilly Co Eli | Anticuerpos agonistas contra pd-1 y usos de estos |
CN112368020A (zh) | 2018-05-07 | 2021-02-12 | 展马博联合股份有限公司 | 抗pd-1抗体和抗组织因子抗体-药物偶联物组合治疗癌症的方法 |
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US11939381B2 (en) * | 2018-07-19 | 2024-03-26 | Eli Lilly And Company | Bispecific antibodies targeting immune checkpoints |
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WO2020056085A1 (en) * | 2018-09-14 | 2020-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | Spd-1 variant - fc fusion proteins |
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2016
- 2016-09-30 HU HUE16774691A patent/HUE059788T2/hu unknown
- 2016-09-30 DK DK16774691.6T patent/DK3368572T3/da active
- 2016-09-30 CA CA3000564A patent/CA3000564A1/en active Pending
- 2016-09-30 RU RU2018115979A patent/RU2750675C1/ru active
- 2016-09-30 WO PCT/EP2016/073421 patent/WO2017055547A1/en active Application Filing
- 2016-09-30 HR HRP20221041TT patent/HRP20221041T1/hr unknown
- 2016-09-30 ES ES16774691T patent/ES2924402T3/es active Active
- 2016-09-30 BR BR112018006257A patent/BR112018006257A2/pt active Search and Examination
- 2016-09-30 PT PT167746916T patent/PT3368572T/pt unknown
- 2016-09-30 US US15/765,337 patent/US11034765B2/en active Active
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