DK3368572T3 - Anti-pd-1-antistoffer og -sammensætninger - Google Patents
Anti-pd-1-antistoffer og -sammensætninger Download PDFInfo
- Publication number
- DK3368572T3 DK3368572T3 DK16774691.6T DK16774691T DK3368572T3 DK 3368572 T3 DK3368572 T3 DK 3368572T3 DK 16774691 T DK16774691 T DK 16774691T DK 3368572 T3 DK3368572 T3 DK 3368572T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibodies
- compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562236341P | 2015-10-02 | 2015-10-02 | |
PCT/EP2016/073421 WO2017055547A1 (en) | 2015-10-02 | 2016-09-30 | Anti-pd-1 antibodies and compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3368572T3 true DK3368572T3 (da) | 2022-08-08 |
Family
ID=57042898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16774691.6T DK3368572T3 (da) | 2015-10-02 | 2016-09-30 | Anti-pd-1-antistoffer og -sammensætninger |
Country Status (28)
Country | Link |
---|---|
US (1) | US11034765B2 (da) |
EP (2) | EP3368572B9 (da) |
JP (1) | JP6875385B2 (da) |
KR (1) | KR20180053752A (da) |
CN (1) | CN108290953B (da) |
AU (1) | AU2016333517B2 (da) |
BR (1) | BR112018006257A2 (da) |
CA (1) | CA3000564A1 (da) |
CO (1) | CO2018003500A2 (da) |
DK (1) | DK3368572T3 (da) |
ES (1) | ES2924402T3 (da) |
HR (1) | HRP20221041T1 (da) |
HU (1) | HUE059788T2 (da) |
IL (1) | IL258214B2 (da) |
LT (1) | LT3368572T (da) |
MX (1) | MX2018003936A (da) |
MY (1) | MY190324A (da) |
PE (1) | PE20181044A1 (da) |
PL (1) | PL3368572T3 (da) |
PT (1) | PT3368572T (da) |
RS (1) | RS63490B1 (da) |
RU (1) | RU2750675C1 (da) |
SA (1) | SA518391262B1 (da) |
SG (1) | SG10201912943RA (da) |
SI (1) | SI3368572T1 (da) |
TW (1) | TWI751981B (da) |
WO (1) | WO2017055547A1 (da) |
ZA (1) | ZA201801852B (da) |
Families Citing this family (53)
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KR20240046641A (ko) | 2015-04-17 | 2024-04-09 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 조율가능한 친화성을 갖는 면역조절 단백질 |
EP3322732A2 (en) | 2015-07-13 | 2018-05-23 | Cytomx Therapeutics Inc. | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
SG10201914109VA (en) | 2015-08-11 | 2020-02-27 | Wuxi Biologics Cayman Inc | Novel anti-pd-1 antibodies |
MA48579A (fr) | 2015-09-01 | 2020-03-18 | Agenus Inc | Anticorps anti-pd1 et méthodes d'utilisation de ceux-ci |
EA201890790A1 (ru) | 2015-09-29 | 2018-10-31 | Селджин Корпорейшн | Связывающие pd-1 белки и способы их применения |
BR112018008891A8 (pt) | 2015-11-03 | 2019-02-26 | Janssen Biotech Inc | anticorpos que se ligam especificamente a pd-1 e tim-3 e seus usos |
MA43552A (fr) | 2016-04-15 | 2018-11-07 | Alpine Immune Sciences Inc | Protéines immunomodulatrices à variants de cd80 et leurs utilisations |
MX2018012472A (es) | 2016-04-15 | 2019-08-12 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras variantes de ligando icos y sus usos. |
JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗pd-l1およびil-2サイトカイン |
WO2018053405A1 (en) | 2016-09-19 | 2018-03-22 | Celgene Corporation | Methods of treating immune disorders using pd-1 binding proteins |
US10766958B2 (en) | 2016-09-19 | 2020-09-08 | Celgene Corporation | Methods of treating vitiligo using PD-1 binding antibodies |
JP7101169B2 (ja) | 2016-09-21 | 2022-07-14 | シーストーン ファーマシューティカルズ | プログラム死1(pd-1)に対する新規モノクローナル抗体 |
MA46708B1 (fr) * | 2016-11-02 | 2021-10-29 | Jounce Therapeutics Inc | Anticorps anti-pd1 et leurs utilisations |
JP7178999B2 (ja) | 2016-11-18 | 2022-11-28 | シムフォゲン・アクティーゼルスカブ | 抗pd-1抗体および組成物 |
BR112019013238A2 (pt) | 2017-01-20 | 2020-02-11 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anticorpos anti-pd-1 e usos dos mesmos |
NZ756395A (en) | 2017-03-16 | 2024-01-26 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
CA3185303A1 (en) | 2017-04-05 | 2018-10-11 | Symphogen A/S | Combination therapies targeting pd-a, tim-3, and lag-3 |
CN106939049B (zh) * | 2017-04-20 | 2019-10-01 | 苏州思坦维生物技术股份有限公司 | 拮抗抑制人pd-1抗原与其配体结合的单克隆抗体及其制备方法与应用 |
WO2019005635A2 (en) * | 2017-06-25 | 2019-01-03 | Systimmune, Inc. | ANTI-PD-1 ANTIBODIES AND METHODS OF PREPARATION AND USE |
CN111356477A (zh) * | 2017-08-01 | 2020-06-30 | Ab工作室有限公司 | 双特异性抗体及其用途 |
KR101917854B1 (ko) * | 2017-08-24 | 2018-11-12 | 한국콜마주식회사 | 세포 수용체 결합능이 있는 펩티드를 포함하는 마이크로 캡슐 및 이를 포함하는 화장료 조성물 |
KR20200085777A (ko) | 2017-10-18 | 2020-07-15 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 변이체 icos 리간드 면역조절 단백질 및 관련 조성물 및 방법 |
AR114127A1 (es) | 2018-03-02 | 2020-07-22 | Lilly Co Eli | Anticuerpos agonistas contra pd-1 y usos de estos |
IL307925A (en) | 2018-05-07 | 2023-12-01 | Genmab As | Combination of an antibody against 1-PD and conjugation of a drug with an antibody against TF for use in the treatment of cancer |
WO2019241758A1 (en) * | 2018-06-15 | 2019-12-19 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
JP2021530511A (ja) * | 2018-07-19 | 2021-11-11 | タユー ファシャ バイオテック メディカル グループ カンパニー, リミテッド | 抗pd−1抗体、投薬量、およびその使用 |
US11939381B2 (en) * | 2018-07-19 | 2024-03-26 | Eli Lilly And Company | Bispecific antibodies targeting immune checkpoints |
AU2019321667A1 (en) * | 2018-08-16 | 2021-03-04 | Musc Foundation For Research Development | Recombinant myxoma viruses and uses thereof |
EP3850003A1 (en) * | 2018-09-14 | 2021-07-21 | The Board of Trustees of the Leland Stanford Junior University | Spd-1 variant - fc fusion proteins |
EP3873941A4 (en) * | 2018-10-31 | 2022-07-27 | Merck Sharp & Dohme Corp. | ANTI-HUMAN PD-1 ANTIBODY CRYSTALS AND METHODS OF USE THEREOF |
CN111349162A (zh) * | 2018-12-21 | 2020-06-30 | 神州细胞工程有限公司 | 人源化抗pd-1抗体及其用途 |
US11352430B2 (en) * | 2018-12-21 | 2022-06-07 | Ose Immunotherapeutics | Humanized anti-human-PD-1 antibody and its use in cancer treatment |
AR118619A1 (es) * | 2019-04-10 | 2021-10-20 | Bio Thera Solutions Ltd | Anticuerpos de unión a pd-1 |
JP6881658B2 (ja) | 2019-07-05 | 2021-06-02 | 小野薬品工業株式会社 | Pd−1/cd3二重特異性タンパク質による血液がん治療 |
US20220332825A1 (en) | 2019-08-08 | 2022-10-20 | Ono Pharmaceutical Co., Ltd. | Bispecific protein |
JP2022547081A (ja) * | 2019-09-06 | 2022-11-10 | シンフォジェン・アクシェセルスケープ | 抗cd73抗体 |
CA3157024A1 (en) * | 2019-10-03 | 2021-04-08 | Xencor, Inc. | Targeted il-12 heterodimeric fc-fusion proteins |
CN113244385A (zh) * | 2020-02-07 | 2021-08-13 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗恶性肿瘤中的用途 |
JP2023549581A (ja) | 2020-11-17 | 2023-11-27 | シージェン インコーポレイテッド | ツカチニブ及び抗pd-1/抗pd-l1抗体の組み合わせによりがんを治療する方法 |
US20240034796A1 (en) * | 2021-02-04 | 2024-02-01 | Genuv Inc. | Anti-pd-1 antibody and use thereof |
GB202107994D0 (en) | 2021-06-04 | 2021-07-21 | Kymab Ltd | Treatment of cancer |
KR20240046323A (ko) | 2021-07-13 | 2024-04-08 | 비온테크 에스이 | 암에 대한 병용 요법에 있어서 cd40 및 cd137에 대한 다중특이 결합제 |
TW202321282A (zh) | 2021-07-19 | 2023-06-01 | 美商再生元醫藥公司 | Il12受體促效劑及其使用方法 |
AU2022331241A1 (en) | 2021-08-16 | 2024-03-28 | Regeneron Pharmaceuticals, Inc. | Novel il27 receptor agonists and methods of use thereof |
CA3233771A1 (en) | 2021-10-04 | 2023-04-13 | Les Laboratoires Servier | Cancer therapy targeting nkg2a |
CA3234647A1 (en) | 2021-10-06 | 2023-04-13 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 in combination therapy |
WO2023083439A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Tlr7 agonist and combinations for cancer treatment |
WO2023220647A1 (en) | 2022-05-11 | 2023-11-16 | Regeneron Pharmaceuticals, Inc. | Multispecific binding molecule proproteins and uses thereof |
WO2023218046A1 (en) | 2022-05-12 | 2023-11-16 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
WO2023230594A1 (en) | 2022-05-27 | 2023-11-30 | Regeneron Pharmaceuticals, Inc. | Interleukin-2 proproteins and uses thereof |
WO2023235848A1 (en) | 2022-06-04 | 2023-12-07 | Regeneron Pharmaceuticals, Inc. | Interleukin-2 proproteins and uses thereof |
US20240067691A1 (en) | 2022-08-18 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Interferon receptor agonists and uses thereof |
WO2024040247A1 (en) | 2022-08-18 | 2024-02-22 | Regeneron Pharmaceuticals, Inc. | Interferon proproteins and uses thereof |
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TWI380996B (zh) * | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ox40l抗體 |
CA2970873C (en) | 2005-05-09 | 2022-05-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
AU2007286451A1 (en) * | 2006-08-17 | 2008-02-21 | F. Hoffmann-La Roche Ag | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
NZ578851A (en) | 2007-03-01 | 2011-09-30 | Symphogen As | Method for cloning cognate antibodies |
BRPI0917352A2 (pt) | 2008-08-29 | 2017-08-22 | Symphogen As | Métodos para produção de uma biblioteca de pares cognatos que compreende sequências ligadas que codificam regiões variáveis e para gerar um vetor que codifica um anticorpo quimérico com regiões de seres humanos constantes e regiões variáveis não humanas, biblioteca de vetores, e método para produção de uma biblioteca de sequências de imunoglobulina derivadas de aves |
CA2736829C (en) * | 2008-09-12 | 2018-02-27 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
US9181342B2 (en) | 2008-09-12 | 2015-11-10 | Isis Innovation Limited | PD-1 specific antibodies and uses thereof |
TW201134488A (en) * | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
WO2011159877A2 (en) | 2010-06-18 | 2011-12-22 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
TR201810298T4 (tr) | 2011-03-31 | 2018-08-27 | Merck Sharp & Dohme | İnsan programlı ölüm reseptörü PD-1'e karşı antikorların stabil formülasyonları ve ilgili tedaviler. |
CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
CR20160319A (es) | 2013-12-12 | 2016-11-08 | Jiangsu Hengrui Medicine Co | Anticuerpo pd-1, fragmento de union al antigeno de este y uso médico de este |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
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EP3916017A1 (en) | 2014-12-22 | 2021-12-01 | PD-1 Acquisition Group, LLC | Anti-pd-1 antibodies |
-
2016
- 2016-09-30 SI SI201631586T patent/SI3368572T1/sl unknown
- 2016-09-30 KR KR1020187011821A patent/KR20180053752A/ko not_active Application Discontinuation
- 2016-09-30 ES ES16774691T patent/ES2924402T3/es active Active
- 2016-09-30 SG SG10201912943RA patent/SG10201912943RA/en unknown
- 2016-09-30 TW TW105131644A patent/TWI751981B/zh active
- 2016-09-30 AU AU2016333517A patent/AU2016333517B2/en active Active
- 2016-09-30 BR BR112018006257A patent/BR112018006257A2/pt active Search and Examination
- 2016-09-30 PE PE2018000485A patent/PE20181044A1/es unknown
- 2016-09-30 US US15/765,337 patent/US11034765B2/en active Active
- 2016-09-30 LT LTEPPCT/EP2016/073421T patent/LT3368572T/lt unknown
- 2016-09-30 DK DK16774691.6T patent/DK3368572T3/da active
- 2016-09-30 WO PCT/EP2016/073421 patent/WO2017055547A1/en active Application Filing
- 2016-09-30 EP EP16774691.6A patent/EP3368572B9/en active Active
- 2016-09-30 RS RS20220762A patent/RS63490B1/sr unknown
- 2016-09-30 EP EP22174837.9A patent/EP4105235A1/en active Pending
- 2016-09-30 CN CN201680069542.1A patent/CN108290953B/zh active Active
- 2016-09-30 HU HUE16774691A patent/HUE059788T2/hu unknown
- 2016-09-30 MY MYPI2018701111A patent/MY190324A/en unknown
- 2016-09-30 PL PL16774691.6T patent/PL3368572T3/pl unknown
- 2016-09-30 HR HRP20221041TT patent/HRP20221041T1/hr unknown
- 2016-09-30 IL IL258214A patent/IL258214B2/en unknown
- 2016-09-30 JP JP2018516765A patent/JP6875385B2/ja active Active
- 2016-09-30 PT PT167746916T patent/PT3368572T/pt unknown
- 2016-09-30 CA CA3000564A patent/CA3000564A1/en active Pending
- 2016-09-30 MX MX2018003936A patent/MX2018003936A/es unknown
- 2016-09-30 RU RU2018115979A patent/RU2750675C1/ru active
-
2018
- 2018-03-20 ZA ZA2018/01852A patent/ZA201801852B/en unknown
- 2018-04-02 SA SA518391262A patent/SA518391262B1/ar unknown
- 2018-04-02 CO CONC2018/0003500A patent/CO2018003500A2/es unknown
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