AR118619A1 - Anticuerpos de unión a pd-1 - Google Patents
Anticuerpos de unión a pd-1Info
- Publication number
- AR118619A1 AR118619A1 ARP200100982A ARP200100982A AR118619A1 AR 118619 A1 AR118619 A1 AR 118619A1 AR P200100982 A ARP200100982 A AR P200100982A AR P200100982 A ARP200100982 A AR P200100982A AR 118619 A1 AR118619 A1 AR 118619A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibodies
- binding
- neutralize
- antigen
- seq
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70521—CD28, CD152
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70532—B7 molecules, e.g. CD80, CD86
Abstract
En el presente documento, se describen anticuerpos que se unen a PD-1 y que comprenden una o más CDR seleccionadas de secuencias de aminoácidos de SEQ ID Nº 13, 14, 15, 16, 17 y 18. Los anticuerpos tienen afinidad alta y tasa de disociación baja para PD-1, así como la capacidad para neutralizar PD-1 in vitro. Los anticuerpos descritos en este documento pueden ser anticuerpos de longitud completa o fragmentos unidos a antígenos. Los anticuerpos pueden utilizarse para detectar PD-1 y elementos similares.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910286677 | 2019-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR118619A1 true AR118619A1 (es) | 2021-10-20 |
Family
ID=72750942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP200100982A AR118619A1 (es) | 2019-04-10 | 2020-04-08 | Anticuerpos de unión a pd-1 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20220204623A1 (es) |
EP (1) | EP3931223A4 (es) |
JP (1) | JP2022538375A (es) |
CN (2) | CN117603355A (es) |
AR (1) | AR118619A1 (es) |
TW (1) | TW202104262A (es) |
WO (1) | WO2020207432A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115776898A (zh) * | 2020-07-07 | 2023-03-10 | 百奥泰生物制药股份有限公司 | 双特异性抗体及其应用 |
EP4226942A1 (en) * | 2020-10-11 | 2023-08-16 | Bio-Thera Solutions, Ltd. | Use of anti-pd-1 antibody in combination medication |
CN115466328A (zh) * | 2021-06-11 | 2022-12-13 | 广东菲鹏制药股份有限公司 | 抗pd-1人源化抗体或其抗原结合片段及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104945508B (zh) * | 2007-06-18 | 2019-02-22 | 默沙东有限责任公司 | 针对人程序性死亡受体pd-1的抗体 |
RU2750675C1 (ru) * | 2015-10-02 | 2021-07-01 | Симфоген А/С | Антитела против pd-1 и композиции |
AU2018242880A1 (en) * | 2017-03-27 | 2019-10-31 | Fuso Pharmaceutical Industries, Ltd. | Anti-PD-L1 antibody for detecting PD-L1 |
WO2018217227A1 (en) * | 2017-05-24 | 2018-11-29 | Immunomedics, Inc. | Novel anti-pd-1 checkpoint inhibitor antibodies that block binding of pd-l1 to pd-1 |
CN108997499B (zh) * | 2018-09-12 | 2020-07-31 | 首都医科大学附属北京胸科医院 | 一种抗人pd-l1抗体及其应用 |
-
2020
- 2020-04-08 AR ARP200100982A patent/AR118619A1/es unknown
- 2020-04-09 US US17/602,715 patent/US20220204623A1/en active Pending
- 2020-04-09 WO PCT/CN2020/083954 patent/WO2020207432A1/en unknown
- 2020-04-09 TW TW109112066A patent/TW202104262A/zh unknown
- 2020-04-09 CN CN202311534081.9A patent/CN117603355A/zh active Pending
- 2020-04-09 CN CN202010275368.4A patent/CN111808190B/zh active Active
- 2020-04-09 JP JP2021560586A patent/JP2022538375A/ja active Pending
- 2020-04-09 EP EP20788554.2A patent/EP3931223A4/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220204623A1 (en) | 2022-06-30 |
CN111808190A (zh) | 2020-10-23 |
WO2020207432A1 (en) | 2020-10-15 |
JP2022538375A (ja) | 2022-09-02 |
TW202104262A (zh) | 2021-02-01 |
CN117603355A (zh) | 2024-02-27 |
EP3931223A1 (en) | 2022-01-05 |
EP3931223A4 (en) | 2023-07-12 |
CN111808190B (zh) | 2023-12-12 |
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