PE20170684A1 - Derivados de heterociclilo opcionalmente condensados de pirimidina utiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncologicas y autoinmunitarias - Google Patents

Derivados de heterociclilo opcionalmente condensados de pirimidina utiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncologicas y autoinmunitarias

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Publication number
PE20170684A1
PE20170684A1 PE2017000166A PE2017000166A PE20170684A1 PE 20170684 A1 PE20170684 A1 PE 20170684A1 PE 2017000166 A PE2017000166 A PE 2017000166A PE 2017000166 A PE2017000166 A PE 2017000166A PE 20170684 A1 PE20170684 A1 PE 20170684A1
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PE
Peru
Prior art keywords
alkyl
metabolic
inflammatory
treatment
autoimmune diseases
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PE2017000166A
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English (en)
Inventor
Glad Sanne Ormholt Schrøder
Nørager Niels Henrik Grøn
Ian David Sarvary
Gouliaev Alex Haahr
Lene Teuber
Luigi Piero Stasi
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Nuevolution As
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Publication of PE20170684A1 publication Critical patent/PE20170684A1/es

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Abstract

Se refiere a un derivado de heterociclilo opcionalmente condensado de pirimidina de formula (I) o las sales, hidratos, solvatos, polimorfos y estereoisomeros de los mismos, donde: Y es NR u O; R es H o alquilo C1-C4 opcionalmente sustituido; R1 es H, -OH, entre otros; R2 es H, halogeno, entre otros; R3a es alquilo C1-C6, alcoxi C1-C6 opcionalmente sustituidos, entre otros; R3b y R3c son H, -CN, entre otros o se combinan para formar un grupo oxo; R4a es H, halogeno, entre otros; R4b es H, oxo, entre otros; R5 es (CR8R9)pOR12, entre otros; n y p son enteros de 0 a 4; R6a y R6b son H, halogeno, alquilo C1-C6, entre otros; R8, R9 y R12 son H, alquilo C1-C6 opcionalmente sustituido, entre otros; B es un sistema de anillo tal como arilo, heteroarilo, entre otros. Es un compuesto seleccionado: N6-ciclopropil-5-fluoro-N4-[[4-(1H-tetrazol-5-ilmetil)fenil]metil]-N6-[[4-(trifluorometil)fenil]metil]pirimidina-4,6-diamina; entre otros. Tambien se refiere a una composicion. Estos compuestos modulan la actividad de un receptor huerfano relacionado con el receptor de acido retinoico (ROR). Dicho compuesto es util en el tratamiento de enfermedades inflamatorias, metabolicas y autoinmunes
PE2017000166A 2014-08-04 2015-07-31 Derivados de heterociclilo opcionalmente condensados de pirimidina utiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncologicas y autoinmunitarias PE20170684A1 (es)

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