AR072249A1 - Inhibidores de amida hidrolasa de acido graso. usos. metodos. - Google Patents

Inhibidores de amida hidrolasa de acido graso. usos. metodos.

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Publication number
AR072249A1
AR072249A1 ARP090101257A ARP090101257A AR072249A1 AR 072249 A1 AR072249 A1 AR 072249A1 AR P090101257 A ARP090101257 A AR P090101257A AR P090101257 A ARP090101257 A AR P090101257A AR 072249 A1 AR072249 A1 AR 072249A1
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Argentina
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optionally substituted
alkyl
independently
carbocyclyl
aryl
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ARP090101257A
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Infinity Pharmaceuticals Inc
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Application filed by Infinity Pharmaceuticals Inc filed Critical Infinity Pharmaceuticals Inc
Publication of AR072249A1 publication Critical patent/AR072249A1/es

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Abstract

Compuestos, y composiciones farmacéuticamente aceptables de ellos, abarcados por cualquiera de las formulas (1), (2), (3), (4), (5) o (6), o sus subgéneros. Métodos para tratar una enfermedad, trastorno o afeccion mediada por FAAH a través de la administracion de una cantidad terapéuticamente efectiva de un compuesto o una composicion que comprende un compuesto de cualquiera de las formulas (1), (2), (3), (4), (5) o (6), o sus subgéneros, a un paciente que lo necesita. Métodos para inhibir FAAH mediante la administracion de una cantidad terapéuticamente efectiva de un compuesto o una composicion que comprende un compuesto de cualquiera de las formulas (1), (2), (3), (4), (5) o (6), o sus subgéneros, a un paciente que lo necesita. Reivindicacion 1: Una composicion farmacéuticamente aceptable que comprende un compuesto de formula (3) o una sal o prodroga farmacéuticamente aceptable de dicho compuesto; en donde: (i) Z1 es -OH o -OR3 y Z2 es -OH, -OR4, un alquilo C1-8 opcionalmente sustituido, alquenilo C2-8 opcionalmente sustituido, alquinilo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, heteroalquenilo C2-8 opcionalmente sustituido, heteroalquinilo C2-8 opcionalmente sustituido, carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, arilo C6-10 opcionalmente sustituido o heteroarilo de 5-10 miembros opcionalmente sustituido; (ii) Z1 y Z2, tomados junto con el átomo de boro al cual están unidos, forman un anillo de 5 a 8 miembros que tiene al menos un átomo de O, S o NR5 directamente unido al átomo de boro; o (iii) Z1 es -OH o -OR3, y Z2 y el Anillo A tomados juntos forman un anillo de 5 a 7 miembros opcionalmente sustituido; W1 y W2 se seleccionan independientemente de CR12, C y N; X es un enlace covalente, -O-, -N=N-, -C=N-, -NR6-, -C(NR6)-, -S-, -C(O)-, -S(O)-, -S(O)2-, o alquileno C1-6 opcionalmente sustituido, en donde una, dos o tres unidades de metileno del alquileno C1-6 están opcional e independientemente reemplazadas por uno o varios grupos seleccionados de -O-, -N=N-, -C=N-, -NR6-, -C(NR6)-, -S-, -C(O)-, -S(O)- y -S(O)2-; RA es hidrogeno, halogeno, -OR7, -CF3, -CN, -NO2, -SO2R7, -SOR7, -C(O)R7, -CO2R7, -C(O)N(R7)2, -N3, -N2R7, -N(R7)2 o el Anillo B que tiene la formula (7) en donde el Anillo B es carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, arilo C6-10 opcionalmente sustituido o heteroarilo de 5-10 miembros opcionalmente sustituido; cada caso de R1 es, independientemente, halogeno, -OR8, -CF3, -CN, -NO2, -SO2R8, -SOR8, -C(O)R8, -CO2R8, -C(O)N(R8)2, -N3, -N2R8, -N(R8)2, -B(OH2), alquilo C1-8 opcionalmente sustituido, alquenilo C2-8 opcionalmente sustituido, alquinilo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, heteroalquenilo C2-8 opcionalmente sustituido, heteroalquinilo C2-8 opcionalmente sustituido, carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, o heteroarilo de 5-10 miembros opcionalmente sustituido; cada caso de R2 es, independientemente, halogeno, -OR9, -CF3, -CN, -NO2, -SO2R9, -SOR9, -C(O)R9, -CO2R9, -C(O)N(R9)2, -N3, -N2R9, -N(R9)2, alquilo C1-8 opcionalmente sustituido, alquenilo C2-8 opcionalmente sustituido, alquinilo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, heteroalquenilo C2-8 opcionalmente sustituido, heteroalquinilo C2-8 opcionalmente sustituido, carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, ariIo C6-10 opcionalmente sustituido o heteroarilo de 5-10 miembros opcionalmente sustituido; cada caso de R3 y R4 es, independientemente, aIquilo C1-8, opcionalmente sustituido, aIqueniIo C2-8 opcionalmente sustituido, aIquiniIo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, heteroalquenilo C2-8 opcionalmente sustituido, heteroalquinilo C2-8 opcionalmente sustituido, carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, ariIo C6-10 opcionalmente sustituido o heteroarilo de 5-10 miembros opcional mente sustituido; cada caso de R5, R6, R7, R8, R9 y R10 es, independientemente, hidrogeno, -SO2R11, -SOR11, -C(O)R11, -CO2R11, -C(O)N(R11)2, -C(O)NH(R1 1), alquilo C1-8 opcionalmente sustituido, alquenilo C2-8 opcionalmente sustituido, aIquiniIo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, heteroalquenilo C2-8 opcionalmente sustituido, heteroalquinilo C2-8 opcionalmente sustituido, carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, ariIo C6-10 opcionalmente sustituido o heteroarilo de 5-10 miembros opcionalmente sustituido; cada caso de R11 es, independientemente, aIquiIo C1-8 opcionalmente sustituido, aIqueniIo C2-8 opcionalmente sustituido, aIquiniIo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, heteroalquenilo C2-8 opcionalmente sustituido, heteroalquinilo C2-8 opcionalmente sustituido, carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, ariIo C6-10 opcionalmente sustituido o heteroarilo de 5-10 miembros opcionalmente sustituido; cada caso de R12 es, independientemente, hidrogeno, halogeno, -CF3, alquilo C1-8 opcionalmente sustituido, alquenilo C2-8 opcionalmente sustituido o aIquinilo C2-8 opcionalmente sustituido; n es, independientemente, 0, 1, 2 o 3 y m es 0, 1, 2, 3, 4 o 5. Reivindicacion 18: Una composicion farmacéuticamente aceptable que comprende un compuesto de formula (4) o una sal o prodroga farmacéuticamente aceptable de dicho compuesto, en donde: (i) Z1 es -OH o -OR3 y Z2 es -OH, -OR4, un alquilo C1-8 opcionalmente sustituido, alquenilo C2-8 opcionalmente sustituido, alquinilo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, heteroalquenilo C2-8 opcionalmente sustituido, heteroalquinilo C2-8 opcionalmente sustituido, carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, arilo C6-10 opcionalmente sustituido o heteroarilo de 5-10 miembros opcionalmente sustituido; (ii) Z1 y Z2, tomados junto con el átomo de boro al cual están unidos, forman un anillo de 5 a 8 miembros que tiene al menos un átomo de O, S o NR5 directamente unido al átomo de boro; o (iii) Z1 es -OH o -OR3, y Z2 y el Anillo A tomados juntos forman un anillo de 5 a 7 miembros opcionalmente sustituido; Y3, Y4 y Y5 se selecciona cada uno independientemente de C, CR13, N, NR14, O y S, con la condicion de que al menos uno de Y3, Y4 o Y5 sea un heteroátomo seleccionado de N, NR14, O o S; Y6 es C o N; X es un enlace covalente, -O-, -N=N-, -C=N-, -NR6-, -C(NR6)-, -S-, -C(O)-, -S(O)-, -S(O)2-, o alquileno C1-6 opcionalmente sustituido, en donde una, dos o tres unidades de metileno del alquileno C1-6 están opcional e independientemente reemplazadas con uno o varios grupos seleccionados de -O-, -N=N-, -C=N-, -NR6-, -C(NR6)-, -S-, -C(O)-, -S(O)-, -S(O)2-, Ra es hidrogeno, halogeno, -OR7, -CF3, -CN, -NO2, -SO2R7, -SOR7, - C(O)R7, -CO2R7, -C(O)N(R7)2, -CHO, -N3, -N2R7, -N(R7)2, o el Anillo B que tiene la formula (7) en donde el Anillo B es carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, ariIo C6-10 opcionalmente sustituido o heteroarilo de 5-10 miembros opcionalmente sustituido; cada caso de R1 es, independientemente, halogeno, -OR8, -CF3, -CN, -NO2, -SO2R8, -SOR8, -C(O)R8, -CO2R8, -C(O)N(R8)2, -N3, -N2R8, -N(R8)2, -B(OH2), alquilo C1-8 opcionalmente sustituido, alquenilo C2-8 opcionalmente sustituido, alquinilo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, heteroalquenilo C2-8 opcionalmente sustituido, heteroalquinilo C2-8 opcionalmente sustituido, carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, o heteroarilo de 5-10 miembros opcionalmente sustituido; cada caso de R2 es, independientemente, halogeno, -OR9, -CF3, -CN, -NO2, -SO2R9, -SOR9, -C(O)R9, -CO2R9, -C(O)N(R9)2, -N3, -N2R9, -N(R9)2, alquilo C1-8 opcionalmente sustituido, alquenilo C2-8 opcionalmente sustituido, alquinilo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, heteroalquenilo C2-8 opcionalmente sustituido, heteroalquinilo C2-8 opcionalmente sustituido, carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, ariIo C6-10 opcionalmente sustituido o heteroarilo de 5-10 miembros opcionalmente sustituido; cada caso de R3 y R4 es, independientemente, aIquilo C1-8, opcionalmente sustituido, aIqueniIo C2-8 opcionalmente sustituido, aIquiniIo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, heteroalquenilo C2-8 opcionalmente sustituido, heteroalquinilo C2-8 opcionalmente sustituido, carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, ariIo C6-10 opcionalmente sustituido o heteroarilo de 5-10 miembros opcional mente sustituido; cada caso de R5, R6, R7, R8, R9, R10 y R14 es, independientemente, hidrogeno, -SO2R11, -SOR11, -C(O)R11, -CO2R11, -C(O)N(R11)2, -C(O)NH(R1 1), alquilo C1-8 opcionalmente sustituido, alquenilo C2-8 opcionalmente sustituido, aIquiniIo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, heteroalquenilo C2-8 opcionalmente sustituido, heteroalquinilo C2-8 opcionalmente sustituido, carbociclilo C3-10 opcionalmente sustituido, heterociclilo de 3-10 miembros opcionalmente sustituido, ariIo C6-10 opcionalmente sustituido o heteroarilo de 5-10 miembros opcionalmente sustituido; cada caso de R11 es, independientemente, aIquiIo C1-8 opcionalmente sustituido, aIqueniIo C2-8 opcionalmente sustituido, aIquiniIo C2-8 opcionalmente sustituido, heteroalquilo C1-8 opcionalmente sustituido, h
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Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
TW201000107A (en) 2008-04-09 2010-01-01 Infinity Pharmaceuticals Inc Inhibitors of fatty acid amide hydrolase
WO2010118155A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2010118159A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2010124113A1 (en) 2009-04-23 2010-10-28 Infinity Pharmaceuticals, Inc. Anti-fatty acid amide hydrolase-2 antibodies and uses thereof
US8927551B2 (en) 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
CN102030770B (zh) * 2009-09-25 2012-10-31 北京大学 一种芳香硼酸酯化合物的制备方法
MX2012004990A (es) 2009-10-30 2012-06-12 Janssen Pharmaceutica Nv Deribados de imidazo [1,2-b] pirimideazina y su uso como inhibidores de la enzima fosfodiesterasa 10.
WO2011085216A2 (en) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating parkinson's disease and restless legs syndrome
CN102834401B (zh) 2010-02-03 2016-08-24 无限药品股份有限公司 脂肪酸酰胺水解酶抑制剂
US8759535B2 (en) 2010-02-18 2014-06-24 High Point Pharmaceuticals, Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
US20130224151A1 (en) 2010-03-31 2013-08-29 United States Of America Use of FAAH Inhibitors for Treating Abdominal, Visceral and Pelvic Pain
EA201591390A1 (ru) 2010-06-24 2016-06-30 Джилид Сайэнс, Инк. Пиразол[1,5-a]пиримидины для противовирусного лечения
EP2624696B1 (en) 2010-10-06 2016-12-21 Glaxosmithkline LLC Benzimidazole derivatives as pi3 kinase inhibitors
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
JP2012232924A (ja) * 2011-04-28 2012-11-29 Tosoh Corp 新規なナフチルボロン酸化合物及びその製造法
BR112013033375B1 (pt) 2011-06-27 2022-05-10 Janssen Pharmaceutica N.V Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
SI3689878T1 (sl) * 2011-07-19 2021-12-31 Merck Sharp & Dohme B.V. 4-imidazopiridazin-1-il-benzamidi in 4-imidazotriazin-1-il-benzamidi kot Btk-zaviralci
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
EP2794611B1 (en) 2011-12-22 2017-10-11 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines as antiviral agents
CN106986869A (zh) 2012-04-17 2017-07-28 吉利德科学公司 用于抗病毒治疗的化合物和方法
CN104411312B (zh) 2012-06-26 2018-03-06 詹森药业有限公司 包括pde2抑制剂例如1‑芳基‑4‑甲基‑[1,2,4]***[4,3‑a]‑喹喔啉化合物和pde10抑制剂的用于在治疗神经病学障碍或代谢障碍中使用的组合
MX362197B (es) 2012-07-09 2019-01-08 Janssen Pharmaceutica Nv Derivados de imidazo[1,2-b]piridazina e imidazo[1,2-a]pirazina como inhibidores de la fosfodiesterasa 10; y el uso de los mismos en el tratamiento de trastornos neurológicos, psiquiátricos y metabólicos.
US9464098B2 (en) * 2012-12-03 2016-10-11 Hoffmann-La Roche Inc. Substituted triazole boronic acid compounds
CA2894399A1 (en) 2012-12-06 2014-06-12 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
WO2014127214A1 (en) 2013-02-15 2014-08-21 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
AU2014219024B2 (en) 2013-02-20 2018-04-05 KALA BIO, Inc. Therapeutic compounds and uses thereof
EP2961746B1 (en) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
AU2014342042B2 (en) 2013-11-01 2017-08-17 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3134418A4 (en) * 2014-04-23 2018-01-03 The Research Foundation for The State University of New York A rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjuction therewith
JP6615876B2 (ja) * 2014-06-26 2019-12-04 モナシュ ユニヴァーシティ 酵素相互作用薬剤
EP3473630B1 (en) * 2014-07-02 2021-01-13 Xavier University Of Louisiana Boron-based prodrug strategy for increased bioavailability and lower-dosage requirements for drug molecules containing at least one phenol (or aromatic hydroxyl) group
WO2016089648A1 (en) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
MA41562B1 (fr) 2015-06-03 2019-05-31 Bristol Myers Squibb Co Agonistes d'apj 4-hydroxy-3-(heteroaryl)pyridine-2-one a utiliser dans le traitement de troubles cardio-vasculaires
CN106800569B (zh) * 2016-12-12 2019-04-16 上海中医药大学附属龙华医院 Atg类似物及其制备方法和应用
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
US10392399B2 (en) 2016-09-08 2019-08-27 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
BR112019004463A2 (pt) 2016-09-08 2019-05-28 Kala Pharmaceuticals Inc formas cristalinas de compostos terapêuticos, seus processos de obtenção e seus métodos de uso
CA3036336A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2018090717A1 (zh) * 2016-11-16 2018-05-24 上海中医药大学附属龙华医院 Atg类似物及其制备方法和应用
EP3759109B1 (en) 2018-02-26 2023-08-30 Gilead Sciences, Inc. Substituted pyrrolizine compounds as hbv replication inhibitors
CN109180712B (zh) * 2018-08-08 2020-12-25 南京医科大学 一类2-茨醇的芳基硼酸酯衍生物及其应用
CN109096043B (zh) * 2018-08-24 2021-03-12 盐城师范学院 一种2,5-二溴碘苯的合成方法
DK3860998T3 (da) 2018-10-05 2024-03-25 Annapurna Bio Inc Forbindelser og sammensætninger til behandlinger af tilstande, der er forbundet med APJ-receptoraktivitet
TW202128675A (zh) 2019-12-06 2021-08-01 美商維泰克斯製藥公司 作為鈉通道調節劑之經取代四氫呋喃
EP4097099A4 (en) 2020-02-07 2023-09-27 Gasherbrum Bio, Inc. HETEROCYCLIC GLP-1 AGONISTS
US11643394B2 (en) 2020-04-30 2023-05-09 Icahn School Of Medicine At Mount Sinai Krüppel-like factor 15 (KLF15) small molecule agonists in kidney disease
AU2021267373A1 (en) 2020-05-06 2022-12-08 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
CN112147273B (zh) * 2020-11-02 2022-08-16 北京市理化分析测试中心 一种检测油品中微量酸的方法
US11827627B2 (en) 2021-06-04 2023-11-28 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
KR102567789B1 (ko) * 2021-06-08 2023-08-17 한국원자력의학원 신규한 벤조사이아졸 유도체 및 붕소 중성자 포획 요법에 있어서의 이의 용도
AU2022292554A1 (en) 2021-06-14 2024-01-04 Scorpion Therapeutics, Inc. Urea derivatives which can be used to treat cancer
WO2023086319A1 (en) 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
WO2023122778A1 (en) 2021-12-22 2023-06-29 Gossamer Bio Services, Inc. Pyridazinone derivatives useful as t cell activators

Family Cites Families (212)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4270537A (en) 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
US4499082A (en) 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
CA1268808A (en) 1985-07-23 1990-05-08 Alan G. Macdiarmid High capacity polyaniline electrodes
CH671400A5 (es) 1986-12-17 1989-08-31 Nii Prikladnych
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
GB8704027D0 (en) 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
DE3807862A1 (de) 1988-03-10 1989-09-21 Merck Patent Gmbh Smektische fluessigkristallphase
US5273680A (en) 1988-03-10 1993-12-28 Merck Patent Gesellschaft Mit Beschrankter Haftung Fluorinated oligophenyls and their use in liquid crystal materials
US5339163A (en) 1988-03-16 1994-08-16 Canon Kabushiki Kaisha Automatic exposure control device using plural image plane detection areas
FR2638359A1 (fr) 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
GB8829296D0 (en) 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
DE59108963D1 (de) 1990-02-01 1998-05-20 Merck Patent Gmbh Verfahren zur Umsetzung von fluorierten Aromaten mit Elektrophilen
DE4014488A1 (de) 1990-05-07 1991-11-14 Merck Patent Gmbh Dioxaborinane und fluessigkristallines medium
US5190521A (en) 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
EP0501268B1 (de) 1991-02-25 1996-06-12 F. Hoffmann-La Roche Ag Flüssigkristalline Verbindungen mit endständigem 1-Alkinylrest
AU2014892A (en) 1991-04-30 1992-12-21 Procter & Gamble Company, The Liquid detergents with an aryl boronic acid
GB2258232B (en) 1991-07-31 1995-03-15 Merck Patent Gmbh Alkoxymethylene fluoroterphenyls and liquid crystalline medium
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (sv) 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
GB9300059D0 (en) 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
CH683522A5 (de) 1992-03-13 1994-03-31 Hoffmann La Roche Verfahren zur Herstellung von Diarylen.
FR2688783A1 (fr) 1992-03-23 1993-09-24 Rhone Poulenc Chimie Nouveaux borates d'onium ou de complexe organometallique amorceurs cationiques de polymerisation.
FR2688790B1 (fr) 1992-03-23 1994-05-13 Rhone Poulenc Chimie Compositions a base de polyorganosiloxanes a groupements fonctionnels reticulables et leur utilisation pour la realisation de revetements anti-adhesifs.
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
PL167141B1 (pl) 1992-05-12 1995-07-31 Wojskowa Akad Tech Sposób otrzymywania związków ciekłokrystalicznych zawierających pierścień 1,3-dioksa- -2-boranu
JP3255965B2 (ja) 1992-05-26 2002-02-12 昭和シェル石油株式会社 反強誘電性液晶化合物
DE4220065A1 (de) 1992-06-19 1993-12-23 Merck Patent Gmbh Verfahren zur Herstellung von Pyrimidin-Derivaten
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
GB9220189D0 (en) 1992-09-24 1992-11-04 Central Research Lab Ltd Dioxane derivatives
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
GB9220750D0 (en) 1992-10-02 1992-11-18 Merck Patent Gmbh Liquid crystalline material forming ananisotropic
DE4236103A1 (de) 1992-10-26 1994-04-28 Hoechst Ag Verfahren zur Kreuzkupplung von aromatischen Boronsäuren mit aromatischen Halogenverbindungen oder Perfluoralkylsulfonaten
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
TW240217B (es) 1992-12-30 1995-02-11 Glaxo Group Ltd
US5576220A (en) 1993-02-19 1996-11-19 Arris Pharmaceutical Corporation Thin film HPMP matrix systems and methods for constructing and displaying ligands
FR2702485B1 (fr) 1993-03-10 1995-04-14 Rhone Poulenc Chimie Compositions à base de polyorganosiloxanes réticulables par voie cationique et leur utilisation dans le domaine de l'antiadhérence papier, de la protection des fibres optiques et des circuits imprimés.
US5563127A (en) 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
US5417885A (en) 1993-08-03 1995-05-23 Showa Shell Sekiyu Kabushiki Kaisha Antiferroelectric liquid crystal compound
US5431842A (en) 1993-11-05 1995-07-11 The Procter & Gamble Company Liquid detergents with ortho-substituted phenylboronic acids for inhibition of proteolytic enzyme
JPH07145174A (ja) 1993-11-22 1995-06-06 Takeda Chem Ind Ltd ジオキサボリナン系化合物、それらの製造方法、該化合物を含む液晶組成物および該組成物を用いた液晶光変調装置
JPH07165717A (ja) 1993-12-16 1995-06-27 Sumitomo Chem Co Ltd 複素環化合物およびその製造法
JPH07206715A (ja) 1994-01-21 1995-08-08 Sumitomo Chem Co Ltd 複素環化合物の製造法
DE19502178A1 (de) 1994-01-27 1995-08-03 Hoechst Ag Thiadiazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Vorprodukte zur Herstellung von Flüssigkristallen
WO1995024176A1 (en) 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5643893A (en) 1994-06-22 1997-07-01 Macronex, Inc. N-substituted-(Dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives, useful as inhibitors of inflammatory cytokines
JP3702426B2 (ja) 1994-08-03 2005-10-05 関東化学株式会社 トリフルオロメチルベンゼン誘導体および液晶組成物
FR2724660B1 (fr) 1994-09-16 1997-01-31 Rhone Poulenc Chimie Amorceurs de reticulation, par voie cationique, de polymeres a groupements organofonctionnels, compositions a base de polyorganosiloxanes reticulables et contenant ces amorceurs et application desdites compositions en antiadherence
JPH0892137A (ja) 1994-09-26 1996-04-09 Sumitomo Chem Co Ltd 芳香族エステル化合物、その製造法および用途
FR2727416A1 (fr) 1994-11-24 1996-05-31 Rhone Poulenc Chimie Nouveaux amorceurs cationiques thermoactivables, de polymerisation et/ou de reticulation et compositions monomeres et/ou polymeres fonctionnels les mettant en oeuvre
DE4445224B4 (de) 1994-12-17 2014-03-27 Merck Patent Gmbh Benzolderivate
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US6271015B1 (en) 1995-06-12 2001-08-07 The Scripps Research Institute Fatty-acid amide hydrolase
JP3783246B2 (ja) 1995-07-18 2006-06-07 大日本インキ化学工業株式会社 ｐ−テルフェニル誘導体
EP0755918B1 (de) 1995-07-28 2000-09-06 Rolic AG Photovernetzbare flüssigkristalline 1,2-Phenylen-Derivate
WO1997006124A1 (fr) 1995-08-09 1997-02-20 Chisso Corporation Derives du cyclohexane et compositions a cristaux liquides
US5893397A (en) 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
FR2745288B1 (fr) 1996-02-27 1998-04-17 Adir Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9605334D0 (en) 1996-03-13 1996-05-15 British Nuclear Fuels Plc Biodecontamination reactor
JP3555325B2 (ja) 1996-04-12 2004-08-18 チッソ株式会社 ビアリール誘導体の製造方法
US5998673A (en) 1996-06-03 1999-12-07 American Cyanamid Company 1, 4-diaryl-2-fluoro-2-butene insecticidal and acaricidal agents
US5892131A (en) 1997-05-29 1999-04-06 American Cyanamid Company Process for the preparation of pesticidal fluoroolefin compounds
US5849958A (en) 1997-03-17 1998-12-15 American Cyanamid Company 1,4,diaryl-2-fluoro-2-butene insecticidal and acaricidal agents
ZA974582B (en) 1996-06-03 1998-11-26 American Cyanamid Co Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds
BG63255B1 (bg) 1996-06-03 2001-07-31 American Cyanamid Company 1,4-диарил-2-флуоро-2-бутенови инсектицидни и акарицидни средства
CA2206192A1 (en) 1996-06-13 1997-12-13 F. Hoffmann-La Roche Ag Modulation of lc132 (opioid-like) receptor function
US5856537A (en) 1996-06-26 1999-01-05 The Scripps Research Institute Inhibitors of oleamide hydrolase
JPH1025261A (ja) 1996-07-09 1998-01-27 Chisso Corp フェノール誘導体の製造方法
DK0933346T3 (da) 1996-07-31 2004-03-29 Shionogi & Co Nye p-terphenylforbindelser
JP3899557B2 (ja) 1996-08-21 2007-03-28 大日本インキ化学工業株式会社 フルオロビフェニル誘導体
FR2752582B1 (fr) 1996-08-21 2003-06-13 Rhone Poulenc Chimie Compositions a base de polyorganosiloxanes a groupements fonctionnels reticulables et leur utilisation pour la realisation de revetements anti-adherents
JP4526605B2 (ja) 1996-08-28 2010-08-18 チッソ株式会社 ラテラルハロゲン置換基を有する４環化合物および液晶組成物
US6177440B1 (en) 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
US5925672A (en) 1996-12-06 1999-07-20 Neurosciences Research Foundation, Inc. Methods of treating mental diseases, inflammation and pain
FR2757530A1 (fr) 1996-12-24 1998-06-26 Rhodia Chimie Sa Utilisation pour la stereophotolithographie - d'une composition liquide photoreticulable par voie cationique comprenant un photoamorceur du type sels d'onium ou de complexes organometalliques
FR2757870B1 (fr) 1996-12-30 1999-03-26 Rhodia Chimie Sa Utilisation de compositions silicones reticulables par voie cationique sous uv et d'un photoamorceur du type borate d'onium, pour le revetements de joints plats, notamment de joints de culasse
FR2758329B1 (fr) 1997-01-16 1999-02-12 Synthelabo Derives d'imidazole-4-butane boronique, leur preparation et leur utilisation en therapeutique
FR2758560B1 (fr) 1997-01-20 2000-02-04 Adir Nouveaux derives d'acides aminophenylboronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2758723B1 (fr) 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
WO1998035924A1 (fr) 1997-02-13 1998-08-20 Chisso Corporation Composes de cristaux liquides de structure bicyclo [1.1.1] pentane, composition pour cristaux liquides et elements d'affichages a cristaux liquides
DE19710614A1 (de) 1997-03-14 1998-09-17 Hoechst Ag (1,2,4)-Thiadiazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
AU8140898A (en) 1997-06-13 1998-12-30 Northwestern University Inhibitors of beta-lactamases and uses therefor
IT1298087B1 (it) 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
DE19909761A1 (de) 1998-04-17 1999-10-21 Merck Patent Gmbh Benzofuran- und Benzodifuran-Derivate
DZ2769A1 (fr) 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
JP2000001463A (ja) 1998-06-12 2000-01-07 Dainippon Ink & Chem Inc ４−シアノベンゼン誘導体の製造方法
GB9814450D0 (en) 1998-07-04 1998-09-02 Sharp Kk Novel compounds
GB2339778A (en) 1998-07-17 2000-02-09 Secr Defence Terphenyl Liquid Crystals
WO2000020466A1 (de) 1998-10-01 2000-04-13 Targor Gmbh Katalysatorsystem
DE19857765A1 (de) * 1998-12-15 2000-06-21 Clariant Gmbh Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren
DE19858594A1 (de) 1998-12-18 2000-06-21 Merck Patent Gmbh Verfahren zur Herstellung von Cyanbenzolboronsäuren
WO2000037476A1 (de) 1998-12-19 2000-06-29 Basell Polyolefine Gmbh Verfahren zur herstellung von mono- oder di-organo-boranen
MXPA01007099A (es) * 1999-01-13 2002-03-27 Univ New York State Res Found Metodo novedoso para disenar inhibidores de la proteina cinasa.
JP4507294B2 (ja) 1999-05-27 2010-07-21 チッソ株式会社 ビアリール誘導体の製造方法
JP2003509507A (ja) 1999-09-21 2003-03-11 キネティック リミテッド 液晶化合物
US6309406B1 (en) 1999-11-24 2001-10-30 Hamit-Darwin-Fresh, Inc. Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening
NZ519183A (en) * 1999-12-03 2005-02-25 Ono Pharmaceutical Co Triazaspiro[5.5]undecane derivatives and pharmaceutical compositions comprising thereof, as an active ingredient
US20030096854A1 (en) 2002-06-12 2003-05-22 Ho-Shen Lin Substituted tricyclics
FR2805273B1 (fr) 2000-02-18 2006-08-11 Rhodia Chimie Sa Traitement de surface de materiau plastique avec une composition a fonctions reactives polymerisable et/ou reticulable
DE10009714A1 (de) 2000-03-01 2001-09-06 Targor Gmbh Verfahren zur Herstellung von Mono- oder Di-organo-boranen
GB2362882A (en) 2000-06-02 2001-12-05 Sharp Kk Liquid crystalline optionally laterally fluorinated terphenyl with chiral 3,4-di[(un)saturated-alkoxy]butoxy or 1,4-di[(un)saturated-alkoxy]but-2-oxy terminus
CA2419238A1 (en) 2000-08-16 2002-02-21 University Of Alberta Non-pressurized methods for the preparation of conjugated solid supports for boronic acids
ATE368653T1 (de) * 2000-08-23 2007-08-15 Lilly Co Eli Oxazolylaryloxyessigsäure derivate und ihre verwendung als ppar agonisten
US6927216B2 (en) 2000-10-03 2005-08-09 Bristol-Myers Squibb Pharma Company Cyclic sulfonyl compounds as inhibitors of metalloproteases
DE60140559D1 (de) 2000-10-05 2009-12-31 Millenium Pharmaceuticals Inc 32144, eine humane fettsäureamid-hydrolase und deren verwendungen
GB0100110D0 (en) 2001-01-04 2001-02-14 Univ Leeds Modulation of calcium channel activity
US20040235792A1 (en) * 2001-01-20 2004-11-25 Deadman John J Serine protease inhibitors compromising a hydrogen-bond acceptor
JP4721027B2 (ja) 2001-03-29 2011-07-13 Ｄｉｃ株式会社 フェニルピリミジン誘導体の製造方法
US20030022864A1 (en) 2001-04-24 2003-01-30 Ishaq Khalid S. 9-[(5-dihydroxyboryl)-pentyl] purines, useful as an inhibitor of inflammatory cytokines
US6617125B2 (en) 2001-06-29 2003-09-09 Perkinelmer Life Sciences, Inc. Compositions for enhanced catalyzed reporter deposition
US6858592B2 (en) 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
DE60205824T2 (de) 2001-07-09 2006-05-18 Merck Patent Gmbh Thienothiophenderivate
WO2003033002A1 (fr) * 2001-10-11 2003-04-24 Ono Pharmaceutical Co Inhibiteurs de l'augmentation de la concentration du calcium intracellulaire
CA2462348A1 (en) 2001-10-12 2003-04-24 Dow Global Technologies Inc. Metal complex compositions and their use as catalysts to produce polydienes
ATE360054T1 (de) 2001-11-07 2007-05-15 Merck Patent Gmbh Flüssigkristalline verbindung, flüssigkristallines medium und flüssigkristallanzeige
GB0126844D0 (en) 2001-11-08 2002-01-02 Qinetiq Ltd Novel compounds
EP2769715A3 (en) 2001-11-26 2014-09-17 Trustees Of Tufts College Methods for treating autoimmune disorders, and reagents related thereto
KR20040077660A (ko) * 2001-12-12 2004-09-06 가부시끼가이샤 도꾸야마 유기 일렉트로루미네선스 소자 재료
DE10201764A1 (de) 2002-01-18 2003-07-31 Bayer Cropscience Ag Substituierte 4-Aminopyridin-Derivate
WO2003064484A1 (en) 2002-01-28 2003-08-07 Dow Global Technologies Inc. Metal complex compositions based on cobalt and their use as polymerization catalyst for olefins and dienes
DE10206759A1 (de) 2002-02-19 2003-08-28 Dragoco Gerberding Co Ag Synergistische Mischungen von 1,2-Alkandiolen
DE10211597A1 (de) 2002-03-15 2003-10-02 Merck Patent Gmbh Verfahren zur Herstellung von Ringverbindungen
AU2003223930A1 (en) 2002-06-14 2003-12-31 Novo Nordisk A/S Pharmaceutical use of boronic acids and esters thereof
NZ537206A (en) 2002-06-27 2007-06-29 Astellas Pharma Inc Aminoalcohol derivatives
EP1388538B1 (en) 2002-07-09 2010-09-01 Merck Patent GmbH Polymerisation Initiator
US20040115475A1 (en) 2002-08-14 2004-06-17 Matsushita Electric Industrial Co., Ltd. Aromatic methylidene compound, methylstyrul compound for producing the same, production electroluminescent element
EP1576127A4 (en) 2002-11-14 2006-10-25 Scripps Research Inst CRYSTAL FORM OF FATTY ACID AMINE HYDROLASE (FAAH)
CN100509792C (zh) 2002-11-27 2009-07-08 默克专利股份有限公司 四氢吡喃衍生物
US6924269B2 (en) 2002-12-04 2005-08-02 Vdf Futureceuticals, Inc. Enzyme inhibitors and methods therefor
US7390806B2 (en) 2002-12-18 2008-06-24 Anacor Pharmaceuticals, Inc. Antibiotics containing borinic acid complexes and methods of use
US7456169B2 (en) * 2003-02-27 2008-11-25 Abbott Laboratories Inc. Heterocyclic kinase inhibitors
JP4787150B2 (ja) 2003-03-06 2011-10-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｊｎｋ阻害剤
WO2004080989A1 (ja) 2003-03-10 2004-09-23 Sumitomo Chemical Company Limited フラン化合物の製造方法
WO2004081008A1 (en) * 2003-03-14 2004-09-23 Astrazeneca Ab Novel fused triazolones and the uses thereof
JP2004292766A (ja) * 2003-03-28 2004-10-21 Tokuyama Corp 有機エレクトロルミネッセンス素子材料
DE10325438A1 (de) 2003-05-21 2004-12-09 Bayer Cropscience Ag Difluormethylbenzanilide
EP2492264A3 (en) 2003-06-03 2012-12-19 Rib-X Pharmaceuticals, Inc. Biaryl Heterocyclic Compounds And Methods Of Making And Using The Same
CA2528587A1 (en) 2003-06-10 2005-01-20 Fulcrum Pharmaceuticals, Inc. .beta.-lactamase inhibitors and methods of use thereof
AU2004262524C1 (en) 2003-06-16 2010-08-19 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
DE10337497A1 (de) 2003-08-14 2005-03-10 Bayer Cropscience Ag 4-Biphenylsubstituierte-Pyrazolidin-3,5-dion-Derivate
WO2005037227A2 (en) 2003-10-16 2005-04-28 Microbia, Inc. Selective cox-2 inhibitors
JP2007512244A (ja) 2003-10-31 2007-05-17 フルクラム・ファーマシューティカルズ・インコーポレーテッド コロナウイルスプロテアーゼの阻害剤およびその使用方法
EP1682499B1 (en) 2003-11-10 2007-08-08 Microbia, Inc. 4-biarylyl-1-phenylazetidin-2-ones
US20070010559A1 (en) 2003-11-25 2007-01-11 Novo Nordisk A/S Indole derivatives for use as chemical uncoupler
JP4491666B2 (ja) 2003-12-02 2010-06-30 東ソー株式会社 フルオレン骨格を有するアリールアミン誘導体の製造方法とその合成中間体
GB2410745B (en) 2004-02-06 2007-07-25 Merck Patent Gmbh Cholestanyl derivatives
EP1717230B1 (en) 2004-02-13 2014-08-06 Msd K.K. Fused-ring 4-oxopyrimidine derivative
GB0403744D0 (en) 2004-02-20 2004-03-24 Astrazeneca Ab Chemical process
DE102004041532A1 (de) 2004-08-27 2006-03-02 Bayer Cropscience Ag Biphenylthiazolcarboxamide
DE102004041530A1 (de) 2004-08-27 2006-03-02 Bayer Cropscience Ag Biphenylthiazolcarboxamide
US20100286211A1 (en) * 2004-10-08 2010-11-11 Biswajit Das Oxazolidinone derivatives as antimicrobials
WO2006050236A2 (en) 2004-11-01 2006-05-11 Nuada, Llc Compounds and methods of use thereof
WO2006050054A2 (en) 2004-11-01 2006-05-11 Nuada, Llc Compounds and methods of use thereof
JP2008518923A (ja) 2004-11-01 2008-06-05 ヌアダ，リミテッド・ライアビリティ・カンパニー 化合物およびその使用方法
WO2006053250A2 (en) 2004-11-12 2006-05-18 Trustees Of Tufts College Lipase inhibitors
DE102005023834A1 (de) 2004-11-20 2006-05-24 Bayer Healthcare Ag Substituierte[(Phenylethanoyl)amino]benzamide
WO2006060625A2 (en) 2004-12-02 2006-06-08 Displaytech, Inc. Liquid crystal compositions comprising an organogermanium compound and methods for using the same
US7553496B2 (en) 2004-12-21 2009-06-30 University Of Kentucky Research Foundation VEGF-A as an inhibitor of angiogenesis and methods of using same
JP2008526980A (ja) 2005-01-14 2008-07-24 ジェネラブズ テクノロジーズ インコーポレーティッド ウイルス感染症を治療するためのインドール誘導体
US20090005321A1 (en) 2005-02-09 2009-01-01 Microbia, Inc. Phenylazetidinone Derivatives
PT3424932T (pt) 2005-02-16 2021-05-19 Anacor Pharmaceuticals Inc Boronoftalidas para utilização terapêutica
GB2436766B (en) 2005-02-22 2012-02-08 Sumation Co Ltd High bandgap arylene polymers
EP1863513A2 (en) 2005-03-11 2007-12-12 The University of North Carolina at Chapel Hill Potent and specific immunoproteasome inhibitors
GB2424881B (en) 2005-04-07 2010-11-24 Merck Patent Gmbh Halophenyl derivatives of bisalkylfluorene
JP4792796B2 (ja) 2005-04-08 2011-10-12 東ソー株式会社 ２，３−ジハロビフェニレン誘導体、その前駆化合物及び製造方法
WO2006122186A2 (en) 2005-05-10 2006-11-16 Microbia, Inc. 1,4-diphenyl-3-hydroxyalkyl-2-azetidinone derivatives for treating hypercholestrolemia
TW200740752A (en) 2005-05-13 2007-11-01 Microbia Inc 4-Biarylyl-1-phenylazetidin-2-ones
US7674876B2 (en) 2005-05-25 2010-03-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Synthesis of novel monomers containing the trifluorovinylidene group and the cyanato group and polymers thereof
JP2008546651A (ja) 2005-06-14 2008-12-25 メルク フロスト カナダ リミテツド モノアミンオキシダーゼａ及びｂの可逆的阻害剤
KR100659088B1 (ko) 2005-07-15 2006-12-21 삼성에스디아이 주식회사 디플루오로피리딘계 화합물 및 이를 이용한 유기 발광 소자
TW200740823A (en) * 2005-08-01 2007-11-01 Ihara Chemical Ind Co Oxadiazole-substituted Sym-triindole derivative and organic el element employing the same
DE102005037925A1 (de) 2005-08-11 2007-02-15 Merck Patent Gmbh Hydro-cyclopenta[a]naphthaline
US7589239B2 (en) * 2005-09-02 2009-09-15 Auspex Pharmaceuticals Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
US7999137B2 (en) 2005-09-13 2011-08-16 Bayer Cropscience Ag Pesticide bi-phenyl-amidine derivatives
CA2630460C (en) * 2005-12-01 2013-01-08 F. Hoffmann-La Roche Ag Heteroaryl substituted piperidine derivatives as l-cpt1 inhibitors
KR101408026B1 (ko) 2005-12-02 2014-06-20 사켐,인코포레이티드 음이온-교환 치환 크로마토그래피 공정 및 음이온-교환치환 크로마토그래피 공정에서 디스플레이서 화합물들로서사용하기 위한 음이온성 유기 화합물들
RU2008131324A (ru) * 2005-12-30 2010-02-10 Анакор Фармасьютикалз, Инк. (Us) Борсодержащие малые молекулы
WO2007076875A2 (en) * 2006-01-06 2007-07-12 Aarhus Universitet Compounds acting on the serotonin transporter
GB0602046D0 (en) * 2006-02-01 2006-03-15 Smithkline Beecham Corp Compounds
ES2728455T3 (es) * 2006-02-16 2019-10-24 Anacor Pharmaceuticals Inc Moléculas pequeñas que contienen boro como agentes antiinflamatorios
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
DE102007009944B4 (de) 2006-03-15 2016-04-28 Merck Patent Gmbh Flüssigkristallines Medium und seine Verwendung
CA2584745A1 (en) 2006-04-13 2007-10-13 Aegera Therapeutics Inc. Use of imidazo(2,1-b) -1,3,4-thiadiazole-2-sulfonamide compounds to treat neuropathic pain
JP5145753B2 (ja) 2006-04-20 2013-02-20 Ｊｎｃ株式会社 フルオロイソプロピル基を側鎖として有する化合物およびこれを用いた液晶組成物
AU2007257689A1 (en) * 2006-06-12 2007-12-21 Anacor Pharmaceuticals, Inc. Compounds for the treatment of periodontal disease
US7838542B2 (en) * 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
EP2046769A2 (en) 2006-07-27 2009-04-15 Cv Therapeutics, Inc. Aldh-2 inhibitors in the treatment of addiction
US8034940B2 (en) * 2006-08-09 2011-10-11 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US8236783B2 (en) * 2006-08-15 2012-08-07 Duke University ROS-sensitive iron chelators and methods of using the same
WO2008019743A1 (de) 2006-08-16 2008-02-21 Merck Patent Gmbh Cyclohexen-verbindungen für flüssigkristalline mischungen
EP1900792B1 (de) 2006-09-13 2010-08-04 Merck Patent GmbH Fluorphenyl-Verbindungen für flüssigkristalline Mischungen
WO2008039829A2 (en) 2006-09-26 2008-04-03 Ironwood Pharmaceuticals, Inc. Diphenylheterocycle cholesterol absorption inhibitors
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
MX2009004233A (es) 2006-10-18 2009-08-12 Pfizer Prod Inc Compuestos de biaril eter urea.
CN101616883B (zh) 2007-01-24 2014-06-18 Jnc株式会社 液晶性化合物、液晶组成物以及液晶显示元件
US7951433B2 (en) 2007-02-28 2011-05-31 Chisso Corporation Five-ring liquid crystal compound having CF2O bonding group, liquid crystal composition, and liquid crystal display device
GB2460784A (en) * 2007-03-07 2009-12-16 Dong A Pharmtech Co Ltd Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators,method of the same,and pharmaceutical composition
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
US7741347B2 (en) * 2007-05-17 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2009011904A1 (en) 2007-07-19 2009-01-22 Renovis, Inc. Compounds useful as faah modulators and uses thereof
TW201000107A (en) 2008-04-09 2010-01-01 Infinity Pharmaceuticals Inc Inhibitors of fatty acid amide hydrolase
CN102015585B (zh) 2008-05-08 2013-06-19 住友化学株式会社 不饱和有机化合物的制造方法
DE102008023801A1 (de) 2008-05-15 2009-11-19 Bayer Schering Pharma Aktiengesellschaft Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine

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WO2009126691A1 (en) 2009-10-15
CA2721060A1 (en) 2009-10-15
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US8957049B2 (en) 2015-02-17
CN102046179A (zh) 2011-05-04
JP5637982B2 (ja) 2014-12-10
US20150368278A1 (en) 2015-12-24
IL208536A0 (en) 2010-12-30
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PE20091838A1 (es) 2009-12-18
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