PE20170664A1 - Agonistas del receptor de apelina(apj) y usos de los mismos - Google Patents

Agonistas del receptor de apelina(apj) y usos de los mismos

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Publication number
PE20170664A1
PE20170664A1 PE2016002511A PE2016002511A PE20170664A1 PE 20170664 A1 PE20170664 A1 PE 20170664A1 PE 2016002511 A PE2016002511 A PE 2016002511A PE 2016002511 A PE2016002511 A PE 2016002511A PE 20170664 A1 PE20170664 A1 PE 20170664A1
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PE
Peru
Prior art keywords
alkyl
apj
apeline
same
receptor agonists
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PE2016002511A
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English (en)
Inventor
Rangan Maitra
James Barnwel Thomas
Scott P Runyon
Sanju Narayanan
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Res Triangle Inst
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Publication of PE20170664A1 publication Critical patent/PE20170664A1/es

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

Se refiere a un compuesto de formula I, donde: R1 es fenilo sustituido; R2 es alquilo C1-C8, heteroarilo, entre otros; R3 es alquilo C1-C8, alquil C1-C8-cicloalquil C3-C8 o cicloalquil C3-C8; R4, R5 y R6 son independientemente adamantanilo, arilo, alquilo C1-C8, entre otros; Z es H2 u =O. Son compuestos preferidos: acido (S)-2-ciclohexil-2-(5-(2,6-dimetoxifenil)-1-(4-fluorofenil)-1H-pirazol-3-carboxamido)acetico; acido (S)-3-(5-(2,6-dimetoxifenil)1-(4-fluorofenil)-1H-pirazol-3-carboxamido)-5-metilhexanoico; entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos son agonistas del receptor de apelina (APJ), siendo utiles en el tratamiento de asma, cardiomiopatia, diabetes, entre otros
PE2016002511A 2014-06-06 2015-06-05 Agonistas del receptor de apelina(apj) y usos de los mismos PE20170664A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462008688P 2014-06-06 2014-06-06
PCT/US2015/034427 WO2015188073A1 (en) 2014-06-06 2015-06-05 Apelin receptor (apj) agonists and uses thereof

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US (2) US10377718B2 (es)
EP (1) EP3152200A1 (es)
JP (1) JP6767878B2 (es)
KR (1) KR102509043B1 (es)
CN (1) CN106459004B (es)
AU (1) AU2015269247B2 (es)
BR (1) BR112016028119A2 (es)
CA (1) CA2949559C (es)
IL (1) IL248988A0 (es)
MA (1) MA39999A (es)
MX (1) MX2016014890A (es)
PE (1) PE20170664A1 (es)
RU (1) RU2705800C2 (es)
WO (1) WO2015188073A1 (es)
ZA (1) ZA201607850B (es)

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