PE20090238A1 - Derivados de pirazol como inhibidores de tirosinquinasas - Google Patents

Derivados de pirazol como inhibidores de tirosinquinasas

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Publication number
PE20090238A1
PE20090238A1 PE2008000770A PE2008000770A PE20090238A1 PE 20090238 A1 PE20090238 A1 PE 20090238A1 PE 2008000770 A PE2008000770 A PE 2008000770A PE 2008000770 A PE2008000770 A PE 2008000770A PE 20090238 A1 PE20090238 A1 PE 20090238A1
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PE
Peru
Prior art keywords
alkyl
pirazole
inhibitors
imidazo
pyridin
Prior art date
Application number
PE2008000770A
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English (en)
Inventor
Audrey Davies
Stephanos Ioannidis
Michelle Lamb
Mei Su
Tao Wang
Hai-Jun Zhang
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Astrazeneca Ab
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Publication date
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Publication of PE20090238A1 publication Critical patent/PE20090238A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
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    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOL DE FORMULA (I) DONDE Q ES N O CR3, EN DONDE R3 ES H, HALO, CN, ALQUILO(C1-C6), ENTRE OTROS; D ES N O CH; R1 ES H, CN, ALQUILO(C1-C6), ALQUENILO(C2-C6), ENTRE OTROS; R2 ES H, HALO, CN, ALQUINILO(C2-C6), NO2, ENTRE OTROS; R4 ES H, CN, ALQUILO(C1-C6), ALQUINILO(C2-C6), ENTRE OTROS; R5 ES HALO, CN, ALQUENILO(C2-C6), ALQUINILO(C2-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[(1S)-1-(5-FLUOROPIRIDIN-2-IL)ETIL]-3-(5-ISOPROPOXI-1H-PIRAZOL-3-IL)-3H-IMIDAZO[4,5-b]PIRIDIN-5-AMINA, 3-(5-CICLOPROPIL-1H-PIRAZOL-3-IL)-N-[(1S)-1-(5-FLUOROPIRIDIN-2-IL)ETIL]-3H-IMIDAZO[4,5-b]PIRIDIN-5-AMINA, N-[(1S)-1-(5-FLUOROPIRIMIDIN-2-IL)ETIL]-3-(5-ISOPROPOXI-1H-PIRAZOL-3-IL)-3H-IMIDAZO[4,5-b]PIRIDIN-5-AMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE TIROSINQUINASAS SIENDO UTILES EN EL TRATAMIENTO DE PSORIASIS, ARTRITIS REUMATOIDE, SARCOMA, ATEROSCLEROSIS, MIELOMA
PE2008000770A 2007-05-04 2008-04-30 Derivados de pirazol como inhibidores de tirosinquinasas PE20090238A1 (es)

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US91627007P 2007-05-04 2007-05-04

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US (3) US8486966B2 (es)
EP (1) EP2152705A1 (es)
JP (1) JP5415403B2 (es)
KR (1) KR101563372B1 (es)
CN (1) CN101679426A (es)
AR (1) AR066429A1 (es)
AU (1) AU2008247159B2 (es)
BR (1) BRPI0811534A2 (es)
CA (1) CA2684693C (es)
CL (1) CL2008001297A1 (es)
CO (1) CO6251294A2 (es)
EC (1) ECSP099751A (es)
IL (1) IL201691A0 (es)
MX (1) MX2009011944A (es)
MY (1) MY147890A (es)
NZ (1) NZ581633A (es)
PE (1) PE20090238A1 (es)
RU (1) RU2481348C2 (es)
SA (1) SA08290271B1 (es)
TW (1) TWI406864B (es)
UA (1) UA99459C2 (es)
UY (1) UY31065A1 (es)
WO (1) WO2008135785A1 (es)
ZA (1) ZA200907679B (es)

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KR101563372B1 (ko) 2015-10-26
AU2008247159A1 (en) 2008-11-13
BRPI0811534A2 (pt) 2014-11-18
AU2008247159B2 (en) 2011-11-10
UA99459C2 (en) 2012-08-27
CA2684693C (en) 2015-06-23
EP2152705A1 (en) 2010-02-17
ZA200907679B (en) 2010-07-28
UY31065A1 (es) 2009-01-05
AR066429A1 (es) 2009-08-19
MX2009011944A (es) 2009-12-11
US8486966B2 (en) 2013-07-16
RU2009144848A (ru) 2011-06-10
JP5415403B2 (ja) 2014-02-12
JP2010526128A (ja) 2010-07-29
TW200902530A (en) 2009-01-16
TWI406864B (zh) 2013-09-01
KR20100019988A (ko) 2010-02-19
IL201691A0 (en) 2010-05-31
CL2008001297A1 (es) 2009-01-16
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ECSP099751A (es) 2009-12-28
RU2481348C2 (ru) 2013-05-10
US20150011545A1 (en) 2015-01-08
US20100324040A1 (en) 2010-12-23
CO6251294A2 (es) 2011-02-21
CN101679426A (zh) 2010-03-24
NZ581633A (en) 2012-01-12
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CA2684693A1 (en) 2008-11-13

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