CO6251294A2 - Derivados de 9-(pirazol-3-il)-9h-purin-2-amina y 3-(pirazol-3-il)-3h-imidazol4,5-b piridin-5-amina y su uso para el tratamiento del cancer - Google Patents
Derivados de 9-(pirazol-3-il)-9h-purin-2-amina y 3-(pirazol-3-il)-3h-imidazol4,5-b piridin-5-amina y su uso para el tratamiento del cancerInfo
- Publication number
- CO6251294A2 CO6251294A2 CO09126884A CO09126884A CO6251294A2 CO 6251294 A2 CO6251294 A2 CO 6251294A2 CO 09126884 A CO09126884 A CO 09126884A CO 09126884 A CO09126884 A CO 09126884A CO 6251294 A2 CO6251294 A2 CO 6251294A2
- Authority
- CO
- Colombia
- Prior art keywords
- carbocyclyl
- 6alkyl
- heterocyclyl
- membered
- pirazol
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 10
- 125000000623 heterocyclic group Chemical group 0.000 abstract 10
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P27/16—Otologicals
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Abstract
1.- Un compuesto de Fórmula (I):o una sal farmacéuticamente aceptable de este, donde Q se selecciona entre N y C(R3); D se selecciona entre N y CH; R1 se selecciona entre H, -CN, C1-6alquilo, C2-6alquenilo, C2-6alquinilo, carbociclilo de 3 a 5 miembros, heterociclilo de 5 miembros, -OR1a, -SR1a, N(R1a)2, -N(R1a)C(O)R1b, -N(R1a)N(R1a)2, -NO2, -C(O)H, -C(O)R1b, -C(O)2R1a, -C(O)N(R1a)2, -OC(O)N(R1a)2, -N(R1a)C(O)2R1a, -N(R1a)C(O)N(R1a)2, -OC(O)R1b, -S(O)R1b, -S(O)2R1b, -S(O)2N(R1a)2, -N(R1a)S(O)2R1b, -C(R1a)=N(R1a) y -C(R1a)=N(OR1a) donde dichos C1-6alquilo, C2-6alquenilo, C2-6alquinilo, carbociclilo de 3 a 5 miembros y heterociclilo de 5 miembros están opcionalmente sustituidos con uno o más R10; Cada vez que aparece R1a se selecciona independientemente entre H y C1-6alquilo, carbociclilo de 3 a 5 miembros y heterociclilo de 5 miembros, donde cada vez que aparecen dichos C1-6alquilo, carbociclilo de 3 a 5 miembros y heterociclilo de 5 miembros están opcional e independientemente sustituidos con uno o más R10; Cada vez que aparece R1b se selecciona independientemente entre C1-6alquilo, C2-6alquenilo, C2-6alquinilo, carbociclilo de 3 a 5 miembros y heterociclilo de 5 miembros, donde cada vez que aparecen dichos C1-6alquilo, C2-6alquenilo, C2-6alquinilo, carbociclilo de 3 a 5 miembros y heterociclilo de 5 miembros están opcional e independientemente sustituidos con uno o más R10;R2 se selecciona entre H, halo, -CN, C1-6alquilo, C2-6alquenilo, C2-6alquinilo, carbociclilo, heterociclilo, OR2a, -SR2a, N(R2a)2, N(R2a)C(O)R2b, -N(R2a)N(R2a)2, -NO2, -C(O)H, -C(O)R2b, -C(O)2R2a, -C(O)N(R2a)2, -OC(O)N(R2a)2, -N(R2a)C(O)2R2a, -N(R2a)C(O)N(R2a)2, -OC(O)R2b, -S(O)R2b, -S(O)2R2b, -S(O)2N(R2a)2, -N(R2a)S(O)2R2b, -C(R2a)=N(R2a) y C(R2a)=N(OR2a), donde dichos C1-6aIquilo, C2-6alquenilo, C2-6alquinilo, carbociclilo y heterociclilo están opcionalmente sustituidos con uno o más R20;Cada vez que aparece R2a se selecciona independientemente entre H, C1-6alquilo, carbociclilo y heterociclilo, donde cada vez que aparecen dichos C1-6alquilo, carbociclilo y heterociclilo están opcional e independientemente sustituidos con uno o más R20; ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US91627007P | 2007-05-04 | 2007-05-04 |
Publications (1)
Publication Number | Publication Date |
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CO6251294A2 true CO6251294A2 (es) | 2011-02-21 |
Family
ID=39592016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CO09126884A CO6251294A2 (es) | 2007-05-04 | 2009-11-09 | Derivados de 9-(pirazol-3-il)-9h-purin-2-amina y 3-(pirazol-3-il)-3h-imidazol4,5-b piridin-5-amina y su uso para el tratamiento del cancer |
Country Status (24)
Country | Link |
---|---|
US (3) | US8486966B2 (es) |
EP (1) | EP2152705A1 (es) |
JP (1) | JP5415403B2 (es) |
KR (1) | KR101563372B1 (es) |
CN (1) | CN101679426A (es) |
AR (1) | AR066429A1 (es) |
AU (1) | AU2008247159B2 (es) |
BR (1) | BRPI0811534A2 (es) |
CA (1) | CA2684693C (es) |
CL (1) | CL2008001297A1 (es) |
CO (1) | CO6251294A2 (es) |
EC (1) | ECSP099751A (es) |
IL (1) | IL201691A0 (es) |
MX (1) | MX2009011944A (es) |
MY (1) | MY147890A (es) |
NZ (1) | NZ581633A (es) |
PE (1) | PE20090238A1 (es) |
RU (1) | RU2481348C2 (es) |
SA (1) | SA08290271B1 (es) |
TW (1) | TWI406864B (es) |
UA (1) | UA99459C2 (es) |
UY (1) | UY31065A1 (es) |
WO (1) | WO2008135785A1 (es) |
ZA (1) | ZA200907679B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA99459C2 (en) * | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
AU2008310097B2 (en) | 2007-10-09 | 2013-05-16 | Merck Patent Gmbh | Pyridine derivatives useful as glucokinase activators |
GB0725218D0 (en) * | 2007-12-24 | 2008-02-06 | Syngenta Ltd | Chemical compounds |
US8299070B2 (en) * | 2009-11-25 | 2012-10-30 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
EP2397482A1 (en) | 2010-06-15 | 2011-12-21 | Almirall, S.A. | Heteroaryl imidazolone derivatives as jak inhibitors |
JP5914667B2 (ja) | 2011-09-22 | 2016-05-11 | ファイザー・インク | ピロロピリミジンおよびプリン誘導体 |
CN102952084A (zh) * | 2012-11-15 | 2013-03-06 | 大连九信生物化工科技有限公司 | 一种4,6-二氯-2-甲硫基-5-硝基嘧啶的合成方法 |
CN105431148A (zh) | 2013-03-07 | 2016-03-23 | 加利菲亚生物公司 | 混合谱系激酶抑制剂及治疗方法 |
CN104003943A (zh) * | 2014-05-06 | 2014-08-27 | 南通常佑药业科技有限公司 | 一种替格瑞洛中间体的制备方法 |
JOP20180094A1 (ar) | 2017-10-18 | 2019-04-18 | Hk Inno N Corp | مركب حلقي غير متجانس كمثبط بروتين كيناز |
GB201717260D0 (en) | 2017-10-20 | 2017-12-06 | Galapagos Nv | Novel compounds and pharma ceutical compositions thereof for the treatment of inflammatory disorders |
US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
EP4110340A1 (en) * | 2020-02-25 | 2023-01-04 | Dana-Farber Cancer Institute, Inc. | Potent and selective degraders of alk |
CA3204701A1 (en) | 2020-12-29 | 2022-07-07 | Pyramid Biosciences, Inc. | Topical pharmaceutical compositions and methods |
WO2023248151A1 (en) | 2022-06-24 | 2023-12-28 | Pyramid Biosciences, Inc. | Method of treating skin field cancerization with actinic keratoses |
Family Cites Families (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1417402A (en) | 1972-03-30 | 1975-12-10 | Boots Co Ltd | Pharmacologically active anilinobenzothiazoles |
DE2426180A1 (de) | 1974-05-29 | 1975-12-18 | Bayer Ag | Verfahren zum faerben von polyurethankunststoffen |
US4485284A (en) | 1982-01-11 | 1984-11-27 | Advanced Moisture Technology, Inc. | Apparatus and process for microwave moisture analysis |
US5006116A (en) | 1988-12-21 | 1991-04-09 | Kimberly-Clark Corporation | Tampon with single layer powder bonded wrap |
HU206337B (en) | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
CA2104053C (en) | 1992-08-31 | 1999-04-13 | Miguel A. Cacho | Automated fluid bed process |
US5543520A (en) | 1993-10-01 | 1996-08-06 | Ciba-Geigy Corporation | Pyrimidine derivatives |
US5935966A (en) | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
AU726058B2 (en) | 1995-09-01 | 2000-10-26 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
IL125686A (en) | 1996-02-13 | 2002-11-10 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical preparations containing them and their use in the manufacture of a drug with an anti-angiogenic effect and / or an effect of reducing vascular permeability |
DE69709319T2 (de) | 1996-03-05 | 2002-08-14 | Astrazeneca Ab | 4-anilinochinazolin derivate |
US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
WO1998044341A1 (de) | 1997-03-27 | 1998-10-08 | Glatt Gmbh | Verfahren zum überwachen und/oder steuern und regeln eines granulations-, agglomerations-, instantisierungs-, coating- und trocknungsprozesses in einer wirbelschicht oder einer bewegten schüttung durch bestimmung der produktfeuchte sowie lufttechnischer apparat zur durchführung des verfahrens |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
ATE245641T1 (de) | 1998-02-17 | 2003-08-15 | Tularik Inc | Antivirale pyrimidinderivate |
US6247246B1 (en) | 1998-05-27 | 2001-06-19 | Denver Instrument Company | Microwave moisture analyzer: apparatus and method |
DE69933680T2 (de) | 1998-08-29 | 2007-08-23 | Astrazeneca Ab | Pyrimidine verbindungen |
WO2000014552A1 (en) | 1998-09-03 | 2000-03-16 | Malcam Ltd. | Moisture measurement device using microwaves |
US6227041B1 (en) | 1998-09-17 | 2001-05-08 | Cem Corporation | Method and apparatus for measuring volatile content |
BRPI9915552B8 (pt) | 1998-11-10 | 2021-05-25 | Janssen Pharmaceutica Nv | pirimidinas inibidoras da reprodução do hiv |
WO2000035455A1 (en) | 1998-12-15 | 2000-06-22 | Telik, Inc. | Heteroaryl-aryl ureas as igf-1 receptor antagonists |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
DE19917785A1 (de) | 1999-04-20 | 2000-10-26 | Bayer Ag | 2,4-Diamino-pyrimidin-Derivate |
IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
US6399780B1 (en) | 1999-08-20 | 2002-06-04 | Cephalon, Inc. | Isomeric fused pyrrolocarbazoles and isoindolones |
ATE309241T1 (de) | 1999-09-10 | 2005-11-15 | Merck & Co Inc | Tyrosin kinase inhibitoren |
SK285240B6 (sk) | 1999-09-24 | 2006-09-07 | Janssen Pharmaceutica N. V. | Antivírusové prostriedky |
US6455525B1 (en) | 1999-11-04 | 2002-09-24 | Cephalon, Inc. | Heterocyclic substituted pyrazolones |
WO2001047921A1 (en) | 1999-12-28 | 2001-07-05 | Pharmacopeia, Inc. | Pyrimidine and triazine kinase inhibitors |
CN1429222A (zh) | 2000-02-17 | 2003-07-09 | 安姆根有限公司 | 激酶抑制剂 |
GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
DK1282607T3 (en) | 2000-05-08 | 2016-02-01 | Janssen Pharmaceutica Nv | Prodrugs of HIV replication inhibiting pyrimidines |
CN1431999A (zh) | 2000-05-31 | 2003-07-23 | 阿斯特拉曾尼卡有限公司 | 具有血管损伤活性的吲哚衍生物 |
CN1255391C (zh) | 2000-07-07 | 2006-05-10 | 安吉奥金尼药品有限公司 | 作为血管破坏剂的colchinol衍生物 |
MXPA02012903A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como inhibidores de angiogenesis. |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
CA2422371C (en) | 2000-09-15 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US7473691B2 (en) | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6610677B2 (en) | 2000-09-15 | 2003-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6613776B2 (en) | 2000-09-15 | 2003-09-02 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US20030105090A1 (en) | 2000-12-21 | 2003-06-05 | David Bebbington | Pyrazole compounds useful as protein kinase inhibitors |
ATE392421T1 (de) | 2001-08-03 | 2008-05-15 | Vertex Pharma | Von pyrazol abgeleitete kinaseinhibitoren und deren verwendung |
CA2456187A1 (en) | 2001-08-03 | 2003-02-13 | Qing Tang | Pyrazole-derived kinase inhibitors and uses thereof |
US6747461B2 (en) | 2001-10-25 | 2004-06-08 | Pioneer Hi-Bred International, Inc. | Apparatus and method for monitoring drying of an agricultural porous medium such as grain or seed |
SE0104140D0 (sv) | 2001-12-07 | 2001-12-07 | Astrazeneca Ab | Novel Compounds |
JP2003231687A (ja) | 2002-02-04 | 2003-08-19 | Japan Tobacco Inc | ピラゾリル縮合環化合物及びその医薬用途 |
BRPI0413563A (pt) * | 2003-08-15 | 2006-10-17 | Irm Llc | compostos e composições como inibidores de atividade do receptor de quìnase de tirosina |
MY141220A (en) | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
JP2006087530A (ja) * | 2004-09-22 | 2006-04-06 | Nakashima Propeller Co Ltd | 橈骨遠位端骨折用内固定器具 |
PT1812440E (pt) | 2004-11-04 | 2011-01-25 | Vertex Pharma | Pirazolo[1,5-a]pirimidinas úteis enquanto inibidores de proteínas cinases |
JP5208516B2 (ja) * | 2004-12-30 | 2013-06-12 | エグゼリクシス, インコーポレイテッド | キナーゼモジュレーターとしてのピリミジン誘導体および使用方法 |
PL1846394T3 (pl) * | 2005-02-04 | 2012-04-30 | Astrazeneca Ab | Pochodne pirazoliloaminopirydyny użyteczne jako inhibitory kinazy |
KR101362621B1 (ko) * | 2005-02-16 | 2014-02-13 | 아스트라제네카 아베 | 화합물 |
WO2006115452A1 (en) | 2005-04-27 | 2006-11-02 | Astrazeneca Ab | Use of pyrazolyl-pyrimidine derivatives in the treatment of pain |
AU2006241825A1 (en) | 2005-04-28 | 2006-11-09 | Mitsubishi Tanabe Pharma Corporation | Cyanopyridine derivative and use thereof as medicine |
US20080194606A1 (en) | 2005-05-05 | 2008-08-14 | Astrazeneca | Pyrazolyl-Amino-Substituted Pyrimidines and Their Use in the Treatment of Cancer |
AU2006248780B2 (en) * | 2005-05-16 | 2010-06-03 | Astrazeneca Ab | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors |
PT1945631E (pt) | 2005-10-28 | 2012-10-15 | Astrazeneca Ab | Derivados de 4-(3-aminopirazole)pirimidina para utilização como inibidores da tirosina-cinase no tratamento do cancro |
BRPI0619708A2 (pt) | 2005-11-03 | 2011-10-11 | Vertex Pharma | composto, composição, método para inibir a atividade da proteìna aurora quinase numa amostra biológica, método para tratar distúrbio proliferativo e método para tratar cáncer |
EP2044063A1 (en) | 2006-06-30 | 2009-04-08 | Astra Zeneca AB | Pyrimidine derivatives useful in the treatment of cancer |
TW200826937A (en) | 2006-11-01 | 2008-07-01 | Astrazeneca Ab | New use |
TW200823196A (en) | 2006-11-01 | 2008-06-01 | Astrazeneca Ab | New use |
UA99459C2 (en) * | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
-
2008
- 2008-02-05 UA UAA200912433A patent/UA99459C2/ru unknown
- 2008-04-30 TW TW097115958A patent/TWI406864B/zh not_active IP Right Cessation
- 2008-04-30 PE PE2008000770A patent/PE20090238A1/es not_active Application Discontinuation
- 2008-05-02 BR BRPI0811534-6A2A patent/BRPI0811534A2/pt not_active IP Right Cessation
- 2008-05-02 RU RU2009144848/04A patent/RU2481348C2/ru not_active IP Right Cessation
- 2008-05-02 UY UY31065A patent/UY31065A1/es not_active Application Discontinuation
- 2008-05-02 KR KR1020097025268A patent/KR101563372B1/ko not_active IP Right Cessation
- 2008-05-02 MX MX2009011944A patent/MX2009011944A/es active IP Right Grant
- 2008-05-02 JP JP2010507002A patent/JP5415403B2/ja not_active Expired - Fee Related
- 2008-05-02 CA CA2684693A patent/CA2684693C/en not_active Expired - Fee Related
- 2008-05-02 US US12/598,473 patent/US8486966B2/en not_active Expired - Fee Related
- 2008-05-02 AR ARP080101879A patent/AR066429A1/es unknown
- 2008-05-02 NZ NZ581633A patent/NZ581633A/en not_active IP Right Cessation
- 2008-05-02 AU AU2008247159A patent/AU2008247159B2/en not_active Ceased
- 2008-05-02 EP EP20080737245 patent/EP2152705A1/en not_active Withdrawn
- 2008-05-02 MY MYPI20094620A patent/MY147890A/en unknown
- 2008-05-02 WO PCT/GB2008/050321 patent/WO2008135785A1/en active Application Filing
- 2008-05-02 CN CN200880019785A patent/CN101679426A/zh active Pending
- 2008-05-03 SA SA8290271A patent/SA08290271B1/ar unknown
- 2008-05-05 CL CL2008001297A patent/CL2008001297A1/es unknown
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2009
- 2009-10-22 IL IL201691A patent/IL201691A0/en unknown
- 2009-11-02 ZA ZA200907679A patent/ZA200907679B/xx unknown
- 2009-11-09 CO CO09126884A patent/CO6251294A2/es active IP Right Grant
- 2009-11-20 EC EC2009009751A patent/ECSP099751A/es unknown
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2013
- 2013-06-21 US US13/923,498 patent/US20140155394A1/en not_active Abandoned
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Also Published As
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SA08290271B1 (ar) | 2012-02-07 |
PE20090238A1 (es) | 2009-04-21 |
KR101563372B1 (ko) | 2015-10-26 |
AU2008247159A1 (en) | 2008-11-13 |
BRPI0811534A2 (pt) | 2014-11-18 |
AU2008247159B2 (en) | 2011-11-10 |
UA99459C2 (en) | 2012-08-27 |
CA2684693C (en) | 2015-06-23 |
EP2152705A1 (en) | 2010-02-17 |
ZA200907679B (en) | 2010-07-28 |
UY31065A1 (es) | 2009-01-05 |
AR066429A1 (es) | 2009-08-19 |
MX2009011944A (es) | 2009-12-11 |
US8486966B2 (en) | 2013-07-16 |
RU2009144848A (ru) | 2011-06-10 |
JP5415403B2 (ja) | 2014-02-12 |
JP2010526128A (ja) | 2010-07-29 |
TW200902530A (en) | 2009-01-16 |
TWI406864B (zh) | 2013-09-01 |
KR20100019988A (ko) | 2010-02-19 |
IL201691A0 (en) | 2010-05-31 |
CL2008001297A1 (es) | 2009-01-16 |
MY147890A (en) | 2013-01-31 |
ECSP099751A (es) | 2009-12-28 |
RU2481348C2 (ru) | 2013-05-10 |
US20150011545A1 (en) | 2015-01-08 |
US20100324040A1 (en) | 2010-12-23 |
CN101679426A (zh) | 2010-03-24 |
NZ581633A (en) | 2012-01-12 |
US20140155394A1 (en) | 2014-06-05 |
WO2008135785A1 (en) | 2008-11-13 |
CA2684693A1 (en) | 2008-11-13 |
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