PE20120172A1 - Compuestos heterociclicos fusionados que contiene nitrogeno como inhibidores de la produccion de beta-amiloide - Google Patents
Compuestos heterociclicos fusionados que contiene nitrogeno como inhibidores de la produccion de beta-amiloideInfo
- Publication number
- PE20120172A1 PE20120172A1 PE2011001502A PE2011001502A PE20120172A1 PE 20120172 A1 PE20120172 A1 PE 20120172A1 PE 2011001502 A PE2011001502 A PE 2011001502A PE 2011001502 A PE2011001502 A PE 2011001502A PE 20120172 A1 PE20120172 A1 PE 20120172A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridine
- beta
- methylimidazol
- triazolo
- pyridin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE R1 Y R2 SON ALQUILO C1-C6, CICLOALQUILO C3-C8, ALQUENILO C2-C6, ALCOXI C1-C6, ENTRE OTROS; EL ANILLO A ES UN GRUPO HETEROCICLICLO AROMATICO DE 5 MIEMBROS FUSIONADO CON UN ANILLO NO AROMATICO DE 5 A 14 MIEMBROS, OPCIONALMENTE SUSTITUIDO ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; X1 ES UN ENLACE INDIVIDUAL, UN GRUPO ALQUILENO C1-C6, UN GRUPO VINILENO, ENTRE OTROS; EL ANILLO B ES UN GRUPO FENILO, PIRIDINA, OXAZOL, FURANO, ENTRE OTROS; m ES UN ENTERO DE 0 A 3; n ES UN ENTERO DE 0 A 2; W ES N O C. SON COMPUESTOS PREFERIDOS: (+)-8-(5-ISOPROPIL-4-METOXI-2-METILFENIL)-2-[6-METOXI-5-(4-METILIMIDAZOL-1-IL)PIRIDIN-2-IL-5,6,7,8-TETRAHIDRO[1,2,4]TRIAZOLO[1,5-a]PIRIDINA, (-)-2-[5-METOXI-6-(4-METILIMIDAZOL-1-IL)PIRIDIN-3-IL]-8-(2-TRIFLUOROMETILFENIL)-5,6,7,8-TETRAHIDRO[1,2,4]TRIAZOLO[1,5-a]PIRIDINA, (-)-8-(4-BROMO-2-TRIFLUOROMETILFENIL)-2-[6-METOXI-5-(4-METILIMIDAZOL-1-IL)PIRIDIN-2-IL]-5,6,7,8-TETRAHIDRO[1,2,4]TRIAZOLO[1,5-a]PIRIDINA, ENTRE OTROS. DICHOS COMPUESTOS INHIBEN LA PRODUCCION DE BETA-AMILOIDES Y SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, SINDROME DE DOWN, DEMENCIA Y AMILOIDOSIS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15569709P | 2009-02-26 | 2009-02-26 | |
JP2009043337 | 2009-02-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120172A1 true PE20120172A1 (es) | 2012-03-08 |
Family
ID=42331601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001502A PE20120172A1 (es) | 2009-02-26 | 2010-02-24 | Compuestos heterociclicos fusionados que contiene nitrogeno como inhibidores de la produccion de beta-amiloide |
Country Status (17)
Country | Link |
---|---|
US (1) | US8754100B2 (es) |
EP (2) | EP2615090A1 (es) |
JP (1) | JP2012519152A (es) |
KR (1) | KR20110122746A (es) |
CN (1) | CN102333777B (es) |
AR (1) | AR075606A1 (es) |
AU (1) | AU2010218714A1 (es) |
CA (1) | CA2753696A1 (es) |
HK (1) | HK1165954A1 (es) |
IL (1) | IL214780A (es) |
MX (1) | MX2011008501A (es) |
NZ (1) | NZ594776A (es) |
PE (1) | PE20120172A1 (es) |
RU (1) | RU2515976C2 (es) |
SG (1) | SG173710A1 (es) |
TW (1) | TW201035101A (es) |
WO (1) | WO2010098487A1 (es) |
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CN101952275B (zh) | 2008-02-22 | 2014-06-18 | 弗·哈夫曼-拉罗切有限公司 | β-淀粉样蛋白的调节剂 |
WO2010040661A1 (en) | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
CN102209537A (zh) | 2008-11-10 | 2011-10-05 | 弗·哈夫曼-拉罗切有限公司 | 杂环γ分泌酶调节剂 |
PT2889033T (pt) | 2008-11-19 | 2018-06-18 | Forum Pharmaceuticals Inc | Tratamento de sintomas negativos da esquizofrenia com (r)-7-cloro-n-(-quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida e sais farmacêuticos resultantes da mesma |
EA019685B1 (ru) | 2009-02-06 | 2014-05-30 | Янссен Фармасьютикалз, Инк. | Новые замещенные бициклические гетероциклические соединения в качестве модуляторов гамма-секретазы |
JP5559309B2 (ja) | 2009-05-07 | 2014-07-23 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | γ分泌酵素調節物質としての新規置換インダゾールおよびアザインダゾール誘導体 |
RU2011150248A (ru) * | 2009-05-11 | 2013-06-20 | Энвиво Фармасьютикалз, Инк. | Лечение когнитивных расстройств с определенными рецепторами альфа-7 никотиновой кислоты в комбинации с ингибиторами ацетилхолинэстеразы |
CA2767764A1 (en) * | 2009-07-13 | 2011-01-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
KR20120050450A (ko) | 2009-07-15 | 2012-05-18 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 치환된 트리아졸 및 이미다졸 유도체 |
CA2784769A1 (en) | 2010-01-15 | 2011-07-21 | Janssen Pharmaceuticals, Inc. | Novel substituted triazole derivatives as gamma secretase modulators |
US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
EP2571874B1 (en) | 2010-05-17 | 2016-03-30 | Forum Pharmaceuticals Inc. | A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate |
JP6069661B2 (ja) | 2010-06-24 | 2017-02-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 種々のアミロイドβペプチドアロフォームレベルの調節における組成物及びその使用 |
BR112013004746A2 (pt) * | 2010-09-02 | 2016-06-07 | Takeda Pharmaceutical | "composto, medicamento, inibidor da produção de beta-amilóide, modulador de gama-secretase, métodos para inibir a produção de beta-amilóide, para modular gama-secretase, e para prevenir ou tratar deficiência cognitiva branda ou mal de alzheimer, e, uso do composto." |
MX2013010970A (es) | 2011-03-24 | 2013-10-17 | Cellzome Ltd | Novedosos derivados de triazolil piperazina y triazolil piperidina sustituidos como moduladores de gamma-secretasa. |
WO2013005354A1 (ja) * | 2011-07-01 | 2013-01-10 | 武田薬品工業株式会社 | 複素環化合物 |
ES2555167T3 (es) * | 2011-07-15 | 2015-12-29 | Janssen Pharmaceuticals, Inc. | Nuevos derivados de indol sustituidos como moduladores de gamma secretasa |
WO2013106328A1 (en) * | 2012-01-09 | 2013-07-18 | Envivo Pharmaceuticals, Inc. | Tetrasubstituted benzenes for treatment of early onset alzheimer's disease |
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JP6106745B2 (ja) | 2012-05-16 | 2017-04-05 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | (特に)アルツハイマー病の治療に有用な置換3,4−ジヒドロ−2H−ピリド[1,2−a]ピラジン−1,6−ジオン誘導体 |
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EP2968296B1 (en) | 2013-03-12 | 2020-09-02 | The Regents of the University of California | Gamma-secretase modulators |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
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TWI696617B (zh) * | 2015-04-28 | 2020-06-21 | 大陸商上海復尚慧創醫藥研究有限公司 | 特定蛋白質激酶抑制劑 |
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CN110642689B (zh) * | 2019-09-05 | 2022-06-24 | 南通大学 | 一种3,6-二溴-2-甲基苯甲醛及其化学合成方法 |
CN112661639A (zh) * | 2020-12-07 | 2021-04-16 | 浙江工业大学 | 一种4-乙酰丁酸酯类化合物合成方法 |
CN116621846B (zh) * | 2023-07-24 | 2023-10-17 | 华润医药研究院(深圳)有限公司 | 双环杂环及三环杂环类化合物及其制备方法和医药用途 |
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JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
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CN102414177B (zh) | 2009-02-26 | 2014-07-02 | 贝林格尔.英格海姆国际有限公司 | 作为缓激肽b1拮抗剂的化合物 |
EP2401277A1 (en) | 2009-02-26 | 2012-01-04 | Eisai R&D Management Co., Ltd. | Salt of tetrahydrotriazolopyridine derivative and crystal thereof |
KR20120050450A (ko) | 2009-07-15 | 2012-05-18 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 치환된 트리아졸 및 이미다졸 유도체 |
EP2475347A4 (en) | 2009-09-11 | 2015-01-07 | Simplisse Inc | NIPPLE |
-
2010
- 2010-02-24 CA CA2753696A patent/CA2753696A1/en not_active Abandoned
- 2010-02-24 SG SG2011058864A patent/SG173710A1/en unknown
- 2010-02-24 US US13/138,504 patent/US8754100B2/en not_active Expired - Fee Related
- 2010-02-24 EP EP13162886.9A patent/EP2615090A1/en not_active Withdrawn
- 2010-02-24 WO PCT/JP2010/053368 patent/WO2010098487A1/en active Application Filing
- 2010-02-24 JP JP2011536639A patent/JP2012519152A/ja not_active Ceased
- 2010-02-24 AU AU2010218714A patent/AU2010218714A1/en not_active Abandoned
- 2010-02-24 MX MX2011008501A patent/MX2011008501A/es active IP Right Grant
- 2010-02-24 RU RU2011139132/04A patent/RU2515976C2/ru not_active IP Right Cessation
- 2010-02-24 CN CN201080009288.9A patent/CN102333777B/zh not_active Expired - Fee Related
- 2010-02-24 NZ NZ594776A patent/NZ594776A/xx not_active IP Right Cessation
- 2010-02-24 KR KR1020117022134A patent/KR20110122746A/ko not_active Application Discontinuation
- 2010-02-24 PE PE2011001502A patent/PE20120172A1/es not_active Application Discontinuation
- 2010-02-24 TW TW099105284A patent/TW201035101A/zh unknown
- 2010-02-24 EP EP10708824.7A patent/EP2401276B1/en active Active
- 2010-02-25 AR ARP100100548A patent/AR075606A1/es not_active Application Discontinuation
-
2011
- 2011-08-22 IL IL214780A patent/IL214780A/en not_active IP Right Cessation
-
2012
- 2012-07-04 HK HK12106517.7A patent/HK1165954A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RU2515976C2 (ru) | 2014-05-20 |
JP2012519152A (ja) | 2012-08-23 |
AU2010218714A1 (en) | 2011-09-08 |
NZ594776A (en) | 2013-05-31 |
EP2615090A1 (en) | 2013-07-17 |
IL214780A (en) | 2014-06-30 |
EP2401276A1 (en) | 2012-01-04 |
WO2010098487A1 (en) | 2010-09-02 |
HK1165954A1 (en) | 2012-10-12 |
RU2011139132A (ru) | 2013-04-20 |
CN102333777B (zh) | 2014-06-25 |
CN102333777A (zh) | 2012-01-25 |
IL214780A0 (en) | 2011-11-30 |
CA2753696A1 (en) | 2010-09-02 |
MX2011008501A (es) | 2011-09-01 |
KR20110122746A (ko) | 2011-11-10 |
US20120053171A1 (en) | 2012-03-01 |
SG173710A1 (en) | 2011-09-29 |
TW201035101A (en) | 2010-10-01 |
US8754100B2 (en) | 2014-06-17 |
EP2401276B1 (en) | 2013-06-05 |
AR075606A1 (es) | 2011-04-20 |
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