PE20020819A1 - COMPUESTOS DE PIRROLOTRIAZINA COMO INHIBIDORES DE CINASAS p38O Y ß - Google Patents

COMPUESTOS DE PIRROLOTRIAZINA COMO INHIBIDORES DE CINASAS p38O Y ß

Info

Publication number
PE20020819A1
PE20020819A1 PE2001001141A PE2001001141A PE20020819A1 PE 20020819 A1 PE20020819 A1 PE 20020819A1 PE 2001001141 A PE2001001141 A PE 2001001141A PE 2001001141 A PE2001001141 A PE 2001001141A PE 20020819 A1 PE20020819 A1 PE 20020819A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
heterocycle
methyl
heteroaryl
Prior art date
Application number
PE2001001141A
Other languages
English (en)
Inventor
Katerina Leftheris
Joel Barrish
Stephen T Wrobleski
John Hynes
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20020819A1 publication Critical patent/PE20020819A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)

Abstract

SE REFIERE A METODO DE TRATAMIENTO DE CONDICIONES ASOCIADAS A CINASAS O Y ß DE p38; TNF-O COMO ASMA, SINDROME DE INSUFICIENCIA RESPIRATORIA, EPOC, DIABETES, ENFERMEDAD INFLAMATORIA DEL INTESTINO UTILIZANDO CARBOXAMIDAS Y BENZAMIDAS DE PIRROLOTRIAZINA DONDE R3 ES H, METILO, PERFLUOROMETILO, METOXI, HALOGENO, CIANO, NH2; X ES O, OCO, S, SO, SO2, CO, CO2, NR10CONR11, ENTRE OTROS; Z ES O, S, N, CR20, SI Z ES CR20, EL CARBONO PUEDE FORMAR ARILO, HETEROARILO BICICLICO; R1 ES H, CH3, OH, SH, SO2R22, SO2NR24R25, NH2, ENTRE OTROS; R2 ES H, SI R2 NO ES H, X ES SO, SO2, NR10CO2, NR10SO2; ALQUILO, ALQUENILO, ALQUINILO; ARILO, HETEROARILO, HETEROCICLO, CICLOALQUILO; R2 ESTA AUSENTE; SI X ES HALOGENO, NITRO, CIANO; R4 ES ARILO OPCIONALMENTE SUSTITUIDO CON NHSO2-ALQUILO, HETEROARILO, CARBOCICLO, ENTRE OTROS; R5 ES H, ALQUILO EXCEPTO SI Z ES O, S, R5 ESTA AUSENTE; R6 ES H, ALQUILO, ARILO, HETEROCICLO, NR7R8, OR7, HALOGENO; R7, R8, R21, R24, R25 SON H, ALQUILO, ARILO, HETEROCICLO; R20 ES H, ALQUILO, R22 ES ALQUILO, ARILO, HETEROCICLO; R10 Y R11 SON H, ALQUILO, ARILO, CICLOALQUILO, HETEROCICLO; TAMBIEN SE REFIERE A COMPUESTOS DE FORMULA II DONDE Y ES CONR23, SO2NR23, R18 Y R23 SON H, ALQUILO, ALCOXI, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-(2,2-DIMETILPROPIL-4-[[5-[(METOXIAMINO)CARBONIL]-2-METILFENIL]AMINO-5-DIMETILPIRROLO[2,1-f][1,2,4]TRIAZIN-6-CARBOXAMIDA; 4-[[5-[(METOXIAMINO)CARBONIL]-2-METILFENIL]AMINO]-5-METIL-N-(1-METILETIL)PIRROLO[2,1-f][1,2,4]TRIAZIN-6-CARBOXAMIDA, ENTRE OTROS
PE2001001141A 2000-11-17 2001-11-16 COMPUESTOS DE PIRROLOTRIAZINA COMO INHIBIDORES DE CINASAS p38O Y ß PE20020819A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24987700P 2000-11-17 2000-11-17
US31056101P 2001-08-07 2001-08-07

Publications (1)

Publication Number Publication Date
PE20020819A1 true PE20020819A1 (es) 2002-09-11

Family

ID=26940426

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001001141A PE20020819A1 (es) 2000-11-17 2001-11-16 COMPUESTOS DE PIRROLOTRIAZINA COMO INHIBIDORES DE CINASAS p38O Y ß

Country Status (32)

Country Link
EP (1) EP1363910B1 (es)
JP (1) JP2004522713A (es)
KR (1) KR100847605B1 (es)
CN (1) CN1622946A (es)
AR (1) AR032637A1 (es)
AT (1) ATE318820T1 (es)
AU (2) AU2002232760B2 (es)
BG (1) BG107750A (es)
BR (1) BR0115446A (es)
CA (1) CA2429628A1 (es)
CY (1) CY1105250T1 (es)
CZ (1) CZ20031370A3 (es)
DE (1) DE60117607T2 (es)
DK (1) DK1363910T3 (es)
EE (1) EE200300227A (es)
ES (1) ES2259051T3 (es)
GE (1) GEP20063915B (es)
HK (1) HK1057555A1 (es)
HR (1) HRP20030485A2 (es)
HU (1) HUP0303897A2 (es)
IL (1) IL155570A0 (es)
IS (1) IS6816A (es)
MX (1) MXPA03004290A (es)
MY (1) MY127066A (es)
NO (1) NO20032229L (es)
NZ (1) NZ525334A (es)
PE (1) PE20020819A1 (es)
PL (1) PL366376A1 (es)
PT (1) PT1363910E (es)
SK (1) SK5402003A3 (es)
WO (1) WO2002040486A2 (es)
YU (1) YU37903A (es)

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Also Published As

Publication number Publication date
WO2002040486A3 (en) 2003-09-12
ATE318820T1 (de) 2006-03-15
EE200300227A (et) 2003-10-15
KR100847605B1 (ko) 2008-07-21
DE60117607D1 (de) 2006-04-27
HRP20030485A2 (en) 2004-08-31
JP2004522713A (ja) 2004-07-29
MY127066A (en) 2006-11-30
GEP20063915B (en) 2006-09-11
AU2002232760C1 (en) 2002-05-27
CA2429628A1 (en) 2002-05-23
AU2002232760B2 (en) 2006-12-14
AR032637A1 (es) 2003-11-19
CN1622946A (zh) 2005-06-01
SK5402003A3 (en) 2004-06-08
NO20032229D0 (no) 2003-05-16
DE60117607T2 (de) 2007-01-25
BR0115446A (pt) 2005-08-09
PL366376A1 (en) 2005-01-24
PT1363910E (pt) 2006-05-31
EP1363910A2 (en) 2003-11-26
HK1057555A1 (en) 2004-04-08
ES2259051T3 (es) 2006-09-16
KR20030045195A (ko) 2003-06-09
EP1363910B1 (en) 2006-03-01
NO20032229L (no) 2003-07-16
IS6816A (is) 2003-05-14
AU3276002A (en) 2002-05-27
CY1105250T1 (el) 2010-03-03
MXPA03004290A (es) 2004-02-12
CZ20031370A3 (cs) 2003-10-15
BG107750A (bg) 2004-01-30
IL155570A0 (en) 2003-11-23
NZ525334A (en) 2005-07-29
DK1363910T3 (da) 2006-06-26
HUP0303897A2 (hu) 2004-03-01
YU37903A (sh) 2006-05-25
WO2002040486A2 (en) 2002-05-23

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