PA8591801A1 - Inhibidores benzamidicos del receptor p2x7. - Google Patents

Inhibidores benzamidicos del receptor p2x7.

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Publication number
PA8591801A1
PA8591801A1 PA20038591801A PA8591801A PA8591801A1 PA 8591801 A1 PA8591801 A1 PA 8591801A1 PA 20038591801 A PA20038591801 A PA 20038591801A PA 8591801 A PA8591801 A PA 8591801A PA 8591801 A1 PA8591801 A1 PA 8591801A1
Authority
PA
Panama
Prior art keywords
benzamid
inhibitors
receiver
disorders
corpd
Prior art date
Application number
PA20038591801A
Other languages
English (en)
Inventor
Mark Anthony Dombrosky
Allen Jacob Duplantier
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8591801A1 publication Critical patent/PA8591801A1/es

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    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
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    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

LA PRESENTE INVENCION PROPORCIONA INHIBIDORES BENZAMIDICOS DEL RECEPTOR P2X7 DE FORMULA I EN LA QUE R1-R3 SON COMO SE HAN DEFINIDO AQUI. LOS COMPUESTOS DE LA INVENCION SON UTILES EN EL TRATAMIENTO DE TRASTORNOS MEDIADOS POR lL-1, INCLUIDOS, SIN LIMITACION, ENFERMEDADES INFLAMATORIAS TALES COMO OSTEOARTRITIS Y ARTRITIS REUMATOIDE ; ALERGIAS, ASMA, CORPD (ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA), CANCER, REPERFUSION O ISQUEMIA EN ACCIDENTE CEREBROVASCULAR O ATAQUE CARDIACO, ENFERMEDADES AUTOINMUNES Y OTROS TRASTORNOS.
PA20038591801A 2002-12-31 2003-12-10 Inhibidores benzamidicos del receptor p2x7. PA8591801A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43750502P 2002-12-31 2002-12-31

Publications (1)

Publication Number Publication Date
PA8591801A1 true PA8591801A1 (es) 2004-07-26

Family

ID=32682427

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038591801A PA8591801A1 (es) 2002-12-31 2003-12-10 Inhibidores benzamidicos del receptor p2x7.

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US (4) US6974812B2 (es)
EP (1) EP1581232B1 (es)
JP (1) JP4560411B2 (es)
KR (1) KR100689138B1 (es)
CN (1) CN1732006A (es)
AP (1) AP1997A (es)
AR (1) AR042673A1 (es)
AU (1) AU2003285716B2 (es)
BR (1) BR0317803A (es)
CA (1) CA2512193C (es)
CL (1) CL2003002765A1 (es)
CO (1) CO5580749A2 (es)
CR (1) CR7884A (es)
DO (1) DOP2003000790A (es)
EA (1) EA008591B1 (es)
EC (1) ECSP055884A (es)
ES (1) ES2464350T3 (es)
GE (1) GEP20084304B (es)
GT (1) GT200300297A (es)
HR (1) HRP20050609A2 (es)
IL (2) IL168513A (es)
IS (1) IS7840A (es)
MA (1) MA27575A1 (es)
MX (1) MXPA05006749A (es)
MY (1) MY141984A (es)
NI (1) NI200500118A (es)
NL (1) NL1025148C2 (es)
NO (1) NO20053587L (es)
NZ (1) NZ539913A (es)
OA (1) OA12978A (es)
PA (1) PA8591801A1 (es)
PE (1) PE20040802A1 (es)
PL (1) PL378251A1 (es)
RS (1) RS20050490A (es)
TN (1) TNSN05174A1 (es)
TW (1) TWI288133B (es)
UA (1) UA82346C2 (es)
UY (1) UY28153A1 (es)
WO (1) WO2004058270A1 (es)
ZA (1) ZA200503912B (es)

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CA2572119A1 (en) * 2004-06-29 2006-01-12 Warner-Lambert Company Llc Combination therapies utilizing benzamide inhibitors of the p2x7 receptor
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SA05260265A (ar) * 2004-08-30 2005-12-03 استرازينيكا ايه بي مركبات جديدة
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