NO20053587L - 3-(3,5-diokso-4,5-dihydro-3H-(1,2,4)triazin-2-yl-)benzamidderivater som P2X7-inhibitorer for behandling av inflammatoriske sykdommer. - Google Patents
3-(3,5-diokso-4,5-dihydro-3H-(1,2,4)triazin-2-yl-)benzamidderivater som P2X7-inhibitorer for behandling av inflammatoriske sykdommer.Info
- Publication number
- NO20053587L NO20053587L NO20053587A NO20053587A NO20053587L NO 20053587 L NO20053587 L NO 20053587L NO 20053587 A NO20053587 A NO 20053587A NO 20053587 A NO20053587 A NO 20053587A NO 20053587 L NO20053587 L NO 20053587L
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- inhibitors
- inflammatory diseases
- triazin
- dioxo
- Prior art date
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- C—CHEMISTRY; METALLURGY
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- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
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- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43750502P | 2002-12-31 | 2002-12-31 | |
PCT/IB2003/006254 WO2004058270A1 (en) | 2002-12-31 | 2003-12-19 | 3-(3,5-dioxo-4,5-dihydro-3h-(1,2,4)triazin-2-yl)-benzamide derivatives as p2x7-inhibitors for the treatment of inflammatory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20053587L true NO20053587L (no) | 2005-08-09 |
Family
ID=32682427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20053587A NO20053587L (no) | 2002-12-31 | 2005-07-22 | 3-(3,5-diokso-4,5-dihydro-3H-(1,2,4)triazin-2-yl-)benzamidderivater som P2X7-inhibitorer for behandling av inflammatoriske sykdommer. |
Country Status (40)
Country | Link |
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US (4) | US6974812B2 (es) |
EP (1) | EP1581232B1 (es) |
JP (1) | JP4560411B2 (es) |
KR (1) | KR100689138B1 (es) |
CN (1) | CN1732006A (es) |
AP (1) | AP1997A (es) |
AR (1) | AR042673A1 (es) |
AU (1) | AU2003285716B2 (es) |
BR (1) | BR0317803A (es) |
CA (1) | CA2512193C (es) |
CL (1) | CL2003002765A1 (es) |
CO (1) | CO5580749A2 (es) |
CR (1) | CR7884A (es) |
DO (1) | DOP2003000790A (es) |
EA (1) | EA008591B1 (es) |
EC (1) | ECSP055884A (es) |
ES (1) | ES2464350T3 (es) |
GE (1) | GEP20084304B (es) |
GT (1) | GT200300297A (es) |
HR (1) | HRP20050609A2 (es) |
IL (2) | IL168513A (es) |
IS (1) | IS7840A (es) |
MA (1) | MA27575A1 (es) |
MX (1) | MXPA05006749A (es) |
MY (1) | MY141984A (es) |
NI (1) | NI200500118A (es) |
NL (1) | NL1025148C2 (es) |
NO (1) | NO20053587L (es) |
NZ (1) | NZ539913A (es) |
OA (1) | OA12978A (es) |
PA (1) | PA8591801A1 (es) |
PE (1) | PE20040802A1 (es) |
PL (1) | PL378251A1 (es) |
RS (1) | RS20050490A (es) |
TN (1) | TNSN05174A1 (es) |
TW (1) | TWI288133B (es) |
UA (1) | UA82346C2 (es) |
UY (1) | UY28153A1 (es) |
WO (1) | WO2004058270A1 (es) |
ZA (1) | ZA200503912B (es) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PA8557501A1 (es) * | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
PA8591801A1 (es) * | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
EP1837330B1 (en) * | 2003-05-12 | 2012-10-24 | Pfizer Products Inc. | Benzamide inhibitors of the P2X7 receptor |
WO2004099146A1 (en) * | 2003-05-12 | 2004-11-18 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
BRPI0512781A (pt) | 2004-06-29 | 2008-04-08 | Pfizer Prod Inc | método para preparação de derivados de 5-{4-(2-hidroxi-propil)-3,5-dioxo-4,5-diidro-3h-[1,2,4]tria zin-2-il}-benzamida através da desproteção dos precursores de protetores de hidroxila |
WO2006003513A1 (en) * | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3h-`1,2,4!-triazin-2-yl!benzamide derivatives with p2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
EP1763353A1 (en) * | 2004-06-29 | 2007-03-21 | Warner-Lambert Company LLC | COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X<sb>7</sb> RECEPTOR |
SA05260265A (ar) * | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
WO2006083214A1 (en) * | 2005-02-02 | 2006-08-10 | Astrazeneca Ab | Pharmaceutical composition comprising a p2x7 receptor antagonist and a hmg-coa reductase inhibitor |
CA2625940A1 (en) * | 2005-08-29 | 2007-03-08 | Irma Bernatchez-Lemaire | Use of histogranin and histogranin-like compounds as inhibitors of p2x7 receptor function and as anti-arthritic agents |
US20100184802A1 (en) * | 2006-03-16 | 2010-07-22 | Kelly Michael G | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof |
GB0622472D0 (en) * | 2006-11-10 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel heterocyclic derivatives |
DK2124562T3 (en) * | 2007-03-09 | 2016-08-01 | Second Genome Inc | BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof |
GB0803729D0 (en) * | 2008-02-29 | 2008-04-09 | Ge Healthcare Ltd | Imaging the central nervous system |
ATE494926T1 (de) | 2008-03-25 | 2011-01-15 | Affectis Pharmaceuticals Ag | Neuartige p2x7r-antagonisten und ihre verwendung |
MX2011010810A (es) | 2009-04-14 | 2012-01-12 | Affectis Pharmaceuticals Ag | Nuevos antagonistas de p2x7r y su uso. |
US20130195919A1 (en) | 2010-03-05 | 2013-08-01 | President And Fellows Of Harvard College | Induced dendritic cell compositions and uses thereof |
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