EA201201548A1 - Новые способы получения p2x7r антагонистов - Google Patents
Новые способы получения p2x7r антагонистовInfo
- Publication number
- EA201201548A1 EA201201548A1 EA201201548A EA201201548A EA201201548A1 EA 201201548 A1 EA201201548 A1 EA 201201548A1 EA 201201548 A EA201201548 A EA 201201548A EA 201201548 A EA201201548 A EA 201201548A EA 201201548 A1 EA201201548 A1 EA 201201548A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- new ways
- p2x7r antagonists
- p2x7r
- antagonists
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Abstract
Описаны новые способы синтеза N-замещенных индол-3-ил-алкиламидных соединений, которые действуют в качестве P2X7R антагонистов, причем указанные способы включают перегруппировку промежуточного оксима.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10162812 | 2010-05-14 | ||
PCT/EP2011/053283 WO2011141194A1 (en) | 2010-05-14 | 2011-03-04 | Novel methods for the preparation of p2x7r antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201201548A1 true EA201201548A1 (ru) | 2013-05-30 |
Family
ID=43924014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201201548A EA201201548A1 (ru) | 2010-05-14 | 2011-03-04 | Новые способы получения p2x7r антагонистов |
Country Status (13)
Country | Link |
---|---|
US (1) | US20130060047A1 (ru) |
EP (2) | EP2386541A1 (ru) |
JP (1) | JP2013526496A (ru) |
CN (1) | CN102858741A (ru) |
AU (1) | AU2011252351A1 (ru) |
BR (1) | BR112012028850A2 (ru) |
CA (1) | CA2799115A1 (ru) |
EA (1) | EA201201548A1 (ru) |
IL (1) | IL222948A0 (ru) |
MX (1) | MX2012013075A (ru) |
SG (1) | SG185400A1 (ru) |
WO (1) | WO2011141194A1 (ru) |
ZA (1) | ZA201209495B (ru) |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB832568A (en) * | 1956-08-03 | 1960-04-13 | Clin Byla Ets | Heterocyclic compounds and production thereof |
US2930798A (en) * | 1956-08-03 | 1960-03-29 | Clin Byla Ets | 3-alkanoyl 1-tertiary-amino-alkyl indol oximes and production thereof |
SE9704545D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
SE9704544D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
SE9704546D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
RU2254333C2 (ru) | 1999-04-09 | 2005-06-20 | Астразенека Аб | Производные адамантана, способ их получения, фармацевтическая композиция на их основе и способы лечения |
SE9901875D0 (sv) | 1999-05-25 | 1999-05-25 | Astra Pharma Prod | Novel compounds |
SE9904505D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
SE9904652D0 (sv) | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
SE9904738D0 (sv) | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
GB0013737D0 (en) | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
SE0103836D0 (sv) | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Novel compounds |
AU2002359524A1 (en) | 2001-11-30 | 2003-06-17 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health A | P2x7 receptor antagonists |
NZ533649A (en) | 2001-12-21 | 2006-01-27 | King Pharmaceuticals Res & Dev | Tyrosyl derivatives and their use as P2X7 receptor modulators |
SE0200920D0 (sv) | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
MXPA05005146A (es) * | 2002-11-15 | 2005-07-22 | Tibotec Pharm Ltd | Indolpiridinio sustituido como compuestos antiinfecciosos. |
PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
CA2511189A1 (en) | 2002-12-31 | 2004-07-15 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
SE0300480D0 (sv) | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
WO2004099146A1 (en) | 2003-05-12 | 2004-11-18 | Pfizer Products Inc. | Benzamide inhibitors of the p2x7 receptor |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
GB0324498D0 (en) | 2003-07-21 | 2003-11-26 | Aventis Pharma Inc | Heterocyclic compounds as P2X7 ion channel blockers |
SE0302139D0 (sv) | 2003-07-28 | 2003-07-28 | Astrazeneca Ab | Novel compounds |
SE0302192D0 (sv) | 2003-08-08 | 2003-08-08 | Astrazeneca Ab | Novel compounds |
WO2005019182A1 (en) | 2003-08-20 | 2005-03-03 | Bayer Healthcare Ag | Pyrazolylmethylbenzamide derivatives as p2xt-receptor antagonists |
JP2007509180A (ja) | 2003-10-21 | 2007-04-12 | インスパイアー ファーマシューティカルズ,インコーポレイティド | 疼痛を治療するための、非ヌクレオチド組成物および方法 |
JP2007535553A (ja) | 2004-04-29 | 2007-12-06 | アボット・ラボラトリーズ | アミノ−テトラゾール類縁体および使用方法 |
EP1758911A1 (en) * | 2004-05-17 | 2007-03-07 | Tibotec Pharmaceuticals Ltd. | 1-heterocyclyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones |
KR20070011588A (ko) * | 2004-05-17 | 2007-01-24 | 티보텍 파마슈티칼즈 리미티드 | 치환된 1-페닐-1,5-디히드로-피리도-[3,2-b]인돌-2-온 및다른 hiv 억제제의 배합물 |
ATE481403T1 (de) * | 2004-05-17 | 2010-10-15 | Tibotec Pharm Ltd | Substituierte 1-phenyl-1,5-dihydro-pyridoä3,2- büindol-2-on-derivate verwendbar als pharmazeutische antiinfektiva |
BRPI0512781A (pt) | 2004-06-29 | 2008-04-08 | Pfizer Prod Inc | método para preparação de derivados de 5-{4-(2-hidroxi-propil)-3,5-dioxo-4,5-diidro-3h-[1,2,4]tria zin-2-il}-benzamida através da desproteção dos precursores de protetores de hidroxila |
WO2006003513A1 (en) | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3h-`1,2,4!-triazin-2-yl!benzamide derivatives with p2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
US7241776B2 (en) | 2004-08-02 | 2007-07-10 | Abbott Laboratories | Cyanoamidine P2X7 antagonists for the treatment of pain |
SA05260265A (ar) | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
SE0402925D0 (sv) | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
EP1831174B1 (en) | 2004-12-24 | 2011-03-02 | AstraZeneca AB | Amide derivatives |
EP1844003A4 (en) | 2005-01-27 | 2010-09-22 | Astrazeneca Ab | NEW BIAROMATIC COMPOUNDS AS INHIBITORS OF THE P2X7 RECEPTOR |
US20060211739A1 (en) | 2005-02-08 | 2006-09-21 | Arturo Perez-Medrano | Use of selective P2X7 receptor antagonists |
US7402596B2 (en) | 2005-03-24 | 2008-07-22 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
WO2006110516A1 (en) | 2005-04-11 | 2006-10-19 | Abbott Laboratories | Acylhydrazide p2x7 antagonists and uses thereof |
EP1885376A1 (en) | 2005-05-05 | 2008-02-13 | Medicure International Inc. | Inhibition of atp-mediated, p2x7 dependent pathways by pyridoxal-5-phosphaste and vitamin b6 related compounds |
CA2625940A1 (en) | 2005-08-29 | 2007-03-08 | Irma Bernatchez-Lemaire | Use of histogranin and histogranin-like compounds as inhibitors of p2x7 receptor function and as anti-arthritic agents |
US20100022531A1 (en) | 2005-09-01 | 2010-01-28 | Renovis, Inc. | Novel compounds as p2x7 modulators and uses thereof |
WO2007056046A1 (en) | 2005-11-07 | 2007-05-18 | Abbott Laboratories | P2x7 receptor antagonists and methods of use |
WO2007056091A2 (en) | 2005-11-09 | 2007-05-18 | Abbott Laboratories | 2-phenyl-2h-pyraz0le derivatives as p2x7 receptor antagonists and uses thereof |
JP5306986B2 (ja) | 2006-03-16 | 2013-10-02 | エボテック (ユーエス) インコーポレイテッド | P2x7調節因子としてのビシクロへテロアリール化合物およびその使用 |
US8546579B2 (en) | 2006-03-16 | 2013-10-01 | Evotec (Us) Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
CA2645652A1 (en) | 2006-03-16 | 2007-09-27 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
US20100184802A1 (en) | 2006-03-16 | 2010-07-22 | Kelly Michael G | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof |
TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為p2x7調節劑之雙環雜芳基化合物與其用途 |
US20100298285A1 (en) | 2006-03-16 | 2010-11-25 | Kelly Michael G | Biclycloheteroaryl Compounds as P2x7 Modulators and Uses Thereof |
ATE489088T1 (de) | 2006-06-06 | 2010-12-15 | Glaxo Group Ltd | N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid- derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegeneration |
GB0611154D0 (en) | 2006-06-06 | 2006-07-19 | Glaxo Group Ltd | Novel receptor antagonists and their methods of use |
US20080076924A1 (en) | 2006-06-30 | 2008-03-27 | Patrick Betschmann | Piperazines as P2X7 antagonists |
MX2009000117A (es) | 2006-07-06 | 2009-01-23 | Glaxo Group Ltd | N-fenilmetil-5-oxo-prolin-2-amidas sustituidas como antagonistas de receptores p2x7 y sus metodos de uso. |
MX2011010810A (es) * | 2009-04-14 | 2012-01-12 | Affectis Pharmaceuticals Ag | Nuevos antagonistas de p2x7r y su uso. |
-
2011
- 2011-03-04 EP EP11156932A patent/EP2386541A1/en not_active Withdrawn
- 2011-03-04 US US13/697,666 patent/US20130060047A1/en not_active Abandoned
- 2011-03-04 JP JP2013509476A patent/JP2013526496A/ja not_active Withdrawn
- 2011-03-04 AU AU2011252351A patent/AU2011252351A1/en not_active Abandoned
- 2011-03-04 MX MX2012013075A patent/MX2012013075A/es not_active Application Discontinuation
- 2011-03-04 BR BR112012028850A patent/BR112012028850A2/pt not_active IP Right Cessation
- 2011-03-04 CA CA2799115A patent/CA2799115A1/en not_active Abandoned
- 2011-03-04 WO PCT/EP2011/053283 patent/WO2011141194A1/en active Application Filing
- 2011-03-04 EA EA201201548A patent/EA201201548A1/ru unknown
- 2011-03-04 EP EP11706814A patent/EP2569281A1/en not_active Withdrawn
- 2011-03-04 SG SG2012080917A patent/SG185400A1/en unknown
- 2011-03-04 CN CN2011800205646A patent/CN102858741A/zh active Pending
-
2012
- 2012-11-08 IL IL222948A patent/IL222948A0/en unknown
- 2012-12-13 ZA ZA2012/09495A patent/ZA201209495B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA201209495B (en) | 2013-08-28 |
US20130060047A1 (en) | 2013-03-07 |
IL222948A0 (en) | 2012-12-31 |
MX2012013075A (es) | 2012-12-17 |
BR112012028850A2 (pt) | 2015-09-15 |
EP2569281A1 (en) | 2013-03-20 |
AU2011252351A1 (en) | 2012-10-11 |
JP2013526496A (ja) | 2013-06-24 |
CA2799115A1 (en) | 2011-11-17 |
CN102858741A (zh) | 2013-01-02 |
SG185400A1 (en) | 2012-12-28 |
WO2011141194A1 (en) | 2011-11-17 |
EP2386541A1 (en) | 2011-11-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12015500263A1 (en) | New bicyclic derivatives | |
PH12014502697B1 (en) | New diazaspirocycloalkane and azaspirocycloalkane | |
EA201990240A1 (ru) | Новые трициклические соединения в качестве противораковых средств | |
ZA201503125B (en) | One-pot method for the synthesis of cu-ssz-13, the compound obtained by the method and use thereof | |
UY34156A (es) | Compuestos inhibidores de metaloenzimas | |
UA108101C2 (xx) | Похідні n3-заміщених n1-сульфоніл-5-фторпіримідинонів | |
MA34091B1 (fr) | Anticorps anti-cd40 | |
MY181898A (en) | Heterocyclic compounds and uses thereof | |
EA201491811A1 (ru) | АНТИ-LgR5 АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ | |
EA201290772A1 (ru) | Новые формы ивабрадина гидрохлорида | |
UA110338C2 (en) | Chemical compounds | |
TR201901886T4 (tr) | DNA-PK inhibitörleri. | |
EA201691272A1 (ru) | Тетрагидропиридопиразины в качестве модуляторов gpr6 | |
UY33925A (es) | Inhibidores tricíclicos de quinasas | |
MA34058B1 (fr) | Formes de rifaximine, et leurs utilisations | |
EA201490567A1 (ru) | Новые бициклические производные дигидрохинолин-2-она | |
UA113062C2 (xx) | Похідні 5-фтор-4-іміно-3-(заміщеного)-3,4-дигідропіримідин-2(1h)ону | |
IN2015DN03029A (ru) | ||
MX370253B (es) | Composiciones de compuestos de jasmonato y métodos de uso de las mismas. | |
JO3154B1 (ar) | عوامل مضادة لـ trpv4 | |
EA201590552A1 (ru) | Аминохинолины в качестве ингибиторов киназы | |
UA106889C2 (uk) | Похідні n1-ацил-5-фторпіримідинону | |
UA107671C2 (en) | N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives | |
UY33976A (es) | Derivados de pirazolo-pirimidina. | |
IN2014KN01062A (ru) |