NO313811B1 - Topiske pÕhelningsformuleringer inneholdende polymert materiale, glycoler og glycerider, og fremgangsmÕte forfremstilling derav - Google Patents

Topiske pÕhelningsformuleringer inneholdende polymert materiale, glycoler og glycerider, og fremgangsmÕte forfremstilling derav Download PDF

Info

Publication number: NO313811B1
Authority: NO; Norway
Prior art keywords: avermectin; volume; formulation according; formulation; hydroxy
Prior art date: 1993-05-10

Application number

NO19954506A

Other languages

English (en)

Norwegian (no)

Other versions

NO954506D0 (no

NO954506L (no

Inventor

Hoo-Kyun Choi

James B Williams

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-10

Filing date

1995-11-09

Publication date

2002-12-09

1995-11-09 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1995-11-09 Publication of NO954506D0 publication Critical patent/NO954506D0/no

1996-01-10 Publication of NO954506L publication Critical patent/NO954506L/no

2002-12-09 Publication of NO313811B1 publication Critical patent/NO313811B1/no

Links

125000005456 glyceride group Chemical group 0.000 title claims abstract description 18
230000000699 topical effect Effects 0.000 title claims description 11
239000000463 material Substances 0.000 title abstract description 7
150000002334 glycols Chemical class 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title description 8
238000000034 method Methods 0.000 title description 3
239000008199 coating composition Substances 0.000 title 1
239000000203 mixture Substances 0.000 claims abstract description 61
238000009472 formulation Methods 0.000 claims abstract description 55
239000005660 Abamectin Substances 0.000 claims abstract description 40
-1 avermectin compound Chemical class 0.000 claims abstract description 35
241001465754 Metazoa Species 0.000 claims abstract description 17
244000079386 endoparasite Species 0.000 claims abstract description 12
244000078703 ectoparasite Species 0.000 claims abstract description 11
239000012049 topical pharmaceutical composition Substances 0.000 claims abstract description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
238000011282 treatment Methods 0.000 claims description 17
229910052739 hydrogen Inorganic materials 0.000 claims description 12
239000001257 hydrogen Substances 0.000 claims description 12
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 12
239000003963 antioxidant agent Substances 0.000 claims description 11
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 10
125000000217 alkyl group Chemical group 0.000 claims description 10
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 9
230000003078 antioxidant effect Effects 0.000 claims description 8
125000004432 carbon atom Chemical group C* 0.000 claims description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
239000002904 solvent Substances 0.000 claims description 7
239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 6
150000002431 hydrogen Chemical class 0.000 claims description 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
229960002446 octanoic acid Drugs 0.000 claims description 6
OVYMWJFNQQOJBU-UHFFFAOYSA-N 1-octanoyloxypropan-2-yl octanoate Chemical compound CCCCCCCC(=O)OCC(C)OC(=O)CCCCCCC OVYMWJFNQQOJBU-UHFFFAOYSA-N 0.000 claims description 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
229940074076 glycerol formal Drugs 0.000 claims description 3
PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims description 3
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
229920000053 polysorbate 80 Polymers 0.000 claims description 3
LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 3
206010061217 Infestation Diseases 0.000 claims description 2
125000003342 alkenyl group Chemical group 0.000 claims description 2
125000000753 cycloalkyl group Chemical group 0.000 claims description 2
NFOQRIXSEYVCJP-UHFFFAOYSA-N 2-propoxycarbonylbenzoic acid Chemical compound CCCOC(=O)C1=CC=CC=C1C(O)=O NFOQRIXSEYVCJP-UHFFFAOYSA-N 0.000 claims 1
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims 1
230000003071 parasitic effect Effects 0.000 claims 1
RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 abstract description 23
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract description 22
150000001875 compounds Chemical class 0.000 abstract description 22
235000013336 milk Nutrition 0.000 abstract description 15
239000008267 milk Substances 0.000 abstract description 15
210000004080 milk Anatomy 0.000 abstract description 15
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract description 12
235000013365 dairy product Nutrition 0.000 abstract description 6
239000004480 active ingredient Substances 0.000 abstract description 3
241000238876 Acari Species 0.000 description 9
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
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NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 7
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KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
239000000654 additive Substances 0.000 description 6
239000000969 carrier Substances 0.000 description 6
230000014759 maintenance of location Effects 0.000 description 6
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CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 5
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CWGATOJEFAKFBK-UHFFFAOYSA-N Ac-(E)-8-Tridecen-1-ol Natural products C1C(O)C(C)C(C(C)CC)OC11OC(CC=C(C)C(OC2OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C2)C(C)C=CC=C2C3(C(C(=O)O4)C=C(C)C(O)C3OC2)O)CC4C1 CWGATOJEFAKFBK-UHFFFAOYSA-N 0.000 description 4
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ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 4
ZPAKHHSWIYDSBJ-QDXJZMFISA-N avermectin b2 Chemical compound O1C(C)C(O)C(OC)CC1OC1C(OC)CC(O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)C(O)C4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)OC1C ZPAKHHSWIYDSBJ-QDXJZMFISA-N 0.000 description 4
PWEOPMBMTXREGV-UHFFFAOYSA-N decanoic acid;octanoic acid;propane-1,2-diol Chemical compound CC(O)CO.CCCCCCCC(O)=O.CCCCCCCC(O)=O.CCCCCCCCCC(O)=O.CCCCCCCCCC(O)=O PWEOPMBMTXREGV-UHFFFAOYSA-N 0.000 description 4
239000004615 ingredient Substances 0.000 description 4
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 4
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 4
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
230000000996 additive effect Effects 0.000 description 3
GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 3
239000003814 drug Substances 0.000 description 3
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 description 3
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ZLBGSRMUSVULIE-GSMJGMFJSA-N milbemycin A3 Chemical class O1[C@H](C)[C@@H](C)CC[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 ZLBGSRMUSVULIE-GSMJGMFJSA-N 0.000 description 3
238000002156 mixing Methods 0.000 description 3
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125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
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102000004169 proteins and genes Human genes 0.000 description 2
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229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
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239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
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241001489151 Trichuris Species 0.000 description 1
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125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
150000001252 acrylic acid derivatives Chemical class 0.000 description 1
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125000005236 alkanoylamino group Chemical group 0.000 description 1
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GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 description 1
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XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Zoology (AREA)
Agronomy & Crop Science (AREA)
Dermatology (AREA)
Engineering & Computer Science (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Pest Control & Pesticides (AREA)
Environmental Sciences (AREA)
Plant Pathology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Compositions Of Macromolecular Compounds (AREA)
Cosmetics (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)

NO19954506A 1993-05-10 1995-11-09 Topiske pÕhelningsformuleringer inneholdende polymert materiale, glycoler og glycerider, og fremgangsmÕte forfremstilling derav NO313811B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US5978793A	1993-05-10	1993-05-10
US5969993A	1993-05-10	1993-05-10
PCT/US1994/004664 WO1994026113A2 (en)	1993-05-10	1994-04-28	Pour-on formulations containinng polymeric material, glycols and glycerides

Publications (3)

Publication Number	Publication Date
NO954506D0 NO954506D0 (no)	1995-11-09
NO954506L NO954506L (no)	1996-01-10
NO313811B1 true NO313811B1 (no)	2002-12-09

Family

ID=26739072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19954506A NO313811B1 (no)	1993-05-10	1995-11-09	Topiske pÕhelningsformuleringer inneholdende polymert materiale, glycoler og glycerider, og fremgangsmÕte forfremstilling derav

Country Status (30)

Country	Link
EP (1)	EP0697814B1 (pt)
JP (1)	JP3001113B2 (pt)
KR (1)	KR0169559B1 (pt)
CN (2)	CN1069169C (pt)
AT (1)	ATE245900T1 (pt)
AU (2)	AU684515C (pt)
BG (1)	BG63376B1 (pt)
BR (1)	BR9406594A (pt)
CA (1)	CA2161703C (pt)
CY (1)	CY2376B1 (pt)
CZ (1)	CZ290726B6 (pt)
DE (1)	DE69432982T2 (pt)
DK (1)	DK0697814T3 (pt)
ES (1)	ES2202324T3 (pt)
FI (1)	FI117371B (pt)
HR (1)	HRP940290B1 (pt)
HU (1)	HU223088B1 (pt)
IL (1)	IL109534A (pt)
LV (1)	LV13220B (pt)
NO (1)	NO313811B1 (pt)
NZ (2)	NZ286586A (pt)
PL (1)	PL173487B1 (pt)
PT (1)	PT697814E (pt)
RO (1)	RO115102B1 (pt)
RU (1)	RU2124290C1 (pt)
SI (1)	SI9420028A (pt)
SK (1)	SK281301B6 (pt)
TW (1)	TW264386B (pt)
UA (1)	UA43335C2 (pt)
WO (1)	WO1994026113A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU764482B2 (en) *	1993-05-10	2003-08-21	Merck Sharp & Dohme Corp.	Pour-on formulations containing polymeric material, glycols and glycerides
AU728221B2 (en)	1996-06-05	2001-01-04	Ashmont Holdings Limited	Injectable compositions
FR2753377B1 (fr) *	1996-09-19	1999-09-24	Rhone Merieux	Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides
GB9825402D0 (en) *	1998-11-19	1999-01-13	Pfizer Ltd	Antiparasitic formulations
AUPQ441699A0 (en) *	1999-12-02	2000-01-06	Eli Lilly And Company	Pour-on formulations
KR20040045440A (ko)	2001-09-17	2004-06-01	일라이 릴리 앤드 캄파니	농약 배합물
JP2003095813A (ja) *	2001-09-25	2003-04-03	Sumika Life Tech Co Ltd	動物の外部寄生虫駆除用液剤
KR100600402B1 (ko) *	2002-05-22	2006-07-14	주식회사 엘지생명과학	피부 도포용 이버멕틴 조성물 및 그 제조방법
JP4728808B2 (ja) *	2003-10-17	2011-07-20	サンケイ化学株式会社	殺虫剤
GB0501220D0 (en) *	2005-01-21	2005-03-02	Norbrook Lab Ltd	Anthelmintic composition
NZ552040A (en) *	2006-12-13	2009-04-30	Bomac Research Ltd	Veterinary formulation comprising an anthelmintic compound and glyceryl acetate
GB0804619D0 (en) *	2008-03-12	2008-04-16	Norbrook Lab Ltd	A topical ectoparasiticide composition
EP2416663A2 (en)	2009-03-18	2012-02-15	Martin Benedict George Donnelly	Parasiticidal formulation
TW201041508A (en) *	2009-04-30	2010-12-01	Dow Agrosciences Llc	Pesticide compositions exhibiting enhanced activity
TW201041509A (en) *	2009-04-30	2010-12-01	Dow Agrosciences Llc	Pesticide compositions exhibiting enhanced activity
TW201041507A (en)	2009-04-30	2010-12-01	Dow Agrosciences Llc	Pesticide compositions exhibiting enhanced activity and methods for preparing same
EP2844225B1 (en) *	2012-05-03	2019-01-09	Norbrook Laboratories Limited	Avermectin pour-on formulation with reduced withdrawal time
WO2019054967A2 (en) *	2017-03-15	2019-03-21	Verano Ilac Sanayi Ve Ticaret Anonim Sirketi	VETERINARY COMPOSITION TO BE POURED COMPRISING EPRINOMECTIN
CN113563395B (zh) *	2021-08-09	2023-06-02	河北威远生物化工有限公司	一种阿维菌素b2衍生物及其制备方法和应用

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ197796A (en) *	1980-08-04	1984-11-09	Merck & Co Inc	Stabilised aqueous formulations containing ivermectin
DE3041814A1 (de) *	1980-11-06	1982-06-03	Bayer Ag, 5090 Leverkusen	Formulierung zur bekaempfung von tierischen ektoparasiten, insbesondere insekten und acarinen
GB8304927D0 (en) *	1983-02-22	1983-03-23	Wellcome Found	Pesticidal formulations
NZ208992A (en) *	1983-08-12	1987-03-06	Ici Australia Ltd	Endoparasiticidal compositions for topical administration,containing ether or glycol carboxylate ester
NZ209100A (en) *	1983-08-22	1987-01-23	Ici Australia Ltd	Topical compositions for control of endoparasites
NZ210505A (en) *	1983-12-22	1988-06-30	Merck & Co Inc	Parasiticidal compositions containing avermectin or milbemycin derivatives
US4587247A (en) *	1985-02-25	1986-05-06	Merck & Co., Inc.	Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use
FR2599220A1 (fr) *	1986-05-29	1987-12-04	Aerosols Ste Mediterraneenne	Nouvelle composition parasiticide a effet prolonge pour la prevention ou le traitement externe de l'homme et des animaux a sang chaud.
GB8613914D0 (en) *	1986-06-07	1986-07-09	Coopers Animal Health	Liquid formulations
GB8803836D0 (en) *	1988-02-18	1988-03-16	Glaxo Group Ltd	Compositions
EP0432494B1 (en) *	1989-12-15	1997-02-05	American Cyanamid Company	Pour-on formulations effective for the control of internal and external parasites of homothermic animals

1994
- 1994-04-28 ES ES94917274T patent/ES2202324T3/es not_active Expired - Lifetime
- 1994-04-28 NZ NZ286586A patent/NZ286586A/en not_active IP Right Cessation
- 1994-04-28 NZ NZ266924A patent/NZ266924A/en not_active IP Right Cessation
- 1994-04-28 RO RO95-01950A patent/RO115102B1/ro unknown
- 1994-04-28 AU AU69042/94A patent/AU684515C/en not_active Expired
- 1994-04-28 CA CA002161703A patent/CA2161703C/en not_active Expired - Lifetime
- 1994-04-28 DE DE69432982T patent/DE69432982T2/de not_active Expired - Lifetime
- 1994-04-28 PT PT94917274T patent/PT697814E/pt unknown
- 1994-04-28 HU HU9503214A patent/HU223088B1/hu active IP Right Grant
- 1994-04-28 UA UA95114803A patent/UA43335C2/uk unknown
- 1994-04-28 SI SI9420028A patent/SI9420028A/sl not_active IP Right Cessation
- 1994-04-28 BR BR9406594A patent/BR9406594A/pt not_active Application Discontinuation
- 1994-04-28 AT AT94917274T patent/ATE245900T1/de active
- 1994-04-28 KR KR1019950704969A patent/KR0169559B1/ko not_active IP Right Cessation
- 1994-04-28 RU RU95122691A patent/RU2124290C1/ru active
- 1994-04-28 CN CN94192050A patent/CN1069169C/zh not_active Expired - Lifetime
- 1994-04-28 PL PL94311637A patent/PL173487B1/pl unknown
- 1994-04-28 JP JP6525472A patent/JP3001113B2/ja not_active Expired - Lifetime
- 1994-04-28 CZ CZ19952965A patent/CZ290726B6/cs not_active IP Right Cessation
- 1994-04-28 SK SK1362-95A patent/SK281301B6/sk not_active IP Right Cessation
- 1994-04-28 WO PCT/US1994/004664 patent/WO1994026113A2/en active IP Right Grant
- 1994-04-28 DK DK94917274T patent/DK0697814T3/da active
- 1994-04-28 EP EP94917274A patent/EP0697814B1/en not_active Expired - Lifetime
- 1994-05-03 IL IL10953494A patent/IL109534A/xx not_active IP Right Cessation
- 1994-05-04 TW TW083104051A patent/TW264386B/zh not_active IP Right Cessation
- 1994-05-09 HR HR940290A patent/HRP940290B1/xx not_active IP Right Cessation
1995
- 1995-11-02 BG BG100113A patent/BG63376B1/bg unknown
- 1995-11-09 FI FI955403A patent/FI117371B/fi not_active IP Right Cessation
- 1995-11-09 NO NO19954506A patent/NO313811B1/no not_active IP Right Cessation
1998
- 1998-03-18 AU AU59383/98A patent/AU5938398A/en not_active Abandoned
2000
- 2000-11-23 CN CNB001283626A patent/CN1205929C/zh not_active Expired - Lifetime
2003
- 2003-09-09 CY CY0300061A patent/CY2376B1/xx unknown
2004
- 2004-06-21 LV LVP-04-70A patent/LV13220B/en unknown

Also Published As

Publication number	Publication date
IL109534A0 (en)	1994-08-26
CN1122565A (zh)	1996-05-15
DK0697814T3 (da)	2003-10-27
HRP940290A2 (en)	1996-08-31
LV13220B (en)	2005-03-20
CZ296595A3 (en)	1996-10-16
NZ266924A (en)	1997-09-22
FI955403A0 (fi)	1995-11-09
CY2376B1 (en)	2004-06-04
AU5938398A (en)	1998-05-21
CN1069169C (zh)	2001-08-08
SK281301B6 (sk)	2001-02-12
HU223088B1 (hu)	2004-03-29
TW264386B (pt)	1995-12-01
EP0697814B1 (en)	2003-07-30
JP3001113B2 (ja)	2000-01-24
IL109534A (en)	1999-11-30
SI9420028A (en)	1996-06-30
WO1994026113A2 (en)	1994-11-24
BG100113A (bg)	1996-04-30
CA2161703C (en)	2000-02-01
FI117371B (fi)	2006-09-29
AU684515C (en)	2002-03-28
DE69432982T2 (de)	2004-04-15
WO1994026113A3 (en)	1995-03-30
CA2161703A1 (en)	1994-11-24
HUT74308A (en)	1996-12-30
AU6904294A (en)	1994-12-12
ATE245900T1 (de)	2003-08-15
JPH08509981A (ja)	1996-10-22
FI955403A (fi)	1995-11-09
NZ286586A (en)	1997-10-24
RO115102B1 (ro)	1999-11-30
ES2202324T3 (es)	2004-04-01
CZ290726B6 (cs)	2002-10-16
AU684515B2 (en)	1997-12-18
PL173487B1 (pl)	1998-03-31
EP0697814A1 (en)	1996-02-28
CN1335131A (zh)	2002-02-13
HRP940290B1 (en)	2005-04-30
PL311637A1 (en)	1996-03-04
NO954506D0 (no)	1995-11-09
NO954506L (no)	1996-01-10
KR0169559B1 (ko)	1999-01-15
PT697814E (pt)	2003-11-28
RU2124290C1 (ru)	1999-01-10
UA43335C2 (uk)	2001-12-17
HU9503214D0 (en)	1996-01-29
CN1205929C (zh)	2005-06-15
SK136295A3 (en)	1996-05-08
BG63376B1 (bg)	2001-12-29
BR9406594A (pt)	1996-01-02
DE69432982D1 (de)	2003-09-04

Legal Events

Date	Code	Title	Description
2014-05-05	MK1K	Patent expired

Publication	Publication Date	Title
NO313811B1 (no)	2002-12-09	Topiske pÕhelningsformuleringer inneholdende polymert materiale, glycoler og glycerider, og fremgangsmÕte forfremstilling derav
EP1887866B1 (en)	2017-12-06	Spot-on formulations for combating parasites
MXPA03008905A (es)	2005-10-05	Composicion antihelmintica e inyectable mejoradora de crecimiento.
EA038168B1 (ru)	2021-07-19	Способ отпугивания эктопаразита от животного
EP1435786A1 (en)	2004-07-14	Pesticidal formulations
AU2001291478A1 (en)	2003-06-05	Pesticidal formulations
NZ510538A (en)	2002-06-28	Sustained-release macrolide compositions for parenteral administration including a low HLB surfactant for treating parasite infections
JP2003520779A (ja)	2003-07-08	局所用有機外部寄生虫駆除製剤
US5516761A (en)	1996-05-14	Pour-on formulations containing polymeric material
US20030040494A1 (en)	2003-02-27	Application of water and organic solvent soluble invermectin for topical and oral use
CA2267617C (en)	2000-04-11	Topical formulations containing polymeric material
AU764482B2 (en)	2003-08-21	Pour-on formulations containing polymeric material, glycols and glycerides
CN115317498B (zh)	2023-12-19	一种治疗犬猫寄生虫和真菌皮肤病的复方滴剂及制备方法
EP3595441B1 (en)	2023-08-02	Stable topical veterinary composition
GB2275193A (en)	1994-08-24	Formulations for the topical delivery of avermectins