NO20064347L - Substituerte 1,2,3,4-tetrahydroisokinolinderivater - Google Patents
Substituerte 1,2,3,4-tetrahydroisokinolinderivaterInfo
- Publication number
- NO20064347L NO20064347L NO20064347A NO20064347A NO20064347L NO 20064347 L NO20064347 L NO 20064347L NO 20064347 A NO20064347 A NO 20064347A NO 20064347 A NO20064347 A NO 20064347A NO 20064347 L NO20064347 L NO 20064347L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- tetrahydroisoquinoline derivatives
- compounds
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
Oppfinnelsen angår hittil ukjente 1,2,3,4-tetrahydroisokinolinderivater og deres anvendelse som aktive ingredienser i fremstillingen av farmasøytiske preparater. Oppfinnelsen angår også relaterte aspekter, herunder fremgangsmåter for fremstillingen av forbindelsene, farmasøytiske preparater inneholdende en eller fiere av disse forbindelser, og behandlingsmetoder omfattende adminisfrasjon av forbindelsene til et pattedyr.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2004002020 | 2004-03-01 | ||
PCT/EP2005/001879 WO2005118548A1 (en) | 2004-03-01 | 2005-02-23 | Substituted 1,2,3,4-tetrahydroisoquinoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20064347L true NO20064347L (no) | 2006-09-26 |
NO337299B1 NO337299B1 (no) | 2016-03-07 |
Family
ID=34960649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20064347A NO337299B1 (no) | 2004-03-01 | 2006-09-26 | Et substituert 1,2,3,4-tetrahydroisokinolinderivat og anvendelse derav som legemiddel |
Country Status (24)
Country | Link |
---|---|
US (2) | US7763638B2 (no) |
EP (1) | EP1751111B1 (no) |
JP (1) | JP4094050B2 (no) |
KR (1) | KR100848747B1 (no) |
CN (1) | CN1926109B (no) |
AR (1) | AR047823A1 (no) |
AU (1) | AU2005250077B2 (no) |
BR (1) | BRPI0508263B8 (no) |
CA (1) | CA2557163C (no) |
CY (1) | CY1116103T1 (no) |
DK (1) | DK1751111T3 (no) |
ES (1) | ES2533389T3 (no) |
HR (1) | HRP20150371T1 (no) |
IL (1) | IL177798A (no) |
MY (1) | MY144992A (no) |
NO (1) | NO337299B1 (no) |
NZ (1) | NZ550216A (no) |
PL (1) | PL1751111T3 (no) |
PT (1) | PT1751111E (no) |
RU (1) | RU2378257C2 (no) |
SI (1) | SI1751111T1 (no) |
TW (1) | TWI301129B (no) |
WO (1) | WO2005118548A1 (no) |
ZA (1) | ZA200606974B (no) |
Families Citing this family (69)
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SI1751111T1 (sl) * | 2004-03-01 | 2015-04-30 | Actelion Pharmaceuticals Ltd. | Substituirani 1,2,3,4-tetrahidroizokinolinski derivati |
MX2008011647A (es) | 2006-03-15 | 2008-09-22 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroisoquinolina para mejorar la funcion de la memoria. |
US8003654B2 (en) | 2006-04-11 | 2011-08-23 | Actelion Pharmaceuticals Ltd. | N-glycinsulfonamide derivatives and uses as orexin receptor antagonists |
WO2007122591A2 (en) * | 2006-04-26 | 2007-11-01 | Actelion Pharmaceuticals Ltd | Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists |
WO2008008517A2 (en) | 2006-07-14 | 2008-01-17 | Merck & Co., Inc. | Bridged diazepan orexin receptor antagonists |
PE20081229A1 (es) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
EP2125823B1 (en) | 2006-12-22 | 2012-02-15 | Actelion Pharmaceuticals Ltd. | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives |
CL2007003827A1 (es) * | 2006-12-28 | 2008-09-26 | Actelion Pharmaceuticals Ltd | Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras. |
WO2008122513A1 (en) | 2007-04-04 | 2008-10-16 | F. Hoffmann-La Roche Ag | Heterocycles as orexin antagonists |
EP2150114A4 (en) | 2007-05-18 | 2012-01-18 | Merck Sharp & Dohme | OXO-BRIDGED DIAZEPANOREXINE RECEPTOR ANTAGONISTS |
WO2008150364A1 (en) | 2007-05-23 | 2008-12-11 | Merck & Co., Inc. | Cyclopropyl pyrrolidine orexin receptor antagonists |
RU2470021C2 (ru) | 2007-05-23 | 2012-12-20 | Мерк Шарп Энд Домэ Корп. | Пиридилпиперидиновые антагонисты рецептора орексинов |
CZ302135B6 (cs) * | 2007-07-09 | 2010-11-10 | Zentiva, A. S. | Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu) |
PE20091010A1 (es) | 2007-10-10 | 2009-08-08 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroquinolina |
JP5100298B2 (ja) * | 2007-10-11 | 2012-12-19 | 株式会社トクヤマ | 光学活性α−スルホニルオキシカルボン酸アミド誘導体及びその製造方法 |
WO2009079637A1 (en) * | 2007-12-18 | 2009-06-25 | Concert Pharmaceuticals, Inc. | Tetrahydroisoquinoline derivatives |
JP5829399B2 (ja) * | 2007-12-28 | 2015-12-09 | アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd | 3置換3,4−ジヒドロ−1h−イソキノリン化合物、その製造方法及びその使用 |
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MX2010013192A (es) | 2008-06-16 | 2010-12-17 | Hoffmann La Roche | Monoamidas heteroaromaticas como antagonistas de receptor orexinina. |
CA2726834A1 (en) * | 2008-06-25 | 2009-12-30 | Actelion Pharmaceuticals Ltd | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds |
CN101402643B (zh) * | 2008-11-11 | 2012-11-28 | 上海现代制药股份有限公司 | 一种适于工业生产的普拉格雷的制备方法 |
EA201170741A1 (ru) | 2008-12-02 | 2011-12-30 | Глэксо Груп Лимитед | Производные n-{[(1r,4s,6r)-3-(2-пиридинилкарбонил)-3-азабицикло[4.1.0]гепт-4-ил]метил}-2-гетероариламина и их применения |
WO2010064212A1 (en) | 2008-12-05 | 2010-06-10 | Actelion Pharmaceuticals Ltd | Method for obtaining an optically pure 1,2,3,4 tetrahydro-isoquinoline derivative |
GB0823467D0 (en) | 2008-12-23 | 2009-01-28 | Glaxo Group Ltd | Novel Compounds |
WO2010095106A1 (en) | 2009-02-20 | 2010-08-26 | Actelion Pharmaceuticals Ltd | Solid forms of ( 2r) -2- { ( is ) -6, 7 -dimethoxy- 1- [2- (4-triflu0r0methyl-phenyl) -ethyl] -3, 4-dihydr0-1h -isoquinolin-2-yl} -n-methyl-2-phenyl-acetamide hydrochloride |
AU2010240871A1 (en) | 2009-04-24 | 2011-10-27 | Glaxo Group Limited | 3 -azabicyclo [4.1.0] heptanes used as orexin antagonists |
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EP2451281A4 (en) * | 2009-07-09 | 2013-03-13 | Merck Sharp & Dohme | ANTAGONISTS OF OREXIN RECEPTORS BASED ON TETRAHYDRONAPHTHYRIDINE |
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